Prof Robert Heyderman

Prof Robert HeydermanTel: 020 3447 5972
Email: r.heyderman@nhs.net

Location:
University College Hospital / Hospital for Tropical Diseases

Specialities:
Tropical and infectious diseases

Professional background

I am a clinician scientist with skills and experience that bridge clinical practice and fundamental understanding of the mechanisms of infectious disease. I trained in Infectious Diseases and General Internal Medicine in London and Zimbabwe. As a senior clinical academic in Bristol for 8 years I took a strong lead in the promotion and delivery of the Infectious Diseases/ Microbiology. Nationally, I led the development of a clinical guideline for the management of meningitis and meningococcal septicaemia in adults. I have recently moved to UCL/ UCLH after directing the highly successful Malawi-Liverpool-Wellcome Trust Programme (MLW) in Malawi for over 8 years.

Research interests

My own research focuses on the endothelial biology & coagulopathy of severe infection; the microbial and immunological basis of severe infection by mucosal pathogens and their prevention through vaccination; regulation of host inflammation; and the diagnosis and management of meningitis and sepsis.

Publications

Selected publications from the previous three years (>210 peer reviewed publications):

 

Peterson I, Bar-Zeev N, Kennedy N, Ho A, Newberry L, SanJoaquin MA, Menyere M, Alaerts M, Gugulethu Mapurisa G, Chilombe M, Mambule I, Lalloo DG, Anderson ST, Katangwe T, Cunliffe N, Nagelkerke N, McMorrow M, Widdowson M-A, French N, Everett D, Heyderman RS. Respiratory virus-associated severe acute respiratory illness (SARI) and viral clustering in Malawian children in a setting with a high prevalence of HIV, malaria and malnutrition. JID 2016 In Press

Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J, Deng X, Wigley P, Barquist Barquist L, Langridge GC, Feltwell T, Harris SR, Mather AE, Fookes M, Aslett M, Msefula C, Kariuki S, Maclennan CA, Onsare RS, Weill FX, Le Hello S, Smith AM, McClelland M, Desai P, Parry CM, Cheesbrough J, French N, Campos J, Chabalgoity JA, Betancor L, Hopkins KL, Nair S, Humphrey TJ, Lunguya O, Cogan TA, Tapia MD, Sow SO, Tennant SM, Bornstein K, Levine MM, Lacharme-Lora L, Everett DB, Kingsley RA, Parkhill J, Heyderman RS, Dougan G, Gordon MA, Thomson NR. Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nat Genet. 2016;48:1211

Peterson I, Ming D, Kelly C, Malisita K, Mallewa J, Mwandumba HC, Lalloo DG, Heyderman RS. Unstructured treatment interruption: an important risk factor for arterial stiffness in adult Malawian antiretroviral (ART) patients. AIDS 2016 In press.

Singletary LA, Karlinsey JE, Libby SJ, Mooney JP, Lokken KL, Tsolis RM, Byndloss MX, Hirao LA, Gaulke CA, Crawford RW, Dandekar S, Kingsley RA, Msefula CL, Heyderman RS, Fang FC. Loss of Multicellular Behavior in Epidemic African Nontyphoidal Salmonella enterica Serovar Typhimurium ST313 Strain D23580. MBio. 2016;7: e02265-15

Heyderman RS, Madhi SA, French N, Cutland C, Ngwira B, Kayambo D, Mboizi R, Koen A, Jose L, Olugbosi M, Wittke F, Slobod K, Dull PM. Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial. Lancet Infect Dis. 2016.

Pitzer VE, Feasey NA, Msefula C, Mallewa J, Kennedy N, Dube Q, Denis B, Gordon MA, Heyderman RS. Mathematical Modeling to Assess the Drivers of the Recent Emergence of Typhoid Fever in Blantyre, Malawi. Clin Infect Dis. 2015;61 Suppl 4:S251-8.

Kulohoma BW, Cornick JE, Chaguza C, Yalcin F, Harris SR, Gray KJ, Kiran AM, Molyneux E, French N, Parkhill J, Faragher B, Everett DB, Bentley SD, Heyderman RS. Comparative genomic analysis of meningitis and bacteremia causing pneumococci identifies a common core genome. Infect Immun. 2015;83:4165-73.

Feasey NA, Everett D, Faragher EB, Roca-Feltrer A, Kang'ombe A, Denis B, Kerac M, Molyneux E, Molyneux M, Jahn A, Gordon MA, Heyderman RS. Modelling the Contributions of Malaria, HIV, Malnutrition and Rainfall to the Decline in Paediatric Invasive Non-typhoidal Salmonella Disease in Malawi. PLoS Negl Trop Dis. 2015;9:e0003979.

Bar-Zeev N, Kapanda L, King C, Beard J, Phiri T, Mvula H, Crampin AC, Mwansambo C, Costello A, Parashar U, Tate JE, Verani JR, Whitney CG, Heyderman RS, Cunliffe NA, French N, VacSurv C. Methods and challenges in measuring the impact of national pneumococcal and rotavirus vaccine introduction on morbidity and mortality in Malawi. Vaccine 2015;33:2637-45.

Feasey NA, Gaskell K, Wong V, Msefula C, Selemani G, Kumwenda S, Allain TJ, Mallewa J, Kennedy N, Bennett A, Nyirongo JO, Nyondo PA, Zulu MD, Parkhill J, Dougan G, Gordon MA, Heyderman RS. Rapid emergence of multidrug resistant, h58-lineage salmonella typhi in Blantyre, Malawi. PLoS Negl Trop Dis. 2015;9:e0003748.

Bar-Zeev N, Kapanda L, Tate JE, Jere KC, Iturriza-Gomara M, Nakagomi O, Mwansambo C, Costello A, Parashar UD, Heyderman RS, French N, Cunliffe NA, VacSurv C. Effectiveness of a monovalent rotavirus vaccine in infants in Malawi after programmatic roll-out: an observational and case-control study. Lancet Infect Dis. 2015;15:422-8.

Nyirenda TS, Gilchrist JJ, Feasey NA, Glennie SJ, Bar-Zeev N, Gordon MA, MacLennan CA, Mandala WL, Heyderman RS Sequential acquisition of T-cells and antibodies to nontyphoidal Salmonella in Malawian Children. J Infect Dis 2014;210:56-64

Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton M, Hibberd ML, Kern K, Langford PR, Ling L, Mlotha R, Ottenhoff THM, Pienaar S, Pillay V, Scott JAG, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B on behalf of the ILULU consortium and KIDS TB Study Group. Diagnosis of childhood TB in High TB/HIV burden African countries by host RNA expression. NEJM 2014;370:1712-23.

Moxon CA, Chisala NV, Wassmer SC, Taylor TE, SeydelKB , Molyneux ME, Faragher B, Kennedy N, Toh CH, Craig AG, Heyderman RS. Persistent endothelial activation and inflammation after Plasmodium falciparum infection in Malawian children. J Infect Dis 2014;209:610-5

Kaforou M, Wright VJ, Oni T, French N, Anderson ST, Bangani N, Banwel CM, Crampin AC, Dockrell HM, Eley B, Heyderman RS, Hibberd ML, Kern F, Langford PR, Ling L, Mendelson M, Ottenhoff TH, Zgambo F, Wilkinson RJ, Coin LJ, Levin M and the ILULU consortium. Diagnosis of active TB in HIV-infected and -uninfected African adults using whole blood RNA expression signatures. PloS Med 2013;10:e1001538

Moxon CA, Wassmer SC, Milner DA, Jr., Chisala NV, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Esmon CT, Downey C, Toh CH, Craig AG, Heyderman RS. Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood. 2013;122:842-51.

GMC/GDC number: 3056444