Dr David Brealey

Dr David BrealeyTel: 020 3447 3363
Fax: 020 3447 0380
Email: david.brealey@uclh.nhs.uk

Location:
University College Hospital

Specialities:
Critical care, Anaesthetics

Professional background

I qualified from University College London Medical School in 1994 and initially started a career in medicine before becoming interested in critical care. I joined the Bloomsbury Institute of Intensive Care Medicine as Clinical Lecturer in 1998 and was a key member of the team that altered the understanding of oxygen utilisation in critical illness. I have published widely in the area and these findings formed the basis for my PhD. During this time I was also involved in a number of other clinical trials, translational and basic science projects. In 2003 I joined the North Central London School of Anaesthesia training programme completing advanced training in both Intensive Care Medicine and Neuroanaesthesia. Following completion of the programme I joined the departments of anaesthesia and critical care at UCH as a consultant in 2010. I am currently clinical lead for critical care trials and the anaesthetic lead for the hyper-acute stroke unit.

Research interests

  • Oxygen utilisation in critical illness
  • Potential metabolic impact of statins in critical illness

Publications

Original Articles

1. Taylor CJ , Robertson F, Brealey.D, et-al. Outcome from endovascular coiling of aneurysms in poor grade subarachnoid haemorrhage patients. Accepted for publication Neurocritical Care. 2010.

2. Svistunenko DA, Davies N, Brealey D, et-al.  Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components. Biochim Biophys Acta. 2006; 175: 262-72.

3. Davies NA, Brealey DA, Stidwill R, et-al. Nitrosyl heme production compared in endotoxemic & hemorrhagic shock. Free Radic Biol Med. 2005;38:41-9.

4. Rabuel C, Renaud E, Brealey D, et-al. Human septic myopathy: induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway. Anesthesiology. 2004;101:583-9.

5. Brealey D, Karyampudi S, Jacques TS, et-al. Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure.  Am J Physiol Regul Integr Comp Physiol. 2004;286:R491-7.

6. Brealey DA, Brand M, Hargreaves I, et-al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 2002: 360: 219-223.

7. Venn RM, Bradshaw CJ, Spencer R, Brealey D, et-al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the ICU. Anaesthesia. 1999; 54: 1136-42.

Chapters and reviews

1.The Handbook of Clinical Anaesthesia, 3rd Edition. Editor: Brian Pollard. Submitted chapters: Anaesthetic considerations for:

  • Primary neuromuscular diseases
  • Neuromuscular Junction Disorders
  • Polyneuropathies

2. Co-author: Critical Care Algorithms, 2nd Edition. Proposal to be submitted.

3. Brealey DA, Singer M, Terblanche M. Metabolic consequences of statin therapy in the critically ill Critical Care Medicine. 2010.

4.  Brealey DA, Hirsch N. Guillain-Barré Syndrome. Commissioned by Anaesthesia.

5. Brealey DA, Singer M. So you want to be…a critical care physician. Br J Hosp Med. 2010;71:M96.

6. Brealey DA, Singer M. Hyperglycemia in Critical illness. J Diabetes Sci Technol. 2009; 3: 1250-60.

7. Brealey DA, Singer M. Mitochondrial Dysfunction in Sepsis. Curr Infect Dis Rep. 2003; 5: 365-371.

8. Brealey DA, Singer M. Cytopathic dysoxia revisited. Crit Care and Shock. 2002; 5: 1-10.

9. Brealey DA, Singer M. Multi organ dysfunction in the critically ill: epidemiology, pathophysiology and management. J R Coll Phys Lond 2000. 34: 424-427.

10. Brealey DA, Singer M. Multi organ dysfunction in the critically ill: effects on different organs. J R Coll Phys Lond. 2000. 34: 428-431.

11. Singer M, Brealey DA. Mitochondrial dysfunction in sepsis. Biochem Soc Symp. 1999; 66: 149-166.

12. Brealey DA, Singer M. Tissue oxygenation in sepsis. Sepsis. 1998; 2: 291-302.