Study name Aim Recruitment
BiG – Babies in Glasses to assess the feasibility of a randomised controlled trial seeking to establish whether 2 year visual and development outcomes are better in children with perinatal brain injury if prescribed near vision glasses from 8 or 16 weeks of age, rather than the current standard care 1. All term infants undergoing therapeutic hypothermia for hypoxic ischaemic encephalopathy (HIE) and part of the formal UCLH neurodevelopmental follow up programme.
2. All preterm infants born at <29 weeks’ gestational age and are part of the formal UCLH neurodevelopmental follow up programme.
Webcam study The aim of the study is to evaluate the impact of webcam use on nursing workload and patient safety, staff perceptions and parent emotional well-being.  All healthcare professionals (including nurses, nursery nurses and midwives) on the neonatal unit working with infants using webcams will be eligible to complete the evaluation and survey. 
All neonatal staff working with the webcams will be eligible to complete the post-implementation survey. 
All parents of infants admitted to a cot with a webcam in UCLH will be eligible for inclusion, depending on the following criteria:
• Able to communicate in English 
• Over the age of 18 
SHP607-202 (Footprints) to assess the effect of SHP607 on reducing the burden of chronic lung disease (CLD), as indicated by a reduction in time to final weaning off respiratory technology support (RTS) through 12 months corrected age (CA), as compared to a standard neonatal care group. 1. Written informed consents must be signed and dated by subject's parent(s)
2. Written informed consents must be signed and dated by the subject's birth mother
3. Initially, subjects between GA of 26 weeks +0 days and 27 weeks +6 days. After approximately 75 subjects  have completed the PMA 40 weeks visit, enrollment of subjects of GA between 23 weeks +0 days and 27 weeks +6 days may be authorised.
Optisurf To assess whether the dose and method of administration of surfactant given to preterm infants with respiratory distress syndrome (RDS) affects neonatal outcomes. • Gestational age of 36+6 weeks+days or less
• Treated with surfactant
• Record of birth-weight available
• Infants born after the initiation date of the study
• Parental opt-out consent
SHP202 (Pedal)  to continue to follow patients who participated in the ROPP-2008-01 study, to evaluate whether receiving Mecasermin Rinfabate (rhIGF-1/rhIGFBP-3) for a short amount of time during that study has long term effects on vision or safety, as compared to the patients who received standard neonatal care during that study. This study will also help examine the long-term effects on cognitive, behavioural, and physical development, and Quality of Life.  
N01349 (Petite) To evaluate the PK of BRV in neonates who have seizures that are not adequately controlled with previous AED treatment, and to identify the optimal BRV dose for the treatment of subjects 1. An Independent Ethics Committee (IEC)-approved written ICF is signed and dated by the parent(s) or legal representative(s).
2a. Confirmation on VEEG of ≥2 minutes of cumulative ENS or ≥3 identifiable ENS prior to entering the Evaluation Period (ENS is defined as a seizure lasting for at least 10 seconds on VEEG), despite receiving previous AED treatment for the treatment of electroencephalographic seizures.
The occurrence of ENS during an up to 1-hour period must be confirmed either by the local or central VEEG reader prior to drug administration. Preferably, the central VEEG reader should confirm the required ENS.
3. Subject is male or female and must be at least 34 weeks of CGA. In addition, term neonates up to 27 days of PNA and preterm neonates up to 40 weeks of PMA and 27 days of PNA can be enrolled.
4. Subject weighs at least 2.3kg at the time of enrollment.
5. Subjects with or without concomitant hypothermia treatment.
Baby Lung To characterise the inflammatory profile and surfactant components, including SP-D in gastric/tracheal aspirates and serum in preterm infants born between 23 and 29+6 weeks gestation that receive ventilatory support with respiratory distress syndrome [RDS] and are at risk of developing BPD. Preterm infants born between 23 weeks and 0 days and 29 weeks and 6 days gestation.  
Brain activity To understand how the neonatal brain matures and handles information. The brain of a baby -especially if premature - is not just a scaled down version of an adult brain, but has functions that are only present at this early stage of life. Therefore, we need to understand how the brain processes and is affected by the environment around the baby (whether in a positive or negative way). This can help us understand, for example, how neonates perceive pain or how we can better protect brain development. Most babies over 28 weeks corrected gestational age are eligible to undergo a research brain recording, which is completely safe and painless. Sometimes we time our brain recordings to coincide with a necessary blood test. Occasionally babies require brain recordings for clinical reasons (not for research), and in those instances we may ask permission to use those clinical data for research purposes.