Dr Sudhin Thayyil

Dr Sudhin ThayyilTel: 020 3108 2009
Email: s.thayyil@ucl.ac.uk

Location:
University College Hospital; Elizabeth Garrett Anderson Wing

Specialities:
Neonatal care

Professional background

Sudhin Thayyil trained in Neonatal Medicine at Leicester, Newcastle, Cambridge and London. He conducted the largest prospective study to date on minimally invasive autopsy by post-mortem magnetic resonance imaging and was awarded a PhD (UCL) for this work. He was awarded a NIHR Clinician Scientist award in 2011 and joined as a Consultant Neonatologist and Senior Clinical Lecturer in Neonatal Medicine at the Institute of Women’s health, UCL in March 2011.

He is a principal investigator on a number of research projects and currently holds an active research income of £1.4 Million.

Research interests

  • Clinical Trials in Neonatal Medicine
  • Magnetic Resonance Biomarkers of neonatal Brain Injury
  • Global Perinatal Health
  • Minimally Invasive Autopsy
  • Evidence Based Neonatal Medicine
  • Meta-analysis and Systematic Reviews
  • Risk Management

Publications

Key five research papers

1. Thayyil S, Chandrasekaran M, Taylor AM, Bainbridge A, Cady EB, Chong WK, Murad S, Omar RZ, Robertson NJ. Cerebral Magnetic Resonance Biomarkers for Predicting Long-Term Neurodevelopmental Outcome Following Neonatal Encephalopathy:  A Meta-Analysis. Pediatrics 2010;125;e382-e395

2. Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM. Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet. 2009;374(9688):467-75

3. Thayyil S, Robertson NJ, Scales A, Sebire NJ, Taylor AM. Parental consent for research and sudden infant death. Lancet. 2008:30;372(9640):715

4. Thayyil S, Robertson NJ, Chitty LS, Brookes JAS, Sebire NJ, Taylor AM. Protocol 08PRT/5409: Post-mortem magnetic resonance imaging in the fetus, infant, and child: a comparative study with conventional autopsy (UKCRN: 6794): Lancet 2010 (http://www.thelancet.com/protocol-reviews/08PRT-5409)

5 Thayyil S, De Vita E, Sebire NJ, Bainbridge A, Thomas D, Gunny R, Chong K, Lythgoe MF, Golay X, Robertson NJ, Cady EB, Taylor AM. Post-mortem cerebral magnetic resonance imaging T(1) and T(2) in fetuses, newborns and infants. Eur J Radiol. 2011 Feb 22.

Other peer reviewed original research work

1. Sebire NJ, Weber MA, Thayyil S, Mushtaq I, Taylor A, Chitty LS. Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination ("keyhole autopsy"): feasibility and initial experience. J Matern Fetal Neonatal Med. 2011 Aug 10

2. Thayyil S, Schievano S, Robertson NJ, Jones R, Chitty LS, Sebire NJ, Taylor AM; MaRIAS (Magnetic Resonance Imaging Autopsy Study) Collaborative group. A semi-automated method for non-invasive internal organ weight estimation by post-mortem magnetic resonance imaging in fetuses, newborns and children. Eur J Radiol. 2008 Sep 1. [Epub ahead of print]

3. Schievano S, Robertson NJ, Sebire NJ, Taylor AM, Thayyil S. Reconstruction of fetal and infant anatomy using rapid prototyping of post-mortem MR images. Insights into Imaging (in press) DOI: 10.1007/s13244-010-0028-5

4. Thayyil S, Chandrasekaran M, Chitty LS, Wade A, Skordis-Worrall J, Bennett-Britton I, Cohen M, Withby E, Sebire NJ, Robertson NJ, Taylor AM. Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review. Eur J Radiol. 2009 Nov 10 [Epub ahead of print]

5. Thayyil S, Robertson NJ, Scales A, Weber MA, Jacques TS, Sebire NJ, Taylor AM; MaRIAS (Magnetic Resonance Imaging Autopsy Study) Collaborative Group. Prospective parental consent for autopsy research following sudden unexpected childhood deaths: a successful model. Arch Dis Child. 2009;94(5):354-8

6. Soe A, Apampa B, Fernando B, Thayyil S. Interventions for reducing medication errors in children in hospital. Cochrane Database (protocol) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006208/pdf

7. Thayyil S, Sheik S, Kempley ST, Sinha A. A gestation- and postnatal age-based reference chart for assessing renal function in extremely premature infants. J Perinatol. 2008;28(3):226-9.

8. Thayyil S, Kempley ST, Sinha A. Can early-onset nonoliguric hyperkalemia be predicted in extremely premature infants? Am J Perinatol. 2008;25(2):129-33.

9. Thayyil S, Nagakumar P, Gowers H, Sinha A. Optimal endotracheal tube tip position in extremely premature infants. Am J Perinatol. 2008;25(1):13-6.

10. Thayyil S, Milligan DW. Single versus double volume exchange transfusion in jaundiced newborn infants. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004592.

11. Thayyil S, Marriott L. Can transcutaneous bilirubinometry reduce the need for serum bilirubin estimations in term and near term infants? Arch Dis Child. 2005 Dec;90(12):1311-2.

12. Thayyil S, Shenoy M, Hamaluba M, Gupta A, Frater J, Verber IG. Is procalcitonin useful in early diagnosis of serious bacterial infections in children? Acta Paediatr. 2005 Feb;94(2):155-8.

13. Thayyil S, Shenoy M, Agrawal K. Delayed orchidopexy: failure of screening or ascending testis. Arch Dis Child. 2004;89(9):890.

14. Thayyil-Sudhan S, Shenoy M, Luyt DK. Is GMSPS useful for predicting mortality in severe meningococcal disease? Arch Dis Child. 2001; 84 (Suppl 1): a10-a13.

15. Thayyil-Sudhan S, Gupta S. Dipstick examination for urinary tract infections. Arch Dis Child. 2000;82(3):271-2.

16. Thayyil-Sudhan S, Kumar A, Singh M, Paul VK, Deorari AK. Safety and effectiveness of BCG vaccination in preterm babies. Arch Dis Child Fetal Neonatal Ed. 1999;81(1):F64-6.

17. Thayyil-Sudhan S, Singh M, Broor S, Xess I, Paul VK, Deorari AK. Is zero dose oral polio vaccine effective in preterm babies? Ann Trop Paediatr. 1998;18(4):321-4.

Other peer reviewed articles and editorials

1. Thayyil S. Brain cooling in babies: are we ready for clinical trials in developing countries? Indian Pediatr. 2011 Jun 7;48(6):441-2.

2. Thayyil S, Bhutta ZA, Ramji S, Costello AM, Robertson NJ. Global applications of therapeutic hypothermia to treat perinatal asphyxial encephalopathy. International Health (Lancet Global Health) 2010; 2(2): 79-81

3. Thayyil S. Less Invasive Autopsy: An Evidence Based Approach. Arch Dis Childhood. Jun 2010 (Epub ahead of print) PMID: 20515965

4. Thayyil S, Chitty LS, Robertson NJ, Taylor AM, Sebire NJ. Post-mortem Magnetic Resonance Imaging in Fetuses: Current Evidence and Issues. Prenatal Diagnosis: Published Online: May 4 2010, DOI: 10.1002/pd.2534

5. Thayyil S, Robertson NJ, Sebire NJ, Taylor AM. Post-mortem MR and CT imaging in fetus, newborns and children. Current Diagnostic Histopathology (in press)

6. Robertson NJ, Kendall GS. Thayyil S. Techniques of cooling in hospital and transport. Semin Fetal Neonatal Med. 2010 Apr 15. [Epub ahead of print]

7. Thayyil S, Kadam S, Pandit A, Bhutta ZA, Horn A, Harrison M, Thomas N, Marlow N, Ramji S, Robertson NJ. Therapeutic Hypothermia for Neonatal Encephalopathy: Global Perspective. BMJ Feb 2010 (rapid response-electronic)

8. Thayyil S and Robertson NJ. University College London Symposia on Neonatal Neurology and Neuro Protection. (Editorial) Indian Pediatrics, May 2010

9. Wilkinson D, Thayyil S, Robertson NJ. Ethical and practical issues relating to the global use of therapeutic hypothermia for newborn infants. Arch Dis Childhood Arch Dis Child Fetal Neonatal Ed. 2011 Jan;96(1):F75-8

10. Thayyil S, Costello A, Shankaran S, Robertson NJ. Therapeutic hypothermia for neonatal encephalopathy implications for neonatal units in India. Indian Pediatr.2009;46(4):283-9.

11. Thayyil S, Omar R, Robertson N. Amplitude-integrated electroencephalography (EEG) for outcome prediction in hypoxic-ischemic encephalopathy:errors in meta-analysis J Child Neurol.2008;23(8):970-1

12. Thayyil S, Ogilvy-Stuart A. Key topics in neonatology, 2nd edition Arch Dis Child. 2005; 90: 988-989

13. Thayyil S, Shenoy S. Saline has similar effect to albumin in critically ill patients. If brain biopsy is as accurate as blood PCR for diagnosis of Herpes encephalitis. Which one would you prefer?  BMJ 2004: http://www.bmj.com/cgi/eletters/328/7444/852-a#67377

14. Thayyil S, Curley AE, Brown N. Lipopolysaccharide binding protein in preterm infants . Arch. Dis. Child. Fetal Neonatal Ed.2004. http://fn.bmj.com/cgi/eletters/89/6/F551

15. Ackland F, Singh R, Thayyil S. Flecainide induced ventricular fibrillation in a neonate. Heart. 2003 Oct;89(10):1261.

16. Thayyil S. Procalcitonin Study: Methadological errors. Pediatrics. 2003: http://pediatrics.aappublications.org/cgi/eletters/112/5/1054

17. Thayyil S, Murthy VN, Thompson F. Sudden infant death due to disseminated pneumococcal infection. Arch Dis Child. 2003 Feb;88(2):157.

18. Sudhan ST, Gupta S, Plutarco C Toe-tourniquet syndrome--accidental or intentional? Eur J Pediatr. 2000;159(11):866.

19. Thayyil-Sudhan S, Paul VK. BCG vaccination: Practical dilemmas. Indian Pediatrics 2000;37: 687-689

20. Thayyil-Sudhan S. Nitrate Kit for the Diagnosis of Urinary Tract Infection. Indian Pediatrics 2000;37:456-458

21. Sudhan S T, Komalavally, K, Muralidharan T D, Mani N S. Successful treatment of dapsone poisoning using commercially available methylene blue crystals J Indian Med Assoc.1999 ;97:396