Photo of Dr Franel Le Grange

Dr Franel Le Grange

Telephone:

Email:

Location:

  • University College Hospital

GMC/GDC number:

6025258

Professional background

Dr Le Grange trained as a clinical oncologist in South Africa and was awarded a CESR in clinical oncology by the Royal College of Radiologists.

She developed an interest in sarcoma during her training and has worked with the London Sarcoma Service at University College Hospital since 2009, specialising exclusively in the in the management of bone and soft tissue sarcomas as well as fibromatosis.

Dr Le Grange has an interest in education and she is involved in teaching both medical students and specialty trainees.

Specialties

Research interests

Dr Le Grange has a special interest in developing the use of advanced radiotherapy techniques for the treatment of sarcomas and to that end she is involved in research funded by the Bone Cancer Research Trust and Cancer Research UK.

Publications

  • Seddon B, Wilson W, Le Grange F, et al. Phase II trial of Intensity Modulated Radiotherapy (IMRT) in primary bone sarcomas, and dosimetric comparison with Proton beam therapy (PBT). International Journal of Particle Therapy. 2024;12(Supplement): 100414
  • Newlands C, Gruber E, Le Grange F, et al. Pleomorphic dermal sarcoma: UK multidisciplinary team members have wide variation in opinions on management and pathways. Clinical Surgical Oncology 2024; 3(4), 100061
  • Tatsis D, Sinha D, Le Grange F, et al. Improving head and neck sarcoma care: The impact of a specialized multidisciplinary team approach on diagnosis and patient outcomes. European Journal of Surgical Oncology 2024; 50(9), 108531
  • Seddon B, Le Grange F, Simões R, et al. The IMRiS Trial: A Phase II Study of Intensity-Modulated Radiotherapy in Extremity Soft Tissue Sarcoma. International Journal of Radiation Oncology • Biology Physics 2024; 120(4): 978-989
  • Rothermundt C, et al. Controversies in the management of patients with soft tissue sarcoma: Recommendations of the Conference on State of Science in Sarcoma 2022. European Journal of Cancer 2023; 180: 158-197 (panellist)
  • Newlands C, Anand R, Gruber E, Keohane S, Le Grange F, Whitley S. Pleomorphic Dermal Sarcoma (PDS) – who should be getting it right first time? British Journal of Oral and Maxillofacial Surgery 2022; 60(10): e97
  • Ingley KM, Maleddu A, le Grange F, et al. Current Approaches to Management of Bone Sarcoma in Adolescent and Young Adult (AYA) Patients. Pediatric Blood & Cancer 2022; 69(2): e29442.
  • Le Grange F (2021). Advanced radiotherapy techniques: Improving outcomes in sarcoma. Doctoral thesis, UCL (University College London). UCL Discovery. (https://discovery.ucl.ac.uk/id/eprint/10123526/)
  • Logan IT, Vroobel KM, le Grange F, et al. Pleomorphic dermal sarcoma: Clinicopathological features and outcomes from a 5-year tertiary referral centre experience. Cancer Reports 2021; 11: e1583.
  • Strauss SJ, Frezza AM, Abecassis N, et al. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up. Annals of Oncology 2021; 32(12): 1520-1536.
  • Gronchi A, Miah AB, Dei Tos AP, et al. Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 2021; 32(11): 1348-65.
  • Casali PG, Blay JY, Abecassis N, et al. Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 2021; 33(1): 20-33
  • Stacchiotti S, Miah AB, Frezza AM, et al. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts. ESMO Open 2021; 6(3): 100170.
  • Radaelli S, Fossati P, Stacchiotti S, et al. The sacral chordoma margin. European Journal of Surgical Oncology. 2020; 46(8):1415-22.
  • Simões R, Miles E, Yang H, Le Grange F, Bhat R, Forsyth S, et al. IMRiS phase II study of IMRT in limb sarcomas: Results of the pre-trial QA facility questionnaire and workshop. Radiography 2020; 26(1):71-5
  • Petkar S, Moinuddin S, Grimes H, Nash S, Le Grange F, Seddon B. Radiotherapy treatment verification in a cohort of limb sarcoma patients: An audit of departmental practice. Radiotherapy and Oncology 2015; 115: S911–S2.
  • Le Grange F, Cassoni A, Seddon B. Late Effects of Radiation Therapy in Extremity Sarcoma. International Journal of Radiation Oncology • Biology • Physics 2014; 90(1): S759-S60.
  • Le Grange F, Cassoni AM, Seddon BM. Tumour volume changes following pre-operative radiotherapy in borderline resectable limb and trunk soft tissue sarcoma. European Journal of Surgical Oncology (EJSO) 2014; 40(4): 394-401
  • Le Grange F, Wickers S, Warry A, et al. Defining the Target in Cancer of the Oesophagus: Direct Radiotherapy Planning with Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography. Clinical Oncology 2015; 27(3): 160-7.