For more information about our obstetrics and neonatal studies, please visit the pages below:
Current research studies
To evaluate the clinical and cost-effectiveness of long-term use of GnRHa with add-back HRT as an alternative treatment to further laparoscopic surgery (excision or ablation of endometriosis) in women who present with recurrence of pain following previous surgery for endometriosis but wish to retain their fertility.
For the purposes of this trial, the term ‘women’ includes all persons assigned female sex at birth.
- Women aged 21–49 years with recurrent pain following conservative laparoscopic surgery for endometriosis (excision or ablation) who wish to avoid removal of ovaries and hysterectomy, irrespective of site and stage of endometriosis, number of previous surgeries or use of postoperative hormonal treatment
- Women who are considered suitable for both treatment arms
- Able and willing to give informed consent to participate and to participate in study procedures, including DEXA scans.
- Willing to undergo pregnancy test prior to intervention
To compare the clinical and cost-effectiveness of medical treatment versus laparoscopic surgery for the management of deep endometriosis.
- Women aged 18–49 years old seeking treatment for pain
- Confirmed deep endometriosis (laparoscopic or MRI)
- Suitable for either medical or surgical management
- Able and willing to give informed consent to participate and to comply with study procedures
To evaluate the impact on sexual function with ‘Early-Salpingectomy’ and ‘Delayed-Oophorectomy’, as a two-step ovarian cancer prevention strategy in premenopausal women at high-risk of ovarian cancer.
- Women at increased risk of OC: BRCA1/BRCA2 mutation carriers; RAD51C/RAD51D/BRIP1 mutation carriers; strong family history* of breast and OC or OC alone.
- Premenopausal ≥30years.
- Completed family (for surgical arms).
To compare the effectiveness of letrozole versus clomifene, metformin versus placebo and letrozole plus metformin versus clomifene plus metformin, in woman with anovulatory PCOS and infertility on live birth rate (≥ 34 weeks of gestation).
- Women diagnosed with PCOS (according to Rotterdam criteria) and evidence of anovulation (anovulation is defined as irregular cycles lasting <21 or more than 35 days or less than 8 periods per year OR absence of raised serum progesterone greater than 20nmol/l 7 days prior to a period)
- Presentation with infertility or wishing to conceive
- Male partner with normal sperm count (≥ 15 million) and progressive motility (≥ 32%) in the last 3 years
For more information on LOCI, visit here.
To determine the effectiveness of laparoscopic removal of endometriosis in the management of chronic pelvic pain in women. The aim of this randomised study is to determine whether laparoscopic removal is of clinical benefit to women with chronic pelvic pain where the only finding is superficial peritoneal endometriosis.
Women over 16 undergoing laparoscopy for the investigation of chronic pelvic pain.
- In women with premature ovarian insufficiency (POI) what is the relative effectiveness, in terms of bone mineral density (BMD), of hormone replacement therapy (HRT) compared to the combined oral contraceptive pill (COC).
- Diagnosis of POI
- Will be aged ≥18 years up to <40 years at randomisation
- Not intending to become pregnant within 12 months
- Not taken any HRT or COC treatment for the last 4 weeks or willing to stop HRT/COC treatment for a minimum period of 4 weeks prior to randomisation
The National Institute for Health Research are recruiting volunteer Research Champions to help spread the word about health research.
Being a Research Champion
You can be a Research Champion if you are passionate about making sure people get the best treatment possible in the future. You don't have to have been part of health research to get involved and make a difference.
- You can commit as much or as little time as you like
- You will have access to free training and support
- You will be part of national network of volunteers and find out about other opportunities to make a difference
- You will be invited to events and get to meet others in your community, and health professionals and researchers.
Want to get involved?
If you are interested in becoming a research champion or finding out more, please get in touch with your local contact: www.nihr.ac.uk/researchchampions