Prof Maria Thom

Dr Maria ThomTel: 020 3448 4236
Fax: 020 3448 4486

National Hospital for Neurology and Neurosurgery

Brain Tumour Service (Neuro-Oncology), Neuropathology, Pathology

Professional background

I have been working in the department of Neuropathology at the National Hospital as an Honorary Consultant since 1996. My main diagnostic and research interests are in the field of epilepsy neuropathology. In general aspects the neurobiology of hippocampal sclerosis, cortical malformations, low-grade tumours and altered neurogenesis in patients undergoing surgical treatment for epilepsy. We also have a large series of postmortem brains from patients with epilepsy and we have been furthering investigations into the effects of seizures and cellular reactions in the brain and neuropathological changes in SUDEP. I am a member of the Professional Affairs Committee of the BNS, audit lead for neuropathology and an ILAE task force member.

Research interests

  • Epilepsy neuropathology (adult) 
  • CSF cytology 
  • Audit in neuropathology 
  • General surgical neuropathology


Recent publications (reviews and original papers):
The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy. George Hadjivassiliou, Lillian Martinian, Waney Squier, Ingmar Blumcke, Eleonora Aronica, Sanjay  M Sisodiya, Maria Thom.  Acta Neuropathoogica (2010)   
Srikandarajah N, Martinian L, Sisodiya SM, Squier W, Blumcke I, Aronica E,Thom M. Doublecortin expression in focal cortical dysplasia in epilepsy.Epilepsia. 2009 Dec;50(12):2619-28.   
Thom,M. (2009). Hippocampal sclerosis: progress since Sommer. Brain Pathology 19(4), 565-572. ISSN: 1015-6305. Review    Sisodiyo,S.M., Fauser,S., Cross,J.H.,
Thom,M. (2009). Focal cortical dysplasia type II: biological features and clinical perspectives. Lancet Neurology 8(9), 830-843. ISSN: 1474-4422. Review   
Thom,M., Martinian,L., Catarino,C., Yogarajah,M., Koepp,M.J., Caboclo,L., Sisodiya,S.M. (2009). Bilateral reorganization of the dentate gyrus in hippocampal sclerosis. A postmortem study. Neurology 73(13), 1033-1040.    
Thom,M., Eriksson,S., Martinian,L., Caboclo,L.O., McEvoy,A.W., Duncan,J.S., Sisodiya,S.M. (2009). Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: neuropathological features. Journal of Neuropathology and Experimental Neurology 68(8), 928-938. ISSN: 0022-3069   
Blümcke I, Vinters HV, Armstrong D, Aronica E, Thom M, Spreafico R.  Malformations of cortical development and epilepsies: neuropathological findings   with emphasis on focal cortical dysplasia. Epileptic Disord. 2009  Sep;11(3):181-93. Epub 2009 Sep 8. Review.

GMC/GDC number: 3283723