Professional background

Adam Rosenthal PhD FRCOG is consultant gynaecologist / lead colposcopist at UCLH. His clinical interests are gynaecological and anal pre-cancers, colposcopy, high-resolution anoscopy, laparoscopic surgery and inherited (familial) gynaecological cancers.

He is also the clinical lead on the UK familial ovarian cancer screening study and medical director of the ALDO project. He is an asociate clinical professor at UCL and has published extensively on screening for gynaecological cancers and their molecular biology, in journals including the Lancet and the Journal of Clinical Oncology.

He is a medical advisor to various charities, including the Eve Appeal and Ovacome. An acknowleged expert on inherited gynaecological cancer, Adam has given interviews on TV and radio on this specialist area.

Research interests

Inherited gynaecological cancers, gynaecological cancer screening, anogenital pre-cancer

Publications

Selected from last five years:

Ovarian and breast cancer risks associated with pathogenic variants in RAD51C and RAD51D. Yang X, Song H, Leslie G, Engel C, Hahnen E, Auber B, Horváth J, Kast K, Niederacher D, Turnbull C, Houlston R, Hanson H, Loveday C, Dolinsky JS, LaDuca H, Ramus SJ, Menon U, Rosenthal AN, et al. J Natl Cancer Inst. 2020 Feb 28:djaa030. doi: 10.1093/jnci/djaa030.

High Resolution Anoscopy Surveillance After Anal Squamous Cell Carcinoma: High-Grade Squamous Intraepithelial Lesion Detection and Treatment May Influence Local Recurrence. Cappello C, Cuming T, Bowring J, Rosenthal AN, Chindawi N, Nathan M.Cappello C, et al. Dis Colon Rectum. 2020;63:1363-1371

The acceptability of high resolution anoscopy examination in patients attending a tertiary referral centre. De-Masi A, Davis E, Cuming T, Chindawi N, Pesola F, Cappello C, Chambers S, Bowring J, Rosenthal AN, Sasieni P, Nathan M. BMC Cancer. 2018;18:554

Performance of Anal Cytology Compared With High-Resolution Anoscopy and Histology in Women With Lower Anogenital Tract Neoplasia. Albuquerque A, Sheaff M, Stirrup O, Cappello C, Bowring J, Cuming T, de Masi A, Rosenthal AN, Nathan M. Clin Infect Dis. 2018 [Epub ahead of print]

Evidence of Stage Shift in Women Diagnosed With Ovarian Cancer During Phase II of the United Kingdom Familial Ovarian Cancer Screening Study. Rosenthal AN, Fraser LSM, Philpott S, Manchanda R, Burnell M, Badman P, Hadwin R, Rizzuto I, Benjamin E, Singh N, Evans DG, Eccles DM, Ryan A, Liston R, Dawnay A, Ford J, Gunu R, Mackay J, Skates SJ, Menon U, Jacobs IJ; United Kingdom Familial Ovarian Cancer Screening Study collaborators. J Clin Oncol. 2017;35:1411-1420 (attracted an accompanying editorial in the same issue)

Media must report celebrity health stories responsibly. Rosenthal AN. BMJ. 2017 Jan 16;356:j192

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women with Ovarian Cancer. Ramus SJ, Song H, Dicks E, Tyrer JP, Rosenthal AN, Intermaggio MP, Fraser L, Gentry-Maharaj A, Hayward J, Philpott S, Anderson C, Edlund CK, Conti D, Harrington P, Barrowdale D, Bowtell DD, Alsop K, Mitchell G; AOCS Study Group, Cicek MS, Cunningham JM, Fridley BL, Alsop J, Jimenez-Linan M, Poblete S, Lele S, Sucheston-Campbell L, Moysich KB, Sieh W, McGuire V, Lester J, Bogdanova N, Dürst M, Hillemanns P; Ovarian Cancer Association Consortium, Odunsi K, Whittemore AS, Karlan BY, Dörk T, Goode EL, Menon U, Jacobs IJ, Antoniou AC, Pharoah PD, Gayther SA. J Natl Cancer Inst. 2015;107(11).

A novel diagnostic index combining HE4, CA125 and age may improve triage of women with suspected ovarian cancer - An international multicenter study in women with an ovarian mass. Karlsen MA, Høgdall EV, Christensen IJ, Borgfeldt C, Kalapotharakos G, Zdrazilova-Dubska L, Chovanec J, Lok CA, Stiekema A, Mutz-Dehbalaie I, Rosenthal AN, Moore EK, Schodin BA, Sumpaico WW, Sundfeldt K, Kristjansdottir B, Zapardiel I, Høgdall CK. Gynecol Oncol. 2015;138:640-6

Sentinel lymph node biopsy in vulval cancer: systematic review and meta-analysis. Meads C, Sutton AJ, Rosenthal AN, Małysiak S, Kowalska M, Zapalska A, Rogozińska E, Baldwin P, Ganesan R, Borowiack E, Barton P, Roberts T, Khan K, Sundar S. Br J Cancer. 2014;110:2837-46

Measuring the nature and duration of symptoms of cervical cancer in young women: developing an interview-based approach. Lim AW, Forbes LJ, Rosenthal AN, Raju KS, Ramirez AJ. BMC Womens Health. 2013;13:45

Imbalance of sex hormones in premenopausal BRCA1/2 mutation-carriers. M Widschwendter*, AN Rosenthal* (*equal contribution), S Philpott, I Rizzuto, L Fraser, J Hayward, S Ramus, S Gayther, L Dubeau, E Fourkala, A Zaikin, U Menon, and IJ Jacobs. Lancet Oncol 2013; 14: 1226-32 (attracted an accompanying editorial in the same issue)

A measurable positive impact on high-grade cervical neoplasia diagnosis from the “Jade Goody Effect”. GM Casey, B Morris, M Burnell, A Parberry, Singh N, AN Rosenthal. Brit J Cancer 2013 2013; 109: 1192-7

Results of Annual Screening in the UK Familial Ovarian Cancer Screening Study (UK FOCSS Phase 1) highlight need for strict adherence to screening schedule. AN Rosenthal, L Fraser, R Manchanda, P Badman, S Philpott, J Mozersky, R Hadwin, FH Cafferty, E Benjamin, N Singh, DG Evans, DM Eccles, SJ Skates, J Mackay, U Menon, IJ Jacobs. J Clin Oncol 2013; 31: 49-57 (attracted an accompanying editorial in the same issue)