Dr Jonathan Cohen

Dr Jonathan CohenTel: 020 3447 7876
Fax: 020 3447 9064
Email: jackie.touray@nhs.net

Location:
University College Hospital

Specialities:
Children and young people's general services, Children and young people's services, Tropical and infectious diseases

Professional background

Jonathan studied medicine at Cambridge University and Oxford University, before moving to London to specialise in paediatrics.  He has subspeciality training in paediatric infectious diseases and immunology, having trained at Great Ormond Street and St Mary’s Hospitals.  He has an MSc (Distinction) in Clinical Paediatrics and a PhD from UCL for his MRC-funded fellowship investigating natural immunity against pneumococcal pneumonia.  Prior to moving to UCH as a general paediatrician, he was an NIHR Clinical Lecturer at the UCL Institute of Child Health.

At UCH, Jonathan runs clinics for children and young people in general paediatrics, along with specialist clinics in infectious diseases, asthma/respiratory and allergy.  Alongside his clinical work, Jonathan jointly leads the paediatric education programme at UCH.

Research interests

  • Pneumococcal disease
  • Infection in immunocompromised children

Publications

1. Jones H, Copland A, Hamstra H, Cohen J, Brown J, Klein N, van der Lay P, Dixon G.  LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A.  Cellular Microbiology, 2013, in press.

2. Chimalapati S, Cohen JM, Camberlein E, MacDonald N, Durmort C, Vernet T, Hermans PWM, Mitchell T, and Brown JS.  Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglycerol transferase gene lgt on ABC transporter function and on growth in vivo.  PLoS One 2012; 7(7): e41393.

3. Cohen JM, Chimalapati S, de Vogel C, van Belkum A Baxendale H, and Brown JS.  Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation.  Vaccine 2012; 30(30):4453-9.  PMID 22561489.

4. Chimalapati S, Cohen JM and Brown JS. Cross-protective immunity against heterologous S. pneumoniae.  Infect Immun 2012; 80:1946.

5. Chimalapati S, Cohen JM, Camberlein E, Durmort C, Baxendale H, de Vogel C, van Belkum A and Brown JS. Infection with conditionally virulent Streptococcus pneumoniae ∆pab bacteria induces antibody to conserved protein antigens but does not protect against systemic infection with heterologous strains.  Infect Immun 2011; 79(12):4965-76. PMID 21947774.

6. Cohen JM, Chimalapati S, Camberlein E, Hyams C, Baxendale HE and Brown JS. Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation.  PLoS One Nov 2011; 6:e25558. PMID 22003400.

7. Worth AJ, Conyers R, Cohen JM, Jagani M, Chiesa R, Rao K, Goulden N, Veys P and Amrolia P.  Pre-emptive rituximab based on viraemia and T-cell reconstitution: highly effective prevention of EBV-associated lymphoproliferative disease following stem cell transplantation.  B J Haem Nov 2011; 155:377-85. PMID 21910716.

8. Yuste J, Sen A, Truedsson L, Jönsson G, Hyams C, Cohen JM, Camberlein E, Sriskandan S, Brown J.  Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency.  Microbes & Infection Aug 2010; 12:626-34. PMID 20417301.

9. Hyams C, Camberlein E, Cohen JM, Bax K and Brown JS.  The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms.  Infect Immun Feb 2010; 78:704-15. PMID 19948837.

10. Basavanna S, Khandavilli S, Yuste J, Cohen JM, Hosie AHF, Webb A, Thomas GH and Brown JS.  Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched chain amino acid ABC transporter, is necessary for disease pathogenesis.  Infect Immun, Aug 2009, 77:3412-23. PMID 19470745.

11. Cohen JM, Whittaker L, Walters S, Lyall H, Tudor-Williams G and Kampmann B.  Presentation, diagnosis and management of tuberculosis in HIV-infected children in the UK.  HIV Medicine, May 2008; 9:277-284. PMID 18331563.

12. Cohen JM, Cuckow P, and Davies EG.  Bladder wall telangiectasis causing life-threatening haematuria in ataxia-telangiectasia: a new observation.  Acta Paediatrica 2008, 97:667-669. PMID 18394116.

13. Cohen JM, Sebire N, Harvey J, Gaspar HB, Cale C, Jones A, Rao K, Cubitt D, Amrolia PJ, Davies EG and Veys P.  Successful treatment of lymphoproliferative disease complicating primary immunodeficiency / immunodysregulatory disorders with reduced-intensity allogeneic stem cell transplantation.  Blood, Sep 2007; 110:2209-2214. PMID 17502458.

14. Cohen JM, Cooper C, Chakrabarti S, Thomson K, Samarasinghe S, Cubitt S, Lloyd C, Woolfrey A, Veys P and Amrolia P.  EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioning.  Leukemia & Lymphoma, Feb 2007; 48:256-69. PMID 17325885.

15. Cohen J, Rogers V, Gaspar HB, Jones A, Davies EG, Rao K, McCloskey D, Gilmour K, Wynn R, Amrolia PJ and Veys P.  Serial transplantation of mismatched donor haematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplant without GVHD in the secondary recipient.  Blood, Sept 2006; 108:2124-6. PMID 16728699.

16. Weil R, Cohen J, Portarena I, Brada M.  Optimal dose of stereotactic radiosurgery for acoustic neuromas: a systematic review.  British Journal of Neurosurgery, Aug 2006; 20:195-202. PMID 16954068.

17. Cohen J, Gandhi M, Naik P, Cubitt D, Rao K, Thaker U, Davies EG, Gaspar HB, Amrolia PJ, Veys P.  Increased incidence of EBV-related disease following paediatric stem cell transplantation with reduced intensity conditioning.  B J Haem, Apr 2005; 129:229-239. PMID 15813851.

18. Cohen J.  The Global Burden of Disease Study: A useful prediction of future global health?  Journal of Public Health Medicine, Dec 2000; 22:518-524. PMID 11192280.

GMC/GDC number: 4530615