Professional background

Consultant histopathologist and professor of gastrointestinal pathology

Research interests

  • Colorectal tumorigenesis
  • Barrett's oesophagus
  • Inflammatory bowel disease
  • Gastrointestinal stromal tumours


Selected publications:
M R Novelli, J A Williamson, I P M Tomlinson, G Elia, S V Hodgson, I C Talbot, W F Bodmer & N A Wright.  Polyclonal Origin of Colonic Adenomas in an XO/XY Patient with FAP.  Science 1996 272: 1187-1190.

M R Novelli, H Wasan, I P M Tomlinson, I Rosewell, J Bee, N A Wright & W F Bodmer.  Polyp number and clonality in Min mouse aggregation chimaeras.  PNAS 1999 96(22):12553-8.
J Tkalcevic, M R Novelli, M Phylactides, J P Iredale, A W Segal & J Roes.  Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.  Immunity 2000 12:201-210.

Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J & Wright NA. Hepatocytes from non-hepatic adult stem cells.
Nature 2000 406(6793):257.

M Novelli, A Cossu, D Oukrif, A Quaglia, S Lakhani, R Poulsom, P Sasieni, P Carta, Marcella Contini?, Anna Pasca, G Palmieri, W Bodmer, F Tanda and N Wright.  X-inactivation patch size in human female tissue confounds the assessment of tumour clonality.  PNAS 2003;100(6):3311-4.

S L Preston, SJ Leedham, D Oukrif, M Deheregoda, RA Goodlad,  R Poulson, MR Alison, N A Wright and M Novelli.  The development of duodenal microadenomas in FAP Patients: the human correlate of the Min mouse  J Pathol 2008;214(3):294-301.

McDonald SA, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M,  Leedham SJ, Taylor RW, Lee CY, Preston SL, Lovell M, Hunt T, Elia G, Oukrif D, Harrison R, Novelli MR, Mitchell I, Stoker D, Turnbull D, Jankowski JAZ & Wright NA. Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells.  Gastroenterology 2008;134(2):500-10.
Leedham SJ, Graham TA, Oukrif D, McDonald SA, Rodriguez-Justo M, Harrison RF, Shepherd NA, Novelli MR, Jankowski JA, Wright NA.  Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.  Gastroenterology. 2009 Feb;136(2):542-50

Saadi A, Shannon NB, Lao-Sirieix P, O'Donovan M, Walker E, Clemons NJ, Hardwick JS, Zhang C, Das M, Save V, Novelli M, Balkwill F, Fitzgerald RC.  Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers.  PNAS 2010 Feb 2;107(5):2177-82.

Thirlwell C, Will OC, Domingo E, Graham TA, McDonald SA, Oukrif D, Jeffrey R, Gorman M, Rodriguez-Justo M, Chin-Aleong J, Clark SK, Novelli MR, Jankowski JA, Wright NA, Tomlinson IP, Leedham SJ.  Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. 
Gastroenterology. 2010 Apr;138(4):1441-54.

Novelli M, Rossi S, Rodriguez-Justo M, Taniere P, Seddon B, Toffolatti L, Sartor C, Hogendoorn PC, Sciot R, Van Glabbeke M, Verweij J, Blay JY, Hohenberger P, Flanagan A, Dei Tos AP.  DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours.  Histopathology. 2010 Aug;57(2):259-70.

Graham TA, Humphries A, Sanders T, Rodriguez-Justo M, Tadrous PJ, Preston SL, Novelli M, Leedham SJ, McDonald SA, Wright NA.  Use of Methylation Patterns to Determine Expansion of Stem Cell Clones in Human Colon Tissue. Gastroenterology. 2010 Dec 28. [Epub ahead of print]

Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M, Leedham SJ, Novelli MR, Gay LJ, Ventayol-Garcia T, Green A, Mitchell I, Stoker DL, Preston SL, Bamba S, Yamada E, Kishi Y, Harrison R, Jankowski JA, Wright NA, McDonald SA.  The Clonal Origins of Dysplasia From Intestinal Metaplasia in the Human Stomach. Gastroenterology. 2011 Jan 9. [Epub ahead of print]