Photo of Dr Mahbubl Ahmed

Dr Mahbubl Ahmed

Telephone:

Email:

Location:

  • University College Hospital

GMC/GDC number:

6076812

Professional background

Dr Mahbubl Ahmed completed his clinical training at St Bartholomew’s and University College London Hospitals. He completed a PhD at the Institute of Cancer Research and the Royal Marsden Hospital, which looked at the genes that predispose patients to prostate cancer. 

Dr Ahmed now specialises in the treatment of soft tissue and bone sarcomas using chemotherapy and radiotherapy. He works in the one of the largest sarcoma centres in Europe and is one of the leading experts in the UK in the treatment of soft tissue sarcoma and bone sarcoma (all body sites except brain) using technical photon and proton radiotherapy. Dr Ahmed has pioneered a new innovative practice changing radiotherapy technique in the treatment of soft tissue and bone sarcomas for patients who cannot have surgery. This technique uses the latest technology which allows the delivery of high doses of radiotherapy that can offer long term control for large soft tissue and bone tumours which were previously untreatable with minimal side effects. This technique can be used in sarcomas all over the body, but in particular for inoperable intra-abdominal and pelvic sarcomas. This technique is currently under development for a national clinal trial in the UK and internationally (HD Sarc) and is currently only available at UCLH. He also offers re-irradiation for sarcomas that have had radiotherapy previously or have been caused by previous radiotherapy.  

Dr Ahmed also has a special interest in breast sarcoma including phyllodes tumours and angiosarcoma of the breast. He was one of the main authors in the UK national phyllodes guidelines and lead nationally for improvement outcomes of breast sarcomas.  

He is a strong advocate in the holistic care of cancer management with focus on diet, exercise and emotional wellbeing. A diagnosis of cancer can often bring a shock to patients’ lives and therefore a reflection and adjustment on individual lifestyle factors in our busy and stressful lives is critical in comprehensive cancer management. Many diseases in our population are due to the contribution of environment, lifestyle and food choices.  

Dr Ahmed has published widely in the field of sarcoma research and continues to contribute with original research.   

Specialties

Research interests

  • High dose radiotherapy (photons and protons) for inoperable or recurrent soft tissue and bone sarcomas 
  • Re-irradiation of sarcomas soft tissue and bone that have had previous radiotherapy  
  • Breast Sarcoma – Phyllodes and Angiosarcoma

Languages spoken

Bengali

Publications

  • M A, S C, J F, C L, A B, L P, Sj S. Incidence and Outcome of Breast Sarcomas in England (2013-2018): An analysis from the National Cancer Registration and Analysis Service. Eur J Cancer. 2022 Oct;174:48-56. doi: 10.1016/j.ejca.2022.06.036. Epub 2022 Aug 12. PMID: 35970036. 
  • Bishr MK, Humphreys A, Ahmed M, Cox K, Hughes A, Isherwood J, Pinder SE, Remoundos DD, Sawyer E, Tamimy MS, Whisker L. Contemporary management of phyllodes tumours of the breast: recommendations from the UK Association of Breast Surgery. Br J Surg. 2025 Aug 1;112(8):znaf152. doi: 10.1093/bjs/znaf152. PMID: 40847758; PMCID: PMC12374188. 
  • Ahmed M, Goh C, Saunders E, Cieza-Borrella C; PRACTICAL consortium, Kote-Jarai Z, Schumacher FR, Eeles R. Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT. Prostate Cancer Prostatic Dis. 2020 Jun;23(2):333-342. doi: 10.1038/s41391-019-0181-y. Epub 2019 Nov 27. PMID: 31776447; PMCID: PMC7237354 
  • Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN, Cieza-Borrella C, Mijuskovic M, Wakerell S, Olama AAA, Schumacher FR, Berndt SI, Benlloch S, Ahmed M et al. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nature communications. 2018;9(1):2256. 
  • Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, et al. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nature genetics. 2018;50(7):928-36. 
  • ​​​​​​​Wedge DC, Gundem G, Mitchell T, Woodcock DJ, Martincorena I, Ghori M,  Zamora J, Butler A, Whitaker H, Kote-Jarai Z, Alexandrov LB, Van Loo P,, Massie CE, Dentro S, Warren AY, Verrill C, Berney DM, Dennis N, Merson S, Hawkins S, Howat W, Lu YJ, Lambert A, Kay J, Kremeyer B, Karaszi K, Luxton H, Camacho N, Marsden L, Edwards S, Matthews L Bo V, Leongamornlert D, McLaren S Ng A, Yu Y, Zhang H, Dadaev T, Thomas S, Easton DF, Ahmed M et al. Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. Nature genetics. 2018;50(5):682-92.​​​​​​​
  • Ahmed M, Eeles, R. Germline genetic profiling in prostate cancer: latest developments and potential Clinical applications. Future Science OA, March 2016 ,Vol. 2, No. 1 , DOI 10.4155/fso.15.87 ​​​​​​​
  • Ahmed M, Dorling L, et al. Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity. British Journal of Cancer, 2016 May 10;114(10):1165-74.​​​​​​​
  • Ahmed M et al. Medical Treatment of Urological Malignancies. Biology of Androgen Dependence and Castration Resistance.   European Association of Urology, (http://uroweb.org/wp-content/uploads/Medical-Treatment-of-Urological-Malignancies-2015.pdf) 
  • ​​​​​​​​​​​​​Eleanor Jones, Christos Mikropoulos Ahmed M. The Future of Immunology in the Treatment of Lung Cancer. Future Medicine, April 2015 ,Vol. 4, No. 2, Pages 57-7 
  • ​​​​​​​​​​​​​​Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, Benlloch S, Hazelett DJ, Wang Z, Saunders E, Leongamornlert D, Lindstrom S, Jugurnauth-Little S, Dadaev T, Tymrakiewicz M, Stram DO, Rand K, Wan P, Stram A, Sheng X, Pooler LC, Park K, Xia L, Tyrer J, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Yeager M, Burdette L, Chung CC, Hutchinson A, Yu K, Goh C, Ahmed M, et al.  A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.  Nature Genetics. 2014 Oct;46(10):1103-9​​​​​​​
  • Woolf D, Ahmed M, Plowman N. Primary Lymphoma of the Ocular Adnexa (Orbital Lymphoma) and Primary Intraocular Lymphoma. Clinical Oncology, Volume 24, Issue 5, June 2012, P 339-344. 
  • ​​​​​​​​​​​​​​​​​​​​​M Ahmed, A. Kosgallana, D. Soon, D. O’Donovan, A. Chaudhuri. Respiratory muscle weakness in a patient with quiescent Crohn’s disease and pneumonia. QJM, 2008, Vol 101, Issue 3, P 245-247.