Professional background

I am a consultant neonatologist with a special interest in brain injury in babies. I was lecturer in paediatrics, University of Cambridge 1985-1987, and held a consultant appointment in Cambridge until 1995. Whilst in Cambridge I was also director of medical studies at Girton College.

I held an appointment as consultant in neonatal medicine at King’s College Hospital in London from 1995-2004. I held a similar post at University College London Hospitals where I was clinical lead in neonatology. I retired from clinical work in December 2018 but continue to teach and conduct research.

I have contributed chapters to the major British textbook of paediatrics and many other books, and co-authored  “Manual of Neonatal Intensive Care 4th Edition” with Dr NRC Roberton. I am the editor of  “Rennie & Roberton’s Textbook of Neonatology 5th Edition” (in preparation), and the Editor of the 4th edition. I was the sole author of “Neonatal Cranial Ultrasound”, and co-author of the updated version entitled “Neonatal cerebral investigation” (highly commended in the BMA Book Prize 2009 and by Doody’s Book Reviews). I was elected a fellow ad eundem of the Royal College of obstetricians and Gynaecologists in 2008.

I am involved in research into neonatal brain injury, and have published many papers on this topic. Our group currently holds a Wellcome technology transfer grant, for work on automated seizure detection, and I was a co-investigator in a European study (FP-7) of antiepileptic drug treatment of neonatal seizures. I was on the board of the Archives of Disease in Childhood for ten years and served on the national executive committee of the British Association of Perinatal Medicine for a similar length of time. I previously served on the board of the Mac Keith Press. I was the chair of the RCPCH specialist advisory committee, responsible for setting standards regarding training in neonatal medicine in the UK, from 2002 to 2005, having been on the committee since 1997. I have advised CESDI, and RCOG-led advisory groups on “Safer Childbirth” and “Standards for Maternity Care”. 

I was chair of the NICE guideline development group on neonatal jaundice 2007-10. I advised the NHS Atain programme. I was the chair of the NICE guideline group on neonatal care, I advise on the NHS Resolution early notification scheme.

Specialties

Research interests

Neonatal brain injury, neonatal seizures, neonatal cranial ultrasound imaging

Publications

Publications from 2011:

2011

Rennie JM Rosenbloom L 2011 When should we get the baby out? A review of the effects of acute profound intrapartum hypoxia and ischaemia The Obstetrician and Gynaecologist 13:169-174

2012

Shah DY, Boylan GB, Rennie JM 2012 Monitoring of seizures in the newborn Archives of Disease in Childhood Fetal & Neonatal Edition 97:F65-F69

Bahjati S, Prentice P, Rennie J 2012 Management of group B streptococcal sepsis risk in well term newborns Acta Paediatrica 101(2):128-131

Lynch NE, Stevenson NJ, Livingstone V, Murphy BP, Rennie JM, Boylan GB 2012 The Temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy Epilepsia 53:485-493

Evonne Low, Geraldine B Boylan, Sean R Mathieson, Deirdre M Murray, Irina Korotchikova, Nathan J Stevenson, Vicki Livingstone, Janet M Rennie 2012 Cooling and seizure burden in term neonates: an observational study. Arch Dis Child Fetal and Neonatal Edition 97:F267-F272

Low E, Dempsey EM, Ryan AC, Rennie JM, Boylan GB 2012 EEG supression associated with apneic episodes in a neonate. Case Reports in Neurological Medicine. DOI: 10.1155/2012/250801

Kendall GS, Mathieson S, Meek J, Rennie JM 2012 Re-cooling for Rebound Seizures following Re-warming in Neonatal Encephalopathy Pediatrics 130(2) e451-5

Hartley C, Berthouze L, Mathieson S, Boylan GB, Rennie JM, Marlow N, Farmer SF 2012 Long range temporal correlations in the EEG bursts of human preterm babies PLoS 1, e pub e 31543

Gholitabar M, McGuire H, Rennie J, Manning D, Lai R 2012 Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia. Cochrane Database of Systematic Reviews ID 23235669.

2013

Uria-Avellanal C, Marlow N, Rennie JM 2013 Outcome following neonatal seizures. Seminars in Fetal and Neonatal Medicine. doi:pii: S1744-165X(13)00003-6.

Sebire NJ, Miller S, Jacques TS, Taylor AM, Rennie JM, Kendall G, Chitty LS 2013 Post-mortem apparent resolution of fetal ventriculomegaly: evidence from magnetic resonance imaging. Prenatal Diagnosis doi: 10.1002/pd.4065. Epub ahead of print.

Azzopardi D, Robertson NJ, Kapetanakis A, Griffiths J, Rennie JM, Mathieson SR, Edwards AD 2013 Anticonvulsant effect of xenon on neonatal asphyxial seizures Archives of Disease in Childhood fetal and neonatal edition 98:5 p F437-F439.

2014

Low E, Mathieson SR, Stevenson NJ, Livingstone V, Ryan A, Bogue CO, Rennie JM, Boylan GB 2014 Early postnatal EEG features of perinatal arterial ischaemic stroke with seizures. PLOS one vol 9 issue 7 e100973

2015

Rennie JM Kendall GS May C Neonatal airway problems: the can’t intubate can’t ventilate scenario – response to a Letter. Archives of Disease in Childhood 2015:100: F92-93

Rennie JM Kendall GS 2015 Advanced magnetic resonance techniques provide more accurate prognostic information than conventional imaging. Developmental Medicine Child Neurology 57 (5) 403-404

Ronit M Pressler, Mats Blennow, Catherine Chiron, et al; for the NEMO consortium (NEonatal seizure treatment with Medication Off-patent). 2015 Evaluation of bumetanide as second line treatment for neonatal seizures in a phase I/II dose finding and feasibility trial (NEMO) Lancet Neurology 14:469-477.

Stevenson NJ, Clancy RR, Vanhatalo S, Rosen I, Rennie JM, Boylan GB 2015 Inter-observer agreement for neonatal seizure detection using multi-channel EEG. Annals of Clinical and Translational Neurology; published open access.

Pressler RM, Boylan GB, Marlow N, de Vries LS, Blennow M, Chiron C, Cross JH, Hallberg B, Hellstrom-Westas L, Jullien V, Magnum B, Murphy B, Murray D,Pons G, Rennie JM, Tiet MC, Zohar S NEMO Consortium 2015 Bumetanide for neonatal seizures – back from the cotside. Nature Reviews Neurology nov 3 e pub ahead of print doi: 10.1038/nrneurol.2015.116

Lynch NE, Stevenson NJ, Livingtone V, Mathieson S, Murphy BP, Rennie JM, Boylan GB 2015 The temporal characteristics of seizures in neonatal hypoxic ischaemic encephalopathy treated with hypothermia. Seizure 33:60-65

2016

Mathieson SR, Stevenson NJ, Low E, Marnane LP, Rennie JM, Temko A, Lightbody G, Boylan GB 2016 Validation of an automated seizure detection algorithm for term neonates. Clinical Neurophysiology 127:156-168

Low E, Stevenson NJ, Mathieson SR, Livingstone V, Ryan CA, Rennie JM, Boylan GB 2016 Short term effects of phenobarbitone on electrographic seizures in neonates. Neonatology 110:40-46

Mathieson S, Rennie J, Livingstone V, Temko A, Low E, Pressler RM, Boylan GB 2016 In depth performance analysis of an EEG based neonatal seizure detection algorithm. Clinical Neurophysiology 127:2246-2256

Mathieson SR, Livingstone V, Low E, Pressler R, Rennie JM, Boylan GB 2016 Phenobarbital reduces EEG amplitude and propogation of neonatal seizures but does not alter performance of automated seizure detection Clinical Neurophysiology 127(10) 3343-3350

2017

Battersby C, Michaelides S, Upton M, Rennie JM 2017 Term admissions to neonatal units in England: a role for transitional care? A retrospective cohort study. BMJ Open e016050.

Mitra S, Rennie J 2017 Neonatal jaundice: aetiology, diagnosis and treatment Br J Hosp Med 78 (12) 699-704

2018

Rennie JM, de Vries LS, Blennow M, Foran A, Shah DK et al 2018 Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience. Archives of Disease in Childhood fetal and neonatal edition 0 1-9

Marsden I, Cuming S, Rennie JM, Michaelides S 2018 A survey of newborn babies admitted for the treatment of jaundice. Infant 14 (5) 173-178

2019

Rennie JM, Beer J, Upton M 2019 Learning from claims: hyperbilirubinaemia and kernicterus. Archives of Disease in Childhood fetal and neonatal edition 104:F202-F204

2020

Pavel AM, Rennie JM, de Vries LS, Blennow M, Foran A, Shah DK, Pressler RM, Kapellou O, Dempsey EM, Mathieson S, Pavlidis E, van Huffelen A C, Livinsgtone V, Toet MC, Weeke LC, Finder M, Mitra S, Murray DM, Marnane P, Boylan GB 2019 A machine learning algorithm for neonatal seizure recognition: a multicentre randomised clinical trial. Lancet Child and Adolescent section, in press