Photo of Mr Neill Patani

Mr Neill Patani

Telephone:

Email:

Location:

  • University College Hospital

GMC/GDC number:

6078267

Professional background

Neill Patani is a consultant oncoplastic and reconstructive breast surgeon at UCLH, with expertise in the management of breast cancer and all aspects of breast disease, including infection, benign conditions and risk-reduction. He has a particular interest in extending the scope of breast conserving surgery with oncoplastic techniques, including therapeutic mammoplasty and in the de-escalation of breast and axillary surgery, including targeted axillary dissection, after neo-adjuvant therapy. He has experience with a range of breast reconstruction techniques, including nipple-sparing approaches and one-stage pre-pectoral implant reconstruction with acellular dermal matrix, in addition to lipo-modelling, nipple reconstruction and symmetrisation surgery.

Neill completed his training at the Royal Marsden Hospital with a National oncoplastic fellowship in breast surgery. He is a fellow of the Royal College of Surgeons of England and undertook his higher surgical training in London and the North-West Thames region, including Charing Cross, Hillingdon, Northwick Park, St Bartholomew's and the Royal London Hospitals, leading to the award of his certificate of completion of training in general surgery with a specialty interest in breast surgery. His basic surgical training was undertaken at UCLH and the Royal Free Hospital. He graduated from UCL Medical School with honours and was awarded undergraduate prizes and distinctions in medicine and surgery.

Neill plays an active role in teaching and training, he is a faculty member of the Royal College of Surgeons of England and national representative for general surgery trainees at the Oncoplastic Breast Surgery Training Interface Group. He was a surgical teaching fellow for Imperial College Medical School and anatomy demonstrator at the Royal Free & UCL Medical School. He also has an interest in quality improvement initiatives and is an honorary clinical fellow for the national Getting It Right First Time (GIRFT) programme, with a national role in evaluating and learning from litigation in breast surgery.

Academic appointments:

  • University College London Cancer Institute, honorary associate professor, Dec 2018 - present.
  • Francis Crick Institute, postdoctoral clinical research fellow, Oct 2018 - present
  • Royal Marsden Hospital, Institute of Cancer Research, PhD student, Oct 2010 - Oct 2013
  • Department of surgery, University College London Hospital, research fellow, Aug 2005 - Aug 2007
  • Department of molecular & applied biosciences, University of Westminster, Aug 2005 - Aug 2007.
  • Department of anatomy & developmental biology, University College London, Aug 2004 - Aug 2005.
  • Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Australia, Oct 2002 - Jan 2003.


Research Awards:

  • Francis Crick Institute, postdoctoral career development fellowship (2018).
  • NIHR Biomedical Research Centre, University College London, project grant (2018).
  • Medical Research Council clinical research training fellowship (2011).
  • Royal College of Surgeons of England & Dunhill medical trust fellowship (2010).
  • Cancer Research UK, core skills & training research scholarship (2005).
  • Ludwig Institute for Cancer Research - training fellowship (2002).
  • Cancer Research Campaign - elective award (2002).
  • British Medical & Dental Students’ Trust bursary (2002).
  • Jackson Lewis Scholarship in life sciences (2001).
  • Wolfson Foundation intercalated scholarship (2000).

Specialties

Research interests

Neill is an honorary associate professor at the UCL Cancer Institute and postdoctoral clinical research fellow at the Francis Crick Institute, with an interest in laboratory, translational and clinical breast cancer research. He works collaboratively with scientists, oncologists and radiologists, exploring how breast cancer metabolism can be targeted for functional imaging and novel therapies. He is currently involved in clinical trials studying the optimal sequencing of breast cancer treatments and the de-escalation of surgery to the breast and axilla according to treatment response.

Neill has undertaken a PhD at the Royal Marsden Hospital and Institute of Cancer Research, studying response and resistance to endocrine therapy, including the development of biomarkers to personalise treatment. He received 1st class honours for his BSc in tumour biology at UCL, investigating some of the earliest genetic events in the multi-step model of breast cancer development.

Publications

Published papers

Defining a metabolic landscape of tumours: genome meets metabolism
British Journal of Cancer, 2020; 122(2):136-149.
Seth Nanda C, Venkateswaran SV, Patani N, Yuneva M.

Multicentre prospective observational study evaluating recommendations for mastectomy by multidisciplinary teams
British Journal of Surgery, 2020; 107(3):227-237.
Mastectomy Decisions Audit (MasDA) Collaborative, on behalf of the West Midlands Research Collaborative.

A ‘best practice’ care pathway improves management of mastitis and breast abscess
British Journal of Surgery, 2018; 105(12):1615-1622.
Patani N, MacAskill F, Eshelby S, Omar A, Kaura A, Contractor K, Thiruchelvam P, Curtis S, Main J, Cunningham D,
Hogben K, Al-Mufti R, Hadjiminas DJ, Leff DR.

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance
Nature Communications, 2017; 8(1):1865.
Martin LA, Ribas R, Simigdala N, Schuster E, Pancholi S, Tenev T, Gellert P, Buluwela L, Harrod A, Thornhill A,
Nikitorowicz-Buniak J, Bhamra A, Turgeon MO, Poulogiannis G, Gao Q, Martins V, Hills M, Garcia-Murillas I,
Fribbens C, Patani N, Li Z, Sikora MJ, Turner N, Zwart W, Oesterreich S, Carroll J, Ali S, Dowsett M.

Differences in the transcriptional response to fulvestrant and oestrogen deprivation in ER-positive breast cancer
Clinical Cancer Research, 2014; 20(15):3962-3973.
Patani N, Dunbier AK, Anderson H, Ghazoui Z, Ribas R, Anderson E, Gao Q, A’Hern R, Mackay A, Lindemann J,
Wellings R, Walker J, Kuter I, Martin L-A, Dowsett M.

Effect of aromatase inhibition on functional gene modules in oestrogen receptor positive breast cancer and their
relationship with antiproliferative response
Clinical Cancer Research, 2014; 20(9):2485-2494.
Gao Q, Patani N, Dunbier AK, Ghazoui Z, Zvelebil M, Martin L-A, Dowsett M.

Understanding response and resistance to oestrogen deprivation in ER-positive breast cancer
Molecular and Cellular Endocrinology, 2014; 382(1):683-694.
Patani N, Martin L-A.

Biomarkers for the clinical management of breast cancer: International perspective
International Journal of Cancer, 2013; 133(1):1-13.
Patani N, Martin L-A, Dowsett M.

Ductal carcinoma in-situ: Recent advances and future prospects
International Journal of Surgical Oncology, 2012; Article ID: 347385, PMID: 22675624.
Lambert KV, Patani N, Mokbel K.

The role of caveolin-1 in human breast cancer
Breast Cancer Research and Treatment, 2012; 131(1):1-15.
Patani N, Martin LA, Reis-Filho JS, Dowsett M.

Non-existence of caveolin-1 gene mutations in human breast cancer
Breast Cancer Research and Treatment, 2012; 131(1): 307-10.
Patani N, Lambros MB, Natrajan R, Dedes KJ, Geyer FC, Ward E, Martin LA, Dowsett M, Reis-Filho JS.

Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis
Histopathology, 2012; 60(6B): 115-130.
Geyer FC, Lacroix-Triki M, Colombo PE, Patani N, Gauthier A, Natrajan R, Lambros MB, Khalifeh I,
Albarracin C, Orru S, Marchio C, Sapino A, MacKay A, Weigelt B, Schmitt FC, Sneige N, Reis-Filho JS.

High TIMM17A expression is associated with adverse pathological & clinical outcomes in human breast cancer
Breast Cancer, 2012; 19(2): 153-160.
Salhab M, Patani N, Jiang W, Mokbel K.

Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human
breast cancer
Anticancer Research, 2011; 31(12): 4115-4125.
Patani N, Jiang WG, Newbold RF, Mokbel K.

Brain-derived neurotrophic factor expression predicts adverse pathological & clinical outcomes in breast cancer
Cancer Cell International, 2011; 11(1): 23.
Patani N, Jiang WG, Mokbel K.

Sentinel lymph node micrometastasis in human breast cancer: an update
Surgical Oncology, 2011; 20(4): 195-206.
Salhab M, Patani N, Mokbel K.

High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform
Laboratory Investigation, 2011; 91(10):1491-501.
Lambros MB, Wilkerson PM, Natrajan R, Patani N, Pawar V, Vatcheva R, Mansour M, Laschet M, Oelze B, Orr N,
Muller S, Reis-Filho JS.

Clinical impact of lymph node status in rectal cancer
Surgical Oncology, 2011; 20(4): 227-33.
Colombo PE, Patani N, Bibeau F, Assenat E, Bertrand MM, Senesse P, Rouanet P.

Direct evidence for concurrent morphological and genetic heterogeneity in an invasive ductal carcinoma
of triple-negative phenotype
Journal of Clinical Pathology, 2011; 64(9): 822-8.
Patani N, Barbashina V, Lambros M, Mansour M, Mackay A, Reis-Filho J.

Clinical significance of sentinel lymph node isolated tumour cells in breast cancer
Breast Cancer Research & Treatment, 2011; 127(2): 325-334.
Patani N, Mokbel K.

Impact of digital mammography on screening a young cohort of women in an urban specialist breast unit
European Radiology, 2011; 21(4): 676-682.
Perry NM, Patani N, Milner SE, Pinker K, Mokbel K, Allgood PC, Duffy SW.

Ductal carcinoma in-situ: An update for clinical practice
Surgical Oncology, 2011; 20(1): 23-31.
Patani N, Khaled Y, Reefy S, Mokbel K.

Tumour suppressor function of MDA-7 / IL-24 in human breast cancer
Cancer Cell International, 2010; 10(1): 29.
Patani N, Douglas-Jones A, Mansel R, Jiang W, Mokbel K.

Oncological & aesthetic considerations of conservational surgery for multifocal / multicentric breast cancer
The Breast Journal, 2010; 16(3): 222-232.
Patani N, Carpenter R.

Prognostic implications of CHIP & LOX expression in human breast cancer
Journal of Carcinogenesis, 2010; 9(1): 9.
Patani N, Jiang W, Newbold R, Mokbel K.

Oncological outcome & patient satisfaction with skin-sparing mastectomy & immediate breast reconstruction:
A prospective observational study
BMC Cancer, 2010; 10(1): 171.
Reefy S, Patani N, Anderson A, Burgoyne G, Osman H, Mokbel K.

Herceptin & breast cancer: An overview for surgeons
Surgical Oncology, 2010; 19(1): 11-21.
Patani N, Mokbel K.

The mRNA expression of SATB1 & SATB2 in human breast cancer
Cancer Cell International, 2009; 9(1): 18.
Patani N, Jiang W, Mansel R, Newbold R, Mokbel K.

The clinical significance of sentinel lymph node micrometastasis in breast cancer
Breast Cancer Research & Treatment, 2009; 114(3): 393-402.
Patani N, Mokbel K.

Prognostic utility of glycosyltransferase expression in breast cancer
Cancer Genomics & Proteomics, 2008; 5(6): 333-340.
Patani N, Jiang W, Mokbel K.

Osteopontin expression profiles predict pathological and clinical outcome in breast cancer
Anticancer Research, 2008; 28(6B): 4105-4110.
Patani N, Jiang W, Mokbel K.

Evidence of a tumour suppressive function of E2F1 gene in human breast cancer
Anticancer Research, 2008; 28(4B): 2135-2139.
Worku D, Jouhra F, Jiang GW, Patani N, Newbold RF, Mokbel K.

The utility of MRI for the screening and staging of breast cancer
International Journal of Clinical Practice, 2008; 62(3): 450-453.
Patani N, Mokbel K.

Oncological safety & patient satisfaction with skin-sparing mastectomy & immediate breast reconstruction
Surgical Oncology, 2008; 17(2): 97-105.
Patani N, Devalia H, Anderson A, Mokbel K.

Oncological & aesthetic considerations of skin-sparing mastectomy
Breast Cancer Research & Treatment, 2008; 111(3): 391-403.
Patani N, Mokbel K.

Current management of DCIS: A review
Breast Cancer Research & Treatment, 2008; 111(1): 1-10.
Patani N, Cutuli B, Mokbel K.

Elevated protein tyrosine phosphatase provokes Eph/Ephrin-facilitated adhesion of pre-B leukemia cells
Blood, 2008; 112(3): 721-732.
Wimmer-Kleikamp S, Nievergall E, Gegenbauer K, Adikari S, Mansour M, Patani N, Lackmann M.

Screening for breast cancer
Oncology News, 2007; 1(5): 26-28.
Patani N, Douek M.

Predictors of axillary lymph node metastasis in breast cancer: A systematic review
European Journal of Surgical Oncology, 2007; 33(4): 409-419.
Patani N, Dwek M, Douek M.

Crohn’s Disease: Surgical implications of a medical revolution
Hospital Doctor, Crohn’s Disease Supplement, 2007; November: 9-10.
Barclay K, Patani N, Cohen R, Windsor A.

Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers
British Journal of Cancer, 2006; 95: 515-519.
Clarke C, Sandle J, Jones A, Sofronis A, Patani N, Lakhani S.

Published case reports

‘Nipped in the Budd’: Hepatic venous outflow obstruction in evolution
European Journal of Gastroenterology & Hepatology, 2005; 17(1): 65-68.
Karageorgiou H, Mookerjee R, Patani N, Usiskin S, Douek M, Jalan R.

Hyperpolarised 13c magnetic resonance imaging: a new horizon for non-invasive diagnosis of
aggressive breast cancer
British Journal of Radiology, 2019; e-pub ahead of print.
Abeyakoon O, Latifoltojar A, Gong F, Papoutsaki MV, Chowdhury R, Glaser M, Jeraj H, Awais R, Holt C, Twyman F,
Arstad E, Gadian, DG, Atkinson, D, Comment A, O'Callaghan J, Smith L, Beeston T, Clemente J, Patani N, Stein R,
Yuneva M, Szabadkai G, Halligan S, Punwani S.

Published letters

Free flap breast reconstruction consent forms should warn against the potential loss of the internal thoracic
artery for coronary artery bypass grafting
Plastic & Reconstructive Surgery, 2012; 129(5): 867-868.
Al-Benna S, Steinstraesser L, Patani N.

Changes in breast cancer incidence rates
Cancer Epidemiology, Biomarkers & Prevention, 2008; 17(3): 742.
Patani N, Jouhra W, Mokbel K.

Osteopontin C mRNA expression is associated with a poor clinical outcome in human breast cancer
International Journal of Cancer, 2008; 122(11): 2646.
Patani N, Jiang W, Mokbel K.

En-Garde! A novel splash guard for use in wound irrigation
Annals of The Royal College of Surgeons of England, 2009; 91: 83-84.
Al-Benna S, Patani N, Al-Ajam Y.

Published abstracts

Neo-adjuvant radiotherapy in mastectomy and immediate autologous free flap reconstruction:
Findings from the primary radiotherapy and DIEP flap (PRADA) trial.
European Journal of Surgical Oncology, 2020; 46 (6), e8.
Hadjiminas D, Thiruchelvam P, Leff D, Cleator S, Wood S, Gujral D, Kirby A, Patani N, Robinson R, Tan M,
James S, Khan A, Rusby J, Somaiah N, MacNeill F.

Neo-adjuvant radiotherapy prior to mastectomy and autologous reconstruction attenuates treatment times.
European Journal of Surgical Oncology, 2020; 46 (6), e42.
Leff D, Thiruchelvam P, Patani N, Robinson R, Paget J, Khan A, Cleator S, Gujral D, Kirby A, Somaiah N, Rusby J,
Wood S, MacNeill F, Hadjiminas D.

Is neo-adjuvant radiotherapy prior to mastectomy and autologous reconstruction safe?
Comparisons between PRADA trial patients and historical controls
European Journal of Surgical Oncology, 2019; 45: 879.
Leff D, Thiruchelvam P, Patani N, Paget J, James S, Wood S, Cleator S, Kirby A, Rusby J, MacNeill F, Hadjiminas D.

Can we trust our data? A comparative analysis of iBRA and HES data
European Journal of Surgical Oncology, 2019; 45: 879.
Chamberlain C, Goburdhun R, Dover N, Sabaratnam R, Patani N, Roche N.

A best-practice pathway for mastitis & breast abscess enables non-specialists to ‘get it right first time’
European Journal of Surgical Oncology, 2018; 44(6): 862-863.
Patani N, MacAskill F, Eshelby S, Omar A, Kaura A, Contractor K, Thiruchelvam P, Curtis S, Main J,
Cunningham D, Hogben K, Al-Mufti R, Hadjiminas DJ, Leff DR.

Comparison of the transcriptional response to fulvestrant and oestrogen deprivation in ER-positive
breast cancer in-vitro and in-vivo
Annals of Oncology, 2013; 24(S3): 109P.
Patani N, Dunbier A, Anderson H, Ribas R, Anderson E, Gao Q, Mackay A, Ghazoui Z, Lindemann J,
Wellings R, Walker J, Kuter I, Martin L-A, Dowsett M.

Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis
Laboratory Investigation, 2012; 92(S1): 41A.
Geyer FC, Lacroix-Triki M, Colombo PE, Patani N, Gauthier A, Natrajan R, Lambros MB, Khalifeh I,
Albarracin C, Orru S, Marchio C, Sapino A, MacKay A, Weigelt B, Schmitt FC, Sneige N, Reis-Filho JS.

Prognostic utility of histone-modifier gene expression profiles in breast cancer
Cancer Research, 2011; 71(24S): 174s.
Patani N, Kasem A, Jiang WG, Newbold RF, Mokbel K.

Brain-derived neurotrophic factor expression is associated with poor prognosis in breast cancer
Cancer Research, 2011; 71(24S): 285s.
Patani N, Kasem A, Jiang WG, Mokbel K.

Src is a potential therapeutic target in endocrine resistant breast cancer exhibiting low ER-transactivation
Cancer Research, 2011; 71(24S): 117s.
Guest K, Pancholi S, Patani N, Dowsett M, Johnston SR, Martin LA.

Frequency & distribution of caveolin-1 mutations in human breast cancer
Annals of Oncology, 2011; 22(S2): 35.
Patani N, Dedes K, Lambros M, Natrajan R, Reis-Filho J, Dowsett M.

Oncological safety & aesthetic outcome of conservational surgery for multifocal / multicentric breast cancer:
Proposal for a prospective randomized controlled trial:
MAMMACE – Multifocality & Multicentricity, Mastectomy & Conservation Evaluation
European Journal of Surgical Oncology, 2010; 36(11): 1118-9.
Patani N, Carpenter R.

High TIMM17A expression is associated with poor clinical outcome & unfavourable pathological
parameters in human breast cancer
European Journal of Cancer, (supplements), 2010; 8(6): 4.
Salhab M, Patani N, Jiang W, Mokbel K.

A prospective observational study on the oncological outcome & patient satisfaction with skin-sparing
mastectomy & immediate breast reconstruction
European Journal of Cancer, (supplements), 2010; 8(3): 138.
Al-Reefy S, Patani N, Anderson A, Burgoyne G, Chao C, Osman H, Mokbel K.

Oncological safety & patient satisfaction with skin-sparing mastectomy & immediate breast reconstruction
European Journal of Surgical Oncology, 2009; 35(11): 1201.
Patani N, Burgoyne G, Reefy S, Anderson A, Mokbel K.

Tumour suppressor function of CHIP & LOX in human breast cancer
European Journal of Surgical Oncology, 2009; 35(11): 1239.
Patani N, Jiang W, Mokbel K.

Osteopontin expression profiles predict pathological and clinical outcome in breast cancer
European Journal of Surgical Oncology, 2008; 34(10): 1196.
Mokbel K, Patani N, Jiang W.

Oncological safety & patient satisfaction with skin-sparing mastectomy & immediate breast reconstruction
European Journal of Cancer, (supplements), 2008; 6(7): 215.
Jouhra F, Patani N, Devalia H, Anderson A, Mokbel K.

The utility of Helix Pomatia Agglutinin as a predictor of axillary lymph node metastasis in breast cancer
British Journal of Surgery, 2007; 94(s3): 28.
Patani N, Dwek M, Sainsbury R, Keshtgar M, Douek M.

The clinical impact of breast magnetic resonance imaging
British Journal of Surgery, 2004; 91(1): 118.
Douek M, Usiskin S, Patani N, Hall-Craggs M.

What is the clinical impact of breast magnetic resonance imaging?
Proceedings of the International Society for Magnetic Resonance in Medicine, 2004; 11: 242.
Usiskin S, Douek M, Patani N, Hall-Craggs M.

Expression and function in modulating tumor cell-cell contacts identifies EphA3 as candidate
cell-surface receptor for tumor targeting strategies
Proceedings of the American Association for Cancer Research, 2004; 45: 1015.
Lackmann M, Wimmer-Kleikamp S, Patani N, Papageorgiou I, Kravets L, Boyd A, Scott A.

Book chapter

Biomarkers of breast cancer
World Breast Cancer Report, 2012
International Prevention Research Institute, Lyon, France. ISBN:978-2-9539268-1-1.
Patani N, Dowsett M.

Acknowledgements

Gene expression profiling in breast cancer: Classification, prognostication and prediction
Lancet, 2011; 378(9805): 1812-23. Pusztai L, Reis-Filho JS.