Contact: Yaa Acheampong, Research Manager: y.acheampong@nhs.net

Current research studies

Aim:

To evaluate the impact on sexual function with ‘Early-Salpingectomy’ and ‘Delayed-Oophorectomy’, as a two-step ovarian cancer prevention strategy in premenopausal women at high-risk of ovarian cancer.

Recruitment:

  • Women at increased risk of OC: BRCA1/BRCA2 mutation carriers; RAD51C/RAD51D/BRIP1 mutation carriers; strong family history* of breast and OC or OC alone.
  • Premenopausal ≥30years.
  • Completed family (for surgical arms).

Aim:

To compare the effectiveness of letrozole versus clomifene, metformin versus placebo and letrozole plus metformin versus clomifene plus metformin, in woman with anovulatory PCOS and infertility on live birth rate (≥ 34 weeks of gestation).

Recruitment:

  • Women diagnosed with PCOS (according to Rotterdam criteria) and evidence of anovulation (anovulation is defined as irregular cycles lasting <21 or more than 35 days or less than 8 periods per year OR absence of raised serum progesterone greater than 20nmol/l 7 days prior to a period)
  • Presentation with infertility or wishing to conceive
  • Male partner with normal sperm count (≥ 15 million) and progressive motility (≥ 32%) in the last 3 years

Aim

To determine if doxycycline administered prior to conception improves pregnancy outcome in women with recurrent miscarriage associated with chronic endometritis and explore the mechanisms by which it could prevent miscarriage.

Recruitment

  • Age (≥18 to <42)
  • 2 or more (consecutive first trimester) miscarriages
  • Not currently pregnancy
  • No known treatable cause of miscarriage 
  • No uncontrolled disease
  • Happy to use barrier contraception for 3 months
  • Not taking antibiotics
  • No known allergy or contraindication to doxycycline
  • Menstrual cycle between 21-42 days

Aim

To assess whether hydroxychloroquine may help improve pregnancies in women with antiphospholipid antibodies (aPL).

Recruitment

  • Women with known aPL who are planning pregnancy.

Aim

Recruitment

To determine the effectiveness of laparoscopic removal of endometriosis in the management of chronic pelvic pain in women. The aim of this randomised study is to determine whether laparoscopic removal is of clinical benefit to women with chronic pelvic pain where the only finding is superficial peritoneal endometriosis.

Women over 16 undergoing laparoscopy for the investigation of chronic pelvic pain.