Prof Huw Morris

Prof Huw MorrisTel: 020 3448 3414
Fax: 020 3448 3954
Email: h.morris@ucl.ac.uk

Location:
National Hospital for Neurology and Neurosurgery

Specialities:
Movement disorders

Professional background

Huw Morris is Consultant Neurologist and Professor of Clinical Neuroscience at the Royal Free Hospital, National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology.  His main clinical and research interests are in Movement Disorders and Neurogenetics, particularly early onset, genetic and familial Parkinson's disease and atypical Parkinsonian disorders such as Progressive Supranuclear Palsy, Cortico-basal degneration and Fronto-temporal dementia with Parkinsonism.  His clinical and research training took place at the National Hospital, Queen Square, the Mayo Clinic and the Western Pacific island of Guam.   He was Senior Lecturer and then Professor of Neurology and Neurogenetics at Cardiff University from 2003 to 2013.  His research is funded by Parkinson's UK, the Medical Research Council, the PSP Association and the Motor Neuron Disease Association.  He is Chair of the Dendron Parkinson's Disease Clinical Studies Group and the Clinical Research and Academic Committee of the Association of British Neurologists.  He serves on the Research Advisory Panels of Parkinson's UK, the Motor Neuron DIsease Association, Cure PSP and the Multiple System Atrophy trust.  He also serves on the Honorary Medical Advisory Panel on Driving and Disorders of the Nervous System for Driver and Vehicle Licensing Authority.

Research interests

His major research interests are Early Onset Parkinson’s disease, Atypical parkinsonism, Progressive Supranuclear Palsy (PSP)/ Cortico-basal syndrome (CBS)

Publications

Fawcett, K., Mehrabian, M., Liu, Y. -. T., Hamed, S., Elahi, E., Revesz, T., . . . Houlden, H. (2013). The frequency of spinocerebellar ataxia type 23 in a UK population. Journal of Neurology, 260 (3), 856-859. doi:10.1007/s00415-012-6721-1

Holmans, P., Moskvina, V., Jones, L., Sharma, M., International Parkinson's Disease Genomics Consortium, Vedernikov, A., . . . Williams, N. M. (2013). A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Hum Mol Genet, 22 (5), 1039-1049. doi:10.1093/hmg/dds492

Moskvina, V., Harold, D., Russo, G., Vedernikov, A., Sharma, M., Saad, M., . . . Williams, N. M. (2013). Analysis of Genome-Wide Association Studies of Alzheimer Disease and of Parkinson Disease to Determine If These 2 Diseases Share a Common Genetic Risk. JAMA Neurol. doi:10.1001/jamaneurol.2013.448

Bettencourt, C., Morris, H. R., Singleton, A. B., Hardy, J., & Houlden, H. (2013). Exome sequencing expands the mutational spectrum of SPG8 in a family with spasticity responsive to L-DOPA treatment. J Neurol. doi:10.1007/s00415-013-7044-6

Jenner, P., Morris, H. R., Robbins, T. W., Goedert, M., Hardy, J., Ben-Shlomo, Y., Grp, P. U. K. D. (2013). Parkinson's Disease - the Debate on the Clinical Phenomenology, Aetiology, Pathology and Pathogenesis. JOURNAL OF PARKINSONS DISEASE, 3 (1), 1-11. doi:10.3233/JPD-130175

Lubbe, S., & Morris, H. R. (2013). Recent advances in Parkinson's disease genetics. J Neurol. doi:10.1007/s00415-013-7003-2

Peall, K. J., Smith, D. J., Kurian, M. A., Wardle, M., Waite, A. J., Hedderly, T., . . . Morris, H. R. (2013). SGCE mutations cause psychiatric disorders: clinical and genetic characterization. Brain, 136 (Pt 1), 294-303. doi:10.1093/brain/aws308

Majounie, E., Cross, W., Newsway, V., Dillman, A., Vandrovcova, J., Morris, C. M., Morris, H. R. (2013). Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging.

O'Dowd, S., Curtin, D., Waite, A. J., Roberts, K., Pender, N., Reid, V., . . . Lynch, T. (2012). C9ORF72 expansion in amyotrophic lateral sclerosis/frontotemporal dementia also causes parkinsonism. MOVEMENT DISORDERS, 27 (8), 1072-1074. doi:10.1002/mds.25022

Mok, K., Traynor, B. J., Schymick, J., Tienari, P. J., Laaksovirta, H., Peuralinna, T., . . . Hardy, J. (2012). Chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiol Aging, 33 (1), 209.e3-209.e8. doi:10.1016/j.neurobiolaging.2011.08.005

Simón-Sánchez, J., Heutink, P., Kilarski, L. L., Holmans, P., Williams, N., Morris, H. R., . . . Brice, A. (2012). Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's Disease. PLoS ONE, 7 (3). doi:10.1371/journal.pone.0028787

Wray, S., Self, M., NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, NINDS ALS iPSC Consortium, Lewis, P. A., . . . Hardy, J. (2012). Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS One, 7 (8), e43099-?. doi:10.1371/journal.pone.0043099

Majounie, E., Renton, A. E., Mok, K., Dopper, E. G., Waite, A., Rollinson, S., . . . Traynor, B. J. (2012). Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol, 11 (4), 323-330. doi:10.1016/S1474-4422(12)70043-1

Morris, H. R., Waite, A. J., Williams, N. M., Neal, J. W., & Blake, D. J. (2012). Recent advances in the genetics of the ALS-FTLD complex. Curr Neurol Neurosci Rep, 12 (3), 243-250. doi:10.1007/s11910-012-0268-5

Kilarski, L. L., Pearson, J. P., Newsway, V., Majounie, E., Williams, N. M., Morris, H. R., . . . Ben-Shlomo, Y. (2012). Systematic Review and UK-Based Study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. Movement Disorders, 27 (12), 1522-1529. doi:10.1002/mds.25132

Charlesworth, G., Gandhi, S., Bras, J. M., Barker, R. A., Burn, D. J., Chinnery, P. F., . . . Wood, N. W. (2012). Tau acts as an independent genetic risk factor in pathologically proven PD. Neurobiol Aging, 33 (4), 838.e7-838.11. doi:10.1016/j.neurobiolaging.2011.11.001

Keller, M. F., Saad, M., Bras, J., Bettella, F., Nicolaou, N., Simón-Sánchez, J., . . . Wellcome Trust Case Control Consortium 2 (WTCCC2). (2012). Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet, 21 (22), 4996-5009. doi:10.1093/hmg/dds335

GMC/GDC number: 3617225