Dr Ke Xu
Telephone:
Location:
- University College Hospital
GMC/GDC number:
7006599
Professional background
Dr Xu is a consultant haematologist with a specialist interest in diagnostic haematology and myeloma. She completed a MD (Doctorate of Medicine) in 2004. She was appointed as postdoc research associate at NYU-Hopsital for joint diseases, Duke University Medical Center and Imperial College London between 2005 to 2009. She completed her postgraduate medical training in general medicine in various London hospitals, and haematology traning at Royal Marsden and St. George's Hospital. She was awarded MRCP in 2013 and FRCPath in 2018.
Specialties
Research interests
- Myeloma bone disease
- Diagnostic haematology
Languages spoken
Chinese
Publications
Ersek A, Xu K, Antonopoulos A, Butters TD, Santo AE, Vattakuzhi Y, Williams LM, Goudevenou K, Danks L, Freidin A, Spanoudakis E, Parry S, Papaioannou M, Hatjiharissi E, Chaidos A, Alonzi DS, Twigg G, Hu M, Dwek RA, Haslam SM, Roberts I, Dell A, Rahemtulla A, Horwood NJ, Karadimitris A. Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease. Journal of Clinical Investigation. 2015 Jun; 125(6): 2279-92.
Hu M, Bassett JH, Danks L, Howell PG, Xu K, Spanoudakis E, Kotsianidis I, Boyde A, Williams GR, Horwood N, Roberts IA, Karadimitris A.Activated Invariant NKT Cells Regulate Osteoclast Development and Function. J Immunol. 2011 Mar 1;186(5):2910-7.
Zennadi R, Chien A, Xu K, Batchvarova M, Telen MJ. Sickle Red Cells Induce Adhesion of Naïve Lymphocytes and Monocytes to Endothelium. Blood. 2008 Oct 15;112(8):3474-83.
Zennadi R, De Castro L, Eyler C, Xu K, Ko M, Telen MJ. Role and Regulation of Sickle Red Cell Interactions with Other Cells: ICAM-4 and Other Adhesion Receptors. Transfusion Clinique et Biologique, 2008 Feb-Mar; 15(1-2):23-28.
Zennadi, R., Moeller, B.J., Whalen, E.J., Batchvarova, M., Xu, K., Shan, S.Q., Delahunty, M., Dewhirst, M.W., Telen, M.J.. Epinephrine-Induced Activation of LW-mediated Sickle Cell Adhesion and Vaso-occlusion In Vivo. Blood, 2007 Oct 1; 110(7): 2708-17.
Sun, A.Q., Balasubramaniyan, N., Xu, K., Liu, C.J., Ponamgi, V., Liu, H., Suchy, F.. Protein-Protein Interaction and Membrane Localization of Human Organic Solute Transporter (hOST). AJP-GI, 2007 Jun; 292(6): G1586-93.
Luan, Y., Yu X.P., Xu, K., Ding, B., Yu, J., Huang, Y., Yang, N., Lengyel, P., Di Cesare, P.E., Liu, C.. The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activity. JBC, 2007 June 8; 282(23): 16860-70.
Liu, C.J., Zhang, Y., Xu, K., Parsons, D., Alfonso, D., Di Cesare, P.E.. Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators. Frontiers in Bioscience, May 1, 2007; 12: 3899-3910.
Xu, K., Zhang, Y., Ilalov, K., Carlson, C., Feng, J., Di Cesare, P.E., Liu, C.. COMP Associate with GEP and Potentiates GEP-Stimulated Chondrocyte Proliferation. JBC, 2007 April 13; 282(15):11347-55.
Liu, C.J., Kong, W., Xu, K., Luan, Y., Ilalov, K., Sehgal, B., Yu, S., Howell, R.D., Di Cesare, P.E.. ADAMTS-12 Associates with and Degrades Cartilage Oligomeric Matrix Protein. JBC, 2006 Jun 9;281(23):15800-8.
Liu, C.J., Kong, W., Ilalov, K., Yu, S., Xu, K., Prazak, L., Fajardo, M., Sehgal B., and Di Cesare, P.E. ADAMTS-7: A Novel Metalloproteinase that Directly Binds to and Degrades Cartilage Oligomeric Matrix Protein. FASEB Journal, 2006 May;20(7):988-90.
Xu, K., Song, H.M., Wei, M.. Lipoprotein (a) stimulates cell proliferation, adhesion and migration of cultured human mesangial cells. Chinese Journal of Pediatrics. 2004 Oct; 42(10): 734-6.