Professional background

Professor David Williams is a consultant obstetric physician who specialises in the clinical management of pregnant women with underlying medical disorders and gestational syndromes. He provides a clinical service for pregnant women with general medical disorders and leads multi-disciplinary clinics for pregnant women with kidney disease and hypertension, rheumatological disorders, liver and gastro-intestinal disease and neurological conditions. He works closely with haematologists, virologists and cardiologists in other pregnancy clinics.

Professor Williams led the development of NICE guidelines for the management of medical disorders during childbirth and was an expert member of the NICE Guideline on The Management of Hypertension in Pregnancy. He is a member of the UK Independent Advisory Group on maternal and neonatal morbidity and mortality and past chairman of the UK Obstetric Medicine Society.

His research team investigates the causes and management of gestational syndromes including pre-eclampsia, acute fatty liver of pregnancy, chronic histiocytic intervillositis (CHI), and the long-term consequences of gestational syndromes on the mother’s future health. He leads an MRC-funded project investigating the role of paternal obesity on fetal growth. His team is also funded by the UCL/UCLH Biomedical Research Centre, the Rosetrees Trust, Wellbeing of Women and partnerships with industry. He is chairman of the Wellbeing of Women Research Advisory Committee.

Research interests

  • Pre-eclampsia
  • Acute fatty liver of pregnancy
  • Chronic istiocytic Intervillositis
  • Intergenerational inheritance of acquired traits
  • Fetal growth
  • Maternal longterm postpartum health


Recent Publications:

1. Åsenius F, Gorrie-Stone TJ, Brew A, Panchbhaya Y, Williamson E, Schalkwyk LC, Rakyan VK, Holland ML, Marzi SJ, Williams DJ. The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations. Plos Genetics 2020

2. Bos M, Harris-Mostert E.T.M.S, van der Meeren L.E, Baelde J.J, Williams D.J, Nikkels P.G.J, Bloemenkamp K.W.M, van der Hoorn M.L.P. Clinical outcomes in chronic intervillositis of unknown etiology. Placenta 2020; 91: 19-23

3. Serrano NC, Quintero-Lesmes DC, Dudbridge F, Leon LJ, Hingorani AD, Williams DJ, Casas JP. Family History of Pre-Eclampsia and Cardiovascular Disease as risk factors for Pre-Eclampsia: the GenPE Case-Control Study. Hypertension in Pregnancy 2020; 39: 56-63

4. Ahmed AS, Williams DJ, Cheed V, Middleton L, Ahmad S, Wang K, Vince AT, Hewett P, Spencer K, Khan KS, Daniels JP for the StAmP trial collaborative group. Pravastatin for early-onset preeclampsia: a randomized, blinded, placebo-controlled trial. BJOG: An International Journal of Obstetrics & Gynaecology 2020; 127: 478-488

5. Williams DJ. Renal Disease in Pregnancy. The Oxford Textbook of Obstetrics and Gynaecology. Eds, Arulkumaran S, Ledger W, Denny L and Doumouchtsis S. 2020. Chapter 14; Edition 1. ISBN: 9780198766360

6. Williams DJ. Physiological changes of normal pregnancy. In Oxford Textbook of Medicine (6th edition), 2020. Eds, Firth JD, Conlon C, Cox TM, Oxford University Press, Oxford, 14.1: DOI: 10.1093/ med/9780198746690.003.0263

7. Williams DJ. Nutrition in Pregnancy. In Oxford Textbook of Medicine (6th edition), 2020. Eds, Firth JD, Conlon C, Cox TM. Oxford University Press, Oxford, 14.2: DOI: 10.1093/med/ 9780198746690.003.0264

8. Williams DJ. Medical Management of normal pregnancy. In Oxford Textbook of Medicine (6th edition), 2020. Eds, Firth JD, Conlon C, Cox TM. Oxford University Press, Oxford, 14.3: DOI: 10.1093/med/9780198746690.003.0265

9. Cohen H, Cuadrado MJ, Erkan D, Duarte Garcia A, Isenberg D, Knight J, Ortel T, Rahman A, Salmon J, Tektonidou M, Williams D, Willis R, Woller S, de Andrade D. 16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends. Lupus (2020 in press)