Photo of Dr Mike Brown

Dr Mike Brown

Telephone:

Email:

Location:

  • Hospital for Tropical Diseases
  • University College Hospital

GMC/GDC number:

4120166

Professional background

  • Consultant in Infectious Diseases, Tropical Medicine and Acute Medicine at UCLH since January 2007
  • Honorary Associate Professor at London School of Hygiene and Tropical Medicine
  • Clinical Director for Division of Infection.
  • Consultant Physician, NCL South Hub TB clinic, Whittington Health

Specialties

Research interests

  • Migrant and Inclusion health
  • helminth infections
  • antimicrobial stewardship
  • tuberculosis
  • pyrexia of unknown origin
  • COVID-19.

Publications

  • Yim YTN, Wallis G, Saeed J, Voo S, Kayani I, Amin Z, Proctor I, McNamara C, Brown M, High diagnostic yield of splenic core biopsy in patients with pyrexia or inflammation of unknown origin: a descriptive analysis of imaging (including FDG-PET) and pathological findings at a major tertiary centre. Br J Haematology 2021 in press
  • Gil E, Sweeney N, Barrett V, Morris-Jones S, Miller RF, Noursadeghi M, Johnston VJ, Brown M. Bedaquiline in the treatment of disseminated non-tuberculous mycobacterial infection in two patients co-infected with HIV. Emerging Infectious Diseases Diseases 2021;27(3):944-948. https://dx.doi.org/10.3201/eid2703.202359
  • Spinner CD, Gottlief RL, Criner GJ et al; GS-US-540-5774 Investigators. Effect of remdesivir vs standard care on clinical status at 11 days in patients with moderate COVID-19: a randomized clinical trial. Journal of the American Medical Association. 2020;324(11):1048-1057. doi:10.1001/jama.2020.16349
  • Manson J, Crooks C, Naja M, Ledlie A, Goulden B, Liddle T, Khan E, Martin- Gutierrez L, Waddington KE, Robinson GA, Ribeiro Santos L, McLoughlin E, Snell A,  Adeney C, Schim Van Der Loeff I, Baker KF, Duncan CJA, Hanrath AT, Lendrem C, De Soyza A, Peng J, J'Bari H, Greenwood M, Hawkins E, Peckham H, Mehta P, Marks M, Rampling T, Luintel A,  Williams B, Brown M, Singer M, West J, Jury EC, Collin M, Tattersall R. COVID-19 associated hyperinflammation (COV-HI) and escalation of patient care: a retrospective longitudinal cohort study. Lancet Rheumatology 2000 https://doi.org/10.1016/S2665-9913(20)30275-7
  • Jones I, Bell L, Manson J and Last A, on behalf of the UCLH CoViD Response team. An adult presentation consistent with PIMS-TS. Lancet Rheumatology 2020 July 21, 2020, https://doi.org/10.1016/ S2665-9913(20)30225-3
  • Wickham H, Tam JCH, Chan XHS, George MJ, Levi M, Brown M. Aortic thrombosis in Covid-19. Clinical Infection in Practice 2020 in press
  • Cunniffe N, Gunter S, Brown M, Burge S, Coyle C, De-Soyza A, Dymond AA, Esmail H, Francis D, Galloway J, Galloway J, Gkrania-Klotsas E, Greenaway J, Katritsis G, Kanagaratnam P, Knolle M, Leonard K, McIntyre Z, Prudon B, Rampling T, Torok E, Warne B, Yates M, Matheson N, Su L, Villar S, Stewar G, Toshner M. Utilising recruitment and registry data from England to inform the design of future experimental medicine studies for COVID-19. BMJ Open 2020 Oct 5;10(10):e044566.
  • Yue SYP, Lucas SB, Brown M, Chiodini PL, Walker SL, Mahadeva U. Utility of an infectious and tropical disease histopathology diagnostic review service. J Clinical Pathology. http://dx.doi.org/10.1136/jclinpath-2020-206546
  • Patterson B, Marks M, Martinez-Garcia G, Bidwell G,Luintel A, Ludwig D, Parks T, Gothard PK, Thomas T, Logan S, Shaw K,Stone N,Brown M. A Novel Cohorting and Isolation Strategy for Suspected COVID-19 Cases during a Pandemic. J Hospital Infection 2020 https://doi.org/10.1016/j.jhin.2020.05.035
  • Odor PM, Neun, M, Bampoe S, Clark, S, Heaton D, Hoogenboom EM, Brown M, Kamming D; Anaesthesia and COVID-19: infection control. British Journal of Anaesthesia 2020. Jul;125(1):16-24.
  • Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 Mar 16. pii: S0140-6736(20)30628-0. doi: 10.1016/S0140-6736(20)30628-0. [Epub ahead of print]
  • Bauchmuller K, Manson J, Tattersall R, Brown M, McNamara C, Singer M and Brett SJ. Haemophagocytic lymphohistiocytosis in adult critical care. J Intensive Care Society 2020 https://doi.org/10.1177/1751143719893865
  • Baker EC, Ming DK, Choudhury Y, Rahman S, Smith PJ, Muñoz J, Chiodini PL, Griffiths CJ, Whitty CJ, Brown M.High Prevalence of Strongyloides among South Asian Migrants in Primary Care-Associations with Eosinophilia and Gastrointestinal Symptoms. Pathogens. 2020 Feb 6;9(2). pii: E103. doi: 10.3390/pathogens9020103.
  • Rampling T, Garcia Mingo A, Brown M. Parasitic infections of the lung. Encyclopedia of Respiratory Medicine 2E. 2020 in press
  • Marks M, Johnston V, Brown M. Fever in the Returned Traveller. Hunter’s Tropical Medicine and Emerging Infectious Diseases, 10th Edition.2020
  • Petrushkin H, Sethi C, Potter J, Martin L, Russell G, White V, Ajamil-Rodanes S, Brown M, Breen R, Lipman M, Cropley I, McDermott R, Roche A, Booth H, Milburn J, Darmalingam M, Lee R, Pavesio C, Stanford M, Kon OM, Bothamley G. Developing a pathway for the diagnosis and management of ocular tuberculosis. The pan-LOndon Ocular tuberculosis Pathway-LOOP. Eye (Lond). 2019 Aug 6. doi: 10.1038/s41433-019-0543-7. [Epub ahead of print]
  • Seedat F, Hargreaves S, Nellums LB, Ouyang J, Brown M, Friedland JS. How effective are approaches to migrant screening for infectious diseases in Europe? A systematic review. Lancet Infect Dis. 2018 Sep;18(9):e259-e271. doi: 10.1016/S1473-3099(18)30117-8.
  • Hunter E, Cliff M, Armstrong M, Manji H, Jäger HR, Chiodini P, Brown M. Active neurocysticercosis at the Hospital for Tropical Diseases, London: a clinical case series.Trans R Soc Trop Med Hyg. 2018 Jul 1;112(7):326-334
  • R Herbert, AN Ashraf, TA Yates, K Spriggs, M Malinnag, E Durward-Brown, D Phillips, E Mewse, A Daniel, M Armstrong, M Kidd, F Burns, R Bailey, M Brown. Nurse-delivered universal point-of-care testing for HIV in an open-access returning traveller clinic. HIV Medicine (2012);13(8):499-504
  • Godbole G, McCann N, Morris-Jones S,  Dallman TJ, Brown M. Ceftriaxone-resistant Salmonella Typhi in a traveller returning from a mass gathering in Iraq, Lancet Infect Dis 2019 May;19(5):467. doi: 10.1016/S1473-3099(19)30176-8.
  • Seedat F, Hargreaves S, Nellums LB, Ouyang J, Brown M, Friedland JS. How effective are approaches to migrant screening for infectious diseases in Europe? A systematic review. Lancet Infect Dis. 2018 Sep;18(9):e259-e271. doi: 10.1016/S1473-3099(18)30117-8.
  • Hunter E, Cliff M, Armstrong M, Manji H, Jäger HR, Chiodini P, Brown M. Active neurocysticercosis at the Hospital for Tropical Diseases, London: a clinical case series.Trans R Soc Trop Med Hyg. 2018 Jul 1;112(7):326-334
  • Murphy ME, Phillips PPJ, Mendel CM, Bongard E, Bateson ALC, Hunt R, Murthy S, Singh KP, Brown M, Crook AM, Nunn AJ, Meredith SK, Lipman M, McHugh TD, Gillespie SH; REMoxTB Consortium. Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis. BMC Med. 2017 Oct 27;15(1):192. doi: 10.1186/s12916-017-0947-9.
  • Nimmo C, Doyle R, Burgess C, Williams R, Gorton R, McHugh TD, Brown M, Morris-Jones S, Booth H, Breuer J. Rapid identification of a Mycobacterium tuberculosis full genetic drug resistance profile through whole genome sequencing directly from sputum. Int J Infect Dis. 2017 Sep;62:44-46.
  • Lukawska JL, Thursfield D, Rotiroti G, Dziadzio M, Brown M.. Adjuvant use of Omalizumab in Beta-Lactam Desensitisation. J Allergy Immunol 2017; 1:003 | Open Access
  • Simpson JK, Fröbel P, Seneviratne SL, Brown M, Lowe DM, Grimbacher B, Fliegauf M, Fearfield L. Invasive dermatophyte infection with trichophyton interdigitale is associated with prurigo induced pseudoperforation and a STAT3 mutation.Br J Dermatol. 2017 Jul 1. doi: 10.1111/bjd.15781. [Epub ahead of print]
  • Lampejo T, Bruce M, Teall A, Dall'Antonia M, Crawley-Boevey E, Grant P, Polhill S, Pillay D, Brown D, Brown M, Nastouli E. Caring for a patient with rabies: implications of the Milwaukee protocol for infection control and public health measures. J Hosp Infect. 2017 Aug;96(4):385-391. doi: 10.1016/j.jhin.2017.04.018. Epub 2017 May 2.
  • Nakiwala D, Kellgren L, Herzmann C, Olaru ID, Brown M, Ferrand R, Khan P, Kranzer K. Language discordance between tuberculosis patients and healthcare providers challenging universal access. Eur Respir J. 2017 Apr 19;49(4). pii: 1700116. doi: 10.1183/13993003.00116-2017.
  • Bharucha T, Rutherford A, Skeoch S, Alavi A, Brown M, Galloway J. Diagnostic yield of PET/CT in Fever of Unknown Origin: A systematic review, meta-analyisis and Delphi exercise. Clinical Radiology, 2017 Sep;72(9):764-771.
  • Newman V, Brown M. Inflammatory mass in a traveller FY journal 2017
  • Maxwell-Scott H, McBride A, Brown M. Investigation and Management of Acute Myopericardial Inflammatory syndromes –  an audit of microbiological investigation. Br J Hosp Med (Lond). 2016 Oct;77(10):604.
  • Buba A, Fisher M, Roberts J, Youssef E, Hassan Ibrahim M, Brown M, Richardson D. The acceptability of routine HIV testing in general medical admissions using a sexual health advisor/healthcare assistant model. Sex Transm Infect. 2016 Feb;92(1):69. doi: 10.1136/sextrans-2015-052335.
  • Requena-Méndez A, Aldasoro E, de Lazzari E, Sicuri E, Brown M, Moore D, Gascon J, Munoz J Prevalence of Chagas Disease in Latin-American Migrants Living in Europe: a systematic review and meta-analysis. PLoS Negl Trop Dis 2015; 9(2): e0003540. doi:10.1371/journal.pntd.0003540
  • Brown M. Pyrexia of unknown origin 90 years on: a paradigm of modern clinical medicine. Postgrad Med J. 2015 Dec;91(1082):665-9. doi: 10.1136/postgradmedj-2015-133554. Epub 2015 Oct 21.
  • Sudarshi D, Brown M. Human African trypanosomiasis in non-endemic countries. Clin Med. 2015 Feb;15(1):70-3
  • Osborne LG, Brown M, Bailey MS. Enteric Fever in a British soldier from Sierra Leone. J R Army Med Corps. 2016 Jun;162(3):226-8. doi: 10.1136/jramc-2015-000470. Epub 2015 Aug 4
  • Sudarshi D, Lawrence S, Pickrell WO, Eligar V, Quaderi S, Walker A, Capewell P, Clucas C, Vincent A, Checchi F, MacLeod A, Brown M. Human African Trypanosomiasis presenting at least 29 years after infection - what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3349
  • Toulza F, Tsang L, Ottenhof T, Brown M, Dockrell: M tuberculosis-specific CD4-T-cell response is increased, and Treg cells decreased, in anti-helminthic treated patients with latent TB. Eur J Immunol 2016; 46:752-61
  • Bharucha T, Cockbain B, Brown M. Pyrexia of Unknown Origin. Revisiting concepts to reflect current clinical practice. Br J Hosp Med (Lond). 2016 Oct;77(10):579-583.
  • Jolobe OM, Bharucha T, Cockbain B, Brown M A role for mycobacterial blood culture and molecular analysis of lymph node tissue. Br J Hosp Med (Lond). 2016 Dec 2;77(12):724.
  • Turienzo CF, Brown M. What midwives should know about Zika. British Journal of Midwifery 2016 24(10):694-700
  • Barrett J, Brown M. Traveller’s Diarrhoea. BMJ. 2016 Apr 19;353:i1937. doi: 10.1136/bmj.i1937
  • Nabarro L, Ahmed A, Morris-Jones S, Stephenson C, Brown M. Lancet Interactive Grand Round. Apr 2016.
  • Brown M. Strongyloidiasis, hookworm and other gut strongyloid nematodes. Oxford Textbook of Medicine 6th edition. 
  • Gillespie SH1, Crook AM, McHugh TD, Mendel CM, Meredith SK, Murray SR, Pappas F, Phillips PP, Nunn AJ; REMoxTB Consortium*.Four-month moxifloxacin-base regimens for drug-sensitive tuberculosis N Engl J Med. 2014 Oct 23;371(17):1577-87. *M Brown named collaborator
  • Pathak S, Horton DL, Lucas S, Brown D, Quaderi S, Polhill S, Walker D, Nastouli E, Núñez A, Wise EL, Fooks AR and Brown M. Diagnosis, management and post-mortem findings of a human case of rabies imported into the United Kingdom from India: a case report. Virology Journal 2014, 11:63
  • Eziefula AC, Sa M, Brown M. The health of recent migrants from resource-poor countries. Medicine 2014; 42; 2
  • Nic Foghartaigh CJ & Brown M. Multidrug-resistant tuberculosis. In: Challenging Concepts in Infectious Diseases & Clinical Microbiology. Oxford University Press 2014.
  • Brown M, Bundy DAP, Brooker S. Intestinal helminths. Principles of Medicine in Africa 4th Edition. 2013.
  • Cosgrove, C., Armstrong, M. , Kidd, M. , Brown, M. and Doherty, T. (2013) Hepatitis E is more common than hepatitis A among returning travellers presenting to tertiary care. World Journal of Cardiovascular Diseases, 3, 519-522. doi: 10.4236/wjcd.2013.38082.
  • S Logan, M Armstrong, E Moore, G Nebbia, J Jarvis, M Suvari, J Bligh, P Chiodini, M Brown, JF Doherty. Acute schistosomiasis in travelers: 14 years' experience at the Hospital for Tropical Diseases, London. AJTMH 2013 Published online March 25, 2013; doi:10.4269/ajtmh.12-0646.
  • F. Burns, S. Edwards, J. Woods, G. Haidari, Y. Calderon, J. Leider, R. Tobin, J. Cartledge, M. Brown. Acceptability and feasibility of universal offer of rapid point of care testing for HIV in an acute admissions unit: results of the RAPID project. PLoS ONE (2012); 7(4): e35212
  • Smith PJ, Theis B, McCartney S, Brown M. Helminths - an unrecognised disease burden prevalent among migrants in the Gastroenterology clinic. Frontline Gastroenterology 2012, re-printed by journal publishers in Postgrad Med J. 2012;88:28-33.
  • Brown M, Varia H, Bassett P, Davidson RN, Wall R, Pasvol G. Prospective study of sputum induction versus gastric lavage for the diagnosis of pulmonary tuberculosis in patients who are unable to expectorate. Clinical Infectious Diseases 2007; 44: 1415-20
  • Peck L, Ferenczi E, Cosgrove C, Burns F, Brown M. Barriers to targeted HIV testing on an acute admissions unit: evaluation of the UK guideline. Quarterly Journal of Medicine 2010;103:147-51.
  • Smith PJ, Theis B, McCartney S. Helminths - an unrecognised disease burden prevalent among migrants in the Gastroenterology clinic. Frontline Gastroenterology 2011; in press
  • Eziefula AC, Brown M. Intestinal nematodes - disease burden, deworming and the potential importance of co-infection. Current Opinion in Infectious Diseases 2008; 21:516-22
  • Eziefula AC, Brown M. The health of migrants from resource-poor countries. Medicine. 2010:38; 60-65
  • Brown M. Strongyloidiasis, hookworm and other gut strongyloid nematodes. Oxford Textbook of Medicine 5th edition.
  • McGregor A, Lau Kuen Wing J, Pollock E, Armstrong-James D, Morris-Jones S, Brown M. Management of quinolone-resistant typhoid osteomyelitis – two cases and a review of the literature. British Journal of Hospital Medicine 2011; 72: 468-9
  • King P1, Smith PJ, Betteridge J, Brown M. 'A lipaemic mystery': a patient with hypertriglyceridaemic pancreatitis and cerebral infarction. BMJ Case Rep. 2011 Dec 20;2011.
  • Checkley AM, Chiodini PL, Dockrell DH, Bates I, Thwaites GE, Booth HL, Brown M, Wright SG, Grant AD, Mabey DC, Whitty CJ, Sanderson F, on behalf of the British Infection Society and The Hospital for Tropical Diseases. Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management. J Infect 2010;60:1-20
  • Brown M. Parasites as aetiological agents in chronic diseases. Epidemiological associations and potential mechanisms of pathogenesis. Parasite Immunology 2009; 31: 653-5 (& guest edited associated special issue, which included most frequently downloaded article in this journal 2006-11)
  • Johnston V, Stockley JM, Dockrell D, Warrell D, Bailey R, Pasvol G, Klein J, Ustianowski A, Jones M, Beeching N, Brown M, Chapman ALN, Sanderson F, Whitty CJM, on behalf of the British Infection Society and the Hospital for Tropical Diseases. Fever in returned travellers presenting in the United Kingdon: Recommendations for investigation and initial management. J Infect 2009, 59:1-18.
  • Peck L, Ferenczi E, Brown M. Recent UK guidelines to increase HIV testing in healthcare settings; implications for junior doctors. Foundation Years Journal 2009
  • Mcgregor A, Brown M. The febrile and confused patient. Foundation Years Journal 2009
  • Sutton J, Brown M, Lockwood DN. Infectious Diseases & Tropical Medicine. Oxford Handbook of Key Clinical Evidence. 2009. Oxford University Press
  • Mcgregor A, Brown M, Thway K, Wright SG. Intestinal perforation after loperamide in a patient with amoebic colitis. J Travel Med 2007; 14:1-3.
  • Brown M, Varia H, Bassett P, Davidson RN, Wall R, Pasvol G. Prospective study of sputum induction versus gastric lavage for the diagnosis of pulmonary tuberculosis in patients who are unable to expectorate. Clinical Infectious Diseases 2007; 44: 1415-20
  • Brown M, Miiro G, Nkurunziza P, Watera C, Quigley MA, Whitworth JAG, Elliott AM. Schistosoma mansoni, nematode infections, and progression to active tuberculosis among HIV-1-infected Ugandans. American  Journal of  Tropical Medicine &  Hygiene 2006; 74: 819-25
  • Brown M, Mawa P, Kaleebu P, Elliott AM. Helminths and HIV infection: epidemiological observations on immunological hypotheses. Parasite Immunology 2006; 28; 613-23.
  • De Silva S, Walsh J, Brown M. Symptomatic Schistosoma mansoni infection as an immune restoration phenomenon in a patient on antiretroviral therapy. Clinical Infectious Diseases 2006;42:303-4
  • Brown M, Cartledge J, Miller RF. Dissemination of Strongyloides stercoralis as an immune reconstitution phenomenon in an HIV-1-infected man on antiretroviral therapy. Int J STD & AIDS 2006;17:560-1.
  • Logan SE, Brown M, Davidson RN. Teicoplanin-induced vasculitis with cutaneous and renal involvement. Journal of Infection 2005;51:e185-6.
  • Brown M, Pasvol G. Chromoblastomycosis – a clinical image. New England Journal of Medicine 2005;352: e19
  • Brown M, Noursadeghi M, Boyle J, Davidson RN. Successful liposomal amphotericin B treatment of Leishmania braziliensis cutaneous leishmaniasis. British Journal of Dermatology 2005;153: 203
  • Logan SE, Brown M, Davidson RN. Teicoplanin-induced vasculitis with cutaneous and renal involvement. Journal of Infection 2005;51:e185-6.
  • Brown M, Pasvol G. Chromoblastomycosis – a clinical image. New England Journal of Medicine 2005;352: e19
  • Brown M. Strongyloidiasis, hookworm and other gut strongyloid nematodes. Oxford Textbook of Medicine 5th edition.
  • Brown M, Grove DI. Strongyloides. www.antimicrobe.org
  • Brown M. Intestinal helminths. Medicine 2005; 33:8: 54-7
  • Newsholme W, Brown M. PUO in the tropics. Tropical Doctor 2005; 35:68-71
  • Brown M, Mawa PA, Joseph S, Bukusuba J, Watera C, Whitworth JAG, Dunne DW, Elliott AM. Treatment of Schistosoma mansoni infection increases helminth-specific type 2 cytokine responses and HIV-1 load in coinfected Ugandan adults. Journal of Infectious Diseases 2005; 191:1648-57.
  • Viney ME, Brown M , Omoding NE, Bailey JW, Gardner MP, Roberts E, Morgan D, Elliott AM, Whitworth JAG.Why does HIV infection not lead to disseminated strongyloidiasis? Journal of Infectious Diseases 2004;190:2175-80.
  • Brown M, Kizza M, Watera C, Quigley MA, Rowland S, Hughes P, Whitworth JAG, Elliott AM. Helminth infection is not associated with faster HIV disease progression in co-infected adults in Uganda. Journal of Infectious Diseases 2004; 190:1869-79.
  • Elliott AM, Kyosiimire J, Quigley MA, Nakiyingi J, Watera C, Brown M, Joseph S, French N, Gilks CF, Whitworth JAG. Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. Transactions of the Royal Society of Tropical Medicine & Hygiene 2003; 97:477-80.
  • Brown M, Bukusuba J, Hughes P, Nakiyingi J, Watera C, Elliott A, Whitworth J. Screening for intestinal helminth infestation in a semi-urban cohort of HIV-infected people in Uganda. A combination of techniques may enhance diagnostic yield in the absence of multiple stool samples. Tropical Doctor 2003; 33: 72-76
  • Brown M, Scarborough M, Brink N, Manji H, Miller R. Varicella-zoster virus-associated neurological disease in HIV-infected patients. International Journal of  STD & AIDS  2001; 12: 79-83
  • Brown M, Williams IG, Miller RF. Deterioration of disseminated cutaneous Mycobacterium avium complex infection with a leukaemoid reaction following institution of highly active antiretroviral therapy. Sexually Transmitted Infection 2001;77:149-50.
  • Brown M, Eykyn S. Non-typhoidal salmonella bacteraemia without gastroenteritis: a marker of underlying immunosuppression. Journal of Infection 2000;41: 256-9
  • Melzer M, Brown M, Mullen J, O’Shea S, Chrystie I & Banatvala J. Undiagnosed symptomatic primary HIV infections in South London. Journal of Infection 2001;42: 297-8
  • Brown M, Miller RF. AIDS & the Lung. Medicine 2001;29:4: 18-21
  • Brown M, Griffin GE. Immune responses in endocarditis. Heart 1998; 79: 1-2.
  • Brown M, Ahmed L, Clayton K & Dunger D. Growth during childhood and final height in insulin-dependent diabetes mellitus. Diabetic Medicine 1994; 11: 182-187.
  • Dunger DB & Brown M. Diabetes and growth in puberty. Growth Matters 1990; 5: 10-14.