Professional background

Dr. Tsui is a consultant academic geriatrician and acute medical physician practising at University College London and St Pancras hospitals. His main clinical interest is in the care of frailer older patients who have experienced acute illnesses such as infections, resulting in confusion known as delirium or worsening physical function, often in the context co-existing cognitive impairment or dementia. 

He is the current holder of a NIHR (National Institute for Health and Care Research) research grant and undertakes his research programme at the MRC Unit for Lifelong Health and Ageing at University College London (UCL). He studied at the University of Oxford medical school, completed his post-graduate medical training in London and received his PhD from UCL in population epidemiology and machine learning models. In his research, he is interested in longitudinal, deep phenotyping prediction and inferential models of acute illness decompensation. His aim is to apply novel approaches to better understand, diagnose and optimise treatments, improving short to long term outcomes, while emphasising the need to understand priorities from the context of the patient. 

Research interests

Delirium, dementia, frailty, acute illness, population epidemiology, machine learning, prediction

Languages spoken



1.    Tsui A, Tsui A, Searle SD, Bowden H, Hoffmann K, Hornby J, Goslett A, Weston- Clarke M, Howes LH, Street R, Perera R, Taee K, Kustermann C, Chitalu P, Razavi B, Magni F, Das D, Kim S, Chaturvedi N, Sampson EL, Rockwood K, Cunningham C, Ely EW, Richardson SJ, Brayne C, Terrera GM, Tieges Z, MacLullich A, Davis D. The impact of baseline cognition and delirium on long-term cognitive impairment and mortality: the Delirium and Population Health Informatics Cohort. Lancet Healthy Longev 2022; 3: e232-e241.
2.    Tsui A, Searle S, Bowden H, Hoffmann K, Hornby J, Goslett A, Weston-Clarke M, Hamill Howes L, Street, R, Perera R, Taee K, Kustermann C, Chitalu P, Razavi B, Magni F, Das D, Kim S, Chaturvedi N, Sampson E, Rockwood K, Cunningham C, Ely WE, Richardson SJ, Brayne C, Muniz Terrera G, Tieges Z, MacLullich A, Davis D. The effect of baseline cognition and delirium on long-term cognitive impairment and mortality: a prospective population-based study. Brain 2023; doi: 10.1093/brain/awad062
3.    Tsui A, Tudosiu P-D, Brudfors M, Jha, A, Cardoso J, Ourselin, S, Ashburner J, Rees, G, Davis D, Nachev P. Predicting mortality in acutely hospitalised older patients. BMC Med 2023; 21(1):10
4.    Tsui A, Richards M, Singh-Manoux A, Udeh-Momoh C, Davis D. Longitudinal associations between diurnal cortisol variation and later life cognitive impairment. Neurology 2020; 94: e133-e144.
5.    Tsui A, Kuh D, Richards M, Davis D. Delirium symptoms are associated with decline in cognitive function between ages 53 and 69 years: Findings from a British birth cohort study. Alzheimer’s Dementia 2018; 14: 617-622.
6.    Chitalu P, Tsui A, Searle SD, Davis D. Life-space, frailty, and health-related quality of life. BMC Geriatr. 2022; 22: 646.
7.    Goodyer E, Mah J, Rangan A et al. and Davis D, Tsui A The relative impact of socioeconomic position and frailty varies by population setting. Aging Med 2022; 5: 10- 16.
8.    Whitby J, Nitchingham A, Caplan G, Davis D, Tsui A. Persistent delirium in older hospital patients: an updated systematic review and meta-analysis. Delirium 2022; Aug 9.
9.    Chalmers LA, Searle SD, Whitby J, Tsui A, Davis D. Do specific delirium aetiologies have different associations with death? A longitudinal cohort of hospitalised patients. Eur Geriatr Med. 2021; 12: 787-791. 
10.    Davis D, Searle SD, Tsui A. The Scottish Intercollegiate Guidelines Network: risk reduction and management of delirium. Age Ageing 2019;48:485-488.
11.    Tsui A, Richards M, Davis D. Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort. Aging Med 2018; 1: 243-248.
12.    Tsui A, Davis D. Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach. Aging Med 2018; 1: 249-253
13.    Tsui A, Kuh D, Cardozo L, Davis D. Vascular risk factors for male and female urgency urinary incontinence at age 68 from a British birth cohort study. BJU Int 2018; 122: 118-125.
14.    Tsui A, Issacs A, Cohen DL, Hamdulay S. A sleepless young man with red eyes and slurred speech? QJM 2014; 107:379-380
15.    Tsui A, Rajani C, Doshi R, De Wolff J, Tennant R, Duncan N, Penn H. Improving recognition and management of acute kidney injury, resulting in improved patient outcomes, following the introduction of a specially designed acute kidney injury care bundle. Acute Med 2014; 13:108-112
16.    Tsui A, Lazarus J, van As AB. Non-operative management of renal trauma in very young children: experiences from a dedicated South African paediatric trauma unit. Injury 2012; 43:1476-1481
17.    Tsui A, Lee MA. Multiple sclerosis and pregnancy. Curr Opin Obstet Gynecol 2011; 23:435-439
18.    Tsui A, Isacson O. Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson’s disease. J Neurol 2011; 258: 1393-1405.
19.    Kuhn A, Tsui A, Brown P et al. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity. Exp Neurol 2009; 215: 380-387.