Prof Laurence Lovat

Dr Laurence LovatTel: 020 3447 7488
Fax: 020 3447 9218
Email: laurence.lovat@nhs.net

Location:
University College Hospital

Specialities:
Gastrointestinal services, Upper Gastrointestinal (GI) Service

Professional background

I am a consultant gastroenterologist specialising in gastroesophageal reflux disease, Barrett’s oesophagus and upper gastrointestinal cancer. I was the lead clinician for Upper Gastrointestinal Cancer at UCLH from 2001-8. I graduated from University College London Medical School in 1987 and obtained my PhD at the Royal Postgraduate Medical School, Hammersmith Hospital. I was appointed as a Consultant Gastroenterologist at UCH and Senior Lecturer in Laser Medicine at the National Medical Laser Centre, UCL in 1999. I have previously chaired the North London Cancer Network Upper Gastrointestinal Tumour Board.

I am active in clinical translational research to prevent oesophageal cancer, with particular interests in photodynamic therapy and novel optical biopsy techniques. I am the chief investigator for the UK National HALO Patient Registry.

Research interests

  • Gastroesophageal reflux disease
  • Barrett’s oesophagus
  • Oesophageal cancer 
  • Nove endoscopic therapies including laser therapy, photodynamic therapy and HALO radiofrequency ablation.

Publications

 MOST IMPORTANT PUBLISHED PAPERS

1.Tennent GA, Lovat LB, Pepys MB.  Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer's disease and systemic amyloidosis.  Proc Natl Acad Sci USA 1995; 92: 4299-4303. 

2.Lovat LB, Persey MR, Madhoo S, Pepys MB, Hawkins PN.  The natural history of hepatic amyloidosis: insights from 123I-SAP scintigraphy in 484 patients.  Gut 1998; 40: 727-734. 

3.Gillmore JD, Lovat LB, Persey MR, Pepys MB, Hawkins PN. Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet 2001;  358: 24-29 

4.Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Barfati T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN.  Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis Nature 2002; 416: 254-9 

5.Lovat LB, Johnson K, Mackenzie GD, Clark BR, Novelli MR, Davies S, O'Donovan M, Selvasekar C, Thorpe SM, Pickard CDO, Fitzgerald, RC, Fearn T, Bigio IJ, Bown SG.  Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus.  Gut 2006; 55: 1078-83 

6.Mackenzie GM, Jamieson NF, Thorpe S, Mosse A, Selvasekar C, Bown SG, Lovat LB.  Photodynamic therapy with 5-aminolaevulinic acid for ablation of dysplasia in Barrett’s oesophagus: factors associated with successful outcome. Lasers Med Sci 2008; 23:203-210

GMC/GDC number: 3257647