Professional background

Dr Dipa Jayaseelan is a consultant neurologist at the National Hospital for Neurology and Neurosurgery and an honorary lecturer at UCL Institute of Neurology.

She did her undergraduate training at the University of Cambridge and University College London. She did her medical and neurology training at the Royal Free Hospital, Hammersmith Hospital, and the National Hospital for Neurology and Neurosurgery. She was awarded an MRC clinical research training fellowship in 2009 and completed a PhD in muscle channelopathies at the UCL Institute of Neurology.

In 2020, Dr Jayaseelan became a consultant at the National Hospital for Neurology and Neurosurgery at the Centre for Neuromuscular Diseases. She currently runs channelopathy clinics and Kennedy’s disease clinics at Queen Square.

Research interests

Dr Jayaseelan’s main research interest is in muscle disease with a particular interest in muscle channelopathies.


  • Raja Rayan, D. L., & Hanna, M. G. (2020). Managing pregnancy and anaesthetics in patients with skeletal muscle channelopathies. Neuromuscular disorders : NMD30(7), 539–545.
  • Suetterlin, K.J, Raja Rayan, D., Matthews, E. & Hanna, M.G. (2020) Mexiletine (NaMuscla) for the treatment of myotonia in non-dystrophic myotonic disorders, Expert Opinion on Orphan Drugs, 8:2-3, 43-49, DOI: 10.1080/21678707.2020.1739519
  • Paterson, R. W., Brown, R. L., Benjamin, L., Nortley, R., Wiethoff, S., Bharucha, T., Jayaseelan, D. L., et al (2020). The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings.
  • Keddie, S., Pakpoor, J., Mousele, C., et al (2020). Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barre syndrome. (in press) Brain
  • Raja Rayan, D.L. and Hanna, M.G. (January 2018) Ion Channels and Human Disorders. In: Encyclopedia Of Life Sciences DOI: 10.1002/9780470015902.a0005166.pub3
  • Matthews E, Neuwirth C, Jaffer F, Scalco RS, Fialho D, Parton M, Raja Rayan D, et al. (2018) Atypical periodic paralysis and myalgia: A novel phenotype. Neurology, 90 (5), pp. e412-e418
  • Neuromuscular Disease: Case Studies from Queen Square - Manji H., Turner C., Evans M.R.B. 1st ed. (2017) Springer London Ltd Chapters 32, 33,36,37 & 45. Book.
  • Challenging Concepts in Neurology (2016) Chinthapalli Krishna, Magdalinou Nadia, Wood Nicholas – Chapter 17:Myotonic Dystrophy. D Raja Rayan. Oxford University Press. Book.
  • Rayan, D., Horga, A., Matthews, E., Sud, R., McCall, S., Hanna, M. (2015). Paramyotonia Congenita & Sodium Channel Myotonia: Are they distinct diseases?. JNNP. 86. e4.13-e4. 10.1136/jnnp-2015-312379.11.
  • Corrochano, S., Männikkö, R., Joyce, P. I., McGoldrick, P., Wettstein, J., Lassi, G, Raja Raja Rayan D.L et al (2014). Novel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis. Brain, 137(Pt 12), 3171-3185. doi:10.1093/brain/awu292
  • Tan, S. V., Z'Graggen, W. J., Boërio, D., Rayan, D. R., et al (2014). Chloride channels in myotonia congenita assessed by velocity recovery cycles.. Muscle Nerve, 49(6), 845-857. doi:10.1002/mus.24069
  • Thor, M.G., Durran, S., Matthews, E., Rayan, D., Sweeney, M., Hanna, M.G., Mannikko, R. (2014). P44 Mutations of the same S4 arginine residue in NaV1.4 can result in either myotonia or hypokalemic periodic paralysis. Neuromuscular Disorders. 24. S18-S19. 10.1016/S0960-8966(14)70060-4.
  • Morrow, J. M., Matthews, E., Raja Rayan, D. L., et al (2013). Muscle MRI reveals distinct abnormalities in genetically proven non-dystrophic myotonias. Neuromuscular Disorders, 23(8), 637-646. doi:10.1016/j.nmd.2013.05.001
  • Horga, A., Rayan, D. L. R., Matthews, E., et al (2013). Prevalence study of genetically defined skeletal muscle channelopathies in England. Neurology, 80(16), 1472-1475. doi:10.1212/WNL.0b013e31828cf8d0
  • Hehir, M. K., Logigian, E., Raja Rayan, D. L., & Ciafaloni, E. (2013). Double trouble in a patient with myotonia.. BMJ case reports, 2013.
  • Tan, S. V., Z'graggen, W. J., Boërio, D., Rayan, D. R., et al (2013). Chloride channels in myotonia congenita assessed by velocity recovery cycles.. Muscle Nerve. doi:10.1002/mus.24069
  • Trivedi, J. R., Bundy, B., Statland, J., Salajegheh, M., Rayan, D. R., et al (2013). Non-dystrophic myotonia: prospective study of objective and patient reported outcomes.. Brain, 136(Pt 7), 2189-2200. doi:10.1093/brain/awt133
  • Statland, J. M., Bundy, B. N., Wang, Y., Rayan, D. R., et al. (2012). Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial. JAMA : the journal of the American Medical Association, 308(13), 1357–65
  • Statland, J. M., Bundy, B. N., Wang, Y., Trivedi, J. R., Raja Rayan, D., et al (2012). A quantitative measure of handgrip myotonia in non-dystrophic myotonia.. Muscle Nerve, 46(4), 482-489.
  • Raja Rayan DL, Haworth A, Sud R, et al. A new explanation for recessive myotonia congenita: Exon deletions and duplications in CLCN1.
    Neurology 78(24):1953-1958 12 Jun 2012
  • Tan SV, Z'graggen WJ, Boërio D, Rayan DL, et al. (2012) Membrane dysfunction in Andersen-Tawil syndrome assessed by velocity recovery cycles. Muscle Nerve 46(2):193-203
  • A.Haworth, L.Bertram, P.Carrera, et al.  Call for participation in the neurogenetics consortium within the Human Variome Project. Neurogentics 2011 Jun 1;1-5.
  • Raja Rayan, D.L & Hanna, M.G Skeletal Muscle Channelopathies: Non-Dystrophic Myotonias and Periodic Paralysis. Current Opinion in Neurology 2010 Oct;23(5):466-76.
  • Raja Rayan, Dipa L and Hanna, Michael G (October 2010) Ion Channels and Human Disorders. In: Encyclopedia Of Life Sciences. 2010, John Wiley & Sons, Ltd: Chichester [DOI: 10.1002/9780470015902.a0005166.pub2]