Dr Rachel Batterham

Dr Rachel Batterham Tel: 020 3447 9419
Fax: 020 3447 9217 / 020 3447 9218
Email: rachel.batterham@uclh.nhs.uk

Location:
University College Hospital

Specialities:
The UCLH centre for weight loss, metabolic and endocrine surgery

Professional background

Dr Rachel Batterham is Head of the UCLH Centre for Weight Loss, Metabolic & Endocrine Surgery. She studied at St Mary’s Hospital Medical School Imperial College and qualified with Distinction in 1989. She then specialised in Diabetes & Endocrinology and developed a specialist interest in obesity. She obtained an MSc in Biochemistry and Molecular Biology and then a PhD in body weight regulation. She was appointed as a Consultant at UCLH in 2005 and she set up the UCLH obesity services in 2007.

Research interests

Dr Batterham is the Head of the Centre for Obesity Research, Department of Medicine, University College London. Her laboratory’s research is centred on increasing our understanding of how body weight is regulated and developing new therapies for the treatment of patients with obesity and type 2 diabetes. In particular, her research is focussed on understanding the mechanisms by which bariatric surgery mediates its beneficial metabolic effects. Dr Batterham has received several prestigious awards for her research including the Linacre Medical from the Royal College of Physicians (2010), the Society for Endocrinology Young Endocrinologist Clinical Lecture Prize (2008) and the European Association for the Study of Obesity Young Investigator Award (2004).

Publications

Scott WR, Batterham RL. Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery .Am J Physiol Regul Integr Comp Physiol. Jul;301(1):R15-27, 2011

King JA, Wasse LC, Emmanuel J, Batterham RL, Stensel DJ:, Differential acylated ghrelin, peptide YY3-36, appetite and food intake responses to equivalent energy deficits created by exercise and food restriction. JCEM, 2011 Apr:96(4):1114-21.
Chandarana K, Gelegen C, Karra E, Choudhury AI, Drew ME, Fauveau V, Viollet B, Andreelli F, Withers DJ, Batterham RL. Diet and gastrointestinal bypass induced weight-loss: the role of ghrelin and PYY. Diabetes, 2011 Mar:60(3):810-8
Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ. Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice. Diabetes, 2011 Mar:60(3);735-45

Karra E, Yousseif A, Batterham RL: Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery. Trends in Endocrinol. and Metab.21(6)337-44, 2010
Neary MT, Batterham RL: Gaining New Insights into Food Reward with Functional Neuroimaging. Forum Nutr 63:152-163, 2010
Symmonds M, Emmanuel JJ, Drew ME, Batterham RL, Dolan RJ: Metabolic state alters economic decision making under risk in humans. PLoS One 16;5(6):e11090, 2010
Karra E, Batterham RL: The role of gut hormones in the regulation of body weight and energy homeostasis. Mol Cell Endocrinol, 2010
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ: Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326:140-144, 2009

Chandarana K, Drew ME, Emmanuel J, Karra E, Gelegen C, Chan P, Cron NJ, Batterham RL: Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans. Gastroenterology 136:2115-2126, 2009

Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ: Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 119:125-135, 2009

Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ: Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 10:343-354, 2009

Neary MT, Batterham RL: Gut hormones: implications for the treatment of obesity. Pharmacol Ther 124:44-56, 2009

Karra E, Chandarana K, Batterham RL: The role of peptide YY in appetite regulation and obesity. J Physiol 587:19-25, 200

Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ: Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. Faseb J 22:807-818, 2008

Rahman S, Scobie AI, Elkalaawy M, Bidlake LE, Fiennes AG, Batterham RL: Can glucose make you faint? Lancet 372:1358, 2008

Chandarana K, Batterham R: Peptide YY. Curr Opin Endocrinol Diabetes Obes 15:65-72, 2008

Chandarana K, Batterham R: Peptide YY. Curr Opin Endocrinol Diabetes Obes 15:65-72, 2008

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ: AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 117:2325-2336, 2007

Batterham RL, ffytche DH, Rosenthal JM, Zelaya FO, Barker GJ, Withers DJ, Williams SC: PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 450:106-109, 2007

le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR: Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147:3-8, 2006

le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V, Shurey S, Ghatei MA, Patel AG, Bloom SR: Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 243:108-114, 2006

Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ: Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 4:223-233, 2006

Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ: The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115:940-950, 2005

Dakin CL, Small CJ, Batterham RL, Neary NM, Cohen MA, Patterson M, Ghatei MA, Bloom SR: Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 145:2687-2695, 2004

Cohen MA, Ellis SM, Le Roux CW, Batterham RL, Park A, Patterson M, Frost GS, Ghatei MA, Bloom SR: Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab 88:4696-4701, 2003

Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, Frost GS, Ghatei MA, Bloom SR: Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab 88:3989-3992, 2003

Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR: Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349:941-948, 2003

Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR: Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650-654, 2002

Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR: Ghrelin causes hyperphagia and obesity in rats. Diabetes 50:2540-2547, 2001