Dr Rachel Batterham

Dr Rachel Batterham Tel: 020 3447 9419
Fax: 020 3447 9217 / 020 3447 9218
Email: rachel.batterham@uclh.nhs.uk

Location:
University College Hospital

Specialities:
UCLH Bariatric Centre for Weight Management and Metabolic Surgery

Professional background

Rachel Batterham is professor of obesity, diabetes and endocrinology. She established and leads the UCLH Bariatric Centre for Weight Management and Metabolic Surgery. She is internationally renown for her expertise in the clinical management of people with obesity and obesity-related diseases and for her obesity research. She is the obesity theme lead for the UCLH/UCL National Institute of Health Research Biomedical Research Centre and she was holds a highly prestigious NIHR Research Professorship (2016-2021).

Rachel plays a key national and international role in determining best care for people with obesity and related disorders and is a trustee for the Association for Study of Obesity, a member of the British Obesity and Metabolic Surgery Society council, a member of member of the Royal College of Physician Advisory Group on Health and Weight and a clinical expert for the National Institute for Health Research.

Professor Batterham is passionate about empowering people affected by obesity to ensure that the patient’s voice is heard.

She studied at St Mary’s Hospital Medical School Imperial College and qualified with distinction in 1989. She then specialised in diabetes and endocrinology and developed a specialist interest in obesity. She obtained an MSc in Biochemistry and Molecular Biology and then a PhD in body weight regulation. She was appointed as a consultant at UCLH in 2005 and she set up the UCLH obesity services in 2007.

Research interests

Professor Batterham is the head of the Centre for Obesity Research, Department of Medicine, University College London. Her research expertise is broad ranging including cutting-edge basic science research, lifestyle interventions, clinical trials and influencing health-care policy. Her work has played a key role in identifying gut hormones as tractable therapeutic targets for obesity. She has received several prestigious awards including the Andre Mayer award from the World Obesity Federation (2016), the Diabetes UK Rank Fund Nutrition Prize (2015), the Lilly Scientific Achievement Award from The Obesity Society (2014), and the Linacre Medical from the Royal College of Physicians (2010). Professor Batterham was awarded the Sir Jules Thorn Award for Biomedical Research (2017-2022) and her programme of research will be focused on maximising the health benefits obtained from bariatric surgery.

Publications

Steven S, Hollingsworth KG, Small PK, Woodcock SA, Pucci A, Aribasala B, Al-Mrabeh A, Batterham RL, Taylor R. Calorie restriction and not glucagon-like peptide-1 explains the acute improvement in glucose control after gastric bypass in Type 2 diabetes. Diabet Med. 2016 Sep 2. doi: 10.1111/dme.13257

Makaronidis JM, Neilson S, Cheung WH, Tymoszuk U, Pucci A, Finer N, Doyle J, Hashemi M, Elkalaawy M, Adamo M, Jenkinson A, Batterham RL 2016 Reported appetite, taste and smell changes following Roux-en-Y gastric bypass and sleeve gastrectomy: Effect of gender, type 2 diabetes and relationship to post-operative weight loss. Appetite Jul 22;107:93-105. doi: 10.1016/j.appet.2016.07.029. [Epub ahead of print]

Steven S, Hollingsworth KG, Small PK, Woodcock SA, Pucci A, Aribisala B, Al-Mrabeh A, Daly AK, Batterham RL, Taylor R 2016 Weight Loss Decreases Excess Pancreatic Triacylglycerol Specifically in Type 2 Diabetes. Diabetes Care 39:158-165

Di Caro S, Cheung WH, Fini L, Keane MG, Theis B, Haidry R, Di Renzo L, De Lorenzo A, Lovat L, Batterham RL, Banks M 2016 Role of body composition and metabolic profile in Barrett's oesophagus and progression to cancer. European Journal of Gastroenterology & Hepatology 28:251-260

Douglas IJ, Bhaskaran K, Batterham RL, Smeeth L 2015 Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care. PLoS Medicine 12:e1001925

Nawal A, Deighton K, King JA, Reischak-Oliveira A, Wasse LK, Jones J, Batterham RL, and Stensel D. "Appetite and Energy Intake Responses to Acute Energy Deficits in Females Versus Males." Medicine and Science in Sports and Exercise (2015).

Jassil FC, Manning S, Lewis N, Steinmo S, Kingett H, Lough F, Pucci A, Cheung WH, Finer A, Walker J, Doyle J, Batterham RL. Feasibility and Impact of a Combined Supervised Exercise and Nutritional-Behavioral Intervention Following Bariatric Surgery: a Pilot Study. Journal of Obesity 2015;2015:693829. doi: 10.1155/2015/693829

Hayes J, Bhaskaran K, Batterham RL, Smeeth L, Douglas I. The effect of sibutramine prescribing in routine clinical practice on cardiovascular outcomes: a cohort study in the United Kingdom. Int J Obesity advance online publication, June 9, 2015; DOI:10.1038/ijo.2015.86.

Douglas IJ, Bhaskaran K, Batterham RL, Smeeth L. The effectiveness of pharmaceutical interventions for obesity: Weight loss with orlistat and sibutramine in a United Kingdom population-based cohort. Br J Clin Pharmacol DOI: 10.1111/bcp.12578 2015 Jun;79(6):1020-7.

Manning S, Pucci A, Carter NC, Elkalaawy M, Querci G, Magno S, Tamberi A, Finer N, Fiennes AG, Hashemi M, Jenkinson A, Anselmino M, Ferrucio S, Adamo M, Batterham RL. Early post-operative weight loss predicts maximal weight loss after sleeve gastrectomy and Roux-en-Y gastric bypass surgery. Surg Endoscopy. Sep 20, 2014.

Manning S, Carter N.C, Pucci A, Jones A, Elkalaawy M, Cheung  W, Mohammadi  B, Finer  N, Fiennes A.G, Hashemi  M, Jenkinson A.D, Adamo  M, Batterham RL. Age- and sex-specific effects on weight loss outcomes in a comparison of sleeve gastrectomy and Roux-en-Y gastric bypass: a retrospective cohort study. BMC Obesity. 1:12. DOI: 10.1186/2052-9538-1-12 2014.

Deighton K, Batterham RL, Stensel DJ. The effect of modest energy deficits on appetite and gut peptide responses to exercise and calorie restriction. Appetite. 2014 Oct;81:52-9. DOI: 10.1016/j.appet.2014.06.003. Epub 2014 Jun 6.

Chandarana K, Gelegen C, Irvine EE, Choudhury AI, Amouyal C, Andreelli F, Withers DJ, Batterham RL. Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance. Molecular Metabolism, 2: 142-152, 2013

Yousseif A, Emmanuel J, Karra E, Millet Q, Elkalaawy M, Jenkinson A, Hashemi M, Adamo M, Finer N, Fiennes A, Withers DJ, Batterham RL. Differential Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on Appetite, Circulating Acyl-ghrelin, Peptide YY3-36 and Active GLP-1 Levels in Non-diabetic Humans. Obesity Surgery:1-12, 2013 DOI 10.1007/s11695-013-1066-0

Mägi R, Manning S, Yousseif A, Pucci A, Santini F, Karra E, Querci G, Pelosini C, McCarthy MI, Lindgren CM, Batterham RL. Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery. PLoS One 8:e70735, 2013

Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Ruther UU, Bruning JC, Withers DJ, Zelaya FO, Batterham RL. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest 123:3539-3551, 2013

Scott WR, Gelegen C, Chandarana K, Karra E, Yousseif A, Amouyal C, Choudhury AI, Andreelli F, Withers DJ, Batterham RL. Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice. PLoS One 8:e59407, 2013

Deighton K, Karra E, Batterham RL, Stensel DJ. Appetite, energy intake, and PYY3-36 responses to energy-matched continuous exercise and submaximal high-intensity exercise. Appl Physiol Nutr Metab 38:947-952, 2013

Wasse LK, Sunderland C, King JA, Batterham RL, Stensel DJ. Influence of rest and exercise at a simulated altitude of 4,000 m on appetite, energy intake, and plasma concentrations of acylated ghrelin and peptide YY. J Appl Physiol 112:552-559, 2012

Gelegen C, Chandarana K, Choudhury AI, Al-Qassab H, Evans IM, Irvine EE, Hyde CB, Claret M, Andreelli F, Sloan SE, Leiter AB, Withers DJ, Batterham RL. Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice. Am J Physiol Endocrinol Metab 303:E659-668, 2012

King JA, Wasse LK, Ewens J, Crystallis K, Emmanuel J, Batterham RL, Stensel DJ. Differential acylated ghrelin, peptide YY3-36, appetite, and food intake responses to equivalent energy deficits created by exercise and food restriction. J Clin Endocrinol Metab 96:1114-1121, 2011

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes 60:735-745, 2011

Chandarana K, Gelegen C, Karra E, Choudhury AI, Drew ME, Fauveau V, Viollet B, Andreelli F, Withers DJ, Batterham RL. Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY. Diabetes 60:810-818, 2011

Symmonds M, Emmanuel JJ, Drew ME, Batterham RL, Dolan RJ. Metabolic state alters economic decision making under risk in humans. PLoS One 5:e11090, 2010

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326:140-144, 2009

Chandarana K, Drew ME, Emmanuel J, Karra E, Gelegen C, Chan P, Cron NJ, Batterham RL. Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans. Gastroenterology 136:2115-2126, 2009

Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ. Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 119:125-135, 2009

Broom DR, Batterham RL, King JA, Stensel DJ. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integr Comp Physiol 296:R29-35, 2009

Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 10:343-354, 2009

Tsilchorozidou T, Batterham RL, Conway GS. Metformin increases fasting plasma peptide tyrosine tyrosine (PYY) in women with polycystic ovarian syndrome (PCOS). Clin Endocrinol (Oxf) 69:936-942, 2008

Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J 22:807-818, 2008

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 117:2325-2336, 2007

Batterham RL, ffytche DH, Rosenthal JM, Zelaya FO, Barker GJ, Withers DJ, Williams SC. PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 450:106-109, 2007

le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147:3-8, 2006

le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V, Shurey S, Ghatei MA, Patel AG, Bloom SR. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 243:108-114, 2006

Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 4:223-233, 2006

Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115:940-950, 2005

Dakin CL, Small CJ, Batterham RL, Neary NM, Cohen MA, Patterson M, Ghatei MA, Bloom SR. Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 145:2687-2695, 2004

Cohen MA, Ellis SM, Le Roux CW, Batterham RL, Park A, Patterson M, Frost GS, Ghatei MA, Bloom SR. Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab 88:4696-4701, 2003

Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, Frost GS, Ghatei MA, Bloom SR. Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab 88:3989-3992, 2003

Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349:941-948, 2003

Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650-654, 2002

Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR. Ghrelin causes hyperphagia and obesity in rats. Diabetes 50:2540-2547, 2001

Case Reports

Pucci A, Cheung WH, Jones J, Manning S, Kingett H, Adamo M, Elkalaawy M, Jenkinson A, Finer N, Doyle J, Hashemi M, Batterham RL 2015 A case of severe anorexia, excessive weight loss and high peptide YY levels after sleeve gastrectomy. Endocrinology, Diabetes & Metabolism Case Reports 2015:150020

Manning S, Pucci A, Batterham RL, Finer N. Latent autoimmune diabetes in adults presenting as diabetes "recurrence" after bariatric surgery: a case report. Diabetes Care 36:e120, 2013

Rahman S, Scobie AI, Elkalaawy M, Bidlake LE, Fiennes AG, Batterham RL. Can glucose make you faint? Lancet 372:1358, 2008

Reviews

Makaronidis JM, Batterham RL. Potential Mechanisms Mediating Sustained Weight Loss Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy. Endocrinol Metab Clin North Am. 2016 Sep;45(3):539-52. doi: 10.1016/j.ecl.2016.04.006. Review.

Batterham, RL & Cummings, D. E. Mechanisms of Diabetes Improvement Following Bariatric/Metabolic Surgery. Diabetes Care 39, 1-9, doi:10.2337/dc.16-0145 (2016).

Muller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Dieguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrere B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschop MH 2015 Ghrelin. Molecular metabolism 4:437-460

Manning S, Pucci A, Batterham RL. Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms. Review Series: Enteric Nervous System, J Clin Invest. 2015;125(3):939–948. doi:10.1172/JCI76305.

Manning S, Batterham RL. Enteroendocrine MC4R and energy balance: linking the long and the short of it. Cell Metab. 2014 Dec 2;20(6):929-31. doi: 10.1016/j.cmet.2014.11.014

Manning S, Pucci A, Batterham RL. GLP-1: a mediator of the beneficial metabolic effects of bariatric surgery? Physiology 2015 Jan;30(1):50-62. Review, 2015.

Pucci A, Manning S, Batterham RL. Obesity: Causes, Consequences and patient-centred therapeutic approaches. HealthManagement 14(3): 21-4, 2014

Manning S, Batterham RL. PYY 12 years on. Annu Rev Physiol 76:585-608,2014.

Chandarana K, Batterham RL. Shedding pounds after going under the knife: metabolic insights from cutting the gut. Nat Med 18:668-669, 2012

Scott WR, Batterham RL. Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery. Am J Physiol Regul Integr Comp Physiol 301:R15-27, 2011

Neary MT, Batterham RL. Gaining new insights into food reward with functional neuroimaging. Forum Nutr 63:152-163, 2010

Karra E, Yousseif A, Batterham RL. Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery. Trends Endocrinol Metab 21:337-344, 2010

Karra E, Batterham RL. The role of gut hormones in the regulation of body weight and energy homeostasis. Mol Cell Endocrinol 316:120-128, 2010

Neary MT, Batterham RL. Peptide YY: food for thought. Physiol Behav 97:616-619, 2009

Neary MT, Batterham RL. Gut hormones: implications for the treatment of obesity. Pharmacol Ther 124:44-56, 2009

Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. J Physiol 587:19-25, 2009

Chandarana K, Batterham RL. Peptide YY. Curr Opin Endocrinol Diabetes Obes 15:65-72, 2008

Renshaw D, Batterham RL. Peptide YY: a potential therapy for obesity. Curr Drug Targets 6:171-179, 2005

Batterham RL, Bloom SR. The gut hormone peptide YY regulates appetite. Ann N Y Acad Sci 994:162-168, 2003

Guidelines

British Obesity and Metabolic Surgery Society 'Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery' 2014.

NICE GUIDELINE CG189 'Obesity-Identification, assessment and management of overweight and obesity in children, young people and adults' November 2014.

Book Chapters

Cheung WH, Pucci A, Batterham RL. The effects of gut-derived hormones peptide YY, oxyntomodulin and ghrelin on energy and glucose homeostasis. Obesity, Bariatric and Metabolic Surgery: A Practical Guide. Edited by S Aggarwal, Springer (in press).

Yousseif A, Karra E, Rahman S, Batterham RL. Obesity, Endocrinology in Clinical Practice, Second Edition, Edited by Philip E. Harris, Pierre-Marc G. Bouloux, CRC Press. Print ISBN: 978-1-84184-951-5.2014

Batterham RL, Cowley MA. Endocrinology of Fat, Metabolism, and Appetite.  Endocrinology: Basic and Clinical Principles, 2nd Edition, pp. 375-390.  Humana Press, Totowa NJ, Melmed SP and Conn M, (Eds) 2005.

GMC/GDC number: 4192064