Dr Rachel Batterham

Dr Rachel Batterham Tel: 020 3447 9419
Fax: 020 3447 9217 / 020 3447 9218
Email: rachel.batterham@nhs.net

Location:
University College Hospital

Specialities:
UCLH Bariatric Centre for Weight Management and Metabolic Surgery

Professional background

Rachel Batterham is Professor of Obesity, Diabetes and Endocrinology. She established and leads the UCLH Bariatric Centre for Weight Management and Metabolic Surgery. She is internationally renowned for her expertise in the clinical management of people with obesity and obesity-related diseases and for her obesity research. She is the Obesity Theme lead for the UCLH/UCL National Institute of Health Research Biomedical Research Centre and she was holds a highly prestigious NIHR Research Professorship (2016-2021).

Rachel plays a key national and international role in determining best care for people with obesity and related disorders and is a trustee for the Association for Study of Obesity, a member of the British Obesity and Metabolic Surgery Society council, a National Bariatric Surgery Registry Committee member, she Chairs the Royal College of Physician Advisory Group on Nutrition, Weight and Health and Weight and a clinical expert for the National Institute for Health and Clinical Excellence

Professor Batterham is passionate about empowering people affected by obesity to ensure that the patient’s voice is heard and established the charity Obesity Empowerment Network UK (https://oen.org.uk)

She studied at St Mary’s Hospital Medical School Imperial College and qualified with distinction in 1989. She then specialised in diabetes and endocrinology and developed a specialist interest in obesity. She obtained an MSc in Biochemistry and Molecular Biology and then a PhD in body weight regulation. She was appointed as a consultant at UCLH in 2005 and she set up the UCLH obesity services in 2007.

Research interests

Professor Batterham is the head of the Centre for Obesity Research, Department of Medicine, University College London. Her research expertise is broad ranging including cutting-edge basic science research, lifestyle interventions, clinical trials and influencing health-care policy. Her work has played a key role in identifying gut hormones as tractable therapeutic targets for obesity. She has received several prestigious awards including the Andre Mayer award from the World Obesity Federation (2016), the Diabetes UK Rank Fund Nutrition Prize (2015), the Lilly Scientific Achievement Award from The Obesity Society (2014), and the Linacre Medical from the Royal College of Physicians (2010). Professor Batterham was awarded the Sir Jules Thorn Award for Biomedical Research (2017-2022) and her programme of research will be focused on maximising the health benefits obtained from bariatric surgery.

Publications

  1. Stahel P, Nahmias A, Sud SK, Lee SJ, Pucci A, Yousseif A, Youseff A, Jackson T, Urbach DR, Okrainec A, Allard JP, Sockalingam S, Yao T, Barua M, Jiao H, Magi R, Bassett AS, Paterson AD, Dahlman I, Batterham RL Dash S. Evaluation of the Genetic Association Between Adult Obesity and Neuropsychiatric Disease. Diabetes 2019;68:2235-2246.
  2. Pucci A, Batterham RL. Mechanisms underlying the weight loss effects of RYGB and SG: similar, yet different. J Endocrinol Invest 2019;42:117-128.
  3. Miras AD, Perez-Pevida B, Aldhwayan M, Kamocka A, McGlone ER, Al-Najim W, Chahal H, Batterham RL, McGowan B, Khan O, Greener V, Ahmed AR, Petrie A, Scholtz S, Bloom SR, Tan TM. Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 2019;7:549-559.
  4. Leitch VD, Brassill MJ, Rahman S, Butterfield NC, Ma P, Logan JG, Boyde A, Evans H, Croucher PI, Batterham RL, Williams GR, Bassett JHD. PYY is a negative regulator of bone mass and strength. Bone 2019;127:427-435.
  5. Dorling JL, Clayton DJ, Jones J, Carter WG, Thackray AE, King JA, Pucci A, Batterham RL, Stensel DJ. A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism. Am J Clin Nutr 2019;110:1055-1066.
  6. Zakeri R, Batterham RL. Potential mechanisms underlying the effect of bariatric surgery on eating behaviour. Curr Opin Endocrinol Diabetes Obes 2018;25:3-11.
  7. Zakeri R, Batterham RL. Obesity: when is specialist referral needed? Br J Gen Pract 2018;68:264-265.
  8. Wang FF, Wu Y, Zhu YH, Ding T, Batterham RL, Qu F, Hardiman PJ. Pharmacologic therapy to induce weight loss in women who have obesity/overweight with polycystic ovary syndrome: a systematic review and network meta-analysis. Obes Rev 2018;19:1424-1445.
  9. Tymoszuk U, Kumari M, Pucci A, Cheung WH, Kirk A, Tschiala A, Carr-Rose K, Kingett H, Doyle J, Jenkinson A, Hashemi M, Adamo M, Elkalaawy M, Stafford M, Batterham RL. Is Pre-operation Social Connectedness Associated with Weight Loss up to 2 Years Post Bariatric Surgery? Obes Surg 2018;28:3524-3530.
  10. Smith OJ, Hachach-Haram N, Greenfield M, Bystrzonowski N, Pucci A, Batterham RL, Hashemi M, Mosahebi A. Body Contouring Surgery and the Maintenance of Weight-Loss Following Roux-En-Y Gastric Bypass: A Retrospective Study. Aesthet Surg J 2018;38:176-182.
  11. Puthucheary ZA, Astin R, McPhail MJW, Saeed S, Pasha Y, Bear DE, Constantin D, Velloso C, Manning S, Calvert L, Singer M, Batterham RL, Gomez-Romero M, Holmes E, Steiner MC, Atherton PJ, Greenhaff P, Edwards LM, Smith K, Harridge SD, Hart N, Montgomery HE. Metabolic phenotype of skeletal muscle in early critical illness. Thorax 2018;73:926-935.
  12. Pucci A, Tymoszuk U, Cheung WH, Makaronidis JM, Scholes S, Tharakan G, Elkalaawy M, Guimaraes M, Nora M, Hashemi M, Jenkinson A, Adamo M, Monteiro MP, Finer N, Batterham RL. Type 2 diabetes remission 2 years post Roux-en-Y gastric bypass and sleeve gastrectomy: the role of the weight loss and comparison of DiaRem and DiaBetter scores. Diabet Med 2018;35:360-367.
  13. McGlone ER, Wingfield LR, Munasinghe A, Batterham RL, Reddy M, Khan OA. A pilot study of primary care physicians' attitude to weight loss surgery in England: are the young more prejudiced? Surg Obes Relat Dis 2018;14:376-380.
  14. Makaronidis JM, Batterham RL. Obesity, body weight regulation and the brain: insights from fMRI. Br J Radiol 2018;91:20170910.
  15. Koppe U, Nitsch D, Mansfield KE, Mathur R, Bhaskaran K, Batterham RL, Smeeth L, Douglas IJ. Long-term effects of bariatric surgery on acute kidney injury: a propensity-matched cohort in the UK Clinical Practice Research Datalink. BMJ Open 2018;8:e020371.
  16. Jassil FC, Carnemolla A, Kingett H, Paton B, O'Keeffe AG, Doyle J, Morris S, Lewis N, Kirk A, Pucci A, Chaiyasoot K, Batterham RL. Protocol for a 1-year prospective, longitudinal cohort study of patients undergoing Roux-en-Y gastric bypass and sleeve gastrectomy: the BARI-LIFESTYLE observational study. BMJ Open 2018;8:e020659.
  17. Dorling J, Broom DR, Burns SF, Clayton DJ, Deighton K, James LJ, King JA, Miyashita M, Thackray AE, Batterham RL, Stensel DJ. Acute and Chronic Effects of Exercise on Appetite, Energy Intake, and Appetite-Related Hormones: The Modulating Effect of Adiposity, Sex, and Habitual Physical Activity. Nutrients 2018;10.
  18. Chaiyasoot K, Sarasak R, Pheungruang B, Dawilai S, Pramyothin P, Boonyasiri A, Supapueng O, Jassil FC, Yamwong P, Batterham RL. Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial. Nutr Diabetes 2018;8:23.
  19. Busetto L, Dicker D, Azran C, Batterham RL, Farpour-Lambert N, Fried M, Hjelmesaeth J, Kinzl J, Leitner DR, Makaronidis JM, Schindler K, Toplak H, Yumuk V. Obesity Management Task Force of the European Association for the Study of Obesity Released "Practical Recommendations for the Post-Bariatric Surgery Medical Management". Obes Surg 2018;28:2117-2121.
  20. Brackenridge L, Finer N, Batterham RL, Pedram K, Ding T, Stephenson J, Barry J, Hardiman P. Pre-pregnancy weight loss in women with obesity requesting removal of their intra-uterine contraceptive device in order to conceive: a pilot study of full meal replacement. Clin Obes 2018;8:244-249.
  21. Wahl S, Drong A, Lehne B, Loh M, Scott WR, Kunze S, Tsai PC, Ried JS, Zhang W, Yang Y, Tan S, Fiorito G, Franke L, Guarrera S, Kasela S, Kriebel J, Richmond RC, Adamo M, Afzal U, Ala-Korpela M, Albetti B, Ammerpohl O, Apperley JF, Beekman M, Bertazzi PA, Black SL, Blancher C, Bonder MJ, Brosch M, Carstensen-Kirberg M, de Craen AJ, de Lusignan S, Dehghan A, Elkalaawy M, Fischer K, Franco OH, Gaunt TR, Hampe J, Hashemi M, Isaacs A, Jenkinson A, Jha S, Kato N, Krogh V, Laffan M, Meisinger C, Meitinger T, Mok ZY, Motta V, Ng HK, Nikolakopoulou Z, Nteliopoulos G, Panico S, Pervjakova N, Prokisch H, Rathmann W, Roden M, Rota F, Rozario MA, Sandling JK, Schafmayer C, Schramm K, Siebert R, Slagboom PE, Soininen P, Stolk L, Strauch K, Tai ES, Tarantini L, Thorand B, Tigchelaar EF, Tumino R, Uitterlinden AG, van Duijn C, van Meurs JB, Vineis P, Wickremasinghe AR, Wijmenga C, Yang TP, Yuan W, Zhernakova A, Batterham RL, Smith GD, Deloukas P, Heijmans BT, Herder C, Hofman A, Lindgren CM, Milani L, van der Harst P, Peters A, Illig T, Relton CL, Waldenberger M, Jarvelin MR, Bollati V, Soong R, Spector TD, Scott J, McCarthy MI, Elliott P, Bell JT, Matullo G, Gieger C, Kooner JS, Grallert H, Chambers JC. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature 2017;541:81-86.
  22. O'Toole SM, Turner BC, Plowman PN, Batterham RL, Drake WM. An unusual adrenal cause of hypoglycaemia. QJM 2017;110:675-676.
  23. Monteiro MP, Batterham RL. The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance. Gastroenterology 2017;152:1707-1717 e2.
  24. MacLean PS, Blundell JE, Mennella JA, Batterham RL. Biological control of appetite: A daunting complexity. Obesity (Silver Spring) 2017;25 Suppl 1:S8-S16.
  25. King JA, Deighton K, Broom DR, Wasse LK, Douglas JA, Burns SF, Cordery PA, Petherick ES, Batterham RL, Goltz FR, Thackray AE, Yates T, Stensel DJ. Individual Variation in Hunger, Energy Intake, and Ghrelin Responses to Acute Exercise. Med Sci Sports Exerc 2017;49:1219-1228.
  26. Busetto L, Dicker D, Azran C, Batterham RL, Farpour-Lambert N, Fried M, Hjelmesaeth J, Kinzl J, Leitner DR, Makaronidis JM, Schindler K, Toplak H, Yumuk V. Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management. Obes Facts 2017;10:597-632.
  27. Aleid M, Muneer A, Renshaw S, George J, Jenkinson AD, Adamo M, Elkalaawy M, Batterham RL, Ralph DJ, Hashemi M, Cellek S. Early Effect of Bariatric Surgery on Urogenital Function in Morbidly Obese Men. J Sex Med 2017;14:205-214.
  28. Steven S, Hollingsworth KG, Small PK, Woodcock SA, Pucci A, Aribisala B, Al-Mrabeh A, Daly AK, Batterham RL, Taylor R. Weight Loss Decreases Excess Pancreatic Triacylglycerol Specifically in Type 2 Diabetes. Diabetes Care 2016;39:158-65.
  29. Steven S, Hollingsworth KG, Small PK, Woodcock SA, Pucci A, Aribasala B, Al-Mrabeh A, Batterham RL, Taylor R. Calorie restriction and not glucagon-like peptide-1 explains the acute improvement in glucose control after gastric bypass in Type 2 diabetes. Diabet Med 2016;33:1723-1731.
  30. Makaronidis JM, Neilson S, Cheung WH, Tymoszuk U, Pucci A, Finer N, Doyle J, Hashemi M, Elkalaawy M, Adamo M, Jenkinson A, Batterham RL. Reported appetite, taste and smell changes following Roux-en-Y gastric bypass and sleeve gastrectomy: Effect of gender, type 2 diabetes and relationship to post-operative weight loss. Appetite 2016;107:93-105.
  31. Makaronidis JM, Batterham RL. Potential Mechanisms Mediating Sustained Weight Loss Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy. Endocrinol Metab Clin North Am 2016;45:539-52.
  32. Di Caro S, Cheung WH, Fini L, Keane MG, Theis B, Haidry R, Di Renzo L, De Lorenzo A, Lovat L, Batterham RL, Banks M. Role of body composition and metabolic profile in Barrett's oesophagus and progression to cancer. Eur J Gastroenterol Hepatol 2016;28:251-60.
  33. Batterham RL, Cummings DE. Mechanisms of Diabetes Improvement Following Bariatric/Metabolic Surgery. Diabetes Care 2016;39:893-901.
  34. Alajmi N, Deighton K, King JA, Reischak-Oliveira A, Wasse LK, Jones J, Batterham RL, Stensel DJ. Appetite and Energy Intake Responses to Acute Energy Deficits in Females versus Males. Med Sci Sports Exerc 2016;48:412-20.
  35. Pucci A, Cheung WH, Jones J, Manning S, Kingett H, Adamo M, Elkalaawy M, Jenkinson A, Finer N, Doyle J, Hashemi M, Batterham RL. A case of severe anorexia, excessive weight loss and high peptide YY levels after sleeve gastrectomy. Endocrinol Diabetes Metab Case Rep 2015;2015:150020.
  36. Muller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Dieguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrere B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschop MH. Ghrelin. Mol Metab 2015;4:437-60.
  37. Manning S, Pucci A, Carter NC, Elkalaawy M, Querci G, Magno S, Tamberi A, Finer N, Fiennes AG, Hashemi M, Jenkinson AD, Anselmino M, Santini F, Adamo M, Batterham RL. Early postoperative weight loss predicts maximal weight loss after sleeve gastrectomy and Roux-en-Y gastric bypass. Surg Endosc 2015;29:1484-91.
  38. Manning S, Pucci A, Batterham RL. GLP-1: a mediator of the beneficial metabolic effects of bariatric surgery? Physiology (Bethesda) 2015;30:50-62.
  39. Manning S, Pucci A, Batterham RL. Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms. J Clin Invest 2015;125:939-48.
  40. Jassil FC, Manning S, Lewis N, Steinmo S, Kingett H, Lough F, Pucci AB, Cheung WH, Finer N, Walker J, Doyle J, Batterham RL. Feasibility and Impact of a Combined Supervised Exercise and Nutritional-Behavioral Intervention following Bariatric Surgery: A Pilot Study. J Obes 2015;2015:693829.
  41. Douglas IJ, Bhaskaran K, Batterham RL, Smeeth L. The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort. Br J Clin Pharmacol 2015;79:1020-7.
  42. Douglas IJ, Bhaskaran K, Batterham RL, Smeeth L. Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care. PLoS Med 2015;12:e1001925.
  43. Yousseif A, Emmanuel J, Karra E, Millet Q, Elkalaawy M, Jenkinson AD, Hashemi M, Adamo M, Finer N, Fiennes AG, Withers DJ, Batterham RL. Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans. Obes Surg 2014;24:241-52.
  44. Manning S, Finer N, Elkalaawy M, Hashemi M, Jenkinson AD, Adamo M, O'Brien P, Batterham RL, Richens Y. Timing of pregnancy in obese women after bariatric surgery. Pregnancy Hypertens 2014;4:235.
  45. Manning S, Carter NC, Pucci A, Jones A, Elkalaawy M, Cheung WH, Mohammadi B, Finer N, Fiennes AG, Hashemi M, Jenkinson AD, Adamo M, Batterham RL. Age- and sex-specific effects on weight loss outcomes in a comparison of sleeve gastrectomy and Roux-en-Y gastric bypass: a retrospective cohort study. BMC Obes 2014;1:12.
  46. Manning S, Batterham RL. The role of gut hormone peptide YY in energy and glucose homeostasis: twelve years on. Annu Rev Physiol 2014;76:585-608.
  47. Manning S, Batterham RL. Enteroendocrine MC4R and energy balance: linking the long and the short of it. Cell Metab 2014;20:929-31.
  48. Deighton K, Batterham RL, Stensel DJ. Appetite and gut peptide responses to exercise and calorie restriction. The effect of modest energy deficits. Appetite 2014;81:52-9.
  49. Scott WR, Gelegen C, Chandarana K, Karra E, Yousseif A, Amouyal C, Choudhury AI, Andreelli F, Withers DJ, Batterham RL. Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice. PLoS One 2013;8:e59407.
  50. Manning SB, Pucci A, Batterham RL, Finer N. Latent autoimmune diabetes in adults presenting as diabetes "recurrence" after bariatric surgery: a case report. Diabetes Care 2013;36:e120.
  51. Magi R, Manning S, Yousseif A, Pucci A, Santini F, Karra E, Querci G, Pelosini C, McCarthy MI, Lindgren CM, Batterham RL. Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery. PLoS One 2013;8:e70735.
  52. Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Ruther UU, Bruning JC, Withers DJ, Zelaya FO, Batterham RL. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest 2013;123:3539-51.
  53. Deighton K, Karra E, Batterham RL, Stensel DJ. Appetite, energy intake, and PYY3-36 responses to energy-matched continuous exercise and submaximal high-intensity exercise. Appl Physiol Nutr Metab 2013;38:947-52.
  54. Chandarana K, Gelegen C, Irvine EE, Choudhury AI, Amouyal C, Andreelli F, Withers DJ, Batterham RL. Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance. Mol Metab 2013;2:142-52.
  55. Wasse LK, Sunderland C, King JA, Batterham RL, Stensel DJ. Influence of rest and exercise at a simulated altitude of 4,000 m on appetite, energy intake, and plasma concentrations of acylated ghrelin and peptide YY. J Appl Physiol (1985) 2012;112:552-9.
  56. Gelegen C, Chandarana K, Choudhury AI, Al-Qassab H, Evans IM, Irvine EE, Hyde CB, Claret M, Andreelli F, Sloan SE, Leiter AB, Withers DJ, Batterham RL. Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice. Am J Physiol Endocrinol Metab 2012;303:E659-68.
  57. Chandarana K, Batterham RL. Shedding pounds after going under the knife: metabolic insights from cutting the gut. Nat Med 2012;18:668-9.
  58. Scott WR, Batterham RL. Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery. Am J Physiol Regul Integr Comp Physiol 2011;301:R15-27.
  59. King JA, Wasse LK, Ewens J, Crystallis K, Emmanuel J, Batterham RL, Stensel DJ. Differential acylated ghrelin, peptide YY3-36, appetite, and food intake responses to equivalent energy deficits created by exercise and food restriction. J Clin Endocrinol Metab 2011;96:1114-21.
  60. Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes 2011;60:735-45.
  61. Chandarana K, Gelegen C, Karra E, Choudhury AI, Drew ME, Fauveau V, Viollet B, Andreelli F, Withers DJ, Batterham RL. Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY. Diabetes 2011;60:810-8.
  62. Symmonds M, Emmanuel JJ, Drew ME, Batterham RL, Dolan RJ. Metabolic state alters economic decision making under risk in humans. PLoS One 2010;5:e11090.
  63. Neary MT, Batterham RL. Gaining new insights into food reward with functional neuroimaging. Forum Nutr 2010;63:152-163.
  64. Karra E, Yousseif A, Batterham RL. Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery. Trends Endocrinol Metab 2010;21:337-44.
  65. Karra E, Batterham RL. The role of gut hormones in the regulation of body weight and energy homeostasis. Mol Cell Endocrinol 2010;316:120-8.
  66. Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009;326:140-4.
  67. Neary MT, Batterham RL. Peptide YY: food for thought. Physiol Behav 2009;97:616-9.
  68. Neary MT, Batterham RL. Gut hormones: implications for the treatment of obesity. Pharmacol Ther 2009;124:44-56.
  69. Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. J Physiol 2009;587:19-25.
  70. Chandarana K, Drew ME, Emmanuel J, Karra E, Gelegen C, Chan P, Cron NJ, Batterham RL. Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans. Gastroenterology 2009;136:2115-26.
  71. Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ. Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 2009;119:125-35.
  72. Broom DR, Batterham RL, King JA, Stensel DJ. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integr Comp Physiol 2009;296:R29-35.
  73. Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 2009;10:343-54.
  74. Tsilchorozidou T, Batterham RL, Conway GS. Metformin increases fasting plasma peptide tyrosine tyrosine (PYY) in women with polycystic ovarian syndrome (PCOS). Clin Endocrinol (Oxf) 2008;69:936-42.
  75. Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J 2008;22:807-18.
  76. Rahman S, Scobie AI, Elkalaawy M, Bidlake LE, Fiennes AG, Batterham RL. Can glucose make you faint? Lancet 2008;372:1358.
  77. Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 2007;117:2325-36.
  78. Batterham RL, ffytche DH, Rosenthal JM, Zelaya FO, Barker GJ, Withers DJ, Williams SC. PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 2007;450:106-9.
  79. le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 2006;147:3-8.
  80. le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V, Shurey S, Ghatei MA, Patel AG, Bloom SR. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006;243:108-14.
  81. Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 2006;4:223-33.
  82. Renshaw D, Batterham RL. Peptide YY: a potential therapy for obesity. Curr Drug Targets 2005;6:171-9.
  83. Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 2005;115:940-50.
  84. Dakin CL, Small CJ, Batterham RL, Neary NM, Cohen MA, Patterson M, Ghatei MA, Bloom SR. Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 2004;145:2687-95.
  85. Cohen MA, Ellis SM, Le Roux CW, Batterham RL, Park A, Patterson M, Frost GS, Ghatei MA, Bloom SR. Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab 2003;88:4696-701.
  86. Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, Frost GS, Ghatei MA, Bloom SR. Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab 2003;88:3989-92.
  87. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003;349:941-8.
  88. Batterham RL, Bloom SR. The gut hormone peptide YY regulates appetite. Ann N Y Acad Sci 2003;994:162-8.
  89. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002;418:650-4.
  90. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA,  Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001;50:2540-7.

Guidelines

British Obesity and Metabolic Surgery Society 'Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery' 2014.

NICE GUIDELINE CG189 'Obesity-Identification, assessment and management of overweight and obesity in children, young people and adults' November 2014.

GMC/GDC number: 4192064