Professional background

I trained at Cambridge and UCLH and I have been consultant microbiologist at UCLH since 1990. I have particular responsibility for antibiotic advice and infection control in critical care. I also help with infection control advice for Camden and Islington. I set up wound surveillance in the Trust which provides surgeons with detailed information on wound infections. I am chairman of the Specialty Training Committee for microbiology for London and the national critical care bacteremia surveillance (ICCQIP).

Research interests

I have a research interest in the treatment and prevention of transmission of hospital-acquired infection. I have run trials on on innovations in the control of infection such as isolation rooms, patient screens and new cleaning methods, new diagnostics and antibiotics. I helped design the main hospital building on the Euston Road and an infection resistant computer keyboard now used at UCLH.

Publications

Publications

1. Ali S, Muzslay M, Wilson P. A Novel Quantitative Sampling Technique for Detection and Monitoring of Clostridium difficile Contamination in the Clinical Environment. Journal of Clinical Microbiology. 2015 Aug;53(8):2570-4. doi: 10.1128/JCM.00376-15. Epub 2015 Jun 3.

2. Jeanes A, Coen PG, Wilson AP, Drey NS, Gould DJ. Collecting the data but missing the point: validity of hand hygiene audit data. Journal of Hospital Infectionion 2015 90: 156-162.

3. Wilson APR, Livermore DM, Otter JA, Warren RE, Jenks P, Enoch DA, Newsholme W, Oppenheim B, Leanord A, McNulty C, Tanner G, Bennett S, Cann M, Bostock J, Collins E, Peckitt S, Ritchie L, Fry C, Hawkey P. Prevention and control of multi-drug-resistant Gram-negative bacteria: recommendations from a Joint Working Party. Journal of Hospital Infection 2016; 92: Suppl 1, S1-S44

4. Tirlapur N, Puthucheary ZA Cooper JA, Sanders J, Coen PG, Moonesinghe SR, Wilson AP, Mythen MG, Montgomery HE. Diarrhoea in the critically ill is common, associated with poor outcome, and rarely due to Clostridium difficile. Scientific Reports 2016 Apr 20;6:24691. doi: 10.1038/srep24691.

5. Ali S, Muzslay M, Bruce M, Jeanes A, Moore G, Wilson AP. Efficacy of two hydrogen peroxide vapour aerial decontamination systems for enhanced disinfection of meticillin-resistant Staphylococcus aureus, Klebsiella pneumoniae and Clostridium difficile in single isolation rooms. Journal of Hospital Infection. 2016 May;93(1):70-7. doi: 10.1016/j.jhin.2016.01.016. Epub 2016 Feb 9.

6. Thornley T, Marshall G, Howard P, Wilson APR. A feasibility service evaluation of screening and treatment of group A streptococcal pharyngitis in community pharmacies. Journal of Antimicrobial Chemotherapy. 2016 Nov;71(11):3293-3299.

7. Muzslay M, Moore G, Alhussaini N, Wilson APR. ESBL-producing Gram-negative organisms in the healthcare environment as a source of genetic material for resistance in human infections. Journal of Hospital Infection 2017; 95: 59-64.

8. Liu Z, Norman G, Iheozor-Ejiofor Z, Wong J, Crosbie E, Wilson P. Nasal decontamination for the prevention of surgical site infection in Staphylococcus aureus carriers. Cochrane Database of Systematic Reviews 2017 10.1002/14651858.CD012462.pub2
a. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012462.pub2/abstract

9. Wilson APR. Sparing carbapenem usage. Journal of Antimicrobial Chemotherapy 2017; 72: 2410–2417 doi:10.1093/jac/dkx181

10. Sofokleous P, Ali S, Wilson P, Buanz A, Gaisford S, Mistry D, Fellows A, Day R. Sustained antimicrobial activity and reduced toxicity of oxidative biocides through biodegradable microparticles. Acta Biomaterialia 2017; 64: 301–312

11. Yui, S., Ali, S., Muzslay, M., Jeanes, A., & Wilson, APR. Identification of Clostridium difficile Reservoirs in The Patient Environment and Efficacy of Aerial Hydrogen Peroxide Decontamination. Infection Control & Hospital Epidemiology, 2017 1-6. doi:10.1017/ice.2017.227

12. Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG). Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2018 Feb 17;391(10121):668-678. doi: 10.1016/S0140-6736(17)32456-X. Epub 2017 Dec 14.

13. Ali S, Wilson APR. Effect of poly-hexamethylene biguanide hydrochloride (PHMB) treated non-sterile medical gloves upon the transmission of Streptococcus pyogenes, carbapenem-resistant E. coli, MRSA and Klebsiella pneumoniae from contact surfaces. BMC Infectious Diseases. 2017 Aug 17;17(1):574. doi: 10.1186/s12879-017-2661-9.

14. Ali S, Yui S, Muzslay M, Wilson APR. Comparison of two whole-room ultraviolet irradiation systems for enhanced disinfection of contaminated hospital patient rooms. Journal of Hospital Infection. 2017 Oct;97(2):180-184. doi: 10.1016/j.jhin.2017.08.011. Epub 2017 Aug 16.

15. Hawkey PM, Warren RE, Livermore DM, McNulty CAM, Enoch DA, Otter JA, Wilson APR. Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party Journal of Antimicrobial Chemotherapy, 2018; 73: Suppl 3, iii2–iii78, https://doi.org/10.1093/jac/dky027

16. Muzslay M, Yui S, Ali S, Wilson APR. Ultraviolet-C decontamination of hand-held tablet devices in the healthcare environment using the Codonics D6000™ disinfection system. Journal of Hospital Infection 2018 Nov;100(3):e60-e63. doi: 10.1016/j.jhin.2018.04.002. Epub 2018 Apr 9.

17. Scriven JE, Scobie A, Verlander NQ, Houston A, Collyns T, Cajic V, Kon OM, Mitchell T, Rahama O, Robinson A, Withama S, Wilson P, Maxwell D, Agranoff D, Davies E, Llewelyn M, Soo SS, Sahota A, Cooper MA, Hunter M, Tomlins J, Tiberi S, Kendall S, Dedicoat M, Alexander E, Fenech T, Zambon M, Lamagni T, Smith EG, Chand M. Mycobacterium chimaera infection following cardiac surgery in the United Kingdom: clinical features and outcome of the first 30 cases. Clinical Microbiology and Infection. 2018 Nov;24(11):1164-1170. doi: 10.1016/j.cmi.2018.04.027. Epub 2018 May 25.PMID:29803845

18. Copanitsanou P, Kechagias VA, Grivas TB, Wilson P. Use of ASEPSIS scoring method for the assessment of surgical wound infections in a Greek orthopaedic department. International Journal of Orthopaedics and Trauma Nursing. 2018 Aug;30:3-7. doi: 10.1016/j.ijotn.2018.03.003. Epub 2018 Mar 28. PMID:29887237

19. Thwaites GE, Scarborough M, Szubert A, Saramago Goncalves P, Soares M, Bostock J, Nsutebu E, Tilley R, Cunningham R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS. Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT. Health Technology Assessment. 2018 Oct;22(59):1-148. doi: 10.3310/hta22590.PMID:30382016

20. Copanitsanou P, Kechagias VA, Galanis P, Grivas TB, Wilson P. Translation and validation of the Greek version of the "ASEPSIS" scoring method for orthopaedic wound infections. International Journal of Orthopaedics and Trauma Nursing. 2018 Dec 1. pii: S1878-1241(18)30057-1. doi: 10.1016/j.ijotn.2018.11.006.

21. Wiley E, Smith C, Thakerar J, Wilson P. Preventing Escherichia coli bacteraemia through improved community urinary tract infection (UTI) management: use of the TARGET Uncomplicated UTI audit tool in primary care. Journal of Hospital Infection. 2019 Apr 28. pii: S0195-6701(19)30187-2. doi: 10.1016/j.jhin.2019.04.018. PMID: 31042553

22. Omar F, Khan A, Wilson P, Montanheiro K, Taylor I, Wiley E. Preventing Escherichia coli bacteraemia through optimized hospital hydration: an inpatient survey on drinks consumption on care of elderly wards. Journal of Hospital Infection. 2019. pii: S0195-6701(19)30144-6. doi: 10.1016/j.jhin.2019.03.011.


23. Wilson P, Gurusamy KS, Morley R, Whiting C, Maeso B, FitzGerald G, Bennett S, Bostock J, Brealey D, Cann M, Kiernan M, Leaper D, Moore M, Oppenheim B, Thompson P, Tingle A. Top research priorities in healthcare-associated infection in the UK. Journal of Hospital Infection 2019 Aug 17. pii: S0195-6701(19)30325-1. doi: 10.1016/j.jhin.2019.08.013.

24. Sukeik M, George D, Gabr A, Kallala R, Wilson P, Haddad FS. Randomised controlled trial of triclosan coated vs uncoated sutures in primary hip and knee arthroplasty.World Journal of Orthopaedics 2019 Jul 18;10(7):268-277. doi: 10.5312/wjo.v10.i7.268. eCollection 2019 Jul 18. Review.

25. Iogna Prat L, Wilson P, Freeman SC, Sutton AJ, Cooper NJ, Roccarina D, Benmassaoud A, Plaz Torres MC, Hawkins N, Cowlin M, Milne EJ, Thorburn D, Pavlov CS, Davidson BR, Tsochatzis E, Gurusamy KS. Antibiotic treatment for spontaneous bacterial peritonitis in people with decompensated liver cirrhosis: a network meta-analysis. Cochrane Database Systematic Reviews. 2019 Sep 16;9(9):CD013120. doi: 10.1002/14651858.CD013120.pub2.PMID: 31524949

26. Yui S, Muzslay M, Karia K, Shuttleworth B, Ali S, Dudzinska N, Wilson P. Evaluation of droplet production by a new design of clinical handwash basin for the healthcare environment. Journal of Hospital Infection. 2019 Sep;103(1):e110-e114. doi: 10.1016/j.jhin.2019.06.014. Epub 2019 Jul 3.PMID: 31278954

27. Budd E, Cramp E, Sharland M, Hand K, Howard P, Wilson P, Wilcox M, Muller-Pebody B, Hopkins S. Adaptation of the WHO Essential Medicines List for national antibiotic stewardship policy in England: being AWaRe. Journal of Antimicrobial Chemotherapy. 2019 Nov 1;74(11):3384-3389. doi: 10.1093/jac/dkz321.

28. Wilson P, Zumla A. Transmission and prevention of acute viral respiratory tract infections in hospitals. Current Opinion Pulmonary Medicine. 2019 May;25(3):220-224. doi: 10.1097/MCP.0000000000000566.

29. Komolafe O, Roberts D, Freeman SC, Wilson P, Sutton AJ, Cooper NJ, Pavlov CS, Milne EJ, Hawkins N, Cowlin M, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS. Antibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis: a network meta-analysis. Cochrane Database Systematic Reviews. 2020 Jan 16;1:CD013125. doi: 10.1002/14651858.CD013125.pub2. Review

30. Yui S, Bercades G, Muzslay M, Blackburn E, Ali S, Smyth D, Macklin A, Ryu JH, Bassett P, MacCallum N, Brealey D, Wilson P. Assessment of a rapid diagnostic test to exclude bacteraemia and effect on clinical decision-making for antimicrobial therapy.
a. Scientific Reports Nature. 2020 Feb 20;10(1):3122. doi: 10.1038/s41598-020-60072-9.

31. MacGowan A, Grier S, Stoddart M, Reynolds R, Rogers C, Pike K, Smartt H, Wilcox M, Wilson P, Kelsey M, Steer J, Gould FK, Perry JD, Howe R, Wootton M. Impact of rapid microbial identification on clinical outcomes in bloodstream infection: the RAPIDO randomized trial. Clin Microbiol Infect. 2020 Mar 25:S1198-743X(20)30056-2. doi: 10.1016/j.cmi.2020.01.030. Online ahead of print.PMID: 32220636
32. Murali M, Ly C, Tirlapur N, Montgomery HE, Cooper JA, Wilson AP. Diarrhoea in critical care is rarely infective in origin, associated with increased length of stay and higher mortality. Journal of Intensive Care Society. 2020 Feb;21(1):72-78. doi: 10.1177/1751143719843423. Epub 2019 May 7.PMID: 32284721

33. Gerver SM, Mihalkova M, Bion JF, Wilson APR, Chudasama D, Johnson AP, Hope R; Infection in Critical Care Quality Improvement Oversight Group. Surveillance of Bloodstream Infections in Intensive Care Units in England, May 2016-April 2017: Epidemiology and Ecology. Journal of Hospital Infection. 2020 May 15:S0195-6701(20)30241-3. doi: 10.1016/j.jhin.2020.05.010. Online ahead of print.PMID: 32422311

34. Yui S, Ali S, Muzslay M, Wilson P. Effect of increased cleaning on keyboard bioburden and employee absence in an office building. Journal of Environmental Health. June 2020. 82 (10): 16-19