Dr Nikhil Sharma

Dr Nikhil SharmaTel: 020 3448 3015
Fax: 020 3448 3111
Email: nikhil.sharma@ucl.ac.uk

Location:
National Hospital for Neurology and Neurosurgery

Specialities:
Motor Neuron Diseases, Neurology and neurosurgery

Professional background

Dr Nikhil Sharma is a Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, Queens Square, London and Senior Clinical Researcher at the MRC Unit for Lifelong Health and Ageing at UCL (LHA). 

He qualified at the University of Liverpool and completed his general medical training at St James’s University Hospital in Leeds and the National Hospital for Neurology and Neurosurgery, Queens Square, London.

In 2007 he was awarded a PhD by the University of Cambridge for work done with Professor Jean-Claude Baron. His thesis used motor imagery and functional magnetic imaging (fMRI) to explore neuroplasticity and neurodegeneration in large-scale motor networks (funded by Brain Entry Scholarship, UK Stroke Association & Raymond and Beverly Sackle fellowships).

He completed his clinical training in Neurology at Kings College Hospital, Hurstwood Park Neuroscience centre and the National Hospital of Neurology.  During this period he spent a number of years as a visiting post-doctoral fellow in Dr Leo Cohen’s laboratory at the National Institute of Health (NIH), Bethesda, USA (http://www.nih.gov).  He was awarded the prestigious NRSA fellowship. His work used transcranial magnetic stimulation (TMS) , functional (resting state fMRI) and structural imaging (Diffusion tensor imaging) to better understand plasticity of the human motor system.

His research program brings together these skills to develop an innovative approach to better understand diseases of the motor system. More specifically he combines ‘system-level’ neuroscience with life course epidemiology with the aim to better understand plasticity of motor system and it’s response to neurodegenerative diseases.

Publications

Effects of healthy ageing on activation pattern within the primary motor cortex during movement and motor imagery: an fMRI study.
N Sharma JC Baron
PLos One June 02, 2014 DOI: 10.1371/journal.pone.0088443

Does motor imagery share neural networks with executed movement: a multivariate fMRI analysis. 
N Sharma JC Baron
Front Hum Neurosci. 2013 Sep 12;7:564.

Neural Plasticity-general principles
N Sharma, J Classen, L Cohen
Handb Clin Neurol. 2013;110:3-12

White matter microstructural correlates of superior long-term skill gained implicitly under randomized practice.
S. Song, N Sharma, E Buche, LG Cohen.
Cereb Cortex. 2012 Jul;22(7):1671-7. Epub 2011 Sep 12

Motor Imagery after stroke: where next?
N Sharma
Imaging in Medicine February 2012, Vol. 4, No. 1, Pages 129-136

External cueing improves motor imagery quality in patients with Parkinson’s disease.
E Heremans Werner Helsen, Alice Nieuwboer, Sarah Vercruysse,  Wim Vandenberghe,
Nikhil Sharma, Peter Feys
Neurorehabil Neural Repair. 2012 Jan;26(1):27-35

Motor imagery ability in patients with early and mid stage Parkinson’s disease.
E Heremans, Werner Helsen, Alice Nieuwboer, Sarah Vercruysse,  Wim Vandenberghe,
Nikhil Sharma, Peter Feys
Neurorehabil Neural Repair. 2011 Feb;25(2):168-77.

Effects of physiological noise in population analysis of diffusion tensor MRI data.
Walker L, Chang LC, Koay CG, Sharma N, Cohen L, Verma R, Pierpaoli C.
Neuroimage. 2011 Jan 15;54(2):1168-77. Epub 2010 Sep 8

The neural substrates of impaired tapping regularity after stroke
Cinzia Calautti, P S Jones, J-Y Guincestre, M Naccarato, MD; Nikhil Sharma, Diana Day, T A Carpenter, Elizabeth Warburton, JC Baron
Neuroimage. 2010 Mar;50(1):1-6. Epub 2009 Dec 11

Motor recovery after stroke
N Sharma, LG Cohen
Dev Psychobiol. 2010 Nov 17.

The relationship between motor deficit and primary motor cortex hemispheric activation balance after stroke: longitudinal fMRI study
C. Calautti, PS Jones, M. Naccarato, N. Sharma, DJ Day, ET Bullmore, EA Warburton, J-C Baron
J Neurol Neurosurg Psychiatry. 2010 Jul;81(7):788-92. Epub 2010 Apr 14.

The Motor System after Stroke: altered effective connectivity during Motor Imagery and Executed Movement.
N Sharma, JC Baron, JB Rowe.
Annals of Neurology. 2009 Nov;66(5):604-16.

The Neural Substrates of Motor Imagery in well recovered Sub-cortical Stroke patients.
 N Sharma, L Simmons, PS Jones, DJ Day, TA Carpenter, V Pomeroy, EA Warburton, JC Baron.
 Stroke. 2009 Apr;40(4):1315-24. Epub 2009 Jan 29.

Feasibility study of Motor Imagery after stroke.
L Simmons, N Sharma, JC Baron, V Pomeroy 
Neurorehabilitation and Neural Repair . 2008 Sep-Oct;22(5):458-67

Mapping the involvement of BA 4a and 4p during Motor Imagery.
N Sharma, PS Jones,  TA Carpenter,  JC Baron.
Neuroimage. 2008 May 15;41(1):92-9. 2008 Feb 20

The relationship between motor deficit and hemisphere activation balance after stroke.
C Calautti, M Naccarato, PS Jones, N Sharma, DJ Day, A Carpenter; ET Bullmore, EA Warburton, J-C Baron.
Neuroimage 34(1),1 January 2007, P 322-331
Motor Imagery: a back door to the motor system after stoke?
N. Sharma, V. Pomeroy, J-C Baron. Stroke 2006 Jul;37(7):1941-52

GMC/GDC number: 4537605 

 Web chat