Dr Anton Emmanuel

Dr Anton EmmanuelTel: 020 3447 9130
Fax: 020 3447 9218
Email: a.emmanuel@ucl.ac.uk

Location:
University College Hospital; National Hospital for Neurology and Neurosurgery

Specialities:
Colorectal service, Gastrointestinal services

Professional background

Anton Emmanuel obtained his medical degree from London University. He is a Senior Lecturer in Neuro-Gastroenterology at University College London and Consultant Gastroenterologist at University College Hospital and the National Hospital for Neurology and Neurosurgery (Queen Square). Prior to this he was Senior Lecturer at Imperial College and Honorary Consultant Gastroenterologist at St Mark's Hospital.

His clinical work encompasses being director of the GI Physiology Unit at University College Hospital as well as providing a general gastroenterology service. His research includes basic gut neurophysiology and the study of the aetiology and management of functional gastrointestinal disorders of the upper and lower gut. He currently supervises 7 post-graduate research fellows undertaking higher degrees. Laboratory work is undertaken jointly with colleagues in UCL. He is the Chairman of the NeuroGastroenterology section of the British Society of Gastroenterology. He is the Editor of the journal Frontline Gastroenterology.

Patients are assessed within a multi-disciplinary environment, with structural and physiological investigations undertaken as a one-stop visit alongside a focussed clinical assessment. The Unit is always happy to discuss cases by phone in order to streamline referral for the patient.

Research interests

Research and clinical areas of interest :

  • IBS and chronic constipation
  • Pelvic floor dysfunction and pain
  • Faecal incontinence
  • Gastro-oesophageal reflux and reflux-induced ENT and chest symptoms;
  • Gastroparesis
  • Appetite control and obesity
  • Chronic intestinal pseudo-obstruction
  • Gut dysfunction in systemic sclerosis
  • Gut dysfunction in spinal cord injury and multiple sclerosis
  • Colorectal sequelae of radiotherapy
  • Colorectal effects of endometriosis
  • Gut-focussed hypnotherapy and biofeedback

Publications

Thoua N, Raeburn A, Denton CP, Emmanuel A. Faecal incontinence in systemic sclerosis is secondary to neuropathy. Am J Gastroenterol (in press)
Emmanuel AV, Kamm MA, Roy AJ, Kerstens R, Vandeplassche L. Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction – a double-blind, placebo-controlled, cross-over, multiple n=1 study. Alimentary Pharmacology and Therapeutics (in press)
Preziosi G, Raptis DA, Storrie J, Raeburn A, Fowler CJ, Emmanuel A. Bowel biofeedback treatment in patients with multiple sclerosis and bowel symptoms. Dis Colon Rectum. 2011 Sep;54(9):1114-21.
Thoua N, Schizas A, Forbes A, Denton CP, Emmanuel AV.  Internal anal sphincter atrophy in patients with Systemic Sclerosis. Rheumatology 2011 Sep;50(9):1596-602.

Schizas AM, Emmanuel AV, Williams AB. Vector volume manometry--methods and normal values. Neurogastroenterol Motil. 2011 Sep;23(9):886-e393

Abdel-Halim M, Crosbie J, Cohen CRG, Emmanuel AV. Temporary Sacral Nerve Stimulation Alters Rectal Sensory Function: A Physiological Study. Diseases Colon Rectum 2011 Sep;54(9):1134-40.

Schizas AM, Emmanuel AV, Williams AB. Anal canal vector volume manometry. Dis Colon Rectum. 2011 Jun;54(6):759-68.

Emmanuel A. Current management strategies and therapeutic targets in chronic constipation. Therap Adv Gastroenterol. 2011 Jan;4(1):37-48

Bajwa, A., Thiruppathy, K., Trivedi, P., Boulos, P., Emmanuel, A. (2010). Effect of rectal distension on voluntary external anal sphincter function in healthy subjects. Colorectal Dis 2011;13(10):1173-9

Emmanuel, A. (2010). Managing neurogenic bowel dysfunction. Clin Rehabil 24, 483-488

Emmanuel, A. (2010). Review of the efficacy and safety of trans-anal irrigation for neurogenic bowel dysfunction. Spinal Cord 48, 664-673

Thoua, N., Bunce, C., Brough, G., Forbes, A., Emmanuel, A., Denton, C. (2010). Assessment of gastrointestinal symptoms in patients with systemic sclerosis in a UK tertiary referral centre. Rheumatol (Oxford) 49, 1770-1775

Bajwa, A., Emmanuel, A. (2009). The physiology of continence and evacuation.. Best Practice and Research Clinical Gastroenterology 23(4), 477-485

Chatoor, D., Soligo, M., Emmanuel, A. (2009). Organising a clinical service for patients with pelvic floor disorders.. Best Pract Res Clin Gastroenterol 23, 611-620

Emmanuel, A. V., Chung, E. A., Kamm, M. A., Middleton, F. (2009). Relationship between gut-specific autonomic testing and bowel dysfunction in spinal cord injury patients.. Spinal Cord 47(8), 623-627

Emmanuel, A., Chatoor, D. (2009). Common proctology scenarios.. Best Practice and Research Clinical Gastroenterology 23(4), 461-461

Emmanuel, A., Tack, J., Quigley, E., Talley, N. (2009). Pharmacological management of constipation. Neurogastroenterol Motility 21(Suppl 2), 41-54

Preziosi, G., Emmanuel, A. (2009). Neurogenic bowel dysfunction: pathophysiology, clinical manifestations and treatment.. Expert Review of Gastroenterology and Hepatology 3(4), 417-423 

Thoua, N. M., Murray, C. D., Winchester, W. J., Roy, A. J., Pitcher, M. C., Kamm, M. A., Emmanuel, A. V. (2009). Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome. Alimentary Pharmacology and Therapeutics 29(5), 552-560 

Hart, A. L., Plamondon, S., Emmanuel, A. V., Kamm, M. A. (2008). Prospective evaluation of the relationship between stress and relapse in ulcerative colitis.. Journal of Clinical Gastroenterology 42(8), 963-964 

Murray, C. D., Le Roux, C. W., Emmanuel, A. V., Halket, J. M., Przyborowska, A. M., Kamm, M. A., Murray-lyon, I. M. (2008). The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion. Appetite 51(3), 747-750 

Thoua, N., Khoo, D., Kalantzis, C., Emmanuel, A. (2008). Acid-related oesophageal sensitivity, not dysmotility, differentiates subgroups of patients with non-erosive reflux disease. Aliment Pharmacol Ther 27, 396-403 

Chaliha, C., Sultan, A. H., Emmanuel, A. V. (2007). Normal ranges for anorectal manometry and sensation in women of reproductive age.. Colorectal Disease 9(9), 839-844 

Chatoor, D. R., Taylor, S. J., Cohen, C. R., Emmanuel, A. V. (2007). Faecal incontinence. Br.J.Surg. 94(2), 134-144 

Kamm, M. A., Jordan, C. C., Leaker, B. R., Nicholson, F. B., Murray, C. D., Taylor, S., Marshall, M., Gibbs, A., Carter, E. G., Emmanuel, A. V. (2007). Pharmacological modulation of gut mucosal and large vessel blood flow. Aliment.Pharmacol.Ther. 25(6), 693-702 

Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton,, L,, Hungin,, P,, Jones,, R,, Kumar,, D,, Rubin,, G,, Trudgill,, N,, Whorwell,, P, (2007). Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 56(12), 1770-1798 

Chung, E. A., Emmanuel, A. V. (2006). Gastrointestinal symptoms related to autonomic dysfunction following spinal cord injury.. Progress in Brain Research 152, 317-333 

Craggs, M. D., Balasubramaniam, A. V., Chung, E. A. L., Emmanuel, A. V. (2006). Aberrant reflexes and function of the pelvic organs following spinal injury in man.. Autonomic Neuroscience 126-127, 355-370 

Murray, C. D. R., Booth, C. E., Bulmer, D. C. E., Kamm, M. A., Emmanuel, A. V., Winchester, W. J. (2006). Ghrelin augments afferent response to distension in rat isolated jejunum.. Neurogastroenterology and Motility 18(12), 1112-1120 

Murray, C. D. R., Le Roux, C. W., Gouveia, C., Bassett, P., Ghatei, M. A., Bloom, S. R., Emmanuel, A. V., Gabe, S. M. (2006). The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients.. Clinical Nutrition 25(4), 626-633 

Soligo, M., Salvatore, S., Emmanuel, A. V., De Ponti, E., Zoccatelli, M., Cortese, M., Milani, R. (2006). Patterns of constipation in urogynecology: clinical importance and pathophysiologic insights.. American Journal of Obstetrics and Gynecology 195(1), 50-55 

Thoua, N., Emmanuel, A. V. (2006). Managing functional GI symptoms. Postgraduate Medical Journal 6(5), 449-452 

Hart, A. L., Al-hassi, H. O., Rigby, R. J., Bell, S. J., Emmanuel, A. V., Knight, S. C., Kamm, M. A., Stagg, A. J. (2005). Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 129(1), 150-165 

Murray, C. D., Martin, N. M., Patterson, M., Taylor, S. A., Ghatei, M. A., Kamm, M. A., Johnston, C., Bloom, S. R., Emmanuel, A. V. (2005). Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut 54(12), 1693-1698 

Emmanuel, A. V., Shand, A., Kamm, M. A. (2004). Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with positive response.. Alimentary Pharmacology and Therapeutics 19(6), 687-694 

Emmanuel, A. V., Stern, J., Traesure, J., Forbes, A., Kamm, M. A. (2004). Anorexia nervosa in gastrointestinal practice. European Journal of Gastroenterology and Hepatology 16(11), 1135-1142 

Jarrett, M. E., Emmanuel, A. V., Vaizey, C. J., Kamm, M. A. (2004). Behavioural therapy (biofeedback) for solitary rectal ulcer syndrome improves symptoms and mucosal blood flow.. Gut 53, 368-370

Murray, C. D., Emmanuel, A. (2004). Ghrelin and Helicobacter pylori. 53(2), 315-315 

Murray, C. D., Flynn, J., Ratcliffe, L., Jacyna, M. R., Kamm, M. A., Emmanuel, A. V. (2004). Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome.. Gastroenterology 127, 1695-1703

Rayner, C. K., Hart, A. L., Hayward, C. M., Emmanuel, A. V., Kamm, M. A. (2004). Azathioprine dose escalation in inflammatory bowel disease.. Alimentary Pharmacology and Therapeutics 20(1), 65-71 

Kenefick, N. J., Emmanuel, A., Nicholls, R. J., Kamm, M. A. (2003). Effect of sacral nerve stimulation on autonomic nerve function.. British Journal of Surgery 90(10), 1256-1260 

Murray, C. D., Kamm, M. A., Bloom, S. R., Emmanuel, A. V. (2003). Ghrelin for the gastroenterologist: history and potential. Gastroenterology 125(5), 1492-1502 

Murray, C., Kamm, M., Bloom, S., Emmanuel, A. (2003). Ghrelin for the gastroenterologist: history and potential. Gastroenterology 125, 1492-1502 

Rayner, C. K., Mccormack, G., Emmanuel, A. V., Kamm, M. A. (2003). Long-term results of low-dose intravenous ciclosporin for acute severe ulcerative colitis.. Alimentary Pharmacology and Therapeutics 18(3), 303-308 

Rutter, M., Saunders, B., Emmanuel, A., Price, A. (2003). Endoscopic snare polypectomy for bleeding postinflammatory polyps.. Endoscopy 35(9), 788-790 

Emmanuel, A. V., Roy, A. J., Nicholls, T. J., Kamm, M. A. (2002). Prucalopride, a systemic enterokinetic, for the treatment of constipation.. Alimentary Pharmacology and Therapeutics 16(7), 1347-1356 

Mimura, T., Emmanuel, A. V., Kamm, M. A. (2002). Pathophysiology of diverticular disease. Best Practice and Research Clinical Gastroenterology 16(4), 563-576 

Murray, C. D., Emmanuel, A. V. (2002). Medical management of diverticular disease. Best Practice and Research Clinical Gastroenterology 16(4), 611-620 

Van Den Bogaerde, J., Cahill, J., Emmanuel, A. V., Vaizey, C. J., Talbot, I. C., Knight, S. C., Kamm, M. A. (2002). Gut mucosal response to food antigens in Crohn’s disease. Alimentary Pharmacology and Therapeutics 16(11), 1903-1915 

Emmanuel, A. V., Kamm, M. A. (2001). Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation.. Gut 49, 209-213

Emmanuel, A. V., Mason, H. J., Kamm, M. A. (2001). Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder.. Gut 49, 214-219

Emmanuel, A. V., Kamm, M. A., Beard, R. W. (2000). A reproducible assessment of vaginal and rectal mucosal and skin blood flow: Laser Doppler fluximetry of pelvic microcirculation. Clinical Science (London) 98(2), 201-207 

Emmanuel, A., Kamm, M. A. (2000). Laser Doppler flowmetry as a measure of extrinsic colonic innervation in functional bowel disease. Gut 46(2), 212-217 

Roy, A. J., Emmanuel, A. V., Storrie, J. B., Bowers, J., Kamm, M. A. (2000). Behavioural treatment (biofeedback) for constipation following hysterectomy. British Journal of Surgery 87(1), 100-105 

Emmanuel, A. V., Kamm, M. A. (1999). Doppler measurement of rectal mucosal blood flow. Gut 46(2), 212-217 

Emmanuel, A. V., Kamm, M. A., Roy, A. J., Antonelli, K. (1998). Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.. Gut 42(4), 511-516 

Emmanuel, A., Kamm, M., Roy, A., Antonelli, K. (1998). Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.. Gut 42, 511-516 

Vaizey, C. J., Van Den Bogaerde, J. B., Emmanuel, A. V., Talbot, I. C., Nicholls, R. J., Kamm, M. A. (1998). Solitary Rectal Ulcer Syndrome. British Journal of Surgery 85(12), 1617-1623 

Vaizey, C., Bogaerde, J. V. D., Emmanuel, A., Talbot, I., Nicholls, J., Kamm, M. (1998). Solitary rectal ulcer syndrome. British J Surgery 85, 1617-1623