Dr John Malcolm Walker

Dr John Malcolm WalkerTel: 020 3447 9951
Email: malcolm.walker12@nhs.net

Cardio-oncology, Cardiology outpatients

Professional background

Graduated from the University of Birmingham (honours in pre-clinical sciences) and undertook clinical training in cardiology at St.Thomas' Hospital & the Brompton Hospital, London and at the John Radcliffe Hospital, Oxford, before taking up the post of Cardiologist and Physician at University College and the Middlesex Hospitals, London in 1987.

My research, leading to an MD in 1983, involved studying the mechanical performance of human heart muscle. This interest in laboratory research led me to set up the Hatter Cardiovascular Institute (HCI) at UCH in 1989, with a non-clinical scientist as the director of research. This Institute moved into its current premises in 2006, occupying a bespoke new building in Chenies Mews. The design incorporated clinical activity with state of the art laboratory research, so that the entire ground floor was designed to house the Cardiovascular Health and Rehabilitation services, including a spacious gymnasium.

As a consequence of my interest in rehabilitation I became Treasurer and then President of the British Association of Cardiovascular Rehabilitation, between 2001 to 2006 as well as a Council member of the British Cardiovascular Society. Involvement with patients with inherited diseases of haemoglobin has led to an active programme of clinical research and service provision with the world's first cardiology clinic set up specifically to provide a diagnostic and treatment service for these young patients with these challenging conditions: the Cardiology Centre for Inherited Diseases of Haemoglobin at the HCI.

I remain committed to general clinical cardiology, including coronary intervention, contributing to the provision of cardiology services for adults at UCLH and the Heart Hospital.

Research interests

  • General adult clinical cardiology, including coronary intervention and pacemaker therapy.
  • Cardiovascular Rehabilitation and Prevention.
  • Cardiovascular complications of inherited diseases of haemoglobin, specifically the thalassaemia syndromes and sickle cell disease.


Selected publication list

1. Anderson L.J., Wonke B., Prescott E., Holden S., Walker J.M., Pennell D.J. Comparison of the effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemai. Lancet 2002; 360(9332): 516-520

2. Gunning M.G., Walker J., Eastick S., Bomanji J.B., Ell P.J., Walker J.M. Exercise training following myocardial infarction improves myocardial perfusion assessed by thallium-201 scintigraphy. Int. J. Cardiol 2002; 84(2-3): 233-239

3. Tanner M.A., Galanello R., Dessi C., Smith G.C., Westwood M.A., Agus A., Penell D.J., Walker J.M. A randomised placebo-controlled, double blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassaemia major, using cardiovascular magnetic resonance. Circulation 2007; 115(14): 1876-1884

4. Walker J.M. The heart in Thalassaemia. Eur Heart J. 2002; 23(2): 102-105

5. Westwood M.A., Sha F., Anderson L.J., Strang J.W., Tanner M.A., Maceira A.M., Walker J.M., Penell D.J. Myocardial tissue characterisation and the role of chronic anaemia in sickle cell cardiomyopathy. J. Magn. Reson Imaging 2007; 26(3): 564-568

6. Kirk P., Roughton M. Porter J., Walker J. M., et al. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassaemia major. Circulation 2009; 120: 1961-1968

7. Walker J.M. and Nair S.V. Detection of the cardiovascular complications of thalassaemia by echocardiography. Annals N.Y. Acad. Sci 2010; 1202: 165-172

GMC/GDC number: 2234618 

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