Photo of Mr Sirwan Hadad

Mr Sirwan Hadad

Telephone:

Email:

Location:

  • University College Hospital

GMC/GDC number:

5200963

Professional background

Mr Sirwan Hadad is a consultant oncoplastic and reconstructive breast surgeon at UCLH, with expertise in the management of breast cancer and all aspects of breast diseases, including infection, benign conditions and risk reduction. He has years’ experience in breast surgical operations including simple, skin-reducing, skin and nipple-sparing mastectomy with immediate implant-based reconstruction; level 1 and 2 oncoplastic breast procedures; reduction mammoplasty; mastopexy; liposuction and lipomodelling; partial breast reconstruction with chest wall perforator flap; immediate and delayed LD flap, and revisional breast surgery.

Mr Hadad completed his PhD in breast cancer molecular oncology at the University of Dundee, with the Baxter Prize award for best clinical research in 2011. He was then awarded the NIHR Clinical Lecturer Fellowship at the University of Sheffield, during which he completed his Higher Surgical Training including an oncoplastic fellowship position at the Royal Marsden Hospital in London, and successfully supervised two PhD students. This led to the award of his certificate of completion of training in general surgery with a specialty interest in breast surgery.

Now Mr Hadad works with the MDT Lead Clinicians, Directorate Management team, the Trust Cancer Executive, Regional Cancer Alliance and Academic Partners to deliver timely, safe, effective, and efficient breast cancer services at UCLH, with a focus on research and teaching.
 

Specialties

Research interests

  • Preoperative Window-of-Opportunity trials (Chief Investigator for NeoMet clinical trial, and Principal Investigator for OPPORTUNE and PIONEER clinical trial)
  • Service improvement (qualified coach by the Flow Coaching Academy)

Languages spoken

Kurdish and Arabic

Publications


Research Article: Recovering elective breast surgery during the era of COVID-19 – using regional anaesthesia to allow day case risk reducing mastectomy and immediate breast reconstruction.
Vol. 32 No. 3 (2022): JODS (Journal of one-day surgery) August 2022. https://jods.online/index.php/jods/article/view/11 

Research Article: Determination of Chemical Irritation Potential Using a Defined Gene Signature Set on Tissue-Engineered Human Skin Equivalents. JID Innovations Volume 1, Issue 2, June 2021, 100011. https://doi.org/10.1016/j.xjidi.2021.100011

Research Article: The NeST (Neoadjuvant systemic therapy in breast cancer) study: National Practice Questionnaire of United Kingdom multi-disciplinary decision making. BMC Cancer. 2021; 21; 90. DOI:  10.1186/s12885-020-07757-6. PMID: 33482770

Clinical Case Report: Myiasis. Seerwan Qaradaghy and Sirwan Hadad. Clinical Case Report 2020 Feb 5;8(3):586. DOI: 10.1002/ccr3.2711.PMID: 32185070 Research Article: Predicting Patients Found to Have Malignancy at Nipple Duct Surgery. Alshurbasi N, Cartlidge C.W.J., Kohlhardt S.R. Hadad S.M. Breast Care 2019.  DOI:10.1159/000504528

Research Article: Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC.
Mol Cell. 2018 Aug 16;71(4):606-620.e7. doi: 10.1016/j.molcel.2018.07.030. PMID: 30118680.

Research Article: Current practice and short-term outcomes of therapeutic mammoplasty in the international TeaM multicentre prospective cohort study. O'Connell RL, Baker E, Trickey A, Rattay T, Whisker L, Macmillan RD, Potter S; TeaM Steering Group; Mammary Fold Academic and Research Collaborative.Br J Surg. 2018 Aug 22. doi: 10.1002/bjs.10959. [Epub ahead of print] PMID: 30132807

Research Article: Effects of prolonged exposure to low dose metformin in thyroid cancer cell lines. Kheder S, Sisley K, Hadad S, Balasubramanian SP. J Cancer. 2017 Apr 9;8(6):1053-1061. doi: 10.7150/jca.16584. eCollection 2017. PMID: 28529619.

Research Article:  A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential core biopsies of primary, untreated breast cancer. Hadad SM, Jordan LB, Roy PG, Purdie CA, Iwamoto T, Pusztai L, Moulder-Thompson SL, Thompson AM. BMC Cancer. 2016 Sep 22;16(1):745. PMID: 27658825.

Clinical Trial: Phase II randomized preoperative window of opportunity study of the PI3K inhibitor Pictilisib plus Anastrozole compared with Anastrozole alone in patients with estrogen receptor-positive breast cancer. Schmid P, Pinder SE, Wheatley D, Macaskill J, Zammit C, Hu J, Price R, Bundred N, Hadad S, Shia A, Lim L, Sarker S-J, Gazinska P, Woodman N, Korbie D, Trau M, Mainwaring P, Parker P, Purushotham A, Thompson AM. J Clin Oncol. 2016 Mar 14. pii: JCO639179. PMID: 26976426

Clinical Trial: Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial. Sirwan M. Hadad, Philip Coates, Lee B. Jordan, Ryan J. O. Dowling, Martin C. Chang, Susan J. Done, Colin A. Purdie, Pamela J. Goodwin, Vuk Stambolic, Stacy Moulder-Thompson, Alastair M. Thompson. Breast Cancer Res Treat. 2015 Feb;150(1):149-55. doi: 10.1007/s10549-015-3307-5. Epub 2015 Feb 15.  PMID: 25682077.

Research article: Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle. Hadad S, Hardie D, Appleyard V, Thompson A. Clin Transl Oncol. 2014 Aug;16(8):746-52. doi: 10.1007/s12094-013-1144-8. Epub 2013 Dec 12. PMID: 24338509.

Clinical Trial: Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S, Hardie DG, Pusztai L, Moulder-Thompson S, Dewar JA, Thompson AM. Breast Cancer Res Treat. 2011 Aug;128(3):783-94. doi: 10.1007/s10549-011-1612-1. Epub 2011 Jun 8.  PMID: 21655990.

Research article: Histological evaluation of AMPK signalling in primary breast cancer. Hadad SM, Baker L, Quinlan PR, Robertson K, Bray S, Thomson G, Kellock D, Jordan LB, Purdie C, Hardie DG, Fleming S, Thompson AM. BMC Cancer. 2009 Sep 1;9:307. doi: 10.1186/1471-2407-9-307.  PMID: 19723334.

Research article: A Candidate molecular signature associated with tamoxifen failure in primary breast cancer. Vendrell JA, Robertson KE, Ravel P, Bray SE, Bajard A, Purdie CA, Nguyen C, Hadad SM, Bieche I, Chabaud S, Bachelot T, Thompson AM, Cohen PA.M Breast Cancer Res. 2008;10(5):R88. doi: 10.1186/bcr2158. Epub 2008 Oct 17.  PMID: 18928543.

Research Article: Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis. Hadad S., Vaidya J., Koh H., Heron T., Thompson A., 2007.
World J Surg. 2007 Jun;31(6):1298-01; discussion 1302-3. Erratum in: World J Surg. 2008 Dec;32(12):2747. Hussain, Kashif [added].  PMID: 17483986.

Review Article: Targeting AMPK: a new therapeutic opportunity in breast cancer. Hadad SM, Fleming S., Thompson AM. July 2008.  67 (2008) 1–7. Crit Rev Oncol Hematol. 2008 Jul;67(1):1-7. doi: 10.1016/j.critrevonc.2008.01.007. Epub 2008 Mar 14. Review.  PMID: 18343152

Letters to Editors:
Comparison of 30-day and in-hospital postoperative mortality for eight different cancer types. Ganti S, Hadad S on behalf of Sheffield Surgical Journal Club. Br J Surg. 2012 Nov;99(11):1602; author reply 1602-3. doi: 10.1002/bjs.8948. PMID: 23027083

Perforated appendicitis in children. Al-Rawashdeh F and Hadad S on behalf of Sheffield Surgical Journal Club. J Am Coll Surg. 2012 Sep;215(3):442-3; author reply 443-4. doi: 10.1016/j.jamcollsurg. 2012.06.016.  PMID: 22901516

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer mode. Hadad SM, Appleyard V, Thompson AM. Breast Cancer Res Treat. 2009 Mar;114(2):391. doi: 10.1007/s10549-008-0016-3. Epub 2008 Apr18.  PMID: 18421577.

Book chapters:

Oncoplastic and Reconstructive Surgery of the Breast, Third Edition, 2016. Co-author with Mrs Jennifer Rusby in 2 chapters: Incisions for nipple-sparing mastectomy. Nipple-sparing in breast ptosis

Oxford Textbook of General Surgery, Breast Section, Epidemiology and Prognosis Chapter.

Book review:

Hadad S., 2007.  Book Review: Recent Advances in Surgery 30. The Surgeon – Journal of the Royal College of Surgeons of Edinburgh and Ireland.  August 2007.  5(4), p.253.

Presentations:

Poster presentation at the ABS 2020.  Title: Lymphoscintigraphy rationalises repeat nodal staging in recurrent breast cancer: a case series. Authors: Daniel Glassman, Natalie Hirst, Nour Al-Shurbasi, Victoria Fung, Sirwan Hadad, Loaie Maraqa, Stan Kohlhardt.

Poster presentation at the ABS 2020. Title: Do expected benign breast pathologies require a follow-up clinic appointment? Authors: Shirley Crawford, Claire Mills, Emma Wright, Sirwan Hadad.

Poster presentation at SABCS, Dec. 2019: Predictors of non-sentinel node positivity in operable primary breast cancer. Authors: Sam Jenkins, Julia Edwards, Nabilah Najib, Joni Tan, Sirwan Hadad.

Poster presentation at the Association of Breast Surgery (ABS) Conference, June 2019, Glasgow, UK.  Title: The unexpected unpleasant surprise: Malignancy on histopathology following duct excision surgery: is it avoidable? Authors: Al-Shurbasi NH, Cartlidge CWJ, Kohlhardt SR. Hadad SM.

Poster presentation at the Association of Breast Surgery (ABS) Conference, June 2018, Birmingham, UK.  Title: The rate of un-necessary axillary node clearance and predictors of level 3 disease.Authors: Sam Jenkins, Joni Tan, Nabilah Najib, Stan Kohlhardt, Sirwan Hadad.

Oral presentation at SABCS, Dec. 2014, San Antonio, Texas.  Title: Preoperative window of opportunity study of the PI3K inhibitor pictilisib (GDC-0941) plus anastrozole vs anastrozole alone in patients with ER+, HER2-negative operable breast cancer (OPPORTUNE study). Authors: Schmid P, Pinder SE, Wheatley D, Macaskill J, Zammit C, Hu J, Price R, Bundred N, Hadad S, Shia A, Lim L, Sarker S-J, Gazinska P, Woodman N, Korbie D, Trau M, Mainwaring P, Parker P, Purushotham A, Thompson AM. 

BJS prize for oral presentation at British Association of Endocrine and Thyroid Surgeons Annual Scientific Conference, Oct 2014, Liverpool, UK.  EJSO, Volume 40, Supplement 1, 9 Oct 2014, Pages S3-S4. Title: Investigating the role of metformin in thyroid cancer.  Authors: Safar Kheder, Sirwan Hadad, Karen Sisley, Saba Balasubramanian.

Invited speaker for the 34th Congress of the European Society of Surgical Oncology in partnership with BASO, Oct 2014, Liverpool, UK.  Title: Promising clinical trial by a FLIMS fellow – oral presentation. 

Poster presentation, Association of Breast Surgery, May 2014, Liverpool, UK.  Title: Reoperation rates for cavity shaves following breast conserving surgery.  Authors: S.M.Hadad, V.P.Chandran, M.W.Reed.

Oral presentation, British Breast Group, January 2014, York, UK.  Title: A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential biopsies of primary, untreated breast cancer.
Authors: S.M.Hadad, L. Jordan, PG Roy, C. Purdie, T. Iwamoto, S. Bray, L. Pusztai, SM. Thompson, J.M.Dewar, A.M.Thompson.

Poster Discussion, San Antonio Breast Cancer Symposium, Dec. 2012, San Antonio, Texas. Title: Evidence for the anti-cancer action of metformin mediated via tumour AMPK, Akt and Ki67 in a preoperative window-of-opportunity trial.  Hadad SM, Authors: Dowling RJO, Chang MC, Done SJ. Purdie CA, Jordan LB, Dewar J, Goodwin PJ, Stambolic V, Thompson AM.

Oral presentation, Yorkshire Annual Breast Education Meeting, Nov 2011, Rotherham, UK. Title: Metformin and breast cancer: current evidence and the way forward.

Poster discussion, ASCO annual meeting, May 2011.  Chicago, USA.  J Clin Oncol 29: 2011 (suppl; abstr 534).  Title: Final analysis of the NEOMET trial of neoadjuvant metformin: Examining effects on Ki67, gene expression, and pathway analysis in primary operable breast cancer. Authors: A. M. Thompson, T. Iwamoto, L. Jordan, C. Purdie, S. E. Bray, L. Baker, G. Hardie, L. Pusztai, S. L. Moulder, J. A. Dewar, S. M. Hadad.

Poster presentation: San Antonio Breast Cancer Symposium, December 2009, Texas, USA. Title: The effect of neo-adjuvant metformin on breast cancer in a clinical trial – results from the pilot phase. Authors: Hadad SM, Dewar JA, Elseedawy E, Jordan L, Bray S, Morris A, Thompson AM.

Poster presentation: National Cancer Research Institute Annual Scientific Conference, October 2008, Birmingham, UK. Title: A-769662 is an AMPK – dependant growth inhibitor in breast cancer cell lines.
Authors: Hadad SM, Appleyard V, Murray K, L Baker, Huang X, Alessi D, Thompson AM.

Poster presentation: ASCO breast cancer symposium, September 2008, Washington DC, USA. Title: A-769662 is an AMPK – dependant growth inhibitor in breast cancer cell lines. Authors: Hadad SM, Appleyard V, Murray K, L Baker, Huang X, Alessi D, Thompson AM.

Poster presentation: San Antonio Breast Cancer Symposium, December 2007, Texas, USA. Title: Identification of IGFBP4 as a marker of tamoxifen failure in primary breast cancer. Authors: S. Hadad, K. Robertson, L. Baker, C. Purdie, L. Jordan, J. Vendrell, P. Cohen, A. Thompson.

Poster presentation: National Cancer Research Institute Annual Scientific Conference, October 2007, Birmingham, UK. Title: Her2 and AMPK prognostic and therapeutic potential in primary breast cancer.
Authors: S. Hadad, S. Fleming, K. Robertson, L. Baker, A. Thompson.

Oral presentation: University of Dundee Postgraduate Symposium, June 2007, Dundee, UK. Title: AMPK and breast cancer.

Nominated Poster of Distinction, ASGBI Conference, 18-20 April 2007, Manchester, UK. Title: Her2, PTEN and AMPK prognostic and therapeutic potential in breast cancer. Authors: S. Hadad, S. Fleming, K. Robertson, L. Baker, A. Thompson.

Oral Presentation at the British Journal of Surgery Prize Session, 7th World Congress of the International Hepato-Pancreato-Biliary Association, 10th Annual Meeting of the Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland.  September 2006.  Edinburgh, UK. Title: Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy in acute cholecystitis. Authors: S M Hadad, J S Vaidya, H C Koh, T P Heron, A M Thompson.