Prof David Isenberg

Prof David IsenbergTel: 020 3447 9487
Fax: 020 3447 9278
Email: uclh.rheumatology@nhs.net

Location:
University College Hospital

Specialities:
Rheumatology, Immunology

Professional background

Professor Isenberg graduated from St Bartholomew’s Hospital in 1973. He trained in General Medicine, Rheumatology, Neurology, Psychiatry and Gastroenterology becoming a Research Fellow at UCL/the Middlesex Hospital in 1979.  Awarded an MD Thesis (in 1984), based on studies of myositis. During a year of research at Tufts University, Boston, he became interested in autoantibody structure/function and origin.  Appointed Consultant Rheumatologist in November 1984 becoming a professor in 1991 and was given the Arthritis Research UK’s Diamond Jubilee chair of Rheumatology at UCL London in 1996.  Has been elected to Fellowships of both the Royal College of Physicians and the Academy of Medical Sciences.  His specialist involvement is in autoimmune rheumatic diseases, notably systemic lupus erythematosus, Sjögren’s syndrome, myositis and the anti-phospholipid antibody syndrome.

His principal clinical interests have been in the development of disease activity and damage assessment tools in patients with lupus. Chair of the British Isles Assessment Group and also the Chair (1998-2003) of the Systemic Lupus International Collaborating Clinics group (SLICC). He has undertaken many roles for the arc in the past 20 years and is the past president of the British Society for Rheumatology (2004-2006) and was chair of the Society’s Biologics Register Committee. He is the 2010 recipient of the Evelyn Hess Prize from the Lupus Foundation of America for his contribution to lupus research and treatment. He chairs the Research Committee for Lupus UK and Division 5 of north London’s local clinical trials network. He is on the Executive Board of Arthritis Research UK and a non-executive Director of the Royal National Orthopaedic Hospital in Stanmore.

Research interests

Disease Activity and Damage Assessments in the Autoimmune Rheumatic Diseases, notably Systemic Lupus Erythematosus, Sjogren's syndrome, myositis, vasculitis and the antiphospholipid antibody syndrome.  Long-term clinical evaluation of patients with these diseases and undertaking clinical trials, mostly using the new biologic agents.

Publications

1. Ehrenstein MR, Evans J, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF ⍺ therapy. J Exp Med 2004; 200: 277-85.

2. Ng K, Manson J, Rahman A, Isenberg DA. Association of anti-nucleosome antibodies in disease flare in serologically active clinical quiescent patients with systemic lupus erythematosus. Arthritis Care Res 2006; 55: 90-4.

3. Chambers SA, Sharman SC, Rahman A, Isenberg DA. Develoopment of autoimmune diseases in a multiethnic cohort of patients with systemic lupus erythematosus with reference to damage and mortality. Ann Rheum Dis 2007; 66: 1173-7.

4. Rahman A, Isenberg DA. Systemic Lupus Erythematosus – Mechanisms of Disease. New Eng J Med 2008; 358: 929-39.

5. Liu TY, Ng K, Cambridge G, Leandro MJ, Edwards JCW, Ehrenstein M, Isenberg DA. A retrospective seven year analysis of the use of B cell depletion in systemic lupus erythematosus at University College Hospital: the first fifty patients. Arthritis Care Res 2009; 61: 482-7.

6. Isenberg DA, Allen E, Farewell V, Cruz DD, Alarcon GS, Aranow C, Bruce IN, Dooley MA, Fortin PR, Ginzler EM, Gladman DD, Hanly JG, Inanc M, Kalunian K, Khamashta M, Merrill JT, Nived O, Petri M, Ramsey-Goldman R, Sturfelt G, Urowitz M, Wallace DJ, Gordon C, Rahman A. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Ann Rheum Dis 011; 70: 54-59.

7. Sultan SM, Allen E, Cooper RG, Agarawal S, Kiley P, Oddis CV, Vencovsky J, Lundberg JE, Dastmalchi M, Hanna MG, Isenberg DA. Inter-rater reliability and aspects of validity of the myositis damage index. Am Rheum Dis 2011; 70: 1272-6.

8. Ezeonyeji AN, Isenberg DA. Early treatment with rituximab in newly diagnosed systemic lupus erythematosus patients: a steroid-sparing regimen. Rheumatology 2012; 51: 476-481.

9. Bosma A, Abdel-Gabhir A, Isenberg DA, Jury E, Mauri C. Lipid antigen presentation by CD1d+B cells is essential for the maintenance of invariant Natural Killer T cells. Immunity 2013; 36: 477-90.

10. Murphy G, Lisnevskaia L, Isenberg DA. Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment. The Lancet 2013: 382: 809-818.

GMC/GDC number: 1643914