Prof Michael Hanna

Prof Michael HannaTel: 020 3448 8014
Fax: 020 3448 3633

National Hospital for Neurology and Neurosurgery

Neuromuscular disease, Neurogenetics Laboratory, Neurology and neurosurgery

Professional background

Professor Michael Hanna is a Consultant Neurologist and Director of the Queen Square Division of UCLH NHS Trust co-leading a team overseeing 1000 staff and a clinical budget of £134m. He runs the Queen Square clinical centre for patients with genetic and acquired muscle disease which includes two nationally commissioned services funded directly by the Department of health £1.5m pa for mitochondrial disease and for neurological channelopathies. He is the Director of the recently established MRC Centre for translational research in neuromuscular disease 2008 £3.4m. This new MRC Centre aims to link basic science advances to clinical trials in patients with progressive muscle wasting neuromuscular diseases including muscular dystrophy, inflammatory myopathies, neuropathies and motor neuron diseases. This centre has established new core activities including neuromuscular clinical trials, translational science PhD programmme, neuromuscular biobanking and neuromuscular MRI. Professor Hanna has recently successfully lead a major fund raising initiative delivering a £2m state of the art neuromuscular clinical trials centre for neuromuscular diseases at Queen Square (April 2009); which will be the hub of all neuromuscular clinical trials activity. He has published over 150 peer reviewed original research papers including New England Journal of Medicine and Lancet. He has raised over £6m external research funding in the last four years in genetic and clinical research including in neurological channelopathies and in mitochondrial disease.

Research interests

Neuromuscular diseases (muscle) including a particular interest in channelopathies.


Publications 2008 onwards

Raja Rayan DL, Hanna MG. Skeletal muscle channelopathies: nondystrophic myotonias and periodic paralysis (2010) Curr Opin Neurol 14 Jul. PMID 20634695
Graves TD, Rajakulendran S, Zuberi SM, Morris HR, Schorge S, Hanna MG, Kullmann DM. Nongenetic factors influence severity of episodic ataxia type 1 in monozygotic twins. (2010)  Neurology 75(4):367-372 27 Jul. PMID 20660867

Rajakulendran S, Tan SV, Hanna MG. Muscle weakness, palpitations and a small chin: the Andersen-Tawil syndrome (2010) Pract Neurol 10(4):227-231 Aug. PMID 20647529

Limongelli G, Rahman S, Pitceathly RDS, Hanna MG, Elliott PM Cardiac manifestations of mitochondrial disorders reply (2010). Eur J Heart Fail. 12(6):637-638 Jun 2010. PMID 20083621

Fratter C, Gorman GS, Stewart JD, Buddles M, Smith C, Evans J, Seller A, Poulton J, Roberts M, Hanna MG, et al. 2010. The clinical, histochemical, and molecular spectrum of PEO1 (Twinkle)-linked adPEO (2010) Neurology. Rahman S, Omer SE, Klopstock T, Schoser B, Kornblum C, Czermin B, Lecky B, Blakely EL, Craig K, Chinnery PF, Turnbull DM, Horvath R, Taylor RW74(20):1619-1626 18 May 2010 PMID 20479361

Rajakulendran S, Kuntzer T, Dunand M, Yau SC, Ashton EJ, Storey H, McCauley J, Abbs S, Thonney F, Leturcq F, Lobrinus JA, Yousry T, Farmer S, Holton JL, Hanna MG. (2010). Marked hemiatrophy in carriers of Duchenne muscular dystrophy.  Arch Neurol 67(4):497-500 Apr. PMID 20385919

Rajakulendran S, Graves TD, Labrum RW, Kotzadimitriou D, Eunson LH, Davis MB, Davies R, Wood N, Kullmann DM, Hanna MG, Schorge S (2010). Genetic and functional characterisation of the P/Q calcium channel in episodic ataxia with epilepsy. J Physiol 15 Feb. PMID 20156848

Matthews E, Hanna MG (2010). Muscle channelopathies: does the predicted channel gating pore offer new treatment options for hypokalaemic periodic paralysis? J Physiol. 1 Feb. PMID 20123788

Hilton-Jones D, Miller A, Parton M, Holton J, Sewry C, Hanna MG (2010). IBM: MRC Centre for Neuromuscular Diseases IBM Workshop, London 13 June 2008. Neuromuscular Disorders, Feb 20(2): 142-7. PMID 20074951.

Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H (2010). Neuromuscul Disord 20(3):166-173 Mar. PMID 20080402

Matthews E, Fialho D, Tan SV, Venance SL, Cannon SC, Sternberg D, Fontaine B, Amato AA, Barohn RJ, Griggs RC, Hanna MG; CINCH Investigators (2010). The non-dystrophic myotonias: molecular pathogenesis, diagnosis and treatment. Brain. Jan;133(Pt 1):9-22. PMID 19917643

Labrum RW, Rajakulendran S, Graves TD, Eunson LH, Bevan R, Sweeney MG, Hammans SR, Tubridy N, Britton T, Carr LJ, et al. Ostergaard JR, Kennedy CR, Al-Memar A, Kullmann DM, Schorge S, Temple K, Davis MB, Hanna MG (2009) Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing (2009) Journal of Medical Genetics 46(11):786-791 Nov  2009. PMID 19586927

Hilton-Jones D, Miller A, Parton M, Holton J, Sewry C, Hanna MG. Neuromuscular Disorders. Inclusion body myositis: MRC Centre for Neuromuscular Diseases, IBM workshop, London, 13 June 2008. 2010 Feb;20(2):142-7 PMID 20074951

Heeroma JH, Henneberger C, Rajakulendran S, Hanna MG, Schorge S, Kullmann DM (2009) Episodic ataxia type 1 mutations differentially affect neuronal excitability and transmitter release Disease Models and Mechanisms 2(11-12):612-619 Nov 2009. PMID 19779067

Benevieste O, Hilton-Jones D, and the IBM Study Group (2009). First International ‘Institute of Myology Workshop’ on Inclusion Body Myositis, held in Paris in May 29, 2009. PMID

Tomlinson SE, Hanna MG, Kullmann DM, Tan SV, Burke D (2009). Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivo.  Clin Neurophysiol 120(10):1768-1776  PMID 19734086

Rajakulendran S, Tan SV, Matthews E, Tomlinson SE, Labrum R, Sud R, Kullmann DM, Schorge S, Hanna MG (2009). A patient with episodic ataxia and paramyotonia congenita due to mutations in kcna1 and scn4a.  Neurology. Sept. 73(12):993-995 PMID 19770477

Matthews E, Labrum R, Seeney M, Schorge S, Kullmann DM, Hanna M (2009). Channel voltage sensor charge loss accounts for most cases of hyopkalemic periodic paralysis . Neurology. May 5;72(18):1540-1. PMID 19118277

Sultan R, Hanna MG, Rahman S, Isenberg DA (2009). Validity testing of new clinical indexes of muscle damage and disease activity in a cohort of patients with inflammatory myopathies.  Journal of Rheumatology. In press.

Rahman SR, Hanna MG (2009). Diagnosis and therapy in neuromuscular disorders: diagnosis and new treatments in mitochondrial diseases. Journal of Neurology, Neurosurgery and Psychiatry.  Sep;80(9):943-53. PMID 19684231

Machado P, Miller A, Holton J, Hanna M (2009). Sporadic inclusion body myositis: an unsolved mystery. Acta Reumatol Portugal. Apr-Jun;34(2A):161-82 PMID 19474772

Meola G, Hanna MG, Fontaine B (2009).Diagnosis and new treatment in muscle channelopathies. J Neurol Neurosurg Psychiatry. Apr;80(4):360-5. PMID 19289476

Trender-Gerhard I, Sweeney MG, Schwingenschuh P, Mir P, Edwards MJ, Gerhard A, Polke JM, Hanna MG, Davis MB, Wood NW, Bhatia KP (2009). Autosomal-dominantGTPCH1-deficient DRD: clinical characteristics and long-term outcome of 34 patients. J Neurol Neurosurg Psychiatry. 4: 371-375 PMID 19332422

Stewart JD, Tennant S, Powell H, Pyle A, Blakely EL, He L, Hudson G, Roberts M, du Plessis D, Gow D, Mewasingh LD, Hanna MG, Omer S, Morris AA, Roxburgh R, Livingston JH, McFarland R, Turnbull DM, Chinnery PF, Taylor RW (2009). Novel POLG1 mutations associated with neuromuscular and liver phenotypes in adults and children J Med Genet. Mar;46(3):209-14. PMID 19251978

Merrison AF, Hanna MG (2009). The bare essentials: muscle disease. Pract Neurol. 9(1):54-65. PMID 19151243

Matthews E, Guet A, Mayer M, Vicart S, Pemble S, Sternberg D, Fontaine B, Hanna MG (2008) Neonatal hypotonia can be a sodium channelopathy: recognition of a new phenotype.Neurology 71(21):1740-1742 18 Nov. PMID 19015492

Fialho D, Kullmann DM, Hanna MG, Schorge S (2008). Non-genomic effects of sex hormones on CLC-1 may contribute to gender differences in myotonia congenita.
Neuromuscul Disord 21:211-216 PMID 18815035

Graves TD, Imbrici P, Kors EE, Terwindt GM, Eunson LH, Frants RR, Haan J, Ferrari MD, Goadsby PJ, Hanna MG, van den Maagdenberg AM, Kullmann DM (2008). Premature stop codons in a facilitating EF-hand splice variant of Ca(V)2.1 cause episodic ataxia type 2.  Neurobiol Disease 21:123-128 PMID 18606230

Hall AM, Unwin RJ, Hanna MG, Duchen MR (2008). Renal function and mitochondrial cytopathy (MC): more questions than answers? QJM, 21:311-315 PMID 18487272

Graves TD, Hanna MG (2008). Episodic ataxia: SLC1A3 and CACNB4 do not explain the apparent genetic heterogeneity.  J Neurol,43:211-214 PMID 18446307

Healy DG, Goadsby PJ, Kitchen ND, Yousry T, Hanna MG (2008). Neurological picture. Spontaneous intracranial hypotension, hygromata and haematomata. J Neurol Neurosurg Psychiatry. 79(4):442. PMID 18344394

Graves TD, Hanna MG (2008). Channeling into the epilepsies. Epilepsy Curr. 8(2):37-8. PMID 18344394

Matthews E, Tan SV, Fialho D, Sweeney MG, Sud R, Haworth A, Stanley E, Cea G, Davis MB, Hanna MG (2008). What causes paramyotonia in the United Kingdom? Common and new SCN4A mutations revealed. Neurology. 1;70(1):50-3. PMID 18166706

Everett CM, Graves TD, Lad S, Jäger HR, Thom M, Isenberg DA, Hanna MG (2008).
Aggressive CNS lupus vasculitis in the absence of systemic disease activity. Rheumatology (Oxford). 47(1):107-9.  PMID 18037608

GMC/GDC number: 3353945 

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