Cellular Pathology - Neuropathology 

Neuropathology provides a specialist histopathology service. Most specimens are brain- and spinal cord tumours and epilepsy lobectomies. Diagnostic biopsies are peripheral nerves and muscle biopsies, CSF cytology and serum screening for antineuronal antibodies.

Molecular pathology diagnostic tests are qPCR for Chromosomes 1p/19q in oligodendrogliomas and MGMT methylation PCR in malignant gliomas. We also  perform neuropathological post-mortem examinations, including prion disease (CJD).We also provide research services for research departments at the Institute of Neurology (UCL).
 
Conditions treated

We diagnose all diseases of the brain, spinal cord, and of the peripheral nerves and the muscles. Our work covers:

  • Brain- and spinal cord tumours and epilepsy lobectomies (ca.1000 p.a.).
  • Diagnostic biopsies are peripheral nerves (around 100 per year)
  • Muscle biopsies (around 250 per year)
  • Paediatric neuromuscular service (including the NCG Service and Dubowitz centre (together with Institute of Child Health and GOSH)
  • CSF cytology (around 800 per year)
  • Serum screening for antineuronal antibodies (around 800 per year)
  • Molecular pathology diagnostic tests are qPCR for Chromosomes 1p/19q in oligodendrogliomas and MGMT methylation PCR in malignant gliomas

Note: we make histological diagnoses on specimens - we do not carry out treatments.

Service performance

Most brain tumours are diagnosed within two to three working days. Diseases of the muscle and nerve take about two to four weeks, depending on the extent of analysis. In the last four years, we have considerably improved turnaround times for epilepsy, and nerve and muscle diseases (from two to three months to two to three weeks).

Prof Sebastian Brandner Brain Tumour Service (Neuro-Oncology), Neuropathology, Cellular Pathology - Neuropathology, Pathology
Prof Janice Holton Neuropathology, Cellular Pathology - Neuropathology, Pathology
Prof Maria Thom Brain Tumour Service (Neuro-Oncology), Neuropathology, Cellular Pathology - Neuropathology, Pathology
Dr Rahul Phadke Neuropathology, Cellular Pathology - Neuropathology

 Contact details

Cellular Pathology - Neuropathology
National Hospital for Neurology and Neurosurgery
Institute of Neurology
Queen Square
London, WC1N 3BG

Patient enquiries
Telephone: 020 3448 4234

GP enquiries
Telephone: 020 3448 4234
Fax: 020 3448 4486
Email: uclh.neuropathology@nhs.net

Other information
Urgent GP advice:
 
sebastian.brandner@nhs.net
(tumours, molecular test, peripheral nerves, creutzfeldt jakob disease)
maria.thom@nhs.net
(epilepsy, brain tumours)
janice.holton@nhs.net
(muscle disease)
(paediatric muscle)

Service manager - Linda Herbert
Email: linda.herbert1@nhs.net

 Useful links