Dr Simon Mead

Dr Simon MeadTel: 020 3448 3015
Fax: 020 3448 4046
Email: simon.mead@uclh.nhs.uk

Location:
University College Hospital; National Hospital for Neurology and Neurosurgery

Specialities:
National Prion Clinic (NPC), Neurology and neurosurgery

Professional background

After medical training at Cambridge and Oxford Universities and a PhD in the genetics of prion diseases at Imperial College London, Simon Mead is now a consultant neurologist and Clinical Lead of the UK National Prion Clinic based at the National Hospital for Neurology and Neurosurgery. His clinical interests include cognitive disorders, particularly the prion diseases such as Creutzfeldt-Jakob disease. Also working at the UK Medical Research Council’s Prion Unit, his research interests include clinical trial-like studies involving prion disease patients, the discovery of genetic factors that cause or influence prion disease and the development of treatments for prion disease based on antibodies.

Research interests

  • CJD
  • Dementia
  • Genetics

Publications

Selected:
Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, Al-Doujaily H, Hummerich H, Beck J, Mein C, Verzilli C, Whittaker J, Alpers M, Collinge J A novel protective prion protein variant co-localises with kuru exposure. N Engl J Med 2009;361:2056–65   
 
Mead S, Poulter M, Uphill J, Beck J, Whitfield J, Webb TE, Campbell T, Adamson G, Deriziotis P, Tabrizi SJ, Hummerich H, Verzilli C, Alpers MP, Whittaker JC, Collinge J Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. Lancet Neurol 2009;8(1):57-66.   
 
Mead S, Stumpf MP, Whitfield J, Beck J, Poulter M, Campbell T, Uphill J, Goldstein D, Alpers MP, Fisher E, Collinge J. Balancing selection at the prion protein gene consistent with prehistoric kuru-like epidemics. Science 2003; 300: 640-3.   
 
Mead S, Poulter M, Beck J, Webb T, Campbell T, Linehan J, Desbruslais M, Joiner S, Wadsworth JD, King A, Lantos P, Collinge J Inherited prion disease with six octapeptide repeat insertional mutation--molecular analysis of phenotypic heterogeneity. Brain 2006;129(9):2297-317.   
 
Webb TE, Poulter M, Beck J, Uphill J, Adamson G, Campbell T, Linehan J, Powell C, Brandner S, Pal S, Siddique D, Wadsworth JD, Joiner S, Alner K, Petersen C, Hampson S, Rhymes C, Treacy C, Storey E, Geschwind MD, Nemeth AH, Wroe S, Collinge J, Mead S Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series. Brain 2008;131(10):2632-46.   
 
Beck J, Rohrer JD, Campbell T, Isaacs A, Morrison KE, Goodall EF, Warrington EK, Stevens J, Revesz T, Holton J, Al-Sarraj S, King A, Scahill R, Warren JD, Fox NC, Rossor MN, Collinge J, Mead S A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain 2008;131(3):706-20.