Prof Nicholas Wood

Prof Nicholas WoodTel: 020 3448 3141
Fax: 020 7278 5616

National Hospital for Neurology and Neurosurgery

Neurogenetics Laboratory, Neurogenetics

Professional background

Nicholas Wood is Research Director of the UCL Institute of Genetics and is Galton Professor of Genetics.  He qualified in medicine from Birmingham University in 1986 and undertook doctoral research at the University of Cambridge and was awarded a PhD in 1994.  He has been a Senior Lecturer, Reader and Professor at the Institute of Neurology, University of London since 1995.  He is currently a Consultant Neurologist, Head of the Department of Molecular Neuroscience and runs the Neurogenetic Laboratory at the UCL National Hospital for Neurology and Neurosurgery and the Institute of Neurology.  In 2004 he was made a Fellow of the Academy of Medical Sciences.  His primary research interest is the genetics of neurological disease with an emphasis on the genetics of Parkinson’s disease and the ataxias.  He has published over 270 peer reviewed articles and is on the board of several international neuroscience journals

Research interests

  • Neurology 
  • Neurogenetics


257. Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A, Plun-Favreau H, Edwards RE, Teismann P, Esposti MD, Morrison AD, Wood NW, Downward J, Martins LM. Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death Differ. 2009 16(3):449-64.   
258. Neumann J, Bras J, Deas E, O'Sullivan SS,, Parkkinen L, Lachmann RH, Li A, Holton J, Guerreiro R, Paudel R, Segarane B, Singleton A, Lees A, Hardy J, Houlden H,  Revesz  T, Wood NW. Glucocerebrosidase Mutations in Clinical and Pathologically Proven Parkinson's Disease.  Brain 2009 132:1783-94   
259. Lynch JM, Tate SK, Kinirons P, Weale ME, Cavalleri GL, Depondt C, Murphy K, O'Rourke D, Doherty CP, Shianna KV, Wood NW, Sander JW, Delanty N, Goldstein DB, Sisodiya SM.  No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. Epilepsy Res. 2009; 83(1):44-51.   
260. Yang YX, Wood NW, Latchman DS. Molecular basis of Parkinson's disease. Neuroreport. 2009 Jan 28;20(2):150-6   
261. Roiser J, De Martino B, Tan G, Kumaran D, Seymour B, Wood NW, Dolan R. A Genetically Mediated Bias in Decision-making Driven by Failure of Amygdala Control. J Neurosci 2009 29(18):5985-91   
262. Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman D, Tabrizi SJ,  Wood NW,  Duchen MR and Abramov AY. PINK1 associated Parkinson’s disease is caused by neuronal vulnerability to calcium induced cell death. Molecular Cell 2009;33:627-38.   
263, Michell AW, Laura M, Blake J, Lunn MP, Cox A, Gibbons VS, Davis MB, Wood NW, Manji H, Houlden H, Murray NM, Reilly MM.GJB1 gene mutations in suspected inflammatory demyelinating neuropathies not responding to treatment. J Neurol Neurosurg Psychiatry. 2009;80:699-700.    
264. Trender-Gerhard I, Sweeney MG, Schwingenschuh P, Mir P, Edwards MJ, Gerhard A, Polke JM, Hanna MG, Davis MB, Wood NW, Bhatia.KP. Autosomal-dominant GTPCH1-deficient DRD: clinical characteristics and long-term outcome of 34 patients. J Neurol Neurosurg Psychiatry. 2009;80:839-45.    
265. Sleiman PM, Healy DG, Muqit MM, Yang YX, Van Der Brug M, Holton JL, Revesz T, Quinn NP, Bhatia K, Diss JK, Lees AJ, Cookson MR, Latchman DS, Wood NW.Characterisation of a novel NR4A2 mutation in Parkinson's disease brain. Neurosci Lett. 2009;457:75-9.    
266. Yao Z, Wood NW.Cell death pathways in Parkinson's disease: Role of mitochondria. Antioxid Redox Signal. 2009 11(9):2135-49   
267. Healy DG, Bressman S, Dickson J, Silveira-Moriyama L, Schneider SA, Sullivan SS, Massey L, Bhatia KP, Shaw K, Bhatia KP, Bomanji J, Wood NW, Lees AJ.Evidence for pre and postsynaptic nigrostriatal dysfunction in the fragile X tremor-ataxia syndrome. Mov Disord. 2009 Jun 15;24(8):1245-7.   
268. Segarane B, Li A, Paudel R, Scholz S, Neumann J, Lees A, Revesz T, Hardy J, Mathias CJ, Wood NW, Holton J, Houlden H. Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy. Neurology. 2009 Mar 31;72(13):1185-6.    
269. Alves da Costa, C, Sunyach, C, Giaime, E, West, A Corti, O, Brice, A, Abou- Sleiman, PM, Wood, NW, Takahashi, H, Goldberg, MS, Shen, J, Checler, F. Transcriptional repression of p53 by parkin and impairment by autosomal recessive juvenile Parkinson’s disease-associated mutations. Nat Cell Biol 2009 11(11):1370-5   
270. Deas E, Plun-Favreau H, Wood NW. Pink1 function in Health and disease. EMBO Mol Med 2009;1:152-165.   
271. Al-Chalabi A, Dürr A, Wood NW, Parkinson MH, Camuzat A, Hulot JS, Morrison KE, Renton A, Sussmuth SD, Landwehrmeyer BG, Ludolph A, Agid Y, Brice A, Leigh PN, Bensimon G; for the NNIPPS Genetic Study Group. Genetic Variants of the alpha-Synuclein Gene SNCA Are Associated with Multiple System Atrophy. PLoS One. 2009 Sep 22;4(9):e7114.   
272. Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009 Dec;41(12):1308-12.    
273. Burchell VS, Gandhi S, Deas E, Wood NW, Abramov AY, Plun-Favreau H. Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. Expert Opin Ther Targets. 2010 Apr;14(4):369-85.   
274. Burchell VS, Gandhi S, Deas E, Wood NW, Abramov AY, Plun-Favreau H. Targeting mitochondrial dysfunction in neurodegenerative disease: Part II. Expert Opin Ther Targets. 2010 Mar 24. [Epub ahead of print]   
275. Tan GC, Doke TF, Ashburner J, Wood NW, Frackowiak RS. Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2. Neuroimage. 2010 Feb 20. [Epub ahead of print]

GMC/GDC number: 3137097