Photo of Professor Tom Lumbers

Professor Tom Lumbers

Telephone:

Email:

GMC/GDC number:

6091176

Professional background

Professor Lumbers is a consultant cardiologist at University College London Hospitals and Barts Heart Centre, and professor of cardiovascular medicine and translational genomics at University College London. His clinical focus is on general cardiology and heart failure, and he leads the acute heart failure service at UCLH. He has contributed to European Society of Cardiology guidelines and serves on the NIH ClinGen Dilated Cardiomyopathy Expert Group and the ICHOM Cardiometabolic Steering Group.

Specialties

Research interests

His research centres on cardiovascular genetics, data science, and clinical informatics. He leads the global HERMES consortium on heart failure and dilated cardiomyopathy genetics and is Co-Director of the Rare Disease Research UK Cardiovascular Initiative. His work aims to define the genetic basis of cardiovascular disease to uncover disease mechanisms and improve diagnosis and treatment. He is also exploring how health record systems can drive quality improvement, translational research, and clinical trials.

Publications

Selected publications:

  • Henry, A., Mo, X., Finan, C., Chaffin, M. D., Speed, D., Issa, H., Denaxas, S., Ware, J. S.,Zheng, S. L., Malarstig, A., Gratton, J., Bond, I., Roselli, C., Miller, D., Chopade, S.,Schmidt, A. F., Abner, E., Adams, L., Andersson, C., … HERMES Consortium. (2025). Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Nature Genetics, 57(4), 815–828.
  • Van Gelder, I. C., Rienstra, M., Bunting, K. V., Casado-Arroyo, R., Caso, V., Crijns, H. J. G. M., De Potter, T. J. R., Dwight, J., Guasti, L., Hanke, T., Jaarsma, T., Lettino, M., Løchen, M.-L., Lumbers, R. T., Maesen, B., Mølgaard, I., Rosano, G. M. C., Sanders, P., Schnabel, R. B., … Sarkozy, A. (2024). 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio Thoracic Surgery (EACTS). European Heart Journal, ehae176.
  • Zheng, S. L., Henry, A., Cannie, D., Lee, M., Miller, D., McGurk, K. A., Bond, I., Xu, X., Issa, H., Francis, C., De Marvao, A., Theotokis, P. I., Buchan, R. J., Speed, D., Abner, E., Adams, L., Aragam, K. G., Ärnlöv, J., Raja, A. A., … Lumbers, R. T. (2024). Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy. Nature Genetics, 1–13.
  • Henry, A., Gordillo-Marañón, M., Finan, C., Schmidt, A. F., Ferreira, J. P., Karra, R., Sundström, J., Lind, L., Ärnlöv, J., Zannad, F., Mälarstig, A., Hingorani, A. D., Lumbers, R. T., & HERMES and SCALLOP Consortia. (2022). Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization. Circulation, 145(16), 1205–1217.
  • Huang, Q. Q., Sallah, N., Dunca, D., Trivedi, B., Hunt, K. A., Hodgson, S., Lambert, S. A., Arciero, E., Wright, J., Griffiths, C., Trembath, R. C., Hemingway, H., Inouye, M., Finer, S., van Heel, D. A., Lumbers, R. T., Martin, H. C., & Kuchenbaecker, K. (2022). Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals. Nature Communications, 13(1), 4664.
  • Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., … Lumbers, R. T. (2020). Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nature Communications, 11(1), 163.
  • Meyer, H. V., Dawes, T. J. W., Serrani, M., Bai, W., Tokarczuk, P., Cai, J., de Marvao, A., Henry, A., Lumbers, R. T., Gierten, J., Thumberger, T., Wittbrodt, J., Ware, J. S., Rueckert, D., Matthews, P. M., Prasad, S. K., Costantino, M. L., Cook, S. A., Birney, E., & O’Regan, D. P. (2020). Genetic and functional insights into the fractal structure of the heart. Nature, 584(7822), 589–594.