Prof Sarah Tabrizi

Dr Sarah TabriziTel: 020 3448 3420
Fax: 020 3448 4786
Email: uclh.nhnn-hdsecs@nhs.net

Location:
National Hospital for Neurology and Neurosurgery

Specialities:
Neurogenetics Laboratory

Professional background

Sarah Tabrizi studied biochemistry and medicine at Edinburgh University where she graduated with the Gold Medal. She then trained in neurology at the National Hospital for Neurology, Queen Square and the Royal Free Hospital in London. She did her PhD, as an MRC Clinical Training Fellow, studying neurodegeneration. Between 2003 and 2007 she was a UK Department of Health National Clinician Scientist and Clinical Senior Lecturer in the Dept of Neurodegenerative Disease at the Institute of Neurology, Queen Square, and consultant neurologist/neurogeneticist at the National Hospital next door. In 2007, she was promoted to Reader in Neurology and Neurogenetics at the Institute of Neurology, UCL.

Her clinical research interests are in neurogenetics and particularly Huntington’s disease (HD), where Dr Tabrizi has a major clinical research initiative in her HD clinic towards the identification of surrogate biomarkers of disease progression as an aid to development of therapeutics; she is currently using proteomics, metabanomics, microarray and imaging techniques amongst others to aid the identification of biomarkers in HD. For full details see her HD research website at www.hdresearch.ucl.ac.uk.

Dr Tabrizi also runs a basic science group based in the Dept of Neurodegenerative Disease at the ION, UCL. Her research focus is on understanding cellular mechanisms of neurodegeneration with a particular emphasis on prion-mediated neurotoxicity and cellular trafficking, and modelling neurodegenerative diseases in vitro, for more details see www.ion.ucl.ac.uk (Dept of Neurodegenerative Disease) and www.prion.mrc.ac.uk. Dr Tabrizi’s funding is from the Medical Research Council, Wellcome Trust, CHDI, UK Huntington’s disease association and the Brain Research Trust.

Research interests

  • Neurogenetics and Neurodegenerative Diseases, particularly Huntington’s Disease

Publications

Book chapters

Tabrizi,S.J. (Forthcoming). Chorea. in Rossor,M.N., Clarke. C., Howard. R.S. (ed.) Disorders section of Queen Square Textbook of Neurology. Blackwell Scientific Publishers

Tabrizi,S.J. (Forthcoming). Huntington's disease. in Wood,N.W. (ed.) Neurogenetics: a guide for clinicians. Cambridge: Cambridge University Press. ISBN: 052154372X

Tabrizi,S.J., Collinge,J. (2003). Transmissable spongiform encephalopathies of humans and animals. Chapter 26 in Cohen,J., Powderly,W.G. (ed.) Infectious diseases. , 2nd edition, 297-305. ISBN: 0323024076

Tabrizi,S.J., Schapira,A.H.V. (2002). Mitochondrial abnormalities in neurodegenerative disorders. Chapter 5 in Schapira,A.H.V., DiMauro,S. (ed.) Mitochondrial disorders in neurology 2. Blue books of practical neurology 26 series. Oxford: Butterworth-Heinemann, 143-174. ISBN: 0-7506-7288-9

Journal articles

Simon Mead, Mark Poulter, James Uphill, John Beck, Tom Webb, Tracy Campbell, Gary Adamson, Eleni Molonou, Pelagia Deriziotis, Sarah J Tabrizi, Holger Hummerich, Claudio Verzilli, John Whittaker, John Collinge. (Forthcoming) Genome-wide association study identifies genetic risk factors for variant Creutzfeldt-Jakob disease. Lancet Neurology ISSN: 1474-4422

Henley,S.M.D., Wild,E.J., Hobbs,N.Z, Frost,C., MacManus,D.G., Barker,R.A., Fox,N.C., Tabrizi,S.J. (Forthcoming). Whole-brain atrophy as a biomarker of progression in early Huntington’s disease. Movement Disorders. ISSN: 0885-3185

Henley,S.M.D., Wild,E.J., Hobbs,N.Z., Scahill,R.I., Ridgway,G.R., MacManus,D.G., Barker,R.A., Fox,N.C., Tabrizi,S.J. (Forthcoming). Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease. Journal of Neurology. ISSN: 0340-5354

Klöppel,S., Chu,C., Tan,G., Draganski,B., Johnson,H., Paulsen,J.S., Kienzle,W., Tabrizi,S.J., Ashburner,J., Frackowiak,R.S.J., Predict-HD investigators of the Huntington Study Group. (Forthcoming). Automatic detection of pre-clinical neurodegeneration: Pre-symptomatic Huntington’s disease. Neurology. ISSN: 0028-3878

Leoni,V*., Mariotti,C*., Tabrizi,S.J*., Valenza,M., Wild,E.J., Henley,S.M.D., Hobbs,N.Z., Mandelli,L., Grisoli,M., Bjorkhem,I., Cattaneo,E., Di Donato,S. (Forthcoming). Plasma 24S-hydroxycholesterol and caudate MRI in premanifest and early Huntington’s disease. Brain. ISSN: 0006-8950 [DOI link] * Equal first author.
Politis,M., Pavese,N., Tai,Y.F., Tabrizi,S J, Barker,R. A., Piccini,P. (Forthcoming). Hypothalamic involvement in Huntington’s disease. An in vivo PET study. Brain. ISSN: 0006-8950

Robert,M.P.A., Nachev,P.C., Hicks,S.L., Golding,C.V.P., Tabrizi,S.J., Kennard,C. (Forthcoming). Saccadometry of Conditional Rules in Pre-symptomatic Huntington’s Disease. Annals of the New York Academy of Sciences. ISSN: 0077-8923

Schippling,S., Schneider,S., Bhatia,K. P.,Münchau,A., Rothwell,J. C., Tabrizi,S. J., Orth,M. (Forthcoming). Abnormal motor cortex excitability in preclinical and very early Huntington’s disease. Biological Psychiatry. ISSN: 0006-3223

Arnulf,I., Nielsen,J., Lohmann,E., Schieffer,J., Wild,E., Jennum,P., Konofal,E., Walker,M., Oudiette,D., Tabrizi,S., Durr,A. (2008). Rapid Eye Movement sleep disturbances in Huntington disease. Archives of Neurology 65(4), 482-488. ISSN: 0003-9942 [DOI link]

Björkqvist,M., Wild,E.J., Thiele,J., Silvestroni,A., Andre,R., Lahiri,N., Raibon,E., Lee,R.V., Benn,C.L., Soulet,D., Magnusson,A., Woodman,B., Landles,C., Pouladi,M.A., Hayden,M.R., Khalili-Shirazi,A., Lowdell,M.W., Brundin,P., Bates,G.P., Leavitt,B.R.,Möller,T., Tabrizi,S.J. (2008). A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. Journal of Experimental Medicine 205(8), 1869-1877. ISSN: 0022-1007 [DOI link]

Henley,S.M.D., Wild,E.J., Hobbs,N.Z., Warren,J.D., Frost,C., Scahill,R.I., Ridgway,G.R., MacManus,D.G., Barker,R.A., Fox,N.C., Tabrizi,S.J. (2008). Defective emotion recognition in early HD is neuropsychologically and anatomically generic. Neuropsychologia 46(8), 2152-2160. ISSN: 0028-3932 [DOI link]

Hicks,S.L., Robert,M.P.A., Golding,C.V.P., Tabrizi,S.J., Kennard,C. (2008). Oculomotor deficits indicate the progression of Huntington's disease. Progress in Brain Research 171, 555-558. ISSN: 0079-6123 [DOI link]

Kloppel,S., Draganski,B., Golding,C.V., Chu,C., Nagy,Z., Cook,P.A., Hicks,S.L., Kennard,C., Alexander,D.C., Parker,G.J., Tabrizi,S.J., Frackowiak,R.S. (2008). White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease. Brain 131(1), 196-204. ISSN: 0006-8950 [DOI link]
Wild,E.J., Mudanohwo,E.E., Sweeney,M.G., Schneider,S.A., Beck,J., Bhatia,K.P., Rossor,M.N., Davis,M.B., Tabrizi,S.J. (2008). Huntington's disease phenocopies are clinically and genetically heterogeneous. Movement Disorders 23(5), 716-720. ISSN: 0885-3185 [DOI link]

Wood,N.I., Goodman,A.O.G., van der Burg,J.M.M., Gazeau,V., Brundin,P., Bjorkqvist,M., Petersen,A., Tabrizi,S.J., Barker,R.A., Morton,A.J. (2008). Increased thirst and drinking in Huntington's disease and the R6/2 mouse. Brain Research Bulletin 76(1-2), 70-79. ISSN: 0361-9230 [DOI link]

Wood-Kaczmar,A., Gandhi,S., Yao,Z., Abramov,A.S.Y., Miljan,E.A., Keen,G., Stanyer,L., Hargreaves,I., Klupsch,K., Deas,E., Downward,J., Mansfield,L., Jat,P., Taylor,J., Heales,S., Duchen,M.R., Latchman,D.L., Tabrizi,S.J*., Wood,N.W*. (2008). PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 3(6), e2455. ISSN: 1932-6203 [DOI link] *Equal senior author

Dalrymple,A., Wild,E.J., Joubert,R., Sathasivam,K., Bjorkqvist,M., Petersen,A., Jackson,G.S., Isaacs,J.D., Kristiansen,M., Bates,G.P., Leavitt,B.R., Keir,G., Ward,M., Tabrizi,S.J. (2007). Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates. Journal of Proteome Research 6(7), 2833-2840. ISSN: 1535-3893 [DOI link]

Kristiansen,M., Deriziotis,P., Dimcheff,D.E., Jackson,G.S., Ovaa,H., Naumann,H., Clarke,A.R., van Leeuwen,F.W.B., Menendez-Benito,V., Dantuma,N.P., Portis,J.L., Collinge,J., Tabrizi,S.J. (2007). Disease-associated prion protein oligomers inhibit the 26S proteasome. Molecular Cell 26(2), 175-188. ISSN: 1097-2765 [DOI link]

Runne,H., Kuhn,A., Wild,E.J., Pratyaksha,W., Kristiansen,M., Isaacs,J.D.,Régulier,E., Delorenzi,M., Tabrizi,S.J*., Luthi-Carter,R*. (2007). Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood. Proceedings of the National Academy of Sciences of the United States of America 104(36), 14424-14429. ISSN: 0027-8424 [DOI link] *Equal senior author

Tai,Y.F., Pavese,N., Gerhard,A., Tabrizi,S.J., Barker,R.A., Brooks,D.J., Piccini,P. (2007). Microglial activation in presymptomatic Huntington's disease gene carriers. Brain 130(7), 1759-1766. ISSN: 0006-8950 [DOI link]

Tai,Y.F., Pavese,N., Gerhard,A., Tabrizi,S.J., Barker,R.A., Brooks,D.J., Piccini,P. (2007). Imaging microglial activation in Huntington's disease. Brain Research Bulletin 72(2-3), 148-151. ISSN: 0361-9230 [DOI link]

Wild,E.J., Tabrizi,S.J. (2007). Genetic causes of dementia. Advances in Clinical Neuroscience and Rehabilitation 7(2), 14-16. ISSN: 1473-9348

Wild,E.J., Petzold,A., Keir,G., Tabrizi,S.J. (2007). Plasma neurofilament heavy chain levels in Huntington's disease. Neuroscience Letters 417(3), 231-233. ISSN: 0304-3940 [DOI link]

Zourlidou,A., Gidalevitz,T., Kristiansen,M., Landles,C., Woodman,B., Wells,D.J., Latchman,D.S., de Belleroche,J., Tabrizi,S.J., Morimoto,R.I., Bates,G.P. (2007). Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. Human Molecular Genetics 16(9), 1078-1090. ISSN: 0964-6906 [DOI link]

Bjorkqvist,M., Petersen,A., Bacos,K., Isaacs,J., Norlen,P., Gil,J., Popovic,N., Sundler,F., Bates,G.P., Tabrizi,S.J., Brundin,P., Mulder,H. (2006). Progressive alterations in the hypothalamic-pituitary-adrenalaxis in the R6/2 transgenic mouse model of Huntington's disease. Human Molecular Genetics 15(10), 1713-1721. ISSN: 0964-6906 [DOI link]

Golding,C.V.P., Danchaivijitr,C., Hodgson,T.L., Tabrizi,S.J., Kennard,C. (2006). Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology 67(3), 485-487. ISSN: 0028-3878 [DOI link]

Henley,S.M., Frost,C., MacManus,D.G., Warner,T.T., Fox,N.C., Tabrizi,S.J. (2006). Increased rate of whole-brain atrophy over 6 months in early Huntington disease. Neurology 67(4), 694-696. ISSN: 0028-3878 [DOI link]

Hye,A., Lynham,S., Thambisetty,M., Causevic,M., Campbell,J., Byers,H.L., Hooper,C., Rijsdijk,F., Tabrizi,S.J., Banner,S., Shaw,C.E., Foy,C., Poppe,M., Archer,N., Hamilton,G., Powell,J., Brown,R.G., Sham,P., Ward,M., Lovestone,S. (2006). Proteome-based plasma biomarkers for Alzheimer's disease. Brain 129(11), 3042-3050. ISSN: 0006-8950 [DOI link]

Tsang,T.M., Woodman,B., McGloughlin,G.A., Griffin,J., Tabrizi,S.J., Bates,G.P., Holmes,E. (2006). Metabolic characterisation of the R6/2 transgenic mouse model of Huntington's Disease by high-resolution MAS 1H NMR spectroscopy. Journal of Proteome Research 5(3), 483-492. ISSN: 1535-3893 

Hirsch,N., Beckett,A., Collinge,J., Scaravilli,F., Tabrizi,S., Berry,S. (2005). Lymphocyte contamination of laryngoscope blades - a possible vector for transmission of variant Creutzfeldt-Jakob disease. Anaesthesia 60(7), 664-667. ISSN: 0003-2409 [Online]

Kristiansen,M., Messenger,M.J., Klohn,P.C., Brandner,S., Wadsworth,J.D., Collinge,J., Tabrizi,S.J. (2005). Disease-related prion protein forms aggresomes in neuronal cells leading to caspase-activation and apoptosis. Journal of Biological Chemistry 280(46), 38851-38861. ISSN: 0021-9258 [DOI link]

Loy,C.T., Sweeney,M.G., Davis,M.B., Wills,A.J., Sawle,G.V., Lees,A.J., Tabrizi,S.J. (2005). Spinocerebellar ataxia type 17: extension of phenotype with putaminal rim hyperintensity on magnetic resonance imaging. Movement Disorders 20(11), 1521-1523. ISSN: 0885-3185 

Strand,A.D., Aragaki,A.K., Shaw,D., Bird,T., Holton,J., Turner,C., Tapscott,S.J., Tabrizi,S.J., Schapira,A.H., Kooperberg,C., Olson,J.M. (2005). Gene expression in Huntington's disease skeletal muscle: a potential biomarker. Human Molecular Genetics 14(13), 1863-1876. ISSN: 0964-6906 [Online]

Tabrizi,S.J., Blamire,A.M., Manners,D.N., Rajagopalan,B., Styles,P., Schapira,A.H., Warner,T.T. (2005). High-dose creatine therapy for Huntington disease: a 2-year clinical and MRS study. Neurology 64(9), 1655-1656. ISSN: 0028-3878 [Online]

Beck,J.A., Poulter,M., Campbell,T.A., Uphill,J.B., Adamson,G., Geddes,J.F., Revesz,T., Davis,M.B., Wood,N.W., Collinge,J., Tabrizi,S.J. (2004). Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease. Human Molecular Genetics 13(12), 1219-1224. ISSN: 0964-6906 [DOI link]

Orth,M., Tabrizi,S.J., Tomlinson,C., Messmer,K., Korlipara,L.V.P., Schapira,A.H.V., Cooper,J.M. (2004). G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damage. Neurochemistry International 45(5), 669-676. ISSN: 0197-0186 [DOI link]

Behrendt,G.C., Tabrizi,S.J., Turner,C., Levine,T.S., Sheppard,M.N. (2003). Idiopathic intimal hyperplasia of small arteries and arterioles affecting intestines and myocardium. Cardiovasc Pathol 12(1), 32-35

Orth,M., Tabrizi,S.J., Schapira,A.H.V., Cooper,J.M. (2003). Alpha-Synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone. Neuroscience Letters 351(1), 29-32. ISSN: 0304-3940

Tabrizi,S.J., Blamire,A.M., Manners,D.N., Rajagopalan,B., Styles,P., Schapira,A.H., Warner,T.T. (2003). Creatine therapy for Huntington's disease: clinical and MRS findings in a 1-year pilot study. Neurology 61(1), 141-142. ISSN: 0028-3878

Orth,M., Tabrizi,S.J., Schapira,A.H.V. (2000). Sporadic inclusion body myositis not linked to prion protein codon 129 methionine homozygosity. Neurology 55(8), 1235-1235. ISSN: 0028-3878 

Tabrizi,S.J., Orth,M., Wilkinson,J.M., Taanman,J.W., Warner,T.T., Cooper,J.M., Schapira,A.H.V. (2000). Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity. Human Molecular Genetics 9(18), 2683-2689. ISSN: 0964-6906 

Tabrizi,S.J., Workman,J., Hart,P.E., Mangiarini,L., Mahal,A., Bates,G., Cooper,J.M., Schapira,A.H.V. (2000). Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse. Annals of Neurology 47(1), 80-86. ISSN: 0364-5134 

Tabrizi,S.J., Schapira,A.H.V. (1999). Secondary abnormalities of mitochondrial DNA associated with neurodegeneration. Biochemical Society Symposium 66, 99-110. ISSN: 0067-8694 

Tabrizi,S.J., Cleeter,M.W., Xuereb,J., Taanman,J.W., Cooper,J.M., Schapira,A.H. (1999). Biochemical abnormalities and excitotoxicity in Huntington's disease brain. Annals of Neurology 45(1), 25-32. ISSN: 0364-5134 

Cock,H., Tabrizi,S.J., Cooper,J.M., Schapira,A.H.V. (1998). The influence of nuclear background on the biochemical expression of 3460 Leber's hereditary optic neuropathy. Annals of Neurology 44(2), 187-193. ISSN: 0364-5134

Lodi,R., Taylor,D.J., Tabrizi,S.J., Hilton-Jones,D., Squier,M.V., Seller,A., Styles,P., Schapira,A.H.V. (1998). Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. Brain 121(11), 2119-2126. ISSN: 0006-8950

Schapira,A.H.V., Gu,M., Taanman,J.W., Tabrizi,S.J., Seaton,T., Cleeter,M., Cooper,J.M. (1998). Mitochondria in the etiology and pathogenesis of Parkinson's disease. Annals of Neurology 44 (S1, S89-S98. ISSN: 0364-5134 

Tabrizi,S.J., Cooper,J.M., Schapira,A.H.V. (1998). Mitochondrial DNA in focal dystonia: a cybrid analysis. Annals of Neurology 44(2), 258-261. ISSN: 0364-5134
Tabrizi,S.J., Schapira,A.H.V. (1998). Primary and secondary deficiencies of the mitochondrial respiratory chain. Neurologist 4(4), 169-179

Lodi,R., Taylor,D.J., Tabrizi,S.J., Kumar,S., Sweeney,M., Wood,N.W., Styles,P., Radda,G.K., Schapira,A.H. (1997). In vivo skeletal muscle mitochondrial function in Leber's hereditary optic neuropathy assessed by 31P magnetic resonance spectroscopy. Annals of Neurology 42(4), 573-579. ISSN: 0364-5134 

Tabrizi,S.J., Scaravilli,F., Howard,R.S., Collinge,J., Rossor,M.N. (1996). Creutzfeldt-Jakob disease in a young woman. Lancet 347(9006), 945-948. ISSN: 0140-6736 
Tabrizi,S.J. (1994). Grand Rounds-Hammersmith Hospital: Nocardia pericarditis. BMJ 309(6967), 1495-1497. ISSN: 0959-8138 

Reviews

Deriziotis,P., Tabrizi,S.J. (Forthcoming). Prions and the proteasome. Biochimica et Biophysica Acta . ISSN: 0167-4889 [DOI link]

Klöppel,S., Henley,S., Hobbs,N., Wolf,R. C., Kassubek,J., Tabrizi,S.J., Frackowiak,RSJ. (Forthcoming). Neuroimaging of Huntington Disease: Preparing for clinical trials. Neuroscience

Wild,E., Bjorkqvist,M., Tabrizi,S.J. (Forthcoming). Immune markers for Huntington’s disease? Expert Review of Neurotherapeutics. ISSN: 1473-7175

Wild,E.J., Tabrizi,S.J. (2008). Biomarkers for Huntington's disease. Expert Opinion on Medical Diagnostics 2(1), 47-62. ISSN: 1753-0059 [DOI link]

Wild,E.J., Tabrizi,S.J. (2007). Huntington's disease phenocopy syndromes. Current Opinion in Neurology 20(6), 681-687. ISSN: 1350-7540 [DOI link]

Wild,E.J., Tabrizi,S.J. (2007). The differential diagnosis of chorea. Practical Neurology 7(6), 360-373. ISSN: 1474-7758 [DOI link]

Wild,E.J., Tabrizi,S.J. (2006). Predict-HD and the future of therapeutic trials. Lancet Neurology 5(9), 724-725. ISSN: 1474-4422 

Holmes,E., Tsang,T.M., Tabrizi,S.J. (2006). The application of NMR-based metabonomics in neurological disorders. NeuroRx 3(3), 358-372. ISSN: 1545-5343 

Henley,S.M., Bates,G.P., Tabrizi,S.J. (2005). Biomarkers for neurodegenerative diseases. Current Opinion in Neurology 18(6), 698-705. ISSN: 1350-7540 

Kristiansen,M., Tabrizi,S.J. (2005). Protein aggregation, the ubiquitin-proteasome system and neurodegenerative diseases. Advances in Clinical Neuroscience and Rehabilitation 5(2), 8-9. ISSN: 1473-9348

McKintosh,E., Tabrizi,S.J., Collinge,J. (2003). Prion diseases. Journal of Neurovirology 9(2), 183-193. ISSN: 1355-0284 
Orth,M., Tabrizi,S.J. (2003). Models of Parkinson's disease. Movement Disorders 18(7), 729-737. ISSN: 0885-3185 [DOI link]

Ahmad-Annuar,A., Tabrizi,S.J., Fisher,E.M.C. (2003). Mouse models as a tool for understanding neurodegenerative diseases. Current Opinion in Neurology 16(4), 451-458. ISSN: 1350-7540

Tabrizi,S.J., Elliott,C.L., Weissmann,C. (2003). Ethical issues in human prion diseases. British Medical Bulletin 66(1), 305-316. ISSN: 0007-1420

Hafezparast,M., Ahmad-Annuar,A., Wood,N.W., Tabrizi,S.J., Fisher,E.M. (2002). Mouse models for neurological disease. Lancet Neurology 1(4), 215-224. ISSN: 1474-4422 

GMC/GDC number: 3666535 

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