Professional background

Dr Zarate-Lopez completed her training in gastroenterology in Barcelona, Spain, awarded by the Universitat Autonoma de Barcelona Autonoma University. Following gastroenterology training, she was awarded the prestigious Canadian Association of Gastroenterology clinical fellowship. Her project integrated basic science and clinical research leading to investigation of the pacemakers of the gut and made the core of her PhD in medicine. She then moved to the UK where she continued further training in neurogastroenterology at St Mark's Hospital, The Royal London Hospital and University College of London.

During her post-CCT training she achieved expertise in most standard, advanced and research gut physiology investigations including upper and lower high-resolution manometry, gastric and rectal barostat, colonic manometry, wireless motility capsule, defecatory proctogram and endoanal ultrasound.

Dr Zarate-Lopez has being a consultant in neurogastroenterology at UCLH and an honorary consultant at Great Ormond Street Hospital since 2017. She runs a specialist outpatient practice receiving more than 400 referrals per annum, including tertiary and quatertiary referrals. She is the point of referral for adolescents with functional/neurogastro disorders for both Great Ormond Street Hospital and the UCLH adolescent team.

Dr Zarate-Lopez has broad experience over the full range of functional and neuromotor gut disorders as well as standard and advanced physiology investigations. In addition, she is interested in diagnostic and therapeutic upper GI endoscopy.

Research interests

Dr Zarate-Lopez is interested in developing new, non-invasive techniques for investigating functional gut disorders with a special interest in the role of MRI functional in evaluating gastric function.

She is also working collaboratively with our expert dieticians and psychologists to improve the multidisciplinal management of patients with complex and severe functional/motility gut disorders.

She is also part of the EDS multidisciplinary team at UCLH working on developing new clinical pathways to improve patient management and investigating mechanisms contributing to gastroenterology symptoms in this cohort of patients.


De Pablo-Fernández E, Passananti V, Zárate-López N, Emmanuel A, Warner T.Colonic transit, high-resolution anorectal manometry and MRI defecography study of constipation in Parkinson's disease. Parkinsonism Relat Disord. 2019;66:195-201.

Fragkos KC, Keetarut K, Cox A, Eady J, Emmanuel AV, Zarate-Lopez N. Joint Hypermobility Syndrome Affects Response to a Low Fermentable Oligosaccharide, Disaccharide, Monosaccharide and Polyol Diet in Irritable Bowel Syndrome Patients: A Retrospective Study. Gastroenterology Res. 2019 Feb;12(1):27-36.

Mari A, Hosadurg D, Martin L, Zarate-Lopez N, Passananti V, Emmanuel A., Adherence with a low-FODMAP diet in irritable bowel syndrome: are eating disorders the missing link? Eur J Gastroenterol Hepatol. 2019 Feb;31(2):178-182.

Tomaselli PJ, Horga A, Rossor AM, Jaunmuktane Z, Cortese A, Blake JC, Zarate-Lopez N, Houlden H, Reilly MM. IGHMBP2 mutation associated with organ-specific autonomic dysfunction. Neuromuscul Disord. 2018

Sanagapalli S, Harrington S, Zarate-Lopez N, Emmanuel A. Posterior Tibial Nerve Stimulation for the Treatment of Fecal Incontinence Following Obstetric Anal Sphincter Injury. Neuromodulation. 2018 Oct;21(7):688-693.

Fragkos KC, Barragry J, Fernando CS, Novelli M, Begent J, Zárate-Lopez N. Severe eosinophilic colitis caused by neuropathic agents in a patient with chronic fatigue syndrome and functional abdominal pain: case report and review of the literature. Z Gastroenterol. 2018 Jun;56(6):573-577.

Sanagapalli S, Neilan L, Lo JYT, Anandan L, Liwanag J, Raeburn A, Athanasakos E, Zarate-Lopez N, Emmanuel A. Efficacy of Percutaneous Posterior Tibial NerveStimulation for the Management of Fecal Incontinence in Multiple Sclerosis: A Pilot Study. Neuromodulation. 2018 Oct;21(7):682-687.

Sanagapalli S, Emmanuel A, Leong R, Kerr S, Lovat L, Haidry R, Banks M, Graham D, Raeburn A, Zarate-Lopez N, Sweis R. Impaired motility in Barrett's esophagus: A study using high-resolution manometry with physiologic challenge.Neurogastroenterol Motil. 2018

Kumar L, Liwanag J, Athanasakos E, Raeburn A, Zarate-Lopez N, Emmanuel AV. Effectiveness of percutaneous tibial nerve stimulation in managing refractory constipation. Colorectal Dis. 2017 Jan;19(1):45-49.

Fragkos KC, Zárate-Lopez N, Frangos CC. What about clonidine for diarrhoea? A systematic review and meta-analysis of its effect in humans. Therap Adv Gastroenterol. 2016 May;9(3):282-301. I