Dr Patricia Limousin

Dr Patricia LimousinTel: 020 3448 8726
Fax: 020 3448 8642
Email: p.limousin@ion.ucl.ac.uk

Location:
National Hospital for Neurology and Neurosurgery

Specialities:
Movement disorders, Neurology and neurosurgery

Professional background

MD, PhD
Neurology training Grenoble University Hospital France
2001-2007 Senior Lecturer in Clinical Neurology, National Hospital for Neurology
Since 2007 Reader in Clinical Neurology, National Hospital for Neurology
Honorary Consultant Neurologist National Hospital for Neurology and Great Ormond Street Hospital

Research interests

Treatment of movement disorders, Parkinson's disease, dystonia, tremor and others

Publications

1. Gervason CL, Pollak P, Limousin P, Perret JE. Reproducibility of motor effects induced by successive subcutaneous apomorphine injections in Parkinson's disease. Clin Neuropharmacol 1993; 16: 113-119.

2. Limousin P, Pollak P, Gervason-Tournier CL, Hommel M, Perret JE. Ro 40-7592, a COMT inhibitor, plus levodopa in Parkinson's disease. Lancet 1993; 341: 1605.

3. Pollak P, Benabid AL, Limousin P, Gervason CL, Jeanneau-Nicolle E. External and implanted pumps for apomorphine infusions in parkinsonism. Acta Neurochir  1993; suppl 58: 48-52.

4. Limousin P, Pollak P, Pfefen JP, Gervason-Tournier CL, Dubuis R, Perret JE. Acute administration of Madopar and tolcapone, a COMT inhibitor, in Parkinson's disease. Clin Neuropharmacol 1995; 18: 258-265.

5. Limousin P, Pollak P, Benazzouz A, Hoffmann D, Le Bas JF, Broussolle E, Perret JE, Benabid AL. Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet 1995; 345: 91-95.

6. Limousin P, Pollak P, Benazzouz A, Hoffmann D, Broussolle E, Perret JE, Benabid AL. Bilateral subthalamic nucleus stimulation for severe Parkinson's disease. Mov Disord 1995; 10: 672-674.

7. The multicenter acute stroke trial-europe group study. Thrombolytic therapy with streptokinase in acute ischemic stroke. N Engl J Med 1996; 335: 145-150.

8. Limousin P, Pollak P, Benazzouz A, Hoffmann D, Le Bas JF, Perret JE, Benabid AL: Abnormal involuntary movements induced by subthalamic nucleus stimulation in parkinsonian patients. Mov Disord 1996; 11: 231-235.

9. Benabid AL, Pollak P, Gao DM, Hoffmann D, Limousin P, Gay E, Payen I, Benazzouz A: Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg 1996; 84: 203-214.

10. Pollak P, Benabid AL, Limousin P, Krack P. New neurosurgical treatment strategies in Parkinson's disease. Eur Neurol 1996; 36: 396-408.

11. Kuntzer T, Ghika J, Pollak P, Benabid AL, Limousin P, Krack P, Zurn AD, Tseng J, Aebischer P. Treatment of Parkinson’s disease. Eur Neurol 1996; 36: 396-408.

12. Limousin P, Memin B, Pollak P. Treatment of dystonia occurring in parkinsonian syndromes by botulinum toxin. Eur Neurol 1997; 37: 66-67.

13. Limousin P, Greene J, Pollak P, Rothwell J, Benabid AL, Frackowiak R. Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's Disease. Ann Neurol 1997; 42: 283-291.

14. Jahanshahi M, Ridding MC, Limousin P, Profice P, Fogel W, Dressler D, Fuller R, Brown RG, Brown P, Rothwell JC. Rapid rate transcranial magnetic stimulation a safety study. Electroencephalogr Clin Neurophysiol 1997; 105: 422-9

15. Krack P, Pollak P, Limousin P, Benabid AL: Levodopa-inhibiting effect of pallidal surgery. Ann Neurol 1997; 42: 129-130.

16. Krack P, Pollak P, Limousin P, Benazzouz A, Benabid AL. Stimulation of the subthalamic nucleus alleviates tremor in Parkinson’s disease. Lancet 1997; 350:1675.

17. Krack P, Limousin P, Pollak P, Benabid AL. Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson’s disease. Lancet 1997; 350: 1676.

18. Krack P, Pollak P, Limousin P, Hoffmann D, Benazzouz A, Le Bas JF, Koudsie A, Benabid AL. Opposite motor effects of pallidal stimulation in Parkinson’s disease. Ann Neurol 1998; 43: 180-192.

19. Krack P, Pollak P, Limousin P, Hoffmann D, Xie J, Benazzouz A, Benabid AL: Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson’ s disease. Brain 1998; 121: 451-457.

20. Krack P, Pollak P, Limousin P, Hoffmann D, Benazzouz A, Benabid AL. Inhibition of levodopa effects by internal pallidal stimulation. Mov Disord 1998; 13: 648-652.

21. Benabid AL, Benazzouz A, Hoffmann D, Limousin P, Krack P, Pollak P. Long-term electrical inhibition of deep brain targets in movement disorders. Mov Dis 1998; 13, supl 3: 119-125.

22. Krack P, Benazzouz A, Pollak P, Limousin P, Piallat B, Hoffmann D, Xie Jing, Benabid AL. Treatment of tremor in Parkinson’s disease by subthalamic nucleus stimulation. Mov Dis 1998; 13: 907- 914.

23. Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, Benabid AL. Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 1998; 339: 1105-1111.

24. Limousin P, Brown RG, Jahanshahi M, Asselman P, Quinn NP, Thomas D, Obeso JA, Rothwell JC. The effects of posteroventral pallidotomy on the preparation and execution of voluntary hand and arm movements in Parkinson’s disease. Brain 1999; 122: 315-327.

25. Limousin P, Speelman JD, Gielen F, Janssens M and study collaborators. Multicenter European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psy 1999; 66: 289-296.

26. Brown RG, Limousin Dowsey P , Brown P, Jahanshahi M, Pollak P, Benabid AL, Rodriguez-Oroz MC, Obeso J, Rothwell JC. Impact of deep brain stimulation on upper limb akinesia in Parkinson’s disease. Ann Neurol 1999, 45: 473-488. 

27. Krack P, Pollak P, Limousin Dowsey P, Benazzouz A, Deuschl G, Benabid A-L. From off-period dystonia to peak-dose chorea. The clinical spectrum of varying subthalamic nucleus activity. Brain 1999, 122: 1133-1146.

28. Lekwuwa GU, Barnes GR, Collins CJS, Limousin P. Progressive bradykinesia and hypokinesia of ocular pursuit in Parkinson’s disease. J Neurol Neurosurg Psy 1999, 66: 746-753.

29. Limousin Dowsey P, Pollak P, Van Blercom N, Krack P, Benazzouz A, Benabid AL. Thalamic, subthalamic nucleus and internal pallidum stimulation in Parkinson’s disease. J Neurol 1999, 246 (suppl 2): 42-45.

30. Benabid AL, Benazzouz A, Gao D, Hoffmann D, Limousin P, Koudsie A, Krack P, Pollak P.  Chronic electrical stimulation of the ventralis intermediate nucleus of the thalamus and other nuclei as a treatment for Parkinson’s disease. Techniques in Neurosurgery 1999; 5: 5-30.

31. Ardouin C, Pillon B, Peiffer E, Bejjani P, Limousin P, Damier P, Arnulf I, Benabid AL, Agid Y,  Pollak P. Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions: a consecutive series of 62 patients. Ann Neurol 1999; 46: 217-23

32. Krack P, Pollak P, Hoffman D, Benazzouz A, Benabid AL, Dowsey PL. Decrease in akinesia seems to result from chronic electrical stimulation of the external (GPe) rather than internal (GPi) pallidum. Mov Disord 1999; 14: 537-540.

33. Jahanshahi M, Ardouin C, Brown RG, Rothwell JC, Obeso J, Albanese A, Rodriguez-Oroz MC, Moro E, Benabid AL, Pollak P, Limousin Dowsey P. The impact of deep brain stimulation on executive function in Parkinson’s disease. Brain 2000; 123: 1142-1154.

34. Benabid AL, Benazzouz A, Limousin P, Koudsie A, Krack P, Piallat B, Pollak P. Dyskinesias and the subthalamic nucleus. Ann Neurol 2000; 47(Suppl 1): S189-92

35. Krack P,  Dowsey-Limousin P, Benabid AL, Acarin N, Benazzouz A, , Kunig G, Leenders KL, Obeso JA, Pollak P. Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism. Neurology 2000; 54: 2182-2184.

36. Moro E, Esselink R, Van Blercom N, Caputo E, Pollak P, Limousin P, Hariz M. Bilateral subthalamic nucleus stimulation in a parkinsonian patient with previous unilateral pallidotomy and thalamotomy. Mov Dis 2000; 15: 753-754.

37. Marsden JF, Ashby P, Limousin-Dowsey P, et al. Coherence between cerebellar thalamus, cortex and muscle in man. Cerebellar thalamus interactions. Brain 2000; 123: 1459-1470.

38. Benabid AL, Krack PP, Benazzouz A, Limousin P, Koudsie A, Pollak P. Deep brain stimulation of the subthalamic nucleus for Parkinson's disease: methodologic aspects and clinical criteria. Neurology 2000; 55 (Suppl 6):S40-4.

39. Kumar R, Lang AE, Rodriguez-Oroz MC, Lozano AM, Limousin P, Pollak P, Benabid AL, Guridi J, Ramos E, van der Linden C, Vandewalle A, Caemaert J, Lannoo E, van den Abbeele D, Vingerhoets G, Wolters M, Obeso JA. Deep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease. Neurology 2000; 55(Suppl 6):S34-9.

40. Marsden JF, Limousin-Dowsey P, Ashby P, Pollak P, Brown P. Subthalamic nucleus, sensorimotor cortex and muscle interrelationships in Parkinson's disease. Brain 2001; 124: 378-88.

41. Limousin-Dowsey P, Fraix V, Benabid AL, Pollak P. Deep brain stimulation for Parkinson’s disease. Funct Neurol 2001; 16: 67-71.

42. Marsden JF, Limousin-Dowsey P, Fraix V, Pollak P, Odin P, Brown P. Intermuscular coherence in Parkinson’s disease: effect of subthalamic nucleus stimulation. Neuroreport 2001; 12: 1113-1117.

43. Lehéricy S, Grand S, Pollak P, Poupon F, Le Bas JF, Limousin P, Jedynak P, Marsault C, Agid Y, Vidailhet M. Clinical characteristics and topography of lesions in movement disorders due to thalamic lesions. Neurology 2001; 57: 1055-1066.

44. Brown P, Marsden J, Defebvre L, Cassim F, Mazzone P, Oliviero A, Altibrandi MG, Di Lazzaro V, Limousin-Dowsey P, Fraix V, Odin P, Pollak P. Intermuscular coherence in Parkinson's disease: relationship to bradykinesia. Neuroreport 2001 12:2577-81.

45. Krack P, Kumar R, Ardouin C, Dowsey P L, McVicker JM, Benabid AL, Pollak P.  Mirthful laughter induced by subthalamic nucleus stimulation. Movement Disorders 2001; 16: 867-875

46. Dowsey-Limousin P, Pollak P. Deep brain stimulation in the treatment of Parkinson’s disease: a review and update. Clin Neurosci Res 2001; 1: 521-526.

47. Jahanshahi M, Rowe J, Saleem T, Brown RG, Limousin-Dowsey P, Rothwell JC, Thomas DGT, Quinn NP. Working memory and executive function in Parkinson's disease before and after unilateral pallidotomy.  J Cognitive Neuroscience 2002, 14, 298-310.

48. Limousin-Dowsey P Postoperative management of Vim DBS for tremor Movement Disorders 2002; 17: S208-211.

49. Brown RG, Jahanshahi M, Limousin-Dowsey P, Thomas D, Quinn NP, Rothwell JC. Pallidotomy and incidental sequence learning in Parkinson's disease. Neuroreport 2003; 14: 21-4.

50. Frackowiak RSJ, Dowsey-Limousin P, Jahanshahi M, Hariz M. Imagerie cerebrale et motricite dans la maladie de Parkinson. Bull Acad Natle Med 2003; 187: 295-304.

51. Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C, Koudsie A, Dowsey Limousin P, Benazzouz A, LeBas JF, Benabid A-L, Pollak P. Five years follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New Engl J Med 2003; 349: 1925-34.

52. Dowsey Limousin P. Les dystonies de la maladie de Parkinson. Rev Neurol 2003; 159: 928-931.

53. Limousin P. Thalamic stimulation in essential tremor. Lancet Neurology 2004; 3: 80.

54. Thobois S, Jahanshahi M, Pinto S, Frackowiak R, Limousin-Dowsey P. PET and SPECT Functional imaging studies in parkinsonian syndromes: from the lesion to its consequences. Neuroimage 2004; 23:1-16.

55. Pinto S, Ozsancak C, Tripoliti E, Thobois S, Limousin-Dowsey P, Auzou P. Parkinson’s disease treatments and dysarthria: an updating of thought. Lancet Neurology 2004; 3:547-556.

56. Hariz M, Blomstedt P, Limousin P. The myth of microelectrode recording in ensuring a precise location of the DBS electrode within the sensorimotor part of the subthalamic nucleus. Mov Disord 2004; 19: 863-4.

57. Tisch S, Silberstein P, Limousin-Dowsey P, Jahanshahi M. The basal ganglia: anatomy, physiology and pharmacology. Psychiatr Clin N Am 2004; 27: 757-799.

58. Kühn AA, Kupsch A, Williams D, Limousin P, Hariz M, Schneider G-H, Yarrow K, Brown P. Event-related desynchronization of beta activity in human subthalamic nucleus correlates with motor performance. Brain 2004; 127:735-46.

59. Bakker M, Esselink RAJ, Renooij J, Limousin-Dowsey P, Speelman JD, Bloem BR. Effects of stereotactic neurosurgery on postural instability and gait in Parkinson’s disease. Mov Disord 2004; 19:1092-9.

60. Mackinnon C.D, Webb R.M, Silberstein P, Tisch S, Asselman P, Limousin P, Rothwell J.C. Stimulation through subthalamic electrodes implanted near the subthalamic nucleus activates projections to motor areas of cerebral cortex in patients with Parkinson’s disease. European Journal of Neuroscience 2005; 21, 1394-1402.

61. Nowak DA, Topka H, Tisch S, Hariz M, Limousin P, Rothwell JC: The beneficial effects of subthalamic nucleus stimulation on manipulative finger force control in Parkinson's disease. Exp Neurol 2005; 193: 427-436.

62. Silberstein P, Pogosyan A, Kühn A, Hotton G, Tisch S, Kupsch A, Dowsey-Limousin P, Hariz M, Brown P. Cortico-cortical coupling in Parkinson's Disease and its modulation by therapy. Brain 2005; 128: 1277-91.

63. Fogelson N, Kühn A, Silberstein P, Dowsey Limousin P, Hariz M, Trottenberg T, Kupsch A, Brown P. Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease. Neuroscience Letters 2005; 382: 5-9.

64. Thobois S, Tisch S, Xie-Brustolin J, Mertens P, Hariz M, Benatru , Broussolle E, Limousin-Dowsey P.  Can chronic subthalamic nucleus stimulation induce de novo tremor in Parkinson’s disease? Mov Disord 2005; 20: 1066-9.

65. Folgelson N, Pogosyan A, Kuhn A, Kupsch A, van Bruggen G, Speelman H, Tijssen M, Quarterone A, Insola A, Mazzone P, Di Lazzaro V, Limousin P, Brown P. Reciprocal interactions between oscillatory activities of different frequencies in the subthalamic region of patients with Parkinson’s disease. Eur J Neurosci 2005; 22: 257-266.

66. Kuhn A, Hariz M, Silberstein P, Tisch S, Kupsch A, Schneider G, Limousin-Dowsey P, Yarrow K, Brown P. Activation of the subthalamic region during emotional processing in Parkinson’s disease. Neurology 2005; 65: 707-713.

67. Limousin-Dowsey P, Tisch S. Surgery for movement disorders: new applications? J Neurol Neurosurg Psychiatry 2005; 76: 904.

68. Tisch S, Limousin P, Rothwell J, Asselman P, Zrinzo L, Jahanshahi M, Bhatia KP, Hariz M. Changes in forearm reciprocal inhibition following pallidal stimulation for dystonia. Neurology 2006; 66:1091-3.

69. Chen CC, Pogosyan A, Zrinzo LU, Tisch S, Limousin P, Ashkan K, Yousry T, Hariz MI, Brown P. Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgery. Exp Neurol. 2006; 198:214-21.

70. Schneider SA, Aggarwal A, Bhatt M, Dupont E, Tisch S, Limousin P, Lee P, Quinn N, Bhatia KP. Severe tongue protrusion dystonia: clinical syndromes and possible treatment. Neurology 2006;67:940-3

71. Rezai AR, Kopell BH, Gross RE, Vitek JL, Sharan AD, Limousin P, Benabid AL. Deep brain stimulation for Parkinson's disease: surgical issues.

Mov Disord 2006; 21 Suppl 14: S197-218

72. Nowak DA, Tisch S, Hariz M, Limousin P, Topka H, Rothwell JC: Sensory timing cues improve akinesia of grasping movements in Parkinson's disease: a comparison to the effects of subthalamic nucleus stimulation. Mov Disord 2006; 21:166-172

73. Tisch S, Limousin P , Rothwell J, Asselman P, Quinn N, Jahanshahi M, Bhatia K, Hariz M. Changes in blink reflex excitability after globus pallidus internus stimulation for dystonia. Mov Disord 2006; 21:1650-5.

74. Chen C, Brücke C, Kempf F, Kupsch A, Lu AC, Lee S, Tisch S, Limousin P, Hariz M, Brown P. Deep brain stimulation of the subthalamic nucleus: a two-edged sword. Current Biology 2006; 16: R952-R953

75. Tripoliti E, Limousin P, Tisch S, Borrell E, Hariz M. Speech in Parkinson’s Disease following Subthalamic Nucleus Deep Brain Stimulation: preliminary results. Journal of Medical Speech and Language Patholog 2006; 14: 309-315.

76. Thobois S, Hotton G, Pinto S, Wilkinson L, Limousin-Dowsey P, Brooks D, Jahanshahi M. STN stimulation alters pallidal-frontal coupling during response selection under competition. Journal of Cerebral Blood Flow and Metabolism 2007; 27: 1173-84.

77. Tisch S, Rothwell JC, Bhatia KP, Quinn N, Zrinzo L, Jahanshahi M, Ashkan K, Hariz M, Limousin P. Pallidal stimulation modifies after-effects of paired associative stimulation on motor cortex excitability in primary generalised dystonia. Exp Neurol. 2007;206:80-5.

78. Chen CC, Litvak V, Gilbertson T, Kühn A, Lu CS, Lee ST, Tsai CH, Tisch S, Limousin P, Hariz M, Brown P. Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease. Exp Neurol. 2007 ;205: 214-21.

79. Ashkan K, Blomstedt P, Zrinzo L, Tisch S, Yousry T, Limousin-Dowsey P, Hariz MI. Variability of the subthalamic nucleus: the case for direct MRI guided targeting. Br J Neurosurg. 2007;21:197-200.

80. Androulidakis AG, Kühn AA, Chen CC, Blomstedt P, Kempf F, Kupsch A, Schneider GH, Doyle L, Dowsey-Limousin P, Hariz MI, Brown P. Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson's disease. Brain. 2007 ;130:457-68.

81. Eusebio A, Chen CC, Lu CS, Lee ST, Tsai CH, Limousin P, Hariz M, Brown P. Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson's disease. Exp Neurol. 2008; 209: 125-30.

82. Tish S, Rothwell J, Limousin P, Hariz M, D Corcos. The physiological effects of pallidal deep brain stimulation in dystonia. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2007; 15: 166-72.

83. Tisch S, Zrinzo L, Limousin P, Bhatia K, Quinn N, Ashkan K, Hariz M. The effect of electrode contact location on clinical efficacy of pallidal deep brain stimulation in primary generalised dystonia. J Neurol Neurosurg and Psychiatry 2007; 78:1314-9.

84. Carmichael D.W., Pinto S., Limousin-Dowsey P., Thobois S., Lemieux L., Hariz M, Yousry T., Thornton J.S. fMRI with active, fully implanted deep brain stimulation systems: safety and potential confounds. Neuroimage. 2007; 37:508-17.

85. Blomstedt P, Hariz MI, Lees A, Silberstein P, Limousin P, Yelnik J, Agid Y. Acute severe depression induced by intraoperative stimulation of the substantia nigra: A case report.Parkinsonism Relat Disord. 2008; 14:253-6

86. Tisch S, Rothwell JC, Zrinzo L, Bhatia KP, Hariz M, Limousin P.Cortical evoked potentials from pallidal stimulation in patients with primary generalized dystonia. Mov Disord. 2008;23:265-73.

87. Gaynor LM, Kühn AA, Dileone M, Litvak V, Eusebio A, Pogosyan A, Androulidakis AG, Tisch S, Limousin P, Insola A, Mazzone P, Di Lazzaro V, Brown P.. Suppression of beta oscillations in the subthalamic nucleus following cortical stimulation in humans. Eur J Neurosci. 2008 Oct;28(8):1686-95.

88. Zrinzo L, Zrinzo LV, Tisch S, Limousin PD, Yousry TA, Afshar F, Hariz MI. Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization. Brain. 2008;131:1588-98.

89. Limousin P, Martinez-Torres I. Deep brain stimulation for Parkinson's disease. Neurotherapeutics. 2008;5:309-19.

90. Tripoliti E, Zrinzo L, Martinez-Torres I, Tisch S, Frost E, Borrell E, Hariz MI, Limousin P. Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation. Mov Disord. 2008;23:2377-83.

91. Visser JE, Allum JH, Carpenter MG, Esselink RA, Limousin-Dowsey P, Honegger F, Borm GF, Bloem BR. Effect of subthalamic nucleus deep brain stimulation on axial motor control and protective arm responses in Parkinson's disease. Neuroscience. 2008;157:798-812.

92. Kühn AA, Fogelson N, Limousin PD, Hariz MI, Kupsch A, Brown P. Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients. Neuroreport. 2009;20:975-8.

93. Martinez-Torres I, Limousin P, Tisch S, Page R, Pinto A, Foltynie T, Bhatia KP, Hariz MI, Zrinzo L. Early and marked benefit with GPi DBS for Lubag syndrome presenting with rapidly progressive life-threatening dystonia. Mov Disord. 2009;24:1710-2.

94. Martinez-Torres I, Hariz MI, Zrinzo L, Foltynie T, Limousin P. Improvement of tics after subthalamic nucleus deep brain stimulation. Neurology. 2009;72:1787-9.

95. Eusebio A, Pogosyan A, Wang S, Averbeck B, Gaynor LD, Cantiniaux S, Witjas T, Limousin P, Azulay JP, Brown P. Resonance in subthalamo-cortical circuits in Parkinson's disease. Brain. 2009;132:2139-50.

96. Zrinzo L, van Hulzen AL, Gorgulho AA, Limousin P, Staal MJ, De Salles AA, Hariz MI. Avoiding the ventricle: a simple step to improve accuracy of anatomical targeting during deep brain stimulation. J Neurosurg. 2009;110:1283-90.

97. Moro E, Allert N, Eleopra R, Houeto JL, Phan TM, Stoevelaar H; International Study Group on Referral Criteria for DBS. A decision tool to support appropriate referral for deep brain stimulation in Parkinson's disease. J Neurol. 2009;256:83-8.

98. Litvak V, Eusebio A, Jha A, Oostenveld R, Barnes GR, Penny WD, Zrinzo L, Hariz MI, Limousin P, Friston KJ, Brown P. Optimized beamforming for simultaneous MEG and intracranial local field potential recordings in deep brain stimulation patients. Neuroimage 2010; 50:1578-88.

99. Timmermann L, Pauls KA, Wieland K, Jech R, Kurlemann G, Sharma N, Gill SS, Haenggeli CA, Hayflick SJ, Hogarth P, Leenders KL, Limousin P, Malanga CJ, Moro E, Ostrem JL, Revilla FJ, Santens P, Schnitzler A, Tisch S, Valldeoriola F, Vesper J, Volkmann J, Woitalla D, Peker S. Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation. Brain 2010;133:701-12

100. Aström M, Tripoliti E, Hariz MI, Zrinzo LU, Martinez-Torres I, Limousin P, Wårdell K. Patient-Specific Model-Based Investigation of Speech Intelligibility and Movement during Deep Brain Stimulation. Stereotact Funct Neurosurg 2010;88:224-233.

101. Cowie D, Limousin P, Peters A, Day B. Insights into the neural control of locomotion from walking through doorways in Parkinson's disease. Neuropsychologia 2010;48:2750-7.

102. Foltynie T, Zrinzo L, Martinez-Torres I, Tripoliti E, Petersen E, Holl E, Aviles-Olmos I, Jahanshahi M, Hariz M, Limousin P. MRI-guided STN DBS in Parkinson’s disease without microelectrode recording:efficacy and safety. Journal of Neurology, neurosurgery and psy 2010 in press

103. Yoshida F, Martinez-Torres I, Pogosyan A, Holl E, Petersen E, Chen CC, Foltynie T, Limousin P, Zrinzo LU, Hariz MI, Brown P. Value of subthalamic nucleus local field potentials recordings in predicting stimulation parameters for deep brain stimulation in Parkinson's disease. J Neurol Neurosurg Psychiatry 2010 81:885-9.

104. Williams A, Gill S, Varma T, Jenkinson C, Quinn N, Mitchell R, Scott R, Ives N, Rick C, Daniels J, Patel S, Wheatley K; PD SURG Collaborative Group. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol. 2010;9:581-91

105. Petersen EA, Holl EM, Martinez-Torres I, Foltynie T, Limousin P, Hariz MI, Zrinzo L.Minimizing brain shift in stereotactic functional neurosurgery. Neurosurgery 2010;67:213-21.

106. Frost E, Tripoliti E, Hariz MI, Pring T, Limousin P. Self-perception of speech changes in patients with Parkinson's disease following deep brain stimulation of the subthalamic nucleus. Int J Speech Lang Pathol. 2010;12:399-404.

107. Pogosyan A, Yoshida F, Chen CC, Martinez-Torres I, Foltynie T, Limousin P, Zrinzo LU, Hariz MI, Brown P. Parkinsonian Impairment Correlates With Spatially Extensive Subthalamic Oscillatory Synchronisation. Neuroscience. 2010; 171:245-57.

108. Hartinger M, Tripoliti E, Hardcastle WJ, Limousin P. Effects of medication and subthalamic nucleus deep brain stimulation on tongue movements in speakers with Parkinson's disease using Electropalatography (EPG): A pilot study. Clinical Linguistics and Phonetics (in press).

109. Tripoliti E, Zrinzo L, Martinez-Torres I, Frost E, Pinto S, Foltynie T, Holl E, Petersen E, Roughton M, Hariz MI, Limousin P. Effects of subthalamic stimulation on speech of consecutive patients with Parkinson's disease. Neurology 2011; 76:80-6.

110. Holl EM, Petersen EA, Foltynie T, Martinez-Torres I, Limousin P, Hariz MI, Zrinzo L.Improving targeting in image-guided frame-based deep brain stimulation. Neurosurgery. 2010 ;67(2 Suppl Operative):437-47.

111. Hariz GM, Nakajima T, Limousin P, Foltynie T, Zrinzo L, Jahanshahi M, Hamberg K. Gender distribution of patients with Parkinson's disease treated with subthalamic deep brain stimulation; a review of the 2000-2009 literature. Parkinsonism Relat Disord. 2010

112. Griffin HJ, Greenlaw R, Limousin P, Bhatia K, Quinn NP, Jahanshahi M. The effect of real and virtual visual cues on walking in Parkinson's disease. J Neurol. 2011

113. Cavanna AE, Eddy CM, Mitchell R, Pall H, Mitchell I, Zrinzo L, Foltynie T, Jahanshahi M, Limousin P, Hariz MI, Rickards H. An approach to deep brain stimulation for severe treatment-refractory Tourette syndrome: the UK perspective. Br J Neurosurg. 2010

114. Litvak V, Jha A, Eusebio A, Oostenveld R, Foltynie T, Limousin P, Zrinzo L, Hariz MI, Friston K, Brown P. Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease. Brain. 2010


 

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