Dr Riyaz Patel

Tel: 020 3447 5540
Fax: 020 3447 9278
Email: riyaz.patel@nhs.net

Location:
UCLH & Barts Heart Centre

Specialities:
Cardiology outpatients, Cardiac services

Professional background

Dr Riyaz Patel is an honorary consultant cardiologist working at both UCLH and Bart's Health NHS Trusts. He trained and qualified locally and has spent a decade also developing an international research portfolio. He has worked at top London and US hospitals which have given him a high degree of experience managing all general cardiology conditions, with a recognised expertise in coronary artery disease risk assessment and prevention.

He also specialises in advanced cholesterol management, hypertension, chest pain assessment, valvular heart disease, neurological and autonomic mediated cardiovascular diseases and secondary prevention of those with established heart disease.

At UCLH, Dr Patel runs a large general cardiology outpatient clinic, having taken this over from Dr Diana Holdright, under whom he trained. He also provides in-patient care for acutely unwell cardiology patients as part of the 7 day UCLH cardiology consult service. Aside from general cardiology Dr Patel is also an accredited and recognised specialist in advanced echocardiography and cardiac CT, providing these services primarily at Bart's but also at UCLH. At Bart's Dr Patel has also established a new CVD prevention service, offering advanced risk stratification and also seeing those with premature coronary disease and those with a significant family history of disease.

Finally, in addition to his clinical work, Dr Patel is a senior research fellow at UCL and is one of only a handful of British Heart Foundation Clinical Intermediate Fellows in the country. This grant was awarded based on his high profile academic and research background and to fund his research into the causes of coronary heart disease and its risk factors, including the genetic basis for the disease.

Research interests

  • Coronary heart disease (CHD) risk with a focus on harnessing and using “big data” through registries, electronic records and hospital informatics
  • Identifying genetic and non-genetic determinants of subsequent event risk in those with established CHD, to improve risk prediction and identify novel drug targets
  • CHD prevention, lipid disorders and risk factor management
  • Clinical trials using novel approaches - to run “cheaper, faster and better” trials
  • Genetics of CHD including use of Mendelian Randomization to determine causality as well as exploring non-genetic biomarkers and metabolomics for CHD risk.
  • Developing and managing bio-banks to study CHD and other cardiovascular diseases
  • Advanced CHD phenotyping using cardiac imaging

Publications

  • Hayek SS, MacNamara J, Tahhan AS, Awad M, Yadalam A, Ko YA, Healy S, Ghaini I, Ahmed H, Gray B, Sher S, Ghasemzadeh N, Patel RS, Kim J, Waller EK, Quyyumi AA. Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease. Circ Res. 2016 Jun 6. pii: CIRCRESAHA.116.308802. [Epub ahead of print] PubMed PMID: 27267067.
  • Patel RS, Ghasemzadeh N, Eapen DJ, Sher S, Arshad S, Ko YA, Veledar E, Samady H, Zafari AM, Sperling L, Vaccarino V, Jones DP, Quyyumi AA. Response to Letter Regarding Article "Novel Biomarker of Oxidative Stress Is Associated With Risk of Death in Patients With Coronary Artery Disease". Circulation. 2016 May 31;133(22):e667. doi: 10.1161/CIRCULATIONAHA.116.022753. PubMed PMID: 27245653.
  • Nioi P, Sigurdsson A, Thorleifsson G, Helgason H, Agustsdottir AB, Norddahl GL, Helgadottir A, Magnusdottir A, Jonasdottir A, Gretarsdottir S, Jonsdottir I, Steinthorsdottir V, Rafnar T, Swinkels DW, Galesloot TE, Grarup N, Jørgensen T, Vestergaard H, Hansen T, Lauritzen T, Linneberg A, Friedrich N, Krarup NT, Fenger M, Abildgaard U, Hansen PR, Galløe AM, Braund PS, Nelson CP, Hall AS, Williams MJ, van Rij AM, Jones GT, Patel RS, Levey AI, Hayek S, Shah SH, Reilly M, Eyjolfsson GI, Sigurdardottir O, Olafsson I, Kiemeney LA, Quyyumi AA, Rader DJ, Kraus WE, Samani NJ, Pedersen O, Thorgeirsson G, Masson G, Holm H, Gudbjartsson D, Sulem P, Thorsteinsdottir U, Stefansson K. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease. N Engl J Med. 2016 Jun 2;374(22):2131-41. doi: 10.1056/NEJMoa1508419. Epub 2016 May 18. PubMed PMID: 27192541.
  • Helgadottir A, Gretarsdottir S, Thorleifsson G, Hjartarson E, Sigurdsson A, Magnusdottir A, Jonasdottir A, Kristjansson H, Sulem P, Oddsson A, Sveinbjornsson G, Steinthorsdottir V, Rafnar T, Masson G, Jonsdottir I, Olafsson I, Eyjolfsson GI, Sigurdardottir O, Daneshpour MS, Khalili D, Azizi F, Swinkels DW, Kiemeney L, Quyyumi AA, Levey AI, Patel RS, Hayek SS, Gudmundsdottir IJ, Thorgeirsson G, Thorsteinsdottir U, Gudbjartsson DF, Holm H, Stefansson K. Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. Nat Genet. 2016 Jun;48(6):634-9. doi: 10.1038/ng.3561. Epub 2016 May 2. PubMed PMID: 27135400.
  • Hammond-Haley M, Patel RS, Providência R, Lambiase PD. Exercise restrictions for patients with inherited cardiac conditions: Current guidelines, challenges and limitations. Int J Cardiol. 2016 Apr 15;209:234-41. doi: 10.1016/j.ijcard.2016.02.023. Epub 2016 Feb 4. Review. PubMed PMID: 26897076.
  • Patel RS, Asselbergs FW. The GENIUS-CHD consortium. Eur Heart J. 2015 Oct 21;36(40):2674-6. PubMed PMID: 26788565.
  • Patel RS, Ghasemzadeh N, Eapen DJ, Sher S, Arshad S, Ko YA, Veledar E, Samady H, Zafari AM, Sperling L, Vaccarino V, Jones DP, Quyyumi AA. Novel Biomarker of Oxidative Stress Is Associated With Risk of Death in Patients With Coronary Artery Disease. Circulation. 2016 Jan 26;133(4):361-9. doi: 10.1161/CIRCULATIONAHA.115.019790. Epub 2015 Dec 16. PubMed PMID: 26673559; PubMed Central PMCID: PMC4722941.
  • Shen J, Poole JC, Topel ML, Bidulescu A, Morris AA, Patel RS, Binongo JG, Dunbar SB, Phillips L, Vaccarino V, Gibbons GH, Quyyumi AA. Subclinical Vascular Dysfunction Associated with Metabolic Syndrome in African Americans and Whites. J Clin Endocrinol Metab. 2015 Nov;100(11):4231-9. doi: 10.1210/JC.2014-4344. Epub 2015 Jul 7. PubMed PMID: 26151335; PubMed Central PMCID: PMC4702465.
  • Rubbo B, Fitzpatrick NK, Denaxas S, Daskalopoulou M, Yu N, Patel RS; UK Biobank Follow-up and Outcomes Working Group, Hemingway H. Use of electronic health records to ascertain, validate and phenotype acute myocardial infarction: A systematic review and recommendations. Int J Cardiol. 2015;187:705-11. doi: 10.1016/j.ijcard.2015.03.075. Epub 2015 Mar 5. Review. PubMed PMID: 25966015.
  • Bjornsson E, Gudbjartsson DF, Helgadottir A, Gudnason T, Gudbjartsson T, Eyjolfsson K, Patel RS, Ghasemzadeh N, Thorleifsson G, Quyyumi AA, Thorsteinsdottir U, Thorgeirsson G, Stefansson K. Common sequence variants associated with coronary artery disease correlate with the extent of coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1526-31. doi: 10.1161/ATVBAHA.114.304985. Epub 2015 Apr 16. PubMed PMID: 25882067.