Dr Ratna Chatterjee

Dr Ratna Chatterjee  Tel: 020 3447 9453
Email: ratna.chatterjee2@nhs.net

Location:
University College Hospital

Specialities:
Reproductive Medicine Unit

Professional background

Clinical Senior Lecturer/ Consultant in reproductive health of adolescent and adult survivors of chronic and serious disease with special interest in haemoglobinopathy, chronic renal disease and recipients of chemotherapy for cancer – IFWH of UCL/ UCLH

It is the first post of this kind in the UK created by joint multidisciplinary venture between various divisions of the UCLH trust and UCL.

Research interests

For the past 3 years I have been actively involved in development of a novel research tool for development and delivery of a teaching modality for global education after generating external funding of 260 K from TIF. 

Dr Rekha Bajoria, Clinical Senior Lecturer/ Consultant and joint Director of MSc have contributed significantly to the course. This degree programme is currently running successfully. This innovative tool can be applied to other streams of medicine and education. We have successfully launched the course in March 2009.  This is in pilot stage (phase 3 of research).

The dissertations of the international students are expected to promote original research and publications in peer reviewed journals.
 
Ovarian Reserve testing in iron load - I am developing 3D imaging of assessment of folliculogenesis and iron loading in patients with Iron load in collaboration with Dr Rehan Salim- of ACU and RMU, EGA.

I am also collaborating with medical engineering and imaging experts on 3D assessment of penile Doppler studies patients with chronic disease presenting with erectile dysfunction.

I am developing global patient care pathway in patients with haemoglobinopathies with Dr Rekha Bajoria and International local doctors on maternal health and endocrine and fertility problems in India, Middle East and Italy, Greece.

Publications

I have 54 publications in peer-reviewed journals. Some recent and relevant publications are given below:

1. Chatterjee R, Banerjee S and Chaudhuri N. A study of malaria in pregnancy. Presented at the Ronald Ross Memorial Lecture in Calcutta, India and published in the Journal of Indian Federation of Obstetrics and Gynaecology 1979, 6: 8-10.

2. Chatterjee R, Banerjee S and Chaudhuri N. A study of the menopause in comparatively young women with endometriosis after total abdominal hysterectomy with bilateral salpingo-oophorectomy. Journal of the Indian Federation of Obstetrics and Gynaecology. 1979, 8: 10-14.

3. Chatterjee R, Banerjee S, Ghosh KK, Chaudhuri N. A study on post pill amenorrhoea. International Journal of obstetrics and Gynaecology. 1980, 18: 113-4.

4. Chatterjee R, Katz M, Wonke B, Hoffbrand AV, Politis D. Induction of puberty in patients with beta-thalassamia major. Birth Defects Artic Ser. 1987; 23: 453-8.

5. Chatterjee R, Mills W, Katz M, McGarrigle HH, Goldstone AH. Induction of ovarian function by using short terms Human Menopausal Gonadotrophin in patients with ovarian failure following cytotoxic chemotherapy for haematological malignancies. Lymphoma and Leukaemia. 1992, 33: 78-86.

6. Chatterjee R, Katz M, Cox TF, Porter JB. A prospective study of hypothalamic-pituitary axis in thalassaemic patients who developed secondary amenorrhoea. Clinical Endocrinology. 1993, 39: 287-296.

7. Chatterjee R, Katz M, Cox T, Bantock H. Evaluation of Growth hormone in thalassaemic boys with failed puberty: Spontaneous vs. provocative test. European J Paediatrics.  1993, 152: 721-726.

8. Chatterjee R, Mills W, Katz M, McGarrigle HH, Goldstone AH. Prospective study of pituitary-gonadal function to evaluate short-term effects of ablative chemotherapy, or total body irradiation with autologous or allogeneic marrow transplantation in female post menarcheal patients with haematological malignancies. Bone Marrow Transplantation. 1994, 13: 511-517.

9. Salooja N, Chatterjee R, McMillan AK, Kelsey SM, Newland, Milligan DW, Franklin IM, Hutchinson RM, Linch DC, Goldstone AH. Successful pregnancies in women following single autologous bone marrow transplantation for acute myeloid leukaemia with a chemotherapy ablation protocol. Bone Marrow Transplantation. 1994,13: 431-435.

10. Chatterjee R, Mills W, Katz M, McGarrigle HH, Goldstone AH Germ cell failure and Leydig cell insufficiency in post pubertal male patients after autologous bone marrow transplantation with BEAM for lymphoma. Bone Marrow Transplantation. 1994,13: 519-522.

11. Mills W, Chatterjee R, McGarrigle HH, Linch DC, Goldstone AH. Partial hypopituitarism following total body irradiation in adult patients with haematological malignancy. Bone Marrow Transplantation. 1994, 14: 471-473.

12. Chatterjee R and Goldstone AH. Gonadal damage and effects on fertility in patients with haematological malignancy undergoing stem cell transplantation. Bone Marrow Transplantation: 1996,17: 5-11.

13. Chatterjee R, Katz M, Oatridge A, Bydder GM, Porter JB.Selective loss of anterior volume with severe pituitary-gonadal insufficiency in poorly compliant male thalassaemic patients with pubertal arrest. Ann N Y Acad Sci 1998,30: 850: 479-82.

14. Chatterjee R and Ralph DJ. Toxic effects on testicular function: Europ Urology Update Series: 1998, 7: 661.

15. Green C, Chatterjee R, McGarrigle HH, Ahmed F, Thomas NS. p107 is active in the nucleolus in non-dividing human granulosa lutein cells. J Mol Endocrinol. 2000;25: 275-86.

16. Chatterjee R, Katz M. Reversible hypogonadotrophic hypogonadism in sexually infantile male thalassaemic patients with transfusional iron overload. Clin Endocrinol (Oxf). 2000;53: 33-42.

17. Chatterjee R, Andrews HO, McGarrigle HH, Kottaridis PD, Lees WR, Mackinnon S, Ralph DJ, Goldstone AH. Cavernosal arterial insufficiency is a major component of erectile dysfunction in some recipients of high-dose chemotherapy/chemo-radiotherapy for haematological malignancies. Bone Marrow Transplant. 2000;25: 1185-9.

18. Bahadur G, Chatterjee R, Ralph D.Testicular tissue cryopreservation in boys. Ethical and legal issues: case report.Hum Reprod. 2000;15: 1416-20.

19. Chatterjee R, Haines GA, Perera DM, Goldstone A, Morris ID. Testicular and sperm DNA damage after treatment with fludarabine for chronic lymphocytic leukaemia. Hum Reprod. 2000;15: 762-6.

20. Kottaridis PD, Peggs K, Lawrence A, Verfuerth S, Chatterjee R, Telfer P, Porter JB, Mackinnon S, Goldstone AH. One antigen mismatched related donor bone marrow transplant in a patient with acute lymphoblastic leukaemia and beta-thalassaemia major: potential cure of both marrow disorders. Bone Marrow Transplant. 2000;25: 677-8.

21. Chatterjee R, Kottaridis PD, Lees WR, Ralph DJ, Goldstone AH. Cavernosal arterial insufficiency and erectile dysfunction in recipients of high-dose chemotherapy and total body irradiation for multiple myeloma. Lancet. 2000;355(9212): 1335-6.

22. Chatterjee R, Haines GA, Perera DM, Goldstone A, Morris ID. Testicular and sperm DNA damage after treatment with fludarabine for chronic lymphocytic leukaemia. Hum Reprod. 2000;15: 762-6.

23. Harris E, Mahendra P, McGarrigle HH, Linch DC, Chatterjee R. Gynaecomastia with hypergonadotrophic hypogonadism and Leydig cell insufficiency in recipients of high-dose chemotherapy or chemo-radiotherapy. Bone Marrow Transplant. 2001;28: 1141-4.

24. Chatterjee R, Kottaridis PD, McGarrigle HH, Papatryphonos A, Goldstone AH. Hypogonadotrophism fails to prevent severe testicular damage induced by total body irradiation in a patient with beta-thalassaemia major and acute lymphoblastic leukaemia. Bone Marrow Transplant. 2001;28: 989-91.

25. Chatterjee R, Kottaridis PD, McGarrigle HH, Eliahoo J, McKeag N, Mackinnon S, Goldstone AH. Patterns of Leydig cell insufficiency in adult males following bone marrow transplantation for haematological malignancies. Bone Marrow Transplant. 2001;28: 497-502.

26. Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P, Van Lint MT, Powles R, Jackson G, Hinterberger-Fischer M, Kolb HJ, Apperley JF. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet. 2001;358(9278): 271-6.

27. Chatterjee R, Kottaridis PD, McGarrigle H, Goldstone AH. Reversal of fludarabine induced testicular damage in a patient with chronic lymphocytic leukaemia (CLL), by suppression of pituitary-testicular axis using gonadotrophin releasing hormone (GnRH). Leuk Lymphoma. 2001;41: 213-5.

28. Chatterjee R, Katz M. Evaluation of gonadotrophin insufficiency in thalassemic boys with pubertal failure: spontaneous versus provocative test. J Pediatr Endocrinol Metab. 2001;14: 301-12.

29. Chatterjee R, Kottaridis PD. Treatment of gonadal damage in recipients of allogeneic or autologous transplantation for haematological malignancies. Bone Marrow Transplant. 2002;30: 629-35.

30. Perera D, Pizzey A, Campbell A, Katz M, Porter J, Petrou M, Irvine DS, Chatterjee R. Sperm DNA damage in potentially fertile homozygous beta-thalassaemia patients with iron overload. Hum Reprod. 2002;17: 1820-5.

31. Chatterjee R, Kottaridis PD, McGarrigle HH, Linch DC. Management of erectile dysfunction by combination therapy with testosterone and sildenafil in recipients of high-dose therapy for haematological malignancies. Bone Marrow Transplant. 2002: 607-10.

32. Bajoria R, Sooranna SR, Ward BS, Chatterjee R. Prospective function of placental leptin at maternal-fetal interface. Placenta. 2002;23: 103-15. Review.

33. Bajoria R, Ward BS, Chatterjee R. Natriuretic peptides in the pathogenesis of cardiac dysfunction in the recipient fetus of twin-twin transfusion syndrome. Am J Obstet Gynecol. 2002;186: 121-7.

34. Helal MA, Mehmet H, Thomas NSB, Cox PM, Ralph DJ, Bajoria R, Chatterjee R  Ontogeny of Human Fetal Testicular Apoptosis during First, Second, and Third Trimesters of Pregnancy  J Clin Endocrinol Metab 2002 87: 1189-1193.

35. Kyriacou C, Kottaridis PD, Eliahoo J, Mckeag N, Bomford J, McGarrigle HH, Linch DC, Mackinnon S and Chatterjee R. Germ cell damage and Leydig cell insufficiency in recipients of non-myeloablative transplantation for haematological malignancies Bone Marrow Transplant 2003;31: 45-50.

36. Bajoria R, Ward S, Chatterjee R. Brain natriuretic peptide and endothelin-1 in the pathogenesis of polyhydramnios-oligohydramnios in monochorionic twins. Am J Obstet Gynecol. 2003;189: 189-94.

37. Chatterjee R, Helal, MA, Wood S, Jenkins N, McGarrigle HH, Lees WR, Ralph DJ  and Neild GH A novel therapy with testosterone and sildenafil for cavernosal arterial insufficiency and Leydig cell dysfunction in renal patients. Journal of Faculty of Family planning and Reproductive Health Care, 2004 APR;30(2): 88-90.

38. Chatterjee R, Palla K, Kottaridis PD.  Cavernosal arterial insufficiency and metabolic syndrome probably represent a common pathology of endothelial dysfunction in recipients of high-dose therapy and stem-cell transplantation. J Clin Oncol. 2004 Jun 1;22(11): 2253-4.

39. Oswal A, Chatterjee R. Cerazette licence extension. J Fam Plann Reprod Health Care. 2005 Apr;31(2): 165.

40. Chatterjee R, Palla K, McGarrigle HH, Mackinnon S, Kottaridis PD. Syndrome 'X' in adult female recipients of bone marrow transplantation for haematological malignancies. Bone Marrow Transplant. 2005 Feb;35(3): 321.

41. Lutchman Singh K, Davies M, Chatterjee R. Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing. Hum Reprod Update. 2005 Jan-Feb;11(1): 69-89.

42. Bajoria R, Sooranna SR, Ward S, Chatterjee R. Elevated IGFBP-1 cause high bone turnover in growth-restricted monochorionic twins with discordant birth weight.Bone. 2006 Jun;38(6): 929-34

43. Bajoria R, Sooranna SR, Chatterjee R. Leptin and bone turnover in monochorionic twins complicated by twin-twin transfusion syndrome. Osteoporos Int. 2007;18(2): 193-200.

44. Lutchman Singh K, Muttukrishna S, Stein RC, McGarrigle HH, Patel A, Parikh B, Groome NP, Davies MC, Chatterjee R. Predictors of ovarian reserve in young women with breast cancer.Br J Cancer. 2007;96(12): 1808-16.

45. Chatterjee R, Deng J, Pellerin D, Todd-Pokropek A, Neild GH, Lees WR, Rodeck CH.Feasibility of dynamic 3-D color Doppler ultrasound for imaging penile vascular change in renal transplant patients with erectile dysfunction responding to sildenafil. Ultrasound Med Biol. 2008;34(6): 885-91.

46. Chatterjee R, Bajoria R. Critical appraisal of growth retardation and pubertal disturbances in thalassemia. Ann N Y Acad Sci, 2010;1202(1): 100-14.

47. Bajoria R and Chatterjee R. Current Perspectives of Fertility and Pregnancy in Thalassemia, Hemoglobin, 2009: 33:1: S131 – S135.

48. Bajoria R, Chatterjee R. Osteopenia-osteoporosis syndrome in patients with thalassemia : understanding of type of bone disease and response to treatment. Hemoglobin. 2009;33 1: S136-8.

49. Chatterjee R, Bajoria R. New concept in natural history and management of diabetes mellitus in thalassemia major. Hemoglobin. 2009;33:1: S127-30.

50. Chatterjee R, Kyriacou C and Bajoria R. Reproductive and sexual dysfunction in recipients of chemotherapy – -Invited editorial- Nature Urology – In press 2012.

51. Bajoria R, Walker M, Shah F, Rodeck CHR, Chatterjee R. Virtual learning using interactive multimedia based tools for knowledge transfer and development of global patient care pathway in press Haemoglobin 2012.

52. Chatterjee R, Mukhopadhyay TN, Chandra S, Bansal R and Bajoria R: Sex steroid priming for induction of puberty and dissection of growth hormone neuro secretory dysfunction in thalassaemia patients with failed or arrested puberty: A global experience. In press Haemoglobin 2012.

53. Hypogoandotrophic hypogonadism and diminished gonadal reserve accounts for dysfunctional gametogenesis in thalassaemia patients with iron load presenting with infertility. Bajoria R and Chatterjee R: In press Haemoglobin 2012.

54. Chatterjee R, Katz M and Bajoria R. Use of HRT for correction of high turnover bone disease in hypogonadal beta thalassaemia major presenting with osteoporosis: comparison with idiopathic premature ovarian failure: In press Haemoglobin 2012
 

GMC/GDC number: 3163001