Professional background

Dr Rajeev Gupta is an associate professor of haematology in the stem cell group at the UCL Cancer Institute. He is also clinical lead for laboratory haematology at UCLH.

Research interests

Haematopoietic stem cell biology


GUPTA R, Turati V, Brian D, Thrussel C, Wilbourn B, May G, Enver T (2020) Nov/CCN3 Enhances Cord Blood Engraftment by Rapidly Recruiting Latent Human Stem Cell Activity. Cell Stem Cell. 26(4):527-541.e8. doi: 10.1016/j.stem.2020.02.012.

GUPTA R, Gant V, Williams B, Enver T (2020) Increased Complement Receptor-3 levels in monocytes and granulocytes distinguish COVID-19 patients with pneumonia from those with mild symptoms. International Journal of Infectious Diseases 99:381-385. doi: 10.1016/j.ijid.2020.08.004

Chen, L.Y., Keddie, S., Lunn, M.P., Bomsztyk, J.a, Vitsaras, E., GUPTA, R. D'Sa, S (2020) IgM paraprotein-associated peripheral neuropathy: small CD20-positive B-cell clones may predict a monoclonal gammopathy of neurological significance and rituximab responsiveness. British Journal of Haematology 188 (4): 511-515 doi: 10.1111/bjh.16210

Diot A, Agnew T, Sanderson J, Liao C, Carver J, Neves RPD, GUPTA R, Guo Y, Waters C, Seto S, Daniels MJ, Dombi E, Lodge T, Morten K, Williams SA, Enver T, Iborra FJ, Votruba M, Poulton J. (2018) Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation. Front Cell Dev Biol. 6:103. Doi: 10.3389/fcell.2018.00103

Boto, C. Quartin, E., Cai, Y, Martín-Lorenzo, A., Cenador, M.B.G., Pinto, S., GUPTA, R., Enver, T., Sanchez-García, I., Hong, D., Das Neves, R.P., Ferreira, L (2017) Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation Nature Communications 8, 15204 doi: 10.1038/ncomms15204

Kato I, Nishinaka Y, Nakamura M, Akarca AU, Niwa A, Ozawa H, Yoshida K, Mori M, Wang D, Morita M, Ueno H, Shiozawa Y, Shiraishi Y, Miyano S, GUPTA R, Umeda K, Watanabe K, Koh K, Adachi S, Heike T, Saito MK, Sanada M, Ogawa S, Marafioti T, Watanabe A, Nakahata T, Enver T. (2017) Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGF Blood. 129:3126 doi: 10.1182/blood-2016-06-721712

Anguita E, GUPTA R, Olariu V, Valk PJ, Peterson C, Delwel R, Enver T (2016) A somatic mutation of GFI1B identified in leukemia alters cell fate via A SPI1 (PU.1) centered genetic regulatory network. Dev Biol 112:277-86 doi: 10.1016/j.ydbio.2016.02.002.
Karlsson G, Rorby E, Pina C, Soneji S, Reckzeh K, Miharada K, Karlsson C, Guo Y, Fugazza C, GUPTA R, Martens JH, Stunneberg HG, Karlsson S, Enver T (2013) Tetraspanin CD9 affords high-affinity capture of all murine haematopoietic stem cells. Cell Reports 4:642-8

das Neves RP, Jones NS, Andreu L, GUPTA R, Enver T, Iborra FJ. (2010) Stochastic partition of mitochondria at mitosis contributes to global transcription rate variability. Plos Biology 8(12):e100056

Ciau-Uitz A, Pinheiro P, GUPTA R, Enver T, Patient R. (2010) Tel specifies blood stem cells through the agency of VEGF signaling. Developmental Cell 18: 569-78

GUPTA R, Vyas P, Enver T. (2009) Molecular targeting of cancer stem cells. Cell Stem Cell 5: 125-126

Hong D, GUPTA R, Ancliff P, Atzberger A, Brown J, Soneji S, Green J, Colman S, Piacibello W, Buckle V, Tsuzuki S, Greaves M, Enver T (2008) Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science. 319: 336-9.

Glasow A, Barrett A, Petrie K, GUPTA R, Boix-Chornet M, Zhou DC, Grimwade D, Gallagher R, von Lindern M, Waxman S, Enver T, Hildebrandt G, Zelent A (2008) DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia. Blood. 111: 2374-7

GUPTA R, Hong D, Iborra F, Sarno S, Enver T. (2007) NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science. 316: 590-3

Tsuzuki S, Hong D, GUPTA R, Matsuo K, Seto M, Enver T. (2007) Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med. 4(5): e172.