Contact: Yaa Acheampong, Research Manager: y.acheampong@nhs.net

Current research studies

Aim:

To evaluate the impact on sexual function with ‘Early-Salpingectomy’ and ‘Delayed-Oophorectomy’, as a two-step ovarian cancer prevention strategy in premenopausal women at high-risk of ovarian cancer.

Recruitment:

  • Women at increased risk of OC: BRCA1/BRCA2 mutation carriers; RAD51C/RAD51D/BRIP1 mutation carriers; strong family history* of breast and OC or OC alone.
  • Premenopausal ≥30years.
  • Completed family (for surgical arms).

For more information on PROTECTOR, visit here.

Aim:

To compare the effectiveness of letrozole versus clomifene, metformin versus placebo and letrozole plus metformin versus clomifene plus metformin, in woman with anovulatory PCOS and infertility on live birth rate (≥ 34 weeks of gestation).

Recruitment:

  • Women diagnosed with PCOS (according to Rotterdam criteria) and evidence of anovulation (anovulation is defined as irregular cycles lasting <21 or more than 35 days or less than 8 periods per year OR absence of raised serum progesterone greater than 20nmol/l 7 days prior to a period)
  • Presentation with infertility or wishing to conceive
  • Male partner with normal sperm count (≥ 15 million) and progressive motility (≥ 32%) in the last 3 years

Aim

To assess whether hydroxychloroquine may help improve pregnancies in women with antiphospholipid antibodies (aPL).

Recruitment

  • Women with known aPL who are planning pregnancy.

Aim

Recruitment

To determine the effectiveness of laparoscopic removal of endometriosis in the management of chronic pelvic pain in women. The aim of this randomised study is to determine whether laparoscopic removal is of clinical benefit to women with chronic pelvic pain where the only finding is superficial peritoneal endometriosis.

Women over 16 undergoing laparoscopy for the investigation of chronic pelvic pain.

 

For more information on ESPrit2, visit here.

Aim:  

  • In women with premature ovarian insufficiency (POI) what is the relative effectiveness, in terms of bone mineral density (BMD), of hormone replacement therapy (HRT) compared to the combined oral contraceptive pill (COC).  

Recruitment 

  • Diagnosis of POI  
  • Will be aged ≥18 years up to <40 years at randomisation 
  • Not intending to become pregnant within 12 months  
  • Not taken any HRT or COC treatment for the last 4 weeks or willing to stop HRT/COC treatment for a minimum period of 4 weeks prior to randomisation 

For more information on POISE, visit here.

Research Champions

The National Institute for Health Research are recruiting volunteer Research Champions to help spread the word about health research.

Being a Research Champion

You can be a Research Champion if you are passionate about making sure people get the best treatment possible in the future. You don't have to have been part of health research to get involved and make a difference.

  • You can commit as much or as little time as you like
  • You will have access to free training and support
  • You will be part of national network of volunteers and find out about other opportunities to make a difference
  • You will be invited to events and get to meet others in your community, and health professionals and researchers.

Want to get involved?

If you are interested in becoming a research champion or finding out more, please get in touch with your local contact: www.nihr.ac.uk/researchchampions