Multi-million pound trial to investigate if statins could become MS treatment 

09/05/2017 00:00 
A phase 3 trial involving more than 1,000 people with multiple sclerosis (MS) is to investigate whether simvastatin could become a treatment for the condition.

The project is led by UCLH consultant Jeremy Chataway and will cost almost £6 million. It is being funded by collaboration between the National Institute for Health Research (NIHR), the MS Society (UK), the National MS Society (US), the NHS and UK universities.

The trial will test simvastatin, a cheap cholesterol lowering drug, in people with the secondary progressive form of MS. There are currently no licensed treatments that can slow or stop disability progression in people with this type of MS.

Dr Chataway, who is supported by the UCLH NIHR BRC, previously led the phase 2 trial into simvastatin that was published in The Lancet in 2014. It involved 140 people with secondary progressive MS. The research found those taking high doses of the drug had a significant reduction in the rate of brain atrophy (brain shrinkage) over two years and also had better disability scores at the end of study.

He said: “This drug holds incredible promise for the thousands of people living with secondary progressive MS in the UK, and around the world, who currently have few options for treatments that have an effect on disability.

“This study will establish definitively whether simvastatin is able to slow the rate of disability progression over a three year period, and we are very hopeful it will.”

More than 100,000 people in the UK are living with MS, which attacks the nervous system. It is often painful and exhausting and can cause problems with how we walk, move, see, think and feel. The condition is unpredictable and different for everyone.

The simvastatin trial will involve 1180 people with secondary progressive MS at almost 30 centres across the UK. It will take six years to complete, with the first people receiving medication later this year.

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