Professor Anton Emmanuel

Dr Anton EmmanuelTel: 0203 447 9130
Fax: 020 3447 9218
Email: uclh.gimedicineenquiries@nhs.net

Location:
University College Hospital; National Hospital for Neurology and Neurosurgery

Specialities:
Colorectal service, Gastrointestinal services

Professional background

Anton Emmanuel obtained his medical degree from London University. He is A Professor in Neuro-Gastroenterology at University College London and Consultant Gastroenterologist at University College Hospital and the National Hospital for Neurology and Neurosurgery (Queen Square). Prior to this he was Senior Lecturer at Imperial College and Honorary Consultant Gastroenterologist at St Mark's Hospital.

His clinical work encompasses being director of the GI Physiology Unit at University College Hospital as well as providing a general gastroenterology service. His research includes gut neurophysiology and the study of the aetiology and management of functional gastrointestinal disorders of the upper and lower gut. He was appointed as editor in chief of Clinical Medicine and Commentary (the journals of the Royal College of Physicians), having served a similar role for eight years at Frontline Gastroenterology. He is deeply committed to developing the journals as a valued asset for members of the College.

Patients are assessed within a multi-disciplinary environment, with structural and physiological investigations undertaken as a one-stop visit alongside a focussed clinical assessment. The Unit is always happy to discuss cases by phone in order to streamline referral for the patient.

Research interests

Research and clinical areas of interest :

  • IBS and chronic constipation
  • Pelvic floor dysfunction and pain
  • Faecal incontinence
  • Gastro-oesophageal reflux and reflux-induced ENT and chest symptoms;
  • Gastroparesis
  • Appetite control and obesity
  • Chronic intestinal pseudo-obstruction
  • Gut dysfunction in systemic sclerosis
  • Gut dysfunction in spinal cord injury and multiple sclerosis
  • Colorectal sequelae of radiotherapy
  • Colorectal effects of endometriosis
  • Gut-focussed hypnotherapy and biofeedback

Publications

  • Development and assessment of the constipation-related disability scale. Chatoor D, Emmanuel A. Aliment Pharmacol Ther. 2012 Feb;35(4):487-8.
  • Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction - a double-blind, placebo-controlled, cross-over, multiple n = 1 study. Emmanuel AV, Kamm MA, Roy AJ, Kerstens R, Vandeplassche L. Aliment Pharmacol Ther. 2012 Jan;35(1):48-55.
  • Fecal Incontinence in Systemic Sclerosis Is Secondary to Neuropathy. Thoua NM, Abdel-Halim M, Forbes A, Denton CP, Emmanuel AV. Am J Gastroenterol. 2011;107(4):597-603
  • Temporary sacral nerve stimulation alters rectal sensory function: a physiological study. Abdel-Halim MR, Crosbie J, Engledow A, Windsor A, Cohen CR, Emmanuel AV. Dis Colon Rectum. 2011 Sep;54(9):1134-40
  • Vector volume manometry - methods and normal values. Schizas AM, Emmanuel AV, Williams AB. Neurogastroenterol Motil. 2011 Neurogastroenterol Motil. 2011 Sep;23(9):886-890
  • Anal canal vector volume manometry. Schizas AM, Emmanuel AV, Williams AB. Dis Colon Rectum. 2011 Jun;54(6):759-68
  • Bowel biofeedback treatment in patients with multiple sclerosis and bowel symptoms. Preziosi G, Raptis DA, Storrie J, Raeburn A, Fowler CJ, Emmanuel A. Dis Colon Rectum. 2011 Sep;54(9):1114-21.
  • Thoua N, Schizas A, Forbes A, Denton CP, Emmanuel AV.  Internal anal sphincter atrophy in patients with Systemic Sclerosis. Rheumatology 2011 Sep; 50(9):1596-1602
  • Emmanuel A. Current management strategies and therapeutic targets in chronic constipation. Therap Adv Gastroenterol. 2011 Jan;4(1):37-48
  • Bajwa, A., Thiruppathy, K., Trivedi, P., Boulos, P., Emmanuel A. Effect of rectal distension on voluntary external anal sphincter function in healthy subjects. Colorectal Dis 2011 Oct;13(10):1173-1179
  • Emmanuel, A. (2010). Managing neurogenic bowel dysfunction. Clin Rehabil 24, 483-488
  • Emmanuel, A. (2010). Review of the efficacy and safety of trans-anal irrigation for neurogenic bowel dysfunction. Spinal cord 48, 664-673
  • Thoua, N., Bunce, C., Brough, G., Forbes, A., Emmanuel, A., Denton, C. (2010). Assessment of gastrointestinal symptoms in patients with systemic slcerosis in a UK tertiary referral centre. Rheumatol (Oxford) 49, 1770-1775
  • Bajwa, A., Emmanuel, A. (2009). The physiology of continence and evacuation.. Best Practice and Research Clinical Gastroenterology 23(4), 477-485
  • Chatoor, D., Soligo, M., Emmanuel, A. (2009). Organising a clinical service for patients with pelvic floor disorders.. Best Pract Res Clin Gastroenterol 23, 611-620
  • Emmanuel, A. V., Chung, E. A., Kamm, M. A., Middleton, F. (2009). Relationship between gut-specific autonomic testing and bowel dysfunction in spinal cord injury patients.. Spinal Cord 47(8), 623-627
  • Emmanuel, A., Chatoor, D. (2009). Common proctology scenarios.. Best Practice and Research Clinical Gastroenterology 23(4), 461-461
  • Emmanuel, A., Tack, J., Quigley, E., Talley, N. (2009). Pharmacological management of constipation. Neurogastroenterol Motility 21(Suppl 2), 41-54
  • Preziosi, G., Emmanuel, A. (2009). Neurogenic bowel dysfunction: pathophysiology, clinical manifestations and treatment.. Expert Review of Gastroenterology and Hepatology 3(4), 417-423 
  • Thoua, N. M., Murray, C. D., Winchester, W. J., Roy, A. J., Pitcher, M. C., Kamm, M. A., Emmanuel, A. V. (2009). Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome.. Alimentary Pharmacology and Therapeutics 29(5), 552-560 
  • Hart, A. L., Plamondon, S., Emmanuel, A. V., Kamm, M. A. (2008). Prospective evaluation of the relationship between stress and relapse in ulcerative colitis.. Journal of Clinical Gastroenterology 42(8), 963-964 
  • Murray, C. D., Le Roux, C. W., Emmanuel, A. V., Halket, J. M., Przyborowska, A. M., Kamm, M. A., Murray-lyon, I. M. (2008). The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion. Appetite 51(3), 747-750 
  • Thoua, N., Khoo, D., Kalantzis, C., Emmanuel, A. (2008). Acid-related oesophageal sensitivity, not dysmotility, differentiates subgroups of patients with non-erosive reflux disease. Aliment Pharmacol Ther 27, 396-403 
  • Chaliha, C., Sultan, A. H., Emmanuel, A. V. (2007). Normal ranges for anorectal manometry and sensation in women of reproductive age.. Colorectal Disease 9(9), 839-844 
  • Chatoor, D. R., Taylor, S. J., Cohen, C. R., Emmanuel, A. V. (2007). Faecal incontinence. Br.J.Surg. 94(2), 134-144 
  • Kamm, M. A., Jordan, C. C., Leaker, B. R., Nicholson, F. B., Murray, C. D., Taylor, S., Marshall, M., Gibbs, A., Carter, E. G., Emmanuel, A. V. (2007). Pharmacological modulation of gut mucosal and large vessel blood flow. Aliment.Pharmacol.Ther. 25(6), 693-702 
  • Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton,, L,, Hungin,, P,, Jones,, R,, Kumar,, D,, Rubin,, G,, Trudgill,, N,, Whorwell,, P, (2007). Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 56(12), 1770-1798  
  • Chung, E. A., Emmanuel, A. V. (2006). Gastrointestinal symptoms related to autonomic dysfunction following spinal cord injury.. Progress in Brain Research 152, 317-333 
  • Craggs, M. D., Balasubramaniam, A. V., Chung, E. A. L., Emmanuel, A. V. (2006). Aberrant reflexes and function of the pelvic organs following spinal injury in man.. Autonomic Neuroscience 126-127, 355-370 
  • Murray, C. D. R., Booth, C. E., Bulmer, D. C. E., Kamm, M. A., Emmanuel, A. V., Winchester, W. J. (2006). Ghrelin augments afferent response to distension in rat isolated jejunum.. Neurogastroenterology and Motility 18(12), 1112-1120 
  • Murray, C. D. R., Le Roux, C. W., Gouveia, C., Bassett, P., Ghatei, M. A., Bloom, S. R., Emmanuel, A. V., Gabe, S. M. (2006). The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients.. Clinical Nutrition 25(4), 626-633 
  • Soligo, M., Salvatore, S., Emmanuel, A. V., De Ponti, E., Zoccatelli, M., Cortese, M., Milani, R. (2006). Patterns of constipation in urogynecology: clinical importance and pathophysiologic insights.. American Journal of Obstetrics and Gynecology 195(1), 50-55 
  • Thoua, N., Emmanuel, A. V. (2006). Managing functional GI symptoms. Postgraduate Medical Journal 6(5), 449-452 
  • Hart, A. L., Al-hassi, H. O., Rigby, R. J., Bell, S. J., Emmanuel, A. V., Knight, S. C., Kamm, M. A., Stagg, A. J. (2005). Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 129(1), 150-165 
  • Murray, C. D., Martin, N. M., Patterson, M., Taylor, S. A., Ghatei, M. A., Kamm, M. A., Johnston, C., Bloom, S. R., Emmanuel, A. V. (2005). Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut 54(12), 1693-1698 
  • Emmanuel, A. V., Shand, A., Kamm, M. A. (2004). Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with positive response.. Alimentary Pharmacology and Therapeutics 19(6), 687-694 
  • Emmanuel, A. V., Stern, J., Traesure, J., Forbes, A., Kamm, M. A. (2004). Anorexia nervosa in gastrointestinal practice. European Journal of Gastroenterology and Hepatology 16(11), 1135-1142 
  • Jarrett, M. E., Emmanuel, A. V., Vaizey, C. J., Kamm, M. A. (2004). Behavioural therapy (biofeedback) for solitary rectal ulcer syndrome improves symptoms and mucosal blood flow.. Gut 53, 368-370
  • Murray, C. D., Emmanuel, A. (2004). Ghrelin and Helicobacter pylori. 53(2), 315-315 
  • Murray, C. D., Flynn, J., Ratcliffe, L., Jacyna, M. R., Kamm, M. A., Emmanuel, A. V. (2004). Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome.. Gastroenterology 127, 1695-1703
  • Rayner, C. K., Hart, A. L., Hayward, C. M., Emmanuel, A. V., Kamm, M. A. (2004). Azathioprine dose escalation in inflammatory bowel disease.. Alimentary Pharmacology and Therapeutics 20(1), 65-71 
  • Kenefick, N. J., Emmanuel, A., Nicholls, R. J., Kamm, M. A. (2003). Effect of sacral nerve stimulation on autonomic nerve function.. British Journal of Surgery 90(10), 1256-1260 
  • Murray, C. D., Kamm, M. A., Bloom, S. R., Emmanuel, A. V. (2003). Ghrelin for the gastroenterologist: history and potential. Gastroenterology 125(5), 1492-1502 
  • Murray, C., Kamm, M., Bloom, S., Emmanuel, A. (2003). Ghrelin for the gastroenterologist: history and potential. Gastroenterology 125, 1492-1502 
  • Rayner, C. K., Mccormack, G., Emmanuel, A. V., Kamm, M. A. (2003). Long-term results of low-dose intravenous ciclosporin for acute severe ulcerative colitis.. Alimentary Pharmacology and Therapeutics 18(3), 303-308 
  • Rutter, M., Saunders, B., Emmanuel, A., Price, A. (2003). Endoscopic snare polypectomy for bleeding postinflammatory polyps.. Endoscopy 35(9), 788-790 
  • Emmanuel, A. V., Roy, A. J., Nicholls, T. J., Kamm, M. A. (2002). Prucalopride, a systemic enterokinetic, for the treatment of constipation.. Alimentary Pharmacology and Therapeutics 16(7), 1347-1356 
  • Mimura, T., Emmanuel, A. V., Kamm, M. A. (2002). Pathophysiology of diverticular disease. Best Practice and Research Clinical Gastroenterology 16(4), 563-576 
  • Murray, C. D., Emmanuel, A. V. (2002). Medical management of diverticular disease. Best Practice and Research Clinical Gastroenterology 16(4), 611-620 
  • Van Den Bogaerde, J., Cahill, J., Emmanuel, A. V., Vaizey, C. J., Talbot, I. C., Knight, S. C., Kamm, M. A. (2002). Gut mucosal response to food antigens in Crohn’s disease. Alimentary Pharmacology and Therapeutics 16(11), 1903-1915 
  • Emmanuel, A. V., Kamm, M. A. (2001). Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation.. Gut 49, 209-213
  • Emmanuel, A. V., Mason, H. J., Kamm, M. A. (2001). Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder.. Gut 49, 214-219
  • Emmanuel, A. V., Kamm, M. A., Beard, R. W. (2000). A reproducible assessment of vaginal and rectal mucosal and skin blood flow: Laser Doppler fluximetry of pelvic microcirculation. Clinical Science (London) 98(2), 201-207 
  • Emmanuel, A., Kamm, M. A. (2000). Laser Doppler flowmetry as a measure of extrinsic colonic innervation in functional bowel disease. Gut 46(2), 212-217 
  • Roy, A. J., Emmanuel, A. V., Storrie, J. B., Bowers, J., Kamm, M. A. (2000). Behavioural treatment (biofeedback) for constipation following hysterectomy. British Journal of Surgery 87(1), 100-105 
  • Emmanuel, A. V., Kamm, M. A. (1999). Doppler measurement of rectal mucosal blood flow. Gut 46(2), 212-217 
  • Emmanuel, A. V., Kamm, M. A., Roy, A. J., Antonelli, K. (1998). Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.. Gut 42(4), 511-516 
  • Emmanuel, A., Kamm, M., Roy, A., Antonelli, K. (1998). Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.. Gut 42, 511-516 
  • Vaizey, C. J., Van Den Bogaerde, J. B., Emmanuel, A. V., Talbot, I. C., Nicholls, R. J., Kamm, M. A. (1998). Solitary Rectal Ulcer Syndrome. British Journal of Surgery 85(12), 1617-1623
  • Vaizey, C., Bogaerde, J. V. D., Emmanuel, A., Talbot, I., Nicholls, J., Kamm, M. (1998). Solitary rectal ulcer syndrome. British J Surgery 85, 1617-1623

GMC/GDC number: 3460674