Prof Peter Brocklehurst

Prof Peter BrocklehurstTel: 020 7679 6060
Fax: 020 3108 2036
Email: p.brocklehurst@ucl.ac.uk

Location:
University College Hospital

Specialities:
Women's health

Professional background

Director of the Institute for Women’s Health at UCL and Co-Director of the Department of Health Policy Research Unit in Maternal Health and Care, University of Oxford. Interim Director of the UCL Clinical Trials Unit.

Graduated in Medicine from Dundee University in 1985. After post-graduate training in Obstetrics and Gynaecology he was admitted to the RCOG in 1991. He was awarded an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine in 1994, and then joined the NPEU as a research fellow in perinatal trials, becoming a consultant clinical epidemiologist and then Director. He is a Fellow of the Royal College of Obstetricians and Gynaecologists and Fellow of the Faculty of Public Health.

Currently leads a programme of clinical trials in perinatal care and is Associate Director of Life Study, a new birth cohort study aiming to recruit up to 90,000 women during pregnancy, to collect biomedical and social data as well as biological samples – with the aim of following surviving children for the rest of their lives.

Chairs numerous steering committees and data monitoring committees, and is a member of the executive and board of the NIHR Medicines for Children Research Network (www.mcrn.org.uk). In 2010 he was made a NIHR Senior Investigator.

Other national roles:

  • NICE lead for Women’s Health for Eyes on Evidence and for Evidence Updates.
  • Chair of UKCRC Regulatory and Governance Forum.
  • Chair of DH Policy Research Programme Commissioning Panel.
  • Chair of Wellbeing of Women Research Advisory Group.

Research interests

  • Randomised controlled trials
  • Observational epidemiology
  • Infections in pregnancy and the newborn

Publications

2009
69. Carr R, Brocklehurst P, Doré CJ, Modi N. Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial. Lancet. 2009;373:226-33.
70. The International Neonatal Immunotherapy Study Collaborative Group. The INIS Study: non-specific intravenous immunoglobulin therapy for suspected or proven neonatal sepsis: an international, placebo controlled, multicentre randomised trial. BMC Pregnancy and Childbirth 2008;8:52.
71. Knight M, Kurinczuk JJ, Nelson-Piercy C, Spark P, Brocklehurst P on behalf of UKOSS. Tuberculosis in pregnancy in the UK: A national population-based descriptive study to describe patterns of disease, management and outcomes. BJOG 2009; 116:584-8.
72. Henderson G, Craig S, Brocklehurst P, McGuire W. Enteral feeding regimens and necrotising enterocolitis in preterm infants: a multicentre case-control study. Arch Dis Child Fetal Neonatal Ed 2009; 94:F120-3.
73. Henderson G, Helps N, Craig S, Brocklehurst P, McGuire W. Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study. Arch Dis Child Fetal Neonatal Ed 2009; 94:F124-8.
74. Knight M, Kurinczuk JJ, Spark P, Brocklehurst P on behalf of UKOSS. Inequalities in maternal health: national cohort study of ethnic variation in severe maternal morbidities. BMJ 2009; 338:b542 doi:10.1136/bmj.b542.
75. Marston L, Peacock JL, Yu K, Brocklehurst P, Calvert SA, Greenough A, et al. Comparing methods of analysing datasets with small clusters: case studies using four paediatric datasets. Paediatric & Perinatal Epidemiology. 2009;23:380-92.
76. Azzopardi D, Strohm B, Edwards AD, Dyet L, Halliday H, Juszczak E, Kapellou O, Levene M, Marlow N, Porter E, Thoresen M, Whitelaw A, Brocklehurst P. Moderate hypothermia to treat perinatal asphyxial encephalopathy: the TOBY randomized controlled trial. N Eng J Med 2009;361:1349-1358.
77. Leaf A, Dorling J, Kempley S, McCormick K, Mannix P, Brocklehurst P. ADEPT – Abnormal Doppler enteral prescription trial. BMC Pediatr. 2009;9:63.

2010
78. Rutherford M, Ramenghi L, Edwards D, Brocklehurst P, Halliday H, Levene M, Strohm B, Thoresen M, Whitelaw A, Azzopardi D. Assessment of brain injury after moderate hypothermia with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol. 2010;9:39-45.
79. Zhang WH, Deneux-Tharaux C, Brocklehurst P, Juszczak E, Joslin M, Alexander S; EUPHRATES Group. Effect of a collector bag for measurement of postpartum blood loss after vaginal delivery: cluster randomised trial in 13 European countries. BMJ. 2010;340:c293.
80. Edwards AD, Brocklehurst P, Gunn A, Halliday H, Juszczak E, Levene M, Strohm B, Thoresen M, Whitelaw A, Azzopardi D. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010;340;c363.
81. Field DJ, Firmin R, Azzopardi DV, Cowan F, Juszczak E, Brocklehurst P and the NEST Study Group. Neonatal ECMO study of temperature (NEST) - a randomised controlled trial. BMC Pediatr. 2010;10:11.
82. Snowdon C, Harvey SE, Brocklehurst P, Tasker RC, Ward Platt MP, Allen E, Elbourne D. BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials. Trials 2010:11;65.
83. Knight M, Kurinzuk JJ, Spark P, Brocklehurst P. Emergency postpartum hysterectomy for uncontrolled postpartum bleeding: a systematic review. Obstet Gynecol 2010;115:1306-7 [author reply].
84. Knight M, Kurinczuk JJ, Spark P, Brocklehurst P. Extreme obesity in pregnancy in the United Kingdom. Obstet Gynecol 2010;115:989-97.
85. Knight M, Tuffnell D, Brocklehurst P, Spark P, Kurinczuk JJ. Incidence and risk factors for amniotic-fluid embolism. Obstet Gynecol 2010;115:910-7.
86. Noyes J, Williams A, Allen D, Brocklehurst P, Carter C, Gregory JW, Jackson C, Lewis M, Lowes L, Russell I, Rycroft-Malone J, Sharp J, Samuels M, Tudor Edwards R, Whitaker R. Evidence into practice:  evaluating a child-centred intervention for diabetes medicine management The EPIC Project. BMC Pediatr. 2010;10:70.
87. Owen A, Marven S, Johnson P, Kurinczuk J, Spark P, Draper ES, Brocklehurst P, Knight M on behalf of BAPS-CASS. Gastroschisis: a national cohort study to describe contemporary surgical strategies and outcomes. Journal of Pediatric Surgery. 2010;45:1808-16.
88. Brocklehurst P and the CAESAR study collaborative group. Caesarean section surgical techniques: a randomized factorial trial (CAESAR). BJOG 2010;117:1366-76.
89. Homer CS, Kurinczuk JJ, Spark P, Brocklehurst P, Knight M. A novel use of a classification system to audit severe maternal morbidity. Midwifery 2010; 26:532-6.
90. Regier DA, Petrou S, Henderson J, Eddama O, Patel N, Strohm B, Brocklehurst P, Edwards AD, Azzopardi D. Cost-Effectiveness of Therapeutic Hypothermia to Treat Neonatal Encephalopathy. Value in Health. 2010;13:695-702.
91. Kenyon S, Pike K, Jones D, Brocklehurst P, Marlow N, Salt A, Taylor D. Has
publication of the results of the ORACLE Children Study changed practice in the UK? BJOG. 2010;117:1344-9.
92. Yates L, Pierce M, Stephens S, Mill AC, Spark P, Kurinczuk JJ, Valappil M, Brocklehurst P, Thomas SH, Knight M. Influenza A/H1N1v in pregnancy: an investigation of the characteristics and management of affected women and the relationship to pregnancy outcomes for mother and infant. Health Technol Assess. 2010;14:109-82.
93. Peebles DM, Marlow N, Brocklehurst P. Antenatal magnesium sulphate. BMJ. 2010;341:c6004.

2011
94. Knight M, Pierce M, Seppelt I, Kurinczuk JJ, Spark P, Brocklehurst P, McLintock, C, Sullivan, E on behalf of the UK’s Obstetric Surveillance System and the Anzic Influenza Investigators the Australasian Maternity Outcomes Surveillance System. Critical illness with AH1N1v influenza in pregnancy: a comparison of two population-based cohorts. BJOG 2011;118:232-9.
95. Kayem G, Kurinczuk JJ, Alfirevic Z, Spark P, Brocklehurst P, Knight M, on behalf of UKOSS. Uterine compression sutures for the management of severe postpartum hemorrhage. Obstetrics & Gynecology 2011;117; 14-20.
96. Knight M, Pierce M, Seppelt I, Kurinczuk J, Spark P, Brocklehurst P, McLintock C, Sullivan E. Influenza AH1N1v in pregnancy. BJOG. 2011;118:1140-1.
97. Strohm B, Hobson A, Brocklehurst P, Edwards AD, Azzopardi D; on behalf of the UK TOBY Cooling Register. Subcutaneous Fat Necrosis After Moderate Therapeutic Hypothermia in Neonates. Pediatrics. 2011;128(2), e450-e452
98. Kayem G, Kurinczuk JJ, Spark P, Brocklehurst P, Knight M. Maternal and obstetrical factors associated with delayed postpartum eclampsia: a national study population. Acta Obstet Gynecol Scand. 2011 90(9), 1017-1023.
99. Pierce M, Kurinczuk JJ, Spark P, Brocklehurst P, Knight M; on behalf of UKOSS. Perinatal outcomes after maternal 2009/H1N1 infection: national cohort study. BMJ. 2011;342:d3214.
100. Stenson B, Brocklehurst P, Tarnow-Mordi W. Increased 36-week survival with high oxygen saturation target in extremely preterm infants. N Engl J Med. 2011;364:1680-2.
101. Kayem G, Kurinczuk JJ, Alfirevic Z, Spark P, Brocklehurst P, Knight M. Specific second-line therapies for postpartum haemorrhage: a national cohort study. BJOG. 2011 Jun;118:856-64.
102. Johnston ED, Boyle B, Juszczak E, King A, Brocklehurst P, Stenson BJ. Oxygen targeting in preterm infants using the Masimo SET Radical pulse oximeter. Arch Dis Child Fetal Neonatal Ed. 2011;96(6), F429-F433.
103. Hollowell J, Oakley L, Kurinczuk JJ, Brocklehurst P, Gray R. The effectiveness of antenatal care programmes to reduce infant mortality and preterm birth in socially disadvantaged and vulnerable women in high-income countries: a systematic review. BMC Pregnancy Childbirth. 2011 Feb 11;11:13.
104. Homer CS, Kurinczuk JJ, Spark P, Brocklehurst P, Knight M. Planned vaginal delivery or planned caesarean delivery in women with extreme obesity. BJOG. 2011;118(4):480-7.
105. Askie LM, Brocklehurst P, Darlow BA, Finer N, Schmidt B, Tarnow-Mordi W for the NeOProM Collaborative Group. NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol. BMC Pediatr. 2011 Jan 17;11:6.
106. Papo JK, Bauni EK, Sanders EJ, Brocklehurst P, Jaffe HW. Exploring the condom gap: is supply or demand the limiting factor - condom access and use in an urban and a rural setting in Kilifi district, Kenya. AIDS. 2011 Jan 14;25:247-55.
107. Jones DR, Pike K, Kenyon S, Pike L, Henderson B, Brocklehurst P, Marlow N, Salt A, Taylor DJ. Routine educational outcome measures in health studies: Key Stage 1 in the ORACLE Children Study follow-up of randomised trial cohorts. Arch Dis Child. 2011;96:25-9.
108. Birthplace in England Collaborative Group. Perinatal and maternal outcomes by planned place of birth for healthy women with low risk pregnancies: the Birthplace in England national prospective cohort study. BMJ 2011;343:d7400
109. Kayem G , Kurinczuk J , Lewis G , Golightly S , Brocklehurst P , et al. Risk Factors for Progression from Severe Maternal Morbidity to Death: A National Cohort Study. 2011 PLoS ONE 6(12): e29077. oi:10.1371/journal.pone.0029077
110. Bush N, Nelson-Piercy C, Spark P, Kurinczuk J, Brocklehurst P, Knight M. Myocardial infarction in pregnancy and postpartum in the UK. Eur J Cardiovasc Prev Rehabil. 2011 Nov 29. [Epub ahead of print] PubMed PMID: 22127355
111. INIS Collaborative Group, Brocklehurst P, Farrell B, King A, Juszczak E, Darlow B, Haque K, Salt A, Stenson B, Tarnow-Mordi W. Treatment of Neonatal Sepsis with Intravenous Immune Globulin. N Engl J Med. 2011;365(13), 1201-1211.
112. Hollowell J, Kurinczuk  JJ, Brocklehurst P, Gray R. Social and Ethnic Inequalities in Infant Mortality: A Perspective from the United Kingdom. Semin Perinatol 2011;35(4), 240-244.
113. Kenyon S, Brocklehurst P. Screening and management of early onset group B streptococcus during labour. BJOG. 2011;118(7), 889
114. Williams A, Noyes J, Chandler-Oatts J, Allen D, Brocklehurst P, Carter C, Gregory J, Lenton S, Threadgold T. Health, Medicines and Self-Care Choices made by Children, Young People and their Families: Information to Support Decision-making. Final report. NIHR Service Delivery and Organisation Programme; 2011.

2012
115. Nuwagaba-Biribonwoha H, Mayon-White RT, Okong P, Brocklehurst P, Carpenter LM. The Impact of HIV on Maternal Morbidity in the Pre-HAART Era in Uganda. J Pregnancy 2012, 508657- doi:10.1155/2012/508657.
116. Pike K, Brocklehurst P, Jones D, Kenyon S, Salt A, Taylor D, Marlow N. Outcomes at 7 years for babies who developed neonatal necrotising enterocolitis: the ORACLE Children Study. Arch Dis Child Fetal Neonatal Ed. 2012 doi:10.1136/archdischild-2011-300244.
117. Crowther CA, Aghajafari F, Askie LM, Asztalos EV, Brocklehurst P, Bubner TK, Doyle LW, Dutta S, Garite TJ, Guinn DA, Hallman M, Hannah ME, Hardy P, Maurel K, Mazumder P, McEvoy C, Middleton PF, Murphy KE, Peltoniemi OM, Peters D, Sullivan L, Thom EA, Voysey M, Wapner RJ, Yelland L, Zhang S. Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: assessing the effects using the best level of evidence) - study protocol. Syst Rev 1(1), 2012- doi: http://dx.doi.org/10.1186/2046-4053-1-12
118. Knight M, Berg C, Brocklehurst P, Kramer M, Lewis G, Oats J, Roberts CL, Spong C, Sullivan E, van Roosmalen J, Zwart J. Amniotic fluid embolism incidence, risk factors and outcomes: a review and recommendations. BMC Pregnancy Childbirth. 2012;12(1), 7.
119. Fitzpatrick KE, Kurinczuk JJ, Alfirevic Z, Spark P, Brocklehurst P, et al. Uterine Rupture by Intended Mode of Delivery in the UK: A National Case-Control Study. PLoS Med 9(3) 2012: e1001184. doi:10.1371/journal.pmed.1001184
120. Schroeder E, Petrou S, Patel N, Hollowell J, Puddicombe D, Redshaw M, Brocklehurst P, on behalf of the Birthplace in England Collaborative Group. Cost effectiveness of alternative planned places of birth in woman at low risk of complications: evidence from the Birthplace in England national prospective cohort study. BMJ 344:e2292 2012
121. Leaf A, Dorling J, Kempley S, McCormick K, Mannix P, Linsell L, Juszczak E, Brocklehurst P, on behalf of the Abnormal Doppler Enteral Prescription Trial Collaborative Group. Early or Delayed Enteral Feeding for Preterm Growth-Restricted Infants: A Randomized Trial. Pediatrics Vol. 129 No. 5 May 1, 2012, pp. e1260 -e1268. doi: 10.1542/peds.2011-2379
122. Marlow N, Pike K, Bower E, Brocklehurst P, Jones D, Kenyon S, Kurinczuk JJ, Taylor D, Salt A Characteristics of children with cerebral palsy in the ORACLE children study. Developmental Medicine& Child Neurology, 2012. doi: 10.1111/j.1469-8749.2012.04274.x
123. Scott CA, Bewley S, Rudd A, Spark P, Kurinczuk JJ, Brocklehurst P, Knight M: Incidence, Risk Factors, Management, and Outcomes of Stroke in Pregnancy. Obstet Gynecol. 2012 Aug;120(2 Pt 1):318-24.
124. Azzopardi D, Strohm B, Linsell L, Hobson A, Juszczak E, Kurinczuk JJ, Brocklehurst P, Edwards AD on behalf of the UK TOBY Cooling Register. Implementation and Conduct of Therapeutic Hypothermia for Perinatal Asphyxial Encephalopathy in the UK - Analysis of National Data. PLoS One (2012) 7 (6) e38504 - ?. 10.1371/journal.pone.0038504.
125. Castanon A, Brocklehurst P, Evans H, Peebles D, Singh N, Walker P, Patnick J, Sasieni P, for the PaCT Study Group. Risk of preterm birth after treatment for cervical intraepithelial neoplasia among women attending colposcopy in England: retrospective-prospective cohort study. BMJ 2012;345:e5174.
126. Sauzet O, Wright KC, Marston L, Brocklehurst P, Peacock JL. Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous. Stat Med. 2012 Oct 1. doi: 10.1002/sim.5638. [Epub ahead of print]
127. Overton TG, Pierce MR, Gao H, Kurinczuk JJ, Spark P, Draper ES, Marven S, Brocklehurst P, Knight M. Antenatal management and outcomes of gastroschisis in the UK. Prenat Diagn. 2012 Nov 8:1-7. doi: 10.1002/pd.3998. [Epub ahead of print]
128. Fitzpatrick KE, Sellers S, Spark P, Kurinczuk JJ, Brocklehurst P, Knight M. Incidence and Risk Factors for Placenta Accreta/Increta/Percreta in the UK: A National Case-Control Study. PLoS One. 2012;7(12):e52893. doi: 10.1371/journal.pone.0052893. Epub 2012 Dec 27.

2013
129. Bramham K, Nelson-Piercy C, Gao H, Pierce M, Bush N, Spark P, Brocklehurst P, Kurinczuk JJ, Knight M. Pregnancy in renal transplant recipients: A UK national cohort study. Clin J Am Soc Nephrol 8(2), 290-298 doi:10.2215/CJN.06170612.
130. Bush N, Nelson-Piercy C, Spark P, Kurinczuk J J, Brocklehurst P, Knight M, UKOSS. Myocardial infarction in pregnancy and postpartum in the UK. Eur J Prev Cardiol 20(1), 12-20 doi:10.1177/1741826711432117.
131. Marlow N, Morris T, Brocklehurst P, Carr R, Cowan FM, Patel N, Petrou S, Redshaw ME, Modi N, Dore C. A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: Outcomes at 2 years. Arch Dis Child Fetal Neonatal Ed 98(1), F46-F53 doi:10.1136/fetalneonatal-2011-301470.
132. Sauzet O, Wright KC, Marston L, Brocklehurst P, Peacock JL. Modelling the hierarchical structure in datasets with very small clusters: A simulation study to explore the effect of the proportion of clusters when the outcome is continuous. Statistics in Medicine 32(8), 1429-1438
133. The BOOST II United Kingdom, Australia, and New Zealand Collaborative Groups.  Oxygen Saturation and Outcomes in Preterm Infants. N Engl J Med 2013; 368:2094-2104. May 30, 2013. DOI: 10.1056/NEJMoa1302298.
134. The CORONIS Collaborative Group. Caesarean section surgical techniques (CORONIS): a fractional, factorial, unmasked, randomised controlled trial. The Lancet, Early Online Publication, 28 May 2013. doi:10.1016/S0140-6736(13)60441-9.
135. Barber V, Linsell L, Locock L, Powell L, Shakeshaft C, Lean K, Colman J, Juszczak E, Brocklehurst P. Electronic fetal monitoring during labour and anxiety levels in women taking part in a RCT. British Journal of Midwifery 21(6):394-403 2013
136. Kempley S, Gupta N,  Linsell L, Dorling J, McCormick K, Mannix P, Juszczak E, Brocklehurst P, Leaf P, on behalf of the ADEPT Trial Collaborative Group. Feeding infants below 29 weeks’ gestation with abnormal antenatal Doppler: analysis from a randomised trial. Arch Dis Child Fetal Neonatal Ed doi:10.1136/archdischild-2013-304393

GMC/GDC number: 3080975