Professional background

Dr Giles Kendall is a consultant in neonatal medicine working within the Elizabeth Garrett Anderson Wing at UCLH. He studied medicine at University College London graduating in 1997. He has an interest in fetal and neonatal neurology, neuroprotection and neuroimaging.

Giles completed a PhD at University College London in the Institute for Women’s Health examining the role of inflammation, hypoxia-ischemia, pH and the TNF family of cytokines in the development of perinatal brain injury. He went on to become academic clinical lecturer in neonatal neuroimaging and neuroprotection at UCLH undertaking research into MR biomarkers of preterm brain injury under the supervision of Professor Nikki Robertson.

He is currently clinical lead for neonatal medicine at UCLH and joint Lead for North Central and East London sector of the London Neonatal Operational Delivery Network.

Specialties

Research interests

Neonatal neurology, fetal neurology, neonatal brain imaging, fetal brain abnormalities

Publications

Thomas MR, Bullock T, Kendall GS, Win N. Use of thawed and washed red cells preserved in extended storage media for neonatal exchange transfusion. Transfus Med. 2019 Apr;29(2):128-130. doi: 10.1111/tme.12574. Epub 2019 Jan 7. PMID: 30618201

Mitra S, Kendall GS, Bainbridge A, Sokolska M, Dinan M, Uria-Avellanal C, Price D, Mckinnon K, Gunny R, Huertas-Ceballos A, Golay X, Robertson NJ. Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia. Arch Dis Child Fetal Neonatal Ed. 2019 Jul;104(4):F424-F432. doi: 10.1136/archdischild-2018-315478. Epub 2018 Oct 15. PMID: 30322975

Bale G, Mitra S, de Roever I, Sokolska M, Price D, Bainbridge A, Gunny R, Uria-Avellanal C, Kendall GS, Meek J, Robertson NJ, Tachtsidis I. Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury. J Cereb Blood Flow Metab. 2019 Oct;39(10):2035-2047. doi: 10.1177/0271678X18777928. Epub 2018 May 18. PMID: 29775114

Mitra S, Bale G, Highton D, Gunny R, Uria-Avellanal C, Bainbridge A, Sokolska M, Price D, Huertas-Ceballos A, Kendall GS, Meek J, Tachtsidis I, Robertson NJ. Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury. J Cereb Blood Flow Metab. 2019 Jan;39(1):118-130. doi: 10.1177/0271678X17733639. Epub 2017 Sep 26. PMID: 28949271

Orasanu E, Melbourne A, Cardoso MJ, Lomabert H, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Cortical folding of the preterm brain: a longitudinal analysis of extremely preterm born neonates using spectral matching. Brain Behav. 2016 May 17;6(8):e00488. doi: 10.1002/brb3.488. eCollection 2016 Aug. PMID: 27257515

Melbourne A, Eaton-Rosen Z, Orasanu E, Price D, Bainbridge A, Cardoso MJ, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Longitudinal development in the preterm thalamus and posterior white matter: MRI correlations between diffusion weighted imaging and T2 relaxometry. Hum Brain Mapp. 2016 Jul;37(7):2479-92. doi: 10.1002/hbm.23188. Epub 2016 Mar 21. PMID: 26996400

Eaton-Rosen Z, Melbourne A, Orasanu E, Cardoso MJ, Modat M, Bainbridge A, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI. Neuroimage. 2015 May 1;111:580-9. doi: 10.1016/j.neuroimage.2015.02.010. Epub 2015 Feb 12. PMID: 25681570

Rennie JM, Kendall GS. Advanced magnetic resonance techniques provide more accurate prognostic information than conventional imaging. Dev Med Child Neurol. 2015 May;57(5):403-4. doi: 10.1111/dmcn.12680. Epub 2015 Jan 13. PMID: 25640201

Eaton-Rosen Z, Melbourne A, Orasanu E, Modat M, Cardoso MJ, Bainbridge A, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Longitudinal measurement of the developing thalamus in the preterm brain using multi-modal MRI. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):276-83. doi: 10.1007/978-3-319-10470-6_35. PMID: 25485389

Melbourne A, Eaton-Rosen Z, De Vita E, Bainbridge A, Cardoso MJ, Price D, Cady E, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Multi-modal measurement of the myelin-to-axon diameter g-ratio in preterm-born neonates and adult controls. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):268-75. doi: 10.1007/978-3-319-10470-6_34. PMID: 25485388

Melbourne A, Eaton-Rosen Z, Bainbridge A, Kendall GS, Cardoso MJ, Robertson NJ, Marlow N, Ourselin S. Measurement of myelin in the preterm brain: multi-compartment diffusion imaging and multi-component T2 relaxometry.Med Image Comput Comput Assist Interv. 2013;16(Pt 2):336-44.

Kendall GS, Melbourne A, Johnson S, Price D, Bainbridge A, Gunny R, Huertas-Ceballos A, Cady EB, Ourselin S, Marlow N, Robertson NJ. White matter NAA/Cho and Cho/Cr ratios at MR spectroscopy are predictive of motor outcome in preterm infants. Radiology. 2014 Apr;271(1):230-8.
Melbourne A, Kendall GS, Cardoso MJ, Gunny R, Robertson NJ, Marlow N, Ourselin S. Preterm birth affects the developmental synergy between cortical folding and cortical connectivity observed on multimodal MRI. Neuroimage. 2014 Apr 1;89:23-34.

Sebire NJ, Miller S, Jacques TS, Taylor AM, Rennie JM, Kendall G, Chitty LS. Post-mortem apparent resolution of fetal ventriculomegaly: evidence from magnetic resonance imaging. Prenat Diagn. 2013 Apr;33(4):360-4.

Melbourne A, Kendall GS, Cardoso MJ, Gunny R, Robertson NJ, Marlow N, Ourselin S. Radial Structure in the preterm cortex: persistence of the preterm phenotype at term equivalent age? Med Image Comput Comput Assist Interv. 201215(2):256-263

Bainbridge A, Kendall GS, De Vita E, Hagmann C, Kapetanakis A, Cady EB, Robertson N. Improved Regional Neonatal Brain Absolute Thermometry by Proton Magnetic Resonance Spectroscopy. NMR Biomed. 2012 Oct 16. doi: 10.1002/nbm.2879. [Epub ahead of print]

Melbourne A, Cardoso MJ, Kendall GS, Modat M, Robertson NJ, Marlow N, Ourselin S. AdaPT: An Adaptive Preterm Segmentation, Algorithm for Neonatal Brain MRI. Neuroimage. 2012 Aug 14;65C:97-108.

Kendall GS, Mathieson S, Meek J, Rennie JM. Re-cooling for Rebound Seizures following Re-warming in Neonatal Encephalopathy. Pediatrics 2012;130(2)e451-455

Kendall GS, Hristova H, Zbarsky V, Clements A, Peebles SM, Robertson NJ, Raivich G. Distribution of pH changes in mouse neonatal hypoxic ischemic insult. Dev Neurosci. 2011;33(6):505-518

Cardoso MJ, Melbourne A, Kendall GS, Modat M, Hagmann CF, Robertson NJ, Marlow N, Ourselin S. Adaptive Neonate Brain Segmentation. Med Image Comput Comput Assist Interv. 2011;14(3):378-86

Kendall GS, Hristova M, Heuer H, Dafou D, Acosta-Saltos A, Almolda B, Zbarsky V, Rumajogee P, Sigrun Horn, Castellano B, Nedospasov SA, Pfeffer K, Peebles DM, Raivich G. TNF Gene Cluster Deletion Abolishes Lipopolysaccharide-Mediated Sensitisation of the Neonatal Brain to Hypoxic Ischemic Insult. Laboratory Investigation 2011 Mar;91(3):328-41. Epub 2010 Dec 6

Kendall GS, Kapetanakis A, Ratnavel N, Azzopardi D, Robertson NJ.Passive Cooling for Initiation of Therapeutic Hypothermia in Neonatal Encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2010;95(6):F408-F412.

Robertson NJ, Kendall GS, Thayyil S. Techniques for therapeutic hypothermia during transport and in hospital for perinatal asphyxial encephalopathy. Sem Fetal Neon Medicine 2010;15(5):276-286.

Rennie JM, Seghal A, De A, Kendall GS, Cole TJ. Range of UK practice regarding thresholds for phototherapy and exchange transfusion in neonatal hyperbilirubinaemia. Arch Dis Child Fetal Neonatal Ed. 2009;94(5):F323-327.

Kendall GS, Robertson NJ, Iwata O, Peebles D, Raivich G. N-methyl-isobutyl-amiloride Ameliorates Brain Injury when Commenced Prior to Hypoxia Ischemia in Neonatal Mice. Pediatr Res 2006;59(2):227-231.

Kendall G, Peebles D. Acute fetal hypoxia: the modulating effect of infection. Early Hum Dev. 2005;81(1):27-34.

Chopra R, Kendall G, Gale RE, Thomas NS, Linch DC. Expression of two alternatively spliced forms of the 5' untranslated region of the GM-CSF receptor alpha chain mRNA. Exp Hematol. 1996 May;24(6):755-762.


Books:
A Manual of Neonatal Intensive Care 5th Edition. Rennie JM, Kendall GS CRC Press 2013

Medicine and Surgery: A Concise Textbook. Kendall G, Shiu KY. Blackwell Science August 2005

MRCPCH Part 2 Practice Exams Third Edition. Kendall G, Pollock I. Pastest October 2004