Prof Nick Fox

Prof Nick FoxTel: 020 3448 3171
Fax: 020 3448 3104

Location:
National Hospital for Neurology and Neurosurgery

Specialities:
Cognitive disorders clinic, Neurology and neurosurgery

Professional background

Professor Nick Fox's first degree was in Physics and Physiology from Cambridge.  He subsequently graduated with honours in medicine from the University of London and then specialised in cognitive neurology.  Since 1993, he has held Research Fellowships from the Alzheimer's Society and the Medical Research Council (MRC).  He is currently Professor of Neurology and MRC Senior Clinical Fellow at the Institute of Nerulogy, University College London.

He co-chairs the Research Advisory Committee of the Alzheimer’s Society and is a member of Alzheimer’s Research UK’s Scientific Advisory Board.

His clinical interests are focussed on young onset and familial dementias.  His research is aimed at improving diagnosis and treatment of cognitive problems.

He has been involved in research on MRI use in Alzehimer's disease and related disorders for the last ten years.  He has shown that AD has a pre-symptomatic period where hippocampal and global cerebral atrophy are already established and accelerating, and that subtle cognitive deficits pre-date overt symptoms.  

He has been an advisor to the NIH and an invited expert to the FDA and EMEA. He is the only non-US member of the MR imaging core of the Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Research interests

  • Dementia
  • MRI
  • Familial Alzehimer's disease
  • Early onset dementia

Publications

  1. Crutch SJ, Lehamnn M, Schott JM, Rabinovici GD, Rossor MN, Fox NC.  Posterior cortical atrophy.  Lancet Neurol  2012 Feb;11(2):170-8.    PMID:  22265212
  2. Seelaar H, Rohrer JD, Pijnenburg YA, Fox NC, van Swieten Jc.  Clinical genetic and pathological heterogeneity of frontotemporal dementia:  a review.  J Neurol Neurosurg Psychiatry.  2011 May;82(5):476-86.  PMID: 20971753
  3. Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P.  Revising the definition of Alzheimer's disease: a new lexicon.  Lancet Neurol. 2010 Nov;9(11):1118-27.  PMID: 20934914
  4. Rossor MN, Fox NC, Mummery CJ, Schott JM, Warren JD.  The diagnosis of young-onset dementia.  Lancet Neurol 2010 Aug 9(8):793-806.  PMID:  20650401
  5. Ridha BH, Barnes J, Bartlett JW, Godbolt A, Pepple T, Rossor MN, Fox NC.  Tracking atrophy progression in familial Alzheimer’s disease:  a serial MRI study.  Lancet Neurology 2006 Oct;5(10):828-34.  PMID: 16987729
  6. Chan D, Janssen JC, Whitwell JL, Watt HC, Jenkins R, Frost C, Rossor MN, Fox NC.  Change in rates of cerebral atrophy over time in early-onset Alzheimer’s disease: longitudinal MRI study.  Lancet 2003 Oct 4;362:1121-1122.  PMID:  14550701
  7. Fox NC, Black RS, Gilman S, Rossor MN,  Griffith SG, Jenkins L, Koller M.  Effects of A immunization (AN1792) on MRI measures of cerebral volume in Alzheimer’s disease. Neurology 2005 May;64(9):1563-72.  PMID: 15883317
  8. Schott JM, Fox NC, Frost C, Scahill RI, Janssen JC, Chan D, Jenkins R, Rossor MN. Assessing the onset of structural change in familial Alzheimer’s disease. Annals of Neurology 2003 Feb;53(2):181-8.  PMID: 12557284
  9. Archer HA, Edison P, Brooks DJ, Barnes J. Frost C, Yeatman T, Fox NC, Rossor MN. Amyloid load and cerebral atrophy in Alzheimer’s disease: an 11C-PIB positron emission tomography study.  Ann Neurol. 2006 Jul;60(1):145-7 
  10. Warren JD, Schott JM, Fox NC, Thom M, Revesz T, Holton JL, Scaravilli F, Thomas DGT, Plant GT, Rudge P, Rossor MN. Brain Biopsy in Dementia. Brain. 2005 Sep;128(Pt 9):2016-25.
  11. Schott J, Fox NC, Frost C, Rossor MN, Price S, Whitwell J. Measuring atrophy in Alzheimer’s disease: a serial MRI study over 6 and 12 months. Neurology 2005 Jul 12;65(1):119-24.
  12. Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, MD,  Fox NC, Eisner L, Kirby L,  Boada Rovira M, Forette F, Orgogozo JM, for the AN1792(QS-21)-201 Study Team.  Clinical effects of A immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005 May 10;64(9):1553-62. PMID: 15883316

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