Professional background

Steve Pereira studied science and medicine at University of New South Wales, Sydney, with postgraduate training in gastroenterology and hepatology mainly at Guy’s and King’s College hospitals, London and advanced endoscopy training in Paris, Amsterdam and Indianapolis. He has been a consultant at University College Hospital since 2000 and at Royal Free Hospital since 2008, and is also a professor of hepatology and gastroenterology at University College London.

His clinical and research interests centre on the causes, early diagnosis and treatment of liver and pancreatic cancer, as well as benign biliary and pancreatic diseases. These conditions represent a significant number of patients referred for specialist opinion to UCLH, and the activity of the research group is linked closely with the clinical hepatopancreaticobiliary service at UCLH and the Royal Free. He is past chairman of the British Society of Gastroenterology Pancreatic Section and President of the Pancreatic Society of GB&I, and current Endoscopy lead on the HPB Board of London Cancer. He also serves on the research committees of the British Society of Gastroenterology and Guts UK.

Research interests

  • Serum biomarkers of pancreaticobiliary malignancy
  • Optical diagnostics and treatment monitoring
  • Cystic tumours of the pancreas
  • Primary sclerosing cholangitis
  • Early diagnosis of pancreatic and biliary tract malignancy
  • Endoscopic ultrasound-guided radiofrequency ablation


Ravì D, Szczotka AB, Pereira SP, Vercauteren T. Adversarial training with cycle consistency for unsupervised super-resolution in endomicroscopy. Med Image Anal 2019; 53: 123-131.

Mohammad GH, Vassileva V, Acedo P, Olde Damink SWM, Malago M, Dhar DK, Pereira SP. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers 2019; 11; 1372.
Saffioti F, Roccarina D, Vesterhus M, Hov JR, Rosenberg W, Pinzani M, Pereira SP, Boberg KM, Thorburn D. Cholangiocarcinoma is associated with a raised enhanced liver fibrosis (ELF) score independent of primary sclerosing cholangitis. Eur J Clin Invest 2019; 49: e13088.

Sheel ARG, Harrison S, Sarantitis I, Nicholson JA, Hanna T, Grocock C, Raraty M, Ramesh J, Farooq A, Costello E, Jackson R, Chapman M, Smith A, Carter R, Mckay C, Hamady Z, Aithal GP, Mountford R, Ghaneh P, Hammel P, Lerch MM, Halloran C, Pereira SP, Greenhalf W. Identification of cystic lesions by secondary screening of familial pancreatic cancer (FPC) kindreds Is not associated with the stratified risk of cancer. Am J Gastroenterol 2019; 114: 155-64.

A, Bhutani MS, Itoi T, Arcidiacono PG, Bories E, Cazacu I, Constantin A, Dietrich CF, Duda DG, Garcia JI, Hocke M, Ignee A, Jenssen C, Jinga M, Khor C, Oppong K, Pereira SP, Petrone M, Santo E, Seicean A, Seo DW, Siyu S, Vilmann P, Waxman I, Yeaton P. Changes in tumor vascularity depicted by contrast-enhanced endoscopic ultrasound as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): Study Protocol. Endosc Ultrasound 2019; 8 235-40.

Wadsworth CA, PH Dixon PH,Taylor-Robinson SD, Kim JU, Zabron AA, Wong JJ, Chapman MH, McKay SC, Spalding DR, Wasan HS, Pereira SP, Thomas HC, Whittaker JC, Williamson C and Khan SA . Polymorphisms in Natural Killer cell receptor protein 2D (NKG2D) as a risk factor for cholangiocarcinoma. J Clin Exp Hepatol 2019; 9: 171-75.

Keane MG, Wehnert N, Perez-Machado M, Fusai GK, Thorburn D, Oppong KW, Carroll N, Metz AJ, Pereira SP. A prospective trial of CONfocal endomicroscopy in CYSTic lesions of the pancreas: CONCYST-01. Endosc Int Open 2019; 7: E1117-22.

Labib PL, Goodchild G, Turbett JP, Skipworth J, Shankar A, Johnson G, Clark S, Latchford A, Pereira SP. Endoscopic ultrasound in the assessment of advanced duodenal adenomatosis in familial adenomatous polyposis. BMJ Open Gastroenterol 2019; 20: e000336.

Eusebi LH, Thorburn D, Toumpanakis C, Frazzoni L, Johnson G, Vessal S, Luong TV, Caplin M, Pereira SP. Endoscopic ultrasound-guided fine-needle aspiration vs fine-needle biopsy for the diagnosis of pancreatic neuroendocrine tumors. Endosc Int Open 2019; 7: E1393-9.

Labib PL, Goodchild G, Pereira SP. Molecular pathogenesis of cholangiocarcinoma. BMC Cancer 2019; 19: 185.

Macias RIR, Kornek M, Rodrigues PM, Paiva NA, Castro RE, Urban S, Pereira SP, Cadamuro M, Rupp C, Loosen SH, Luedde T, Banales JM. Diagnostic and prognostic biomarkers in cholangiocarcinoma. Liver Int 2019; 39 Suppl 1: 108-22.

Ney A, Pereira SP. Acute pancreatitis. Medicine 2019; 47: 241-9.

Hirschfield GM, Dyson JK, Alexander GJM, Chapman MH, Collier J, Hübscher S, Patanwala I, Pereira SP, Thain C, Thorburn D, Tiniakos D, Walmsley M, Webster G, Jones DEJ. The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines. Gut 2018; 67: 1568-94.

Chapman MH, Thorburn D, Hirschfield GM, Webster GJ, Rushbrook SM, Alexander GJ, Collier J, Dyson JK, Jones DE, Patanwala I, Thain C, Walmsley M, Pereira SP. British Society of Gastroenterology and UK-PSC Guidelines for the Diagnosis and Management of Primary Sclerosing Cholangitis. Gut 2019; 68: 1356-78.

Keane MG, Dadds HR, El Sayed G, Luong TV, Davidson BR, Fusai GK, Thorburn D, Pereira SP. Clinical and radiological features that predict malignant transformation in cystic lesions of the pancreas: a retrospective case note review. AMRC Open Research 2020: 1: 4.

Keane MG, Oppong KW, Pereira SP. Response to letter: Endoscopic ultrasound-guided confocal endomicroscopy requires high-quality imaging and interpretation for diagnostic evaluation of pancreatic cystic lesions. Endosc Int Open 2020; 8: E312.

Săftoiu A, Hassan C, Areia M, Bhutani MS, Bisschops R, Bories E, Cazacu IM, Dekker E, Deprez PH, Pereira SP, Senore C, Capocaccia R, Antonelli G, van Hooft J, Messmann H, Siersema PD, Dinis-Ribeiro M, Ponchon T. Role of gastrointestinal endoscopy in the screening of digestive tract cancers in Europe: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy 2020; 52: 293-304.

Szczotka AB, Shakir DI, Ravì D, Clarkson MJ, Pereira SP, Vercauteren T. Learning from irregularly sampled data for endomicroscopy super-resolution: a comparative study of sparse and dense approaches. Int J Comput Assist Radiol Surg 2020; 15: 1167-1175.

Pereira SP, Oldfield L, Ney A, Hart PA, Keane MG, Pandol SJ, Li D, Greenhalf W, Jeon CY, Koay EJ, Almario CV, Halloran C, Lennon AM, Costello E. Early detection of pancreatic cancer. Lancet Gastroenterol Hepatol 2020; 5: 698-710.