Dr David Williams

Dr David WilliamsTel: 020 3447 9719 / 020 3447 2697
Email: loladaranijoh@nhs.net

Location:
University College Hospital; Elizabeth Garrett Anderson Wing

Specialities:
Maternity services, Women's health

Professional background

Dr David Williams is a Consultant Obstetric Physician at The Institute for Women’s Health. He trained in renal medicine and general internal medicine before specialising in obstetric medicine; the management of pregnant women with medical disorders. His clinical work also includes pre-pregnancy assessment of women with chronic diseases planning pregnancy and their post-natal management. At UCLH, he runs multi-disciplinary clinics for pregnant women who have general medical disorders, including hypertension, kidney disease, rheumatological disorders, liver and gastro-intestinal disease and neurological conditions.

Dr Williams has helped develop national guidelines for the management of medical disorders in pregnancy through NICE. He was an expert member of the NICE Guideline on The Management of Hypertension in Pregnancy, then chairman of the topic expert group for clinical standards. He is now chairman of the guideline for Intrapartum Care of high risk pregnancies affected by medical disorders. He is a member of the UK Independent Advisory Group on maternal and neonatal morbidity and mortality and past chairman of the UK Obstetric Medicine Society.

His research team is investigating the causes of pre-eclampsia and fetal growth restriction and the long-term consequences of gestational syndromes on women’s health. A current MRC-funded project is investigating the role of paternal obesity on fetal growth. Dr Williams is also funded by the UCL/UCLH Biomedical Research Centre, the Rosetrees Trust, Wellbeing of Women, BMA and partnerships with industry. His team are developing strategies to prevent and ameliorate pre-eclampsia.

Research interests

  • Hypertension in pregnancy 
  • Pre-eclampsia 
  • Kidney disease in pregnancy 
  • Rheumatic disease in pregnancy 
  • Neurological disease in pregnancy 
  • Liver disease in pregnancy 
  • Endocrine disorders of pregnancy

Publications

  • Hillman SL, Kubba T, Williams DJ. Delivery of a growth-restricted offspring and the association with early-onset impaired maternal endothelial function. Ultrasound in Obstetrics & Gynecology 2017; 49: 150-154.
  • Nadkarni S, Smith J, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Mauro C, Williams DJ, Farsky SHP, Marelli-Berg FM, Perretti M. Neutrophils induce pro-angiogenic T cells with a regulatory phenotype in pregnancy. Proceedings of the National Academy of Sciences of the USA (PNAS) 2016: 113 (52): E8415-E8424.
  • Flint J, Panchal S, Hurrell A, et al, on behalf of the BSR and BHPR Standards, Guidelines and Audit Working Group. BSR & BHPR guideline on prescribing drugs in pregnancy and breastfeeding. Part I: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford) 2016; Jan 10; PMID: 26750125).
  • Flint J, Panchal S, Hurrell A, et al, on behalf of the BSR and BHPR Standards, Guidelines and Audit Working Group. BSR & BHPR guideline on prescribing drugs in pregnancy and breastfeeding. Part 2: analgesics and other drugs used in rheumatology practice. Rheumatology; 2016: Jan 10.
  • Staff AC, Redman CWG, Williams D, et al for the Global Pregnancy Collaboration (CoLab). Pregnancy and long-term maternal cardiovascular health: progress through harmonization of research cohorts and biobanks. Hypertension 2016; 67(2): 251-60
  • Burke O, Benton S, Szafranski P et al for the Global Pregnancy Collaboration. Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms. Pregnancy Hypertens 2016; 6(1): 53-59
  • Williams DJ (Editor). Maternal Medicine. Best Practice and Research Clinical Obstetrics and Gynaecology. 2015: Vol 29.5 (doi:10.1016/j.bpobgyn.2015.04.008)
  • Abu-Hayyeh S, Ovadia C, Lieu TM, et al. Prognostic and Mechanistic Potential of Progesterone Sulfates in Intrahepatic Cholestasis of Pregnancy and Pruritus Gravidarum. Hepatology, 2015 DOI: 10.1002/hep.28265
  • Finer S, Mathews C, Lowe R, Smart M, Hillman S, Foo L, Sinha A, Williams D, Rakyan VK, Hitman GA. Maternal Gestational Diabetes Is Associated with Genome-wide DNA Methylation Variation In Placenta And Cord Blood Of Exposed Offspring. Human Molecular Genetics 2015; 24 (11): 3021-9.
  • Hillman SL, Finer S, Smart MC, Mathews C, Lowe R, Rakyan VK, Hitman GA, Williams DJ. Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates Epigenetics. 2015; 10 (1): 50-61.
  • Hypponen E, Cavadino A, Williams D et al. Vitamin D and pre-eclampsia: original data, systematic review and meta-analysis. Annals of Nutrition and Metabolism 2013; 63 (4): 331-40. (DOI; 10.1159/000358338)
  • Minassian C, Thomas SL, Williams DJ, Campbell O, Smeeth L. Acute maternal infection and risk of pre-eclampsia: a population-based case-control study. Plos One (3rd September 2013 journal.pone.0073047)
  • Hillman S, Peebles DM, Williams DJ. Paternal Metabolic and Cardiovascular Risk Factors for Fetal Growth Restriction: A case-control study. Diabetes Care 2013; 36 (6): 1675-1680
  • Wright HV and Williams DJ. Thyrotoxicosis in Pregnancy. Fetal and Maternal Medicine Review 2013; 24: 2 108-128
  • Williams D and Craft N. Pre-eclampsia. BMJ 2012; 345: e4437.
  • Nelson-Piercy C, Mackillop L, Williams DJ, Williamson C, de Swiet M, Redman C. Maternal mortality in the UK and the need for obstetric physicians. BMJ 2011; 343: d4993
  • Williams DJ. Pregnancy outcome; a fertile barometer for women’s health. International Journal of Epidemiology 2011 Aug; 40(4): 920-1
  • Smeeth L and Williams D. Can a dietary supplement prevent pre-eclampsia? BMJ 2011; 342: d2777
  • Williams DJ. Long-term complications of pre-eclampsia. Seminars in Nephrology. 2011; 31: 111-122.
  • Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ. Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation 2010 Aug 3; 122 (5): 478-87.
  • David AL, Ataullah I, Yates R, Sullivan I, Charles P, Williams D. Congenital fetal heart block: a potential therapeutic role for intravenous immunoglobulin. Obstet & Gynecol 2010 Aug; 116 Suppl 2: 543-7.
  • Williams DJ. Nutrition in Pregnancy. In Oxford Textbook of Medicine, 5th edition. Eds, Warrell DA, Cox TM, Firth JD. Oxford University Press 2010 14.2; 2079-84.
  • Heaney D, Williams DJ, O’Brien P, Elton C. Neurological disorders in obstetric practice. De Swiet’s medical disorders in pregnancy. Elsevier Press (2010; 15: 371-403).
  • Bellamy L, Casas JP, Hingorani AD, Williams DJ. Type 2 Diabetes mellitus after Gestational Diabetes: a systematic review and meta-analysis. Lancet, 2009; 373: 1773-79
  • Williams D and Davison J. Review; Chronic Kidney Disease in Pregnancy. BMJ 2008; 336: 211-15.
  • Bachy V, Williams DJ, Ibrahim MAA. Altered dendritic cell function in normal pregnancy. J Reprod Immunol 2008; 78: 11-21.
  • Williams DJ and Mayahi L. Prescribing in pregnancy. ‘Maternal medicines and the fetus’ Rodeck & Whittle’s Fetal Development 2nd Edition, Pp 158-180. 2008
  • Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and the risk of cardiovascular disease and cancer in later life: a systematic review and meta-analysis. BMJ 2007; 335: 974-97

GMC/GDC number: 2982894