Dr Doreen Fialho

Tel: 020 3448 4752
Email: UCLH.Neurophysiology@nhs.net

National Hospital for Neurology and Neurosurgery


Professional background

I completed my medical degree at the Ernst-Moritz-Arndt University in Greifswald, Germany, in 1996 (state exam) and undertook my post-graduate training in the UK. I obtained a PhD in skeletal muscle channelopathies at UCL in 2009. I gained my CCT in Clinical Neurophysiology in 2010. I was elected FRCP in 2016. Since May 2010 I have been a Consultant in Clinical Neurophysiology. At the National Hospital for Neurology and Neurosurgery I am part of the skeletal muscle channelopathy team funded centrally via the highly specialised commissioned services and I provide electrophysiological evaluation of patients with these rare conditions.

Research interests

Neuromuscular disorders, skeletal muscle channelopathies.


Since 2010:

  • 1: Fialho D, Griggs RC, Matthews E. Periodic paralysis. Handb Clin Neurol.
    2018;148:505-520. PubMed PMID: 29478596.
  • 2: Matthews E, Neuwirth C, Jaffer F, Scalco RS, Fialho D, Parton M, Raja Rayan D,
    Suetterlin K, Sud R, Spiegel R, Mein R, Houlden H, Schaefer A, Healy E, Palace J,
    Quinlivan R, Treves S, Holton JL, Jungbluth H, Hanna MG. Atypical periodic
    paralysis and myalgia: A novel RYR1 phenotype. Neurology. 2018 Jan
    30;90(5):e412-e418. PubMed PMID: 29298851; PubMed Central PMCID: PMC5791790.
  • 3: McClelland VM, Fialho D, Flexney-Briscoe D, Holder GE, Elze MC, Gimeno H,
    Siddiqui A, Mills K, Selway R, Lin JP. Somatosensory Evoked Potentials and
    Central Motor Conduction Times in children with dystonia and their correlation
    with outcomes from Deep Brain Stimulation of the Globus pallidus internus. Clin
    Neurophysiol. 2017 Nov 24. pii: S1388-2457(17)31164-1. PubMed PMID: 29254860; PubMed
    Central PMCID: PMC5786451.
  • 4: Scalco RS, Gardiner AR, Pitceathly RD, Hilton-Jones D, Schapira AH, Turner C,
    Parton M, Desikan M, Barresi R, Marsh J, Manzur AY, Childs AM, Feng L, Murphy E,
    Lamont PJ, Ravenscroft G, Wallefeld W, Davis MR, Laing NG, Holton JL, Fialho D,
    Bushby K, Hanna MG, Phadke R, Jungbluth H, Houlden H, Quinlivan R. CAV3 mutations
    causing exercise intolerance, myalgia and rhabdomyolysis: Expanding the
    phenotypic spectrum of caveolinopathies. Neuromuscul Disord. 2016
    Aug;26(8):504-10. PubMed PMID: 27312022.
  • 5: Suetterlin KJ, Bugiardini E, Kaski JP, Morrow JM, Matthews E, Hanna MG, Fialho
    D. Long-term Safety and Efficacy of Mexiletine for Patients With Skeletal Muscle
    Channelopathies. JAMA Neurol. 2015 Dec;72(12):1531-3. PubMed PMID: 26658970.
  • 6: Spillane J, Fialho D, Hanna MG. Diagnosis of skeletal muscle channelopathies.
    Expert Opin Med Diagn. 2013 Nov;7(6):517-29. PubMed PMID: 24066928.
  • 7: Trivedi JR, Bundy B, Statland J, Salajegheh M, Rayan DR, Venance SL, Wang Y,
    Fialho D, Matthews E, Cleland J, Gorham N, Herbelin L, Cannon S, Amato A, Griggs
    RC, Hanna MG, Barohn RJ; CINCH Consortium. Non-dystrophic myotonia: prospective
    study of objective and patient reported outcomes. Brain. 2013 Jul;136(Pt
    7):2189-200. PubMed PMID: 23771340; PubMed Central PMCID: PMC3692030.
  • 8: Horga A, Raja Rayan DL, Matthews E, Sud R, Fialho D, Durran SC, Burge JA,
    Portaro S, Davis MB, Haworth A, Hanna MG. Prevalence study of genetically defined
    skeletal muscle channelopathies in England. Neurology. 2013 Apr 16;80(16):1472-5.
    PubMed PMID: 23516313; PubMed Central PMCID: PMC3662361.
  • 9: Raja Rayan DL, Haworth A, Sud R, Matthews E, Fialho D, Burge J, Portaro S,
    Schorge S, Tuin K, Lunt P, McEntagart M, Toscano A, Davis MB, Hanna MG. A new
    explanation for recessive myotonia congenita: exon deletions and duplications in
    CLCN1. Neurology. 2012 Jun 12;78(24):1953-8. Epub 2012 May 30. PubMed PMID: 22649220; PubMed Central PMCID: PMC3369509.
  • 10: Tan SV, Matthews E, Barber M, Burge JA, Rajakulendran S, Fialho D, Sud R,
    Haworth A, Koltzenburg M, Hanna MG. Refined exercise testing can aid DNA-based
    diagnosis in muscle channelopathies. Ann Neurol. 2011 Feb;69(2):328-40. PubMed PMID: 21387378; PubMed Central PMCID: PMC3051421.
  • 11: Matthews E, Fialho D, Tan SV, Venance SL, Cannon SC, Sternberg D, Fontaine B,
    Amato AA, Barohn RJ, Griggs RC, Hanna MG; CINCH Investigators. The non-dystrophic
    myotonias: molecular pathogenesis, diagnosis and treatment. Brain. 2010
    Jan;133(Pt 1):9-22. PubMed PMID: 19917643; PubMed Central PMCID: PMC2801326.

GMC/GDC number: 4556093