Professional background

Dr Manjit Matharu is a senior lecturer at The Institute of Neurology and Honorary consultant neurologist at The National Hospital for Neurology and Neurosurgery, Queen square, London, UK.

He is the clinical lead of the headache group at The National Hospital for Neurology and Neurosurgery. Dr Matharu gained his BSc and MBChB from the University of Manchester in 1991 and 1994, respectively. He completed his general medical training in London leading up to obtaining the membership of the Royal College of Physicians (MRCP) in 1998.

He subsequently obtained a PhD at The Institute of Neurology, Queen Square, London on structural and functional neuroimaging in primary headache syndromes. He completed his residency in neurology at The National Hospital for Neurology and Neurosurgery, The Royal London Hospital and Homerton Hospital in London in 2007.

Dr Matharu’s major research interests include functional and structural imaging in primary headaches, trigeminal autonomic cephalalgias and neurostimulation for intractable headaches. He has authored numerous scientific papers.

Research interests



Zrinzo L, Matharu MS. Deep Brain Stimulation in Cluster Headache: Hypothalamus or Midbrain Tegmentum? Curr Pain Headache Rep 2010;14:154-163.    Cittadini E, Matharu MS. Symptomatic trigeminal autonomic cephalalgias. Neurologist 2009;15:305-312.   
Tyagi A, Matharu M. Evidence base for the medical treatments used in cluster headache. Curr Pain Headache Rep 2009;13:168-178.   
Matharu M, May A. Functional and structural neuroimaging in trigeminal autonomic cephalalgias. Curr Pain Headache Rep 2008; 12: 132-7.   
Levy MJ, Matharu M, Goadsby PJ. Chronic headache and pituitary tumors. Curr Pain Headache Rep 2008;12(1):74-78.    Cittadini E, Matharu MS, Goadsby PJ. Paroxysmal hemicrania: a prospective clinical study of 31 cases. Brain 2008;131(Pt 4):1142-1155.   
Cohen AS, Matharu MS, Goadsby PJ. Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy. Neurology 2007;69:668-675.   
Matharu MS. The hypothalamus, pain, and primary headaches. Headache 2007; 47: 963-8.   
Cohen AS, Matharu MS, Goadsby PJ. Trigeminal autonomic cephalalgias: current and future treatments. Headache 2007; 47: 969-80.   
May A, Matharu M. New insights into migraine: application of functional and structural imaging. Curr Opin Neurol 2007; 20: 306-9.   
Goadsby PJ, Cohen AS, Matharu MS. Trigeminal autonomic cephalalgias: diagnosis and treatment. Curr Neurol Neurosci Rep 2007;7:117-25.   
Matharu MS, Schwedt TJ, Dodick DW. Thunderclap headache: an approach to a neurologic emergency. Curr Neurol Neurosci Rep 2007;7:101-9.   
Cohen AS, Matharu MS, Goadsby PJ. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)-a prospective clinical study of SUNCT and SUNA. Brain 2006; 129: 2746-60.   
Matharu MS. Are the current diagnostic criteria for cluster headache too restrictive for clinical practice? Nature Clinical Practice Neurology 2006;2: 422-423   
Kernick D, Matharu MS, Goadsby PJ. Cluster headache in primary care: unmissable, underdiagnosed and undertreated. Br J Gen Pract 2006; 56: 486-7.   
Paemeleire K, Bahra A, Evers S, Matharu MS, Goadsby PJ. Medication-overuse headache in patients with cluster headache. Neurology 2006; 67: 109-13.   
Schwedt TJ, Matharu MS, Dodick DW. Thunderclap headache. Lancet Neurol 2006; 5: 621-31.   
Everett CM, Matharu MS, Gawler J. Neuropathy progressing to myeloneuropathy 20 years after partial gastrectomy. Neurology 2006; 66: 1451.   
Cohen AS, Matharu MS, Goadsby PJ. Paroxysmal hemicrania in a family. Cephalalgia 2006; 26: 486-8.   
Elliott B, Patel P, Matharu MS, Amos R, Machin S, Liu C, et al.
Prophylaxis of venous thromboembolism during early inpatient rehabilitation after acquired brain injury: How guidelines change management. Disabil Rehabil 2006; 28: 333-7.   
Matharu MS, Cohen AS, Frackowiak RS, Goadsby PJ. Posterior hypothalamic activation in paroxysmal hemicrania. Ann Neurol 2006; 59: 535-545.   
Matharu MS, Bradbury P, Swash M. Hemicrania continua: side alternation and response to topiramate. Cephalalgia 2006; 26: 341-4.   
Matharu MS, Goadsby PJ. Triggers for trigeminal activation: clinical abstracts and commentary. Headache Currents 2005; 2: 104-107.   
Matharu MS, Goadsby PJ. Functional brain imaging in hemicrania continua: implications for nosology and pathophysiology. Curr Pain Headache Rep 2005; 9: 281-8.   
Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ. The clinical characteristics of headache in patients with pituitary tumours. Brain 2005; 128: 1921-30.   
Matharu MS, Goadsby P. Cluster headache: causes and current approaches to treatment. Prescriber 2005;16:33-41.   
Afridi SK, Matharu MS, Lee L, Kaube H, Friston KJ, Frackowiak RS, et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain 2005;128:932-939.   
Matharu MS, Goadsby PJ. Bilateral paroxysmal hemicrania or bilateral paroxysmal cephalalgia, another novel indomethacin-responsive primary headache syndrome? Cephalalgia 2005;25:79-81.   
Bhatt H, Matharu MS, Henderson K, Greenwood R. An audit of first seizures presenting to an Accident and Emergency Department. Seizure 2005; 14: 58-61.   
Matharu MS, van Vliet JA, Ferrari MD, Goadsby PJ. Verapamil induced gingival enlargement in cluster headache. J Neurol Neurosurg Psychiatry 2005; 76:124-127.   
Levy MJ, Matharu MS, Bhola R, Meeran K, Goadsby P. Octreotide is not effective in the acute treatment of migraine. Cephalalgia 2005; 25:48-55.   
Matharu M, Cohen A, Goadsby P. SUNCT syndrome responsive to intravenous lidocaine. Cephalalgia 2004; 24:985-92.   
Matharu MS, Levy MJ, Meeran K, Goadsby PJ. Subcutaneous octreotide in cluster headache: Randomized placebo-controlled double-blind crossover study. Ann Neurol 2004; 56:488-494.   
Matharu MS, Cohen AS, McGonigle DJ, Ward N, Frackowiak RS, Goadsby PJ. Posterior hypothalamic and brainstem activation in hemicrania continua. Headache 2004; 44:747-61.   
Matharu MS, Goadsby PJ. Cluster headache: focus on emerging therapies. Expert Rev Neurother 2004;4:895-907.   
Cohen AS, Matharu MS, Goadsby PJ. SUNCT syndrome in the elderly. Cephalalgia 2004; 24:508-509.   
Levy MJ, Jager HR, Powell M, Matharu MS, Meeran K, Goadsby PJ. Pituitary volume and headache: size is not everything. Arch Neurol 2004; 61:721-5.   
Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain 2004; 127:220-230.   
Matharu MS, Levy MJ, Merry RT, Goadsby PJ. SUNCT syndrome secondary to prolactinoma. J Neurol Neurosurg Psychiatry 2003;74:1590-1592.   
Matharu MS, Good CD, May A, Bahra A, Goadsby PJ. No change in the structure of the brain in migraine: a voxel-based morphometric study. Eur J Neurol 2003;10(1):53-7.   
Matharu MS, Cohen AS, Boes CJ, Goadsby PJ. Short-lasting Unilateral Neuralgiform headache with Conjunctival Injection and Tearing Syndrome: A Review. Current Pain and Headache Reports 2003;7:308-318.   
Levy MJ, Matharu MS, Bhola R, Lightman S, Goadsby PJ. Somatostatin infusion withdrawal: a study of patients with migraine, cluster headache and healthy volunteers. Pain 2003;102:235-241.   
Levy MJ, Matharu MS, Goadsby PJ. Prolactinomas, dopamine agonists and headache: two case reports. Eur J Neurol 2003;10:169-173.   
Matharu MS, Boes CJ, Goadsby PJ. Management of trigeminal autonomic cephalgias and hemicrania continua. Drugs 2003;63:1637-1677.   
Boes C, Matharu M, Goadsby P. The paroxysmal hemicrania-tic syndrome. Cephalalgia 2003;23(1):24-28.   
Boes CJ, Matharu MS, Goadsby PJ. Benign cough headache. Cephalalgia 2002;22(10):772-9.   
Boes CJ, Matharu MS, Goadsby PJ. Migraine and stroke. Stroke Review 2002; 6:1-4.   
Boes CJ, Capobianco DJ, Matharu MS, Goadsby PJ. Wilfred Harris' early description of cluster headache. Cephalalgia 2002; 22:320-326.   
Matharu MS, Goadsby PJ. Trigeminal autonomic cephalgias. J Neurol Neurosurg Psychiatry 2002; 72(Suppl II):ii19-ii26.   
Matharu MS, Boes CJ, Goadsby PJ. SUNCT Syndrome: Prolonged Attacks, Refractoriness and Response to Topiramate. Neurology 2002; 58:1307.   
Matharu MS, Levy MJ, Goadsby PJ. Understanding migraine in women. Practitioner 2002; 246:272-8.   
Matharu MS, Goadsby PJ. Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 2002; 125:976-84.   
Matharu MS, Goadsby PJ. Cluster headache: Update on a common problem. Practical Neurology 2001;1(1):42-49.   
Matharu MS, Boes C, Goadsby PJ, Managing the patient with migraine. Practitioner, 2001. 245; 511-529.   
Goadsby PJ, Matharu MS, Boes CJ. SUNCT syndrome or trigeminal neuralgia with lacrimation. Cephalalgia 2001;21:82-83.   
Boes CJ, Matharu MS, Goadsby PJ. Management of difficult migraine. Advances in Clinical Neuroscience & Rehabilitation 2001;1:6-8.   
Bahra A, Matharu MS, Buchel C, Frackowiak RS, Goadsby PJ. Brainstem activation specific to migraine headache. Lancet 2001;357:1016-7.   
Matharu MS, Goadsby PJ. Post-traumatic chronic paroxysmal hemicrania (CPH) with aura. Neurology 2001;56:273-5.   
Metcalfe DH, Matharu M. Students' perception of good and bad teaching: report of a critical incident study. Med Educ 1995;29:193-7.   
Matharu MS, Hollingsworth M. Purinoceptors mediating relaxation and spasm in the rat gastric fundus. Br J Pharmacol 1992;106:395-403.   
Malhi GS, Matharu MS, Hale AS. Neurology for Psychiatrists. London: Martin Dunitz Ltd; 2000.   
Matharu MS, Goadsby PJ. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome. In: Goadsby PJ, Silberstein SD and Dodick DW, editors. Chronic Daily Headache for Clinicians. London: Decker Inc, 2005: 89-103.   
Matharu MS, Goadsby PJ. Sudden unilateral neuralgiform pain with conjunctival injection and tearing. In: Olesen J, Goadsby PJ, Ramadan N, Tfelt-Hansen P and Welch KM, editors. The Headaches. Philadelphia: Lippincott Williams & Wilkins, 2005: 823-830.   
Matharu MS, Goadsby PJ. Trigeminal Autonomic Cephalalgias: Diagnosis and Management. In: Silberstein S, Lipton R and Dodick D, editors. Wolff's Headache and Other Head Pain. Eighth Edition. New York: Oxford University Press, 2007: 379-430.   
Matharu MS. Cluster headache and other trigeminal autonomic cephalagias. In: Kernick D and Goadsby P, editors. Headache: A Practical Manual. New York: Oxford University Press, 2008: 143-166.