Dr Katie Sidle

Dr Katie SidleTel: 020 3448 3899
Fax: 020 3448 3111

Location:
National Hospital for Neurology and Neurosurgery

Specialities:
Motor Neuron Diseases, Neurology and neurosurgery

Professional background

Dr Sidle is a consultant neurologist specializing in the field of Motor Neurone Disease (MND). She is the Co-Director of the NHNN MND Association Regional Care and Research Centre for patients with MND and she is responsible for the care of patients with MND in the weekly MND clinic. She has a background in molecular genetics and is an Honorary Senior lecturer in the neighbouring Institute of Neurology where she is currently researching on disease mechanisms in MND.

Publications

Johnson JO, … Malaspina A, Sidle KC, Fratta P, … Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci. 2014 May;17(5):664-6.

Beck J…, Sidle K, Mead S.  Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.Am J Hum Genet. 2013 Mar 7;92(3):345-53.

Majounie E, Renton AE, Mok K, Dopper EG, Orrell RW, Mead S, Sidle KC, Traynor BJ (2012).  Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study.  Lancet Neurol.  Apr;11(4):323-30.

UKMND-LiCALS Study Group, Morrison KE, Dhariwal S, Hornabrook R, ……. Clarke J, Eziefula C, Howard R, Orrell R, Sidle K, Sylvester R.   … Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial.Lancet Neurol. 2013 Apr;12(4):339-45.

Al-Chalabi A, Shaw PJ, Young CA, Morrison KE, Sidle K, Davies N (2011) Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS). BMC Neurol. Sep 21;11:111. doi: 10.1186/1471-2377-11-111.

Collinge, J., Palmer, M.S., Campbell, T.A., Sidle, K.C.L., Carroll, D., and Harding, A.E. (1993). Inherited prion disease (PrP lysine 200) in Britain: two case reports. BMJ 306, 301-302.

Collinge, J., Palmer, M.S., Campbell, T.A., Mahal, S., Sidle, K.C.L., and Humphreys, C. (1994a). New approaches to diagnosis in human prion diseases. J Neurology Supp to Vol 241, S25(Abstract)

Collinge, J., Palmer, M.S., Sidle, K.C.L., Mahal, S., Campbell, T.A., Hardy, J., and Brown, J. (1994c). Familial Pick’s disease and dementia of frontal lobe degeneration of non-Alzheimer type are not variants of prion disease. J. Neurol. Neurosurg. Psychiatry 57, 762-768.

Collinge, J., Whittington, M.A., Sidle, K.C.L., Smith, C.J., Palmer, M.S., Clarke, A.R., and Jefferys, J.G.R. (1994d). Prion protein is necessary for normal synaptic function. Nature 370, 295-297.

Collinge, J., Palmer, M.S., Sidle, K.C.L., Gowland, I., Medori, R., Ironside, J., and Lantos, P.L. (1995b). Transmission of fatal familial insomnia to laboratory animals. Lancet 346, 569-570.

Collinge, J., Palmer, M.S., Sidle, K.C.L., Hill, A.F., Gowland, I., Meads, J., Asante, E., Bradley, R., Doey, L.J., and Lantos, P.L. (1995c). Unaltered susceptibility to BSE in transgenic mice expressing human prion protein. Nature 378, 779-783.

Collinge, J., Sidle, K.C.L., Meads, J., Ironside, J., and Hill, A.F. (1996). Molecular analysis of prion strain variation and the aetiology of ‘new variant’ CJD. Nature 383, 685-690.

Collinge, J., Hill, A.F., Sidle, K.C.L., and Ironside, J. (1997b). Biochemical typing of scrapie strains. Nature 386, 564

Hill, A.F., Desbruslais, M., Joiner, S., Sidle, K.C.L., Gowland, I., and Collinge, J. (1997). The same prion strain causes vCJD and BSE. Nature 389, 448-450.

Whittington, M.A., Sidle, K.C.L., Gowland, I., Meads, J., Hill, A.F., Palmer, M.S., Jefferys, J.G.R., and Collinge, J. (1995). Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein. Nature Genetics 9, 197-201.

Windl, O., Dempster, M., Estibeiro, J.P., Lathe, R., De Silva, R., Esmonde, T., Will, R., Springbett, A., Campbell, T.A., Sidle, K.C.L., Palmer, M.S., and Collinge, J. (1996). Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene. Hum. Genet. 98, 259-264.

Almer G., Hainfellner H.A., Jellinger K., Kleinert R., Bayer G., Windl O., Kretzschmar H., Hill A., Sidle K.C., Collinge J., and Budka H. (1999) Fatal familial insomnia: a new Austrian family. Brain 122, 5-16.

GMC/GDC number: 4738767