Photo of Professor Tom Lumbers

Professor Tom Lumbers

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GMC/GDC number:

6091176

Professional background

Professor Tom Lumbers is an honorary consultant cardiologist at University College London Hospitals (UCLH) and Barts Heart Centre, professorial research fellow at University College London, and a visiting scientist at the Broad Institute of Harvard and MIT.

After graduating in medicine from Cambridge University with double distinction he trained in clinical cardiology at UCLH and Barts Heart Centre. Alongside his clinical work, he received a Ph.D. in Molecular Biology from Imperial College London and completed post-doctoral training in Genetic Epidemiology at University College London, as an NIHR Clinical Lecturer in Cardiology and UKRI Rutherford Fellow.

Tom’s clinical work is based at UCLH and the Barts Heart Centre with interests in general cardiology, atrial fibrillation and heart failure. He leads the inpatient heart failure service at UCLH. He works with the European Society of Cardiology on clinical practice guidelines, with is a member of the NIH ClinGen Dilated Cardiomyopathy Expert Group, and the International Consortium for Heath Outcomes Measurement Cardiometabolic group.

Specialties

Research interests

Professor Lumbers' research focuses on cardiovascular genetics, data science, and clinical informatics. He is the principal investigator of the global HERMES consortium for heart failure and dilated cardiomyopathy genetics, and Co-Director of the MRC/NIHR Rare Disease Research UK Cardiovascular Initiative. His research focuses on defining the genetic basis of cardiovascular disease to generate insights into disease mechanisms to improve diagnosis and treatment.

Languages spoken

French

Publications

  • Henry, A., Mo, X., Finan, C., Chaffin, M. D., Speed, D., Issa, H., Denaxas, S., Ware, J. S.,Zheng, S. L., Malarstig, A., Gratton, J., Bond, I., Roselli, C., Miller, D., Chopade, S.,Schmidt, A. F., Abner, E., Adams, L., Andersson, C., … HERMES Consortium. (2025). Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Nature Genetics, 57(4), 815–828.
  • Van Gelder, I. C., Rienstra, M., Bunting, K. V., Casado-Arroyo, R., Caso, V., Crijns, H. J. G. M., De Potter, T. J. R., Dwight, J., Guasti, L., Hanke, T., Jaarsma, T., Lettino, M., Løchen, M.-L., Lumbers, R. T., Maesen, B., Mølgaard, I., Rosano, G. M. C., Sanders, P., Schnabel, R. B., … Sarkozy, A. (2024). 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio Thoracic Surgery (EACTS). European Heart Journal, ehae176.
  • Zheng, S. L., Henry, A., Cannie, D., Lee, M., Miller, D., McGurk, K. A., Bond, I., Xu, X., Issa, H., Francis, C., De Marvao, A., Theotokis, P. I., Buchan, R. J., Speed, D., Abner, E., Adams, L., Aragam, K. G., Ärnlöv, J., Raja, A. A., … Lumbers, R. T. (2024). Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy. Nature Genetics, 1–13.
  • Henry, A., Gordillo-Marañón, M., Finan, C., Schmidt, A. F., Ferreira, J. P., Karra, R., Sundström, J., Lind, L., Ärnlöv, J., Zannad, F., Mälarstig, A., Hingorani, A. D., Lumbers, R. T., & HERMES and SCALLOP Consortia. (2022). Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization. Circulation, 145(16), 1205–1217.
  • Huang, Q. Q., Sallah, N., Dunca, D., Trivedi, B., Hunt, K. A., Hodgson, S., Lambert, S. A., Arciero, E., Wright, J., Griffiths, C., Trembath, R. C., Hemingway, H., Inouye, M., Finer, S., van Heel, D. A., Lumbers, R. T., Martin, H. C., & Kuchenbaecker, K. (2022). Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals. Nature Communications, 13(1), 4664.
  • Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., … Lumbers, R. T. (2020). Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nature Communications, 11(1), 163.
  • Meyer, H. V., Dawes, T. J. W., Serrani, M., Bai, W., Tokarczuk, P., Cai, J., de Marvao, A., Henry, A., Lumbers, R. T., Gierten, J., Thumberger, T., Wittbrodt, J., Ware, J. S., Rueckert, D., Matthews, P. M., Prasad, S. K., Costantino, M. L., Cook, S. A., Birney, E., & O’Regan, D. P. (2020). Genetic and functional insights into the fractal structure of the heart. Nature, 584(7822), 589–594.