Dr Michael Chapman

Dr Michael ChapmanTel: 020 3447 9229
Fax: 020 3447 9218
Email: michael.chapman1@nhs.net

University College Hospital

Endoscopy Unit, Pancreatobiliary service, Gastrointestinal services

Professional background

Dr Chapman qualified in 1997 from UCL Medical School and completed specialist training in London. His practice includes general gastroenterology with a specialist interest in Pancreatobiliary medicine and Hepatology. Conditions of particular interest include primary sclerosing cholangitis, IgG4 related cholangitis and pancreatitis, gallstones, chronic pancreatitis, hereditary pancreatitis, duodenal polyps, pancreatic cancer and cholangiocarcinoma. He performs general and therapeutic endoscopy (including leading on the duodenal polyp service) and complex ERCP including pancreatic endotherapy and cholangioscopy.

Research interests

  • Endoscopy including ERCP
  • Endoscopic management of biliary and pancreatic cancer
  • Pancreatic diseases including IgG4 disease
  • Primary sclerosing cholangitis
  • Gallstone disease
  • Complications of chronic pancreatitis
  • Biomarkers of pancreaticobiliary malignancy
  • Cystic tumours of the pancreas


  1. British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis. Chapman MH, Thorburn D, Hirschfield GM, Webster GGJ, Rushbrook SM, Alexander G, Collier J, Dyson JK, Jones DE, Patanwala I, Thain C, Walmsley M, Pereira SP. Gut. 2019 Aug;68(8):1356-1378
  2. Polymorphisms in Natural Killer Cell Receptor Protein 2D (NKG2D) as a Risk Factor for Cholangiocarcinoma. Wadsworth CA, Dixon PH, Taylor-Robinson S, Kim JU, Zabron AA, Wong JH, Chapman MH, McKay SC, Spalding DR, Wasan HS, Pereira SP, Thomas HC, Whittaker JC, Williamson C, Khan SA. J Clin Exp Hepatol. 2019 Mar-Apr;9(2):171-175.
  3. Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer. Sheel ARG, Harrison S, Sarantitis I, Nicholson JA, Hanna T, Grocock C, Raraty M, Ramesh J, Farooq A, Costello E, Jackson R, Chapman M, Smith A, Carter R, Mckay C, Hamady Z, Aithal GP, Mountford R, Ghaneh P, Hammel P, Lerch MM, Halloran C, Pereira SP, Greenhalf W. Am J Gastroenterol. 2019 Jan;114(1):155-164.
  4. The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines. Hirschfield GM, Dyson JK, Alexander GJM, Chapman MH, Collier J, Hübscher S, Patanwala I, Pereira SP, Thain C, Thorburn D, Tiniakos D, Walmsley M, Webster G, Jones DEJ. Gut. 2018 Sep;67(9):1568-1594.
  5. Preventing Post-ERCP Pancreatitis: The Role of Prophylactic Pancreatic Duct Stenting in the Rectal NSAID Era. Bekkali NL, Thomas T, Keane MG, Murray S, Joshi D, Elsayed G, Johnson GJ, Chapman MH, Pereira SP, Webster GJM. JOP. 2017 Jul;18(4):316-319.
  6. Paediatric pancreaticobiliary endoscopy: a 21-year experience from a tertiary hepatobiliary centre and systematic literature review. Keane MG, Kumar M, Cieplik N, Thorburn D, Johnson GJ, Webster GJ, Chapman MH, Lindley KJ, Pereira SP. BMC Pediatr. 2018 Feb 9;18(1):42.
  7. Bekkali NLH, Murray S, Winter L, Sehgal V, Webster GJM, Chapman MH, Bandula S, Amin Z, Read S, Pereira SP, Johnson GJ. The role of multidisciplinary meetings for benign pancreatobiliary diseases: a tertiary centre experience. Frontline Gastroenterol. 2017 Jul;8(3):210-213.
  8. Bekkali NL, Murray S, Johnson GJ, Bandula S, Amin Z, Chapman MH, Pereira SP, Webster GJ. Pancreatoscopy-Directed Electrohydraulic Lithotripsy for Pancreatic Ductal Stones in Painful Chronic Pancreatitis Using SpyGlass. 2017 Apr;46(4):528-530.
  9. Keane MG, Huggett MT, Chapman MH, Johnson GJ, Webster GJ, Thorburn D, Mackay J, Pereira SP. Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology. Br J Cancer. 2017 Jan;116(3):349-355.
  10. Bekkali NH, Thomas T, Keane MG, Murray S, Joshi D, Elsayed G, Johnson GJ, Chapman MH, Pereira SP, Webster GJM Preventing Post-ERCP Pancreatitis: The Role of Prophylactic Pancreatic Duct Stenting in the Rectal NSAID Era. JOP. J Pancreas (Online) 2017 May 05; 18(4):216.
  1. Education and Imaging. Gastrointestinal: Covered duodenal metal stent fracture and its removal with "lasso" technique. Sze SF, Chapman MH, Webster GJ. J Gastroenterol Hepatol. 2015 Dec;30(12):1693.
  2. Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis is associated with extrapancreatic organ failure, malignancy, and mortality in a prospective UK cohort. Huggett MT, Culver EL, Kumar M, Hurst JM, Rodriguez-Justo M, Chapman MH, Johnson GJ, Pereira SP, Chapman RW, Webster GJ, Barnes E. Am J Gastroenterol. 2014 Oct;109(10):1675-83.
  3. Identification of potential serum peptide biomarkers of biliary tract cancer using MALDI MS profiling. Sandanayake NS, Camuzeaux S, Sinclair J, Blyuss O, Andreola F, Chapman MH, Webster GJ, Smith RC, Timms JF, Pereira SP. BMC Clin Pathol. 2014 Feb 4;14(1):7.
  4. Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer. Dhar DK, Olde Damink SW, Brindley JH, Godfrey A, Chapman MH, Sandanayake NS, Andreola F, Mazurek S, Hasan T, Malago M, Pereira SP. Cancer. 2013 Feb 1;119(3):575-85.
  5. Cholangiocarcinoma and dominant strictures in patients with primary sclerosing cholangitis: a 25-year single-centre experience. Chapman MH, Webster GJ, Bannoo S, Johnson GJ, Wittmann J, Pereira SP. Eur J Gastroenterol Hepatol. 2012 Sep;24(9):1051-8.
  6. Chapman MH, Andreola F, Sandanayake NS, Tidswell R, Cerec V, Lee A, Swanton RC, Dooley JS & Pereira SP.  Whole genome RNA expression profiling of endoscopic biliary brushings provides data suitable for biomarker discovery in cholangiocarcinoma J Hepatol 2012 Apr;56(4):877-85
  7. Chapman MH, Sandanayake NS, Andreola F, Dhar DK, Webster GJ, Dooley JS & Pereira SP.  Circulating CYFRA 21-1 is a highly specific diagnostic and prognostc biomarker in biliary tract cancer. J Clin Exp Hepatol 2011; 1(1):6-12.
  8. Sandanayake NS, Sinclair J, Andreola F, Chapman MH, Xue A, Clarkson A, Gill A, Webster GJ,Norton ID, Smith RC, Timms JF & Pereira SP. Serum leucine-rich alpha-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures. Brit J Cancer, 2011 Epub
  9. Kalaitzakis E, Levy M, Kamisawa T, Johnson GJ, Baron TH, Topazian MD, Takahashi N, Kanno A, Okazaki K, Egawa N, Uchida K, Sheikh K, Amin Z, Shimosegawa T,  Sandanayake NS, Church NI, Chapman MH, Pereira SP, Chari S &Webster GJM. Endoscopic retrograde cholangiography does not reliably distinguish IgG4-associated cholangitis from PSC or cholangiocarcinoma. Clin Gastro Hep 2011; 9(9):800-803
  10. Wadsworth CA, Dixon PH, Wong JH, Chapman MH, McKay SC, Sharif A, Spalding DR, Pereira SP, Thomas H, Taylor-Robinson SD, Whittaker J, Williamson C & Khan SA. Genetic factors in the pathogenesis of cholangiocarcinoma. Dig Dis. 2011;29(1):93-97
  11. Sugumar A, Levy MJ, Kamisawa T, Webster GJ, Kim MH, Enders F, Amin Z, Baron TH, Chapman MH, Church NI, Clain JE, Egawa N, Johnson G, Okazaki K, Pearson RK, Pereira SP, Peterson BT, Read S, Sah RP, Sandanayake NS, Takahashi N, Topazian MD, Uchida K, Vege SS & Chari ST.  Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis: an international multicenter study. Gut 2011;60: 666-670
  12. Matull WR, Dhar DK, Ayaru L, Sandanayake NS, Chapman MH, Dias A, Bridgewater J, Bong JJ, Davidson BR, Pereira SP, R0 but not R1/R2 resection is associated with better survival than palliative photodynamic therapy in biliary tract cancer. Liv Int. 2010; 31(1):99-107
  13. Chapman MH, Kajihara M, Borges G, O’Beirne J, Patch D, Dhillon AP, Crozier A & Morgan MY.  Acute severe liver injury associated with chewing khat (cath edulis). NEJM. 2010;362(17):1642-1644
  14. Chapman MH & Pereira SP.  Cholangiocarcinoma: Improving biliary drainage with PDT. PDPDT 2009;6(2):82-83
  15. Pereira SP, Matull WR, Dhar DK, Ayaru L, Sandanayake NS & Chapman MH.  Palliative photodynamic therapy for biliary tract carcinoma improves survival and has a similar outcome to attempted curative surgery with positive resection margins. Proceedings of SPIE. 2009: June:7380
  16. Sandanayake NS, Church NI, Chapman MH, Johnson GJ, Dhar DK, Amin Z, Deheragoda MG, Novelli M, Winstanley A, Rodriguez-Justo M, Hatfield AR, Pereira SP & Webster GJ.  Presentation and Management of Post-treatment Relapse in Autoimmune Pancreatitis / Immunoglobulin G4-Associated Cholangitis. Clin Gastroenterol Hepatol. 2009;7(10):1089-96
  17. Chapman MH & Sanderson IR. Intestinal flora and the mucosal immune system.  Probiotics in Children, Annales Nestle, 2003;6/12.
  18. Garland J, Buscombe JR, Bouvier C, Bouloux P, Chapman MH, Chow AC, Reynolds N & Caplin ME.  Sandostatin LAR (long-acting octreotide acetate) for malignant carcinoid syndrome: a 3 year experience. Aliment Pharmacol Ther. 2003;17(3):437-44
  19. Robertson KE, Chapman MH, Adams A, Tickle C, Darling SM.  Cellular Analysis of the Mouse Mutant Hypodactyly. Developmental Genetics 1996;19:9-25

Published abstracts not listed.

GMC/GDC number: 4414571